EFFECTIVE UTILIZATION OF FOUNDRY SAND AND GROUND GRANULATED BLAST FURNACE SLAG IN GEOPOLYMER CONCRETE

Nowadays, concrete is most widely used material used in construction industry. Global use of concrete is second after the water utilization. The component of concrete i.e. Cement, Sand, Aggregate, Admixtures are contributing the strength and various properties in concrete but various environmental issues are related with concrete. In which cement leads to affect environment by emission of CO2. Geopolymer concrete is the best example in which total replacement of cement can be done by fly ash and ground granulated blast furnace slag. Geopolymer concrete is a concrete which does not utilize any Portland cement in its production. Waste-foundry sand and Ground granulated blast furnace slag are the by-product of ferrous and nonferrous metal casting industries. Foundries successfully recycle and reuse the sand many times in a foundry in process of mould and core making and after reuse of sand is discarded as waste foundry sand which cannot be again use in casting along with Ground granulated blast furnace slag. In this study an effort is made to found out the effectiveness of used foundry sand as a partial replacement of fine aggregate in geopolymer concrete at various percent. A concrete made by using GGBS, Fly ash replacing cement totally and partially replacement of fine sand by Foundry sand at various replacement level done and the strength of these Geopolymerised foundry sand concrete carried out

INVESTIGATION OF MECHANICAL PROPERTY OF VARIOUS MIX DESIGN IN CONCRETE BY REPLACING FINE SAND WITH FOUNDRY SAND

Nowadays, concrete become most widely used material in construction. The demand of concrete increases day by day. Other way, Foundry sand is the byproduct of Ferrous and Non-Ferrous metal casting foundries where the river sand is used many times for the core and mould production with the binders. After a time these sand become unusual for the core production n called waste foundry sand. In this research paper, replacement of fine sand of concrete is done with the foundry sand, so the disposal problem related with the foundries have to be reduce so minor environmental issues create and the cost of concrete also reduced so with the increase in the strength of concrete by using foundry sand in it. Mix design of M30 and M25 were adopted for the replacement of fine sand. The fine sand has been replaced by foundry sand accordingly at replacement of 10%, 20% & 30% by weight for M-30 and M-25 Grade concrete. Concrete mixtures were produced, tested and compared in terms of different strength and different grade with the conventional concrete. Testing of these samples were carried out to calculate the Compressive strength for 7, 14 and 28 days. As a result, the compressive increased up to 20% addition of used foundry sand in M-30 grade and for M-25 the strength increment noticed at 1% replacement. This research work is anxious with experimental investigation on strength of concrete and optimum percentage of the partial replacement of foundry sand by replacing fine aggregate via 10%, 20%, and 30% with M30 and M-25 Grade. Keeping all this view, the aim of investigation is the behavior of concrete while adding of waste foundry sand with various proportions of various mix in concrete by replacing fine sand using tests on various strength

IDPpred: a new sequence-based predictor for identification of intrinsically disordered protein with enhanced accuracy

Discovery of intrinsically disordered proteins (IDPs) and protein hybrids that contain both intrinsically disordered protein regions (IDPRs) along with ordered regions has changed the sequence–structure–function paradigm of protein. These proteins with lack of persistently fixed structure are often found in all organisms and play vital roles in various biological processes. Some of them are considered as potential drug targets due to their overrepresentation in pathophysiological processes. The major bottlenecks for characterizing such proteins are their occasional overexpression, difficulty in getting purified homogeneous form and the challenge of investigating them experimentally. Sequence-based prediction of intrinsic disorder remains a useful strategy especially for many large-scale proteomic investigations. However, worst accuracy still occurs for short disordered regions with less than ten residues, for the residues close to order–disorder boundaries, for regions that undergo coupled folding and binding in presence of partner, and for prediction of fully disordered proteins. Annotation of fully disordered proteins mostly relies on the far-UV circular dichroism experiment which gives overall secondary structure composition without residue-level resolution. Current methods including that using secondary structure information failed to predict half of target IDPs correctly in the recent Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment. This study utilized profiles of random sequential appearance of physicochemical properties of amino acids and random sequential appearance of order and disorder promoting amino acids in protein together with the existing CIDER feature for the prediction of IDP from sequence input. Our method was found to significantly outperform the existing predictors across different datasets. Communicated by Ramaswamy H. Sarma</p

Acacetin—A simple flavone exhibiting diverse pharmacological activities

Acacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes. A comprehensive overview of the potential therapeutic applications of acacetin was prepared after collating selected peer-reviewed papers, accessed from online scientific databases, specifically PubMed, Web of Science and Scopus. The mechanism of action, dose forms and structure-activity relationships of the molecule are some of the aspects discussed in the review, to facilitate further research and use of this molecule