Una aproximación al expresionismo. Josep Soler:Análisis de «Sonidos de la noche», «Concierto para Clave» y «Le Christ dans la banlieue»

This article is on the language of one of the more reknown and polemic Catalan composers of the 20th Century, this music, featured as by radical expressionism, has provoked the warmest praises by his supporters, and the hashest criticáis by his detractors as well. This discussion, often centered on his personal figure and not on his work, has given as a result a usually wrong perspective about his music, there is shown his work, and the way in which his autor do it, besides (this work, and the way in which his another do it, is shown here), the influence it has from the serial and dodecaphonic world related to the Viennese School, not forgetting its sensitive and aesthetic aspects, this two phases of creation, the serial one, and the actual phase, based on a harmonic system starting from the wagnerian Tristan's chord, compose a strongly drammatic language, otherwise singular in Spanish 20th Century music.Este artículo trata el lenguaje de uno de los compositores catalanes del siglo XX más reconocido y polémico. Su música, de carácter expresionista acérrimo, ha provocado desde los más encendidos elogios por parte de sus defensores hasta las más ásperas críticas de sus detractores. Esa discusión, que a menudo se ha centrado sobre su persona y no sobre su trabajo, nos ha dado una visión a menudo errónea de su música. Aquí se muestra el trabajo y el modo en que el autor lo realiza, junto a la influencia que aquella posee del mundo serial y dodecafónico relacionado con la escuela vienesa, sin olvidar sus aspectos sensorial y estético. Sus dos etapas de creación, la serial y la actual, basada en un sistema armónico que parte del acorde wagneriano del Tristan e Isolda, conforman un lenguaje de enorme dramatismo, por otra parte singular en la música española del siglo XX

Ramón Barce, un compositor entre la vanguardia y un lenguaje personalizado. Análisis de Canadá trío y la Sinfonía número 3

Ramón Barce, there is no doubt, are one of the more prolific Spanish composers writing about problems surrounding 20th Century music. His thought has influenced to many composers, helping them, indirectly, to take their own compositive way. This article, from the analytical point of view, is about two of his more significant works for his creative corpus, detailing the employed systems for those compositions and their formal development. Since this perspective, this article shows the influence of Barce's collaboration with the more committed new tendencies and with the construction of a personal compositional system, being these two distinctive features which marks the majority of his production.Ramón Barce es, sin duda, uno de los compositores españoles que más ha escrito sobre la problemática de la música del siglo XX. Sus reflexiones han influenciado a un nada despreciable número de compositores a los cuales, indirectamente, ha ayudado a tomar una dirección u otra en su propio proceder compositivo. Este trabajo aborda, desde el área analítica, dos de las obras de mayor trascendencia en su corpus creativo, pormenorizado en los sistemas empleados en aquellas y en su desarrollo formal. Desde esa perspectiva, este trabajo pone de manifiesto la influencia de su participación en las vanguardias más comprometidas y en la elaboración de un sistema compositivo propio, características ambas que marcan la mayor parte de su obra

Detecting Airborne Mercury by Use of Palladium Chloride

Palladium chloride films have been found to be useful as alternatives to the gold films heretofore used to detect airborne elemental mercury at concentrations of the order of parts per billion (ppb). Somewhat more specifically, when suitably prepared palladium chloride films are exposed to parts-per-billion or larger concentrations of airborne mercury, their electrical resistances change by amounts large enough to be easily measurable. Because airborne mercury adversely affects health, it is desirable to be able to detect it with high sensitivity, especially in enclosed environments in which there is a risk of leakage of mercury from lamps or other equipment. The detection of mercury by use of gold films involves the formation of gold/mercury amalgam. Gold films offer adequate sensitivity for detection of airborne mercury and could easily be integrated into an electronic-nose system designed to operate in the temperature range of 23 to 28 C. Unfortunately, in order to regenerate a gold-film mercury sensor, one must heat it to a temperature of 200 C for several minutes in clean flowing air. In preparation for an experiment to demonstrate the present sensor concept, palladium chloride was deposited from an aqueous solution onto sets of gold electrodes and sintered in air to form a film. Then while using the gold electrodes to measure the electrical resistance of the films, the films were exposed, at a temperature of 25 C, to humidified air containing mercury at various concentrations from 0 to 35 ppb (see figure). The results of this and other experiments have been interpreted as signifying that sensors of this type can detect mercury in room-temperature air at concentrations of at least 2.5 ppb and can readily be regenerated at temperatures <40 C

The transcription factor PU.1 is involved in macrophage proliferation

PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a decrease in proliferation compared with controls. In contrast, bone marrow macrophages transfected with a sense PU.1 expression construct displayed enhanced macrophage colony- stimulating factor (M-CSF)-dependent proliferation. Interestingly, there was no effect of sense or antisense constructs of PU.1 on the proliferation of the M-CSF-independent cell line, suggesting that the response was M-CSF dependent. This was further supported by the finding that macrophages transfected with a sense or an antisense PU.1 construct showed, respectively, an increased or a reduced level of surface expression of receptors for M-CSF. The enhancement of proliferation seems to be selective for PU.1, since transfections with several other members of the ets family, including ets-2 and fli-1, had no effect. Various mutants of PU.1 were also tested for their ability to affect macrophage proliferation. A reduction in macrophage proliferation was found when cells were transfected with a construct in which the DNA-binding domain of PU.1 was expressed. The PEST (proline-, glutamic acid-, serine-, and threonine-rich region) sequence of the PU.1 protein, which is an important domain for protein-protein interactions in B cells, was found to have no influence on PU.1- enhanced macrophage proliferation when an expression construct containing PU.1 minus the PEST domain was transfected into bone marrow- derived macrophages. In vivo, PU.1 is phosphorylated on several serine residues. The transfection of plasmids containing PU.1 with mutations at each of five serines showed that only positions 41 and 45 are critical for enhanced macrophage proliferation. We conclude that PU.1 is necessary for the M-CSF-dependent proliferation of macrophages. One of the proliferation-relevant targets of this transcription factor could be the M-CSF receptor

Writer's positioning in literature reviews in English and Spanish computing doctoral theses

Making appropriate reference to other texts is an essential feature of successful academic writing (Hyland, 2000; Myers, 1990). Writers are expected to integrate others' ideas into their arguments to indicate what is already known about the area of study of the discipline, or to point out weaknesses, aligning themselves with a particular disciplinary framework (Thompson & Tribble, 2001). Literature reviews (LRs) of PhD theses provide support for the writer's position and show the novelty of her/his work. This study analysed the resources of evaluation at both rhetorical and linguistic levels used by the writers of 20 PhD LRs in computing in English and Spanish. The data reveal that the Spanish and the English PhD LRs have a similar rhetorical structure. However, the English writers use more strategies for the development of each move than the Spanish writers. Attitude markers are the most usual devices doctoral writers use to express opinion in both sets. Epistemic modality and a variety of discourse-based markers are typically found in the English LRs while the Spanish LRs seem to rely mainly on adversatives and certainty markers. Differences respond partly to individual writing styles, but also reflect rhetorical variation in the relationship with the audience. © 2014 Elsevier Ltd. All rights reservedGil Salom, ML.; Soler Monreal, C. (2014). Writer's positioning in literature reviews in English and Spanish computing doctoral theses. Journal of English for Academic Purposes. 16:23-39. doi:10.1016/j.jeap.2014.08.002S23391

Effect of renin-angiotensin-aldosterone system blockade in adults with diabetes mellitus and advanced chronic kidney disease not on dialysis : a systematic review and meta-analysis

The presumed superiority of renin-angiotensin-aldosterone system (RAAS)-blocking agents over other antihypertensive agents in patients with diabetes to delay development of end-stage kidney disease (ESKD) has recently been challenged. In addition, there is ongoing uncertainty whether RAAS-blocking agents reduce mortality and/or delay ESKD in patients with diabetes and chronic kidney disease (CKD) stages 3-5. In this subgroup, there might be an expedited need for renal replacement therapy (RRT) when RAAS-blocking agents are used. We conducted a meta-analysis of randomized controlled trials (RCTs) of at least 6-months duration in adult patients with diabetes who also have non-dialysis CKD stages 3-5. RCTs comparing single RAAS-blocking agents to placebo or alternative antihypertensive agents were included. Outcomes of interest were allcause mortality, cardiovascular morbidity, progression of renal function, ESKD and adverse events. A total of nine trials (n = 9797 participants with CKD stages 3-5) fit our inclusion criteria. There was no difference between the RAAS group and control group regarding all-cause mortality {relative risk [RR] = 0.97 [95% confidence interval (CI) 0.85-1.10]}, cardiovascular mortality [RR = 1.03 (95% CI 0.75-1.41)] and adverse events [RR = 1.05 (95% CI 0.89-1.25)]. There was a trend for a favourable effect for non-fatal cardiovascular events [RR = 0.90 (95% CI 0.81-1.00)] and a lower risk of the composite endpoint need for RRT/doubling of serum creatinine [RR = 0.81 (95% CI 0.70-0.92)] in the RAAS-blocking agents group versus the control group. We found evidence that in patients with diabetes mellitus and CKD stages 3-5, treatment with RAAS-blocking agents did not result in a clear survival advantage. The effect on renal outcomes did depend on the selected outcome measure. However, we did not find evidence that the use of RAAS-blocking agents expedited the need for RRT in patients with CKD stages 3-5

Real-time navigation by fluorescence-based enhanced reality for precise estimation of future anastomotic site in digestive surgery.

Fluorescence-based enhanced reality (FLER) is a technique to evaluate intestinal perfusion based on the elaboration of the Indocyanine Green fluorescence signal. The aim of the study was to assess FLER's performances in evaluating perfusion in an animal model of long-lasting intestinal ischemia. An ischemic segment was created in 18 small bowel loops in 6 pigs. After 2 h (n = 6), 4 h (n = 6), and 6 h (n = 6), loops were evaluated clinically and by FLER to delineate five regions of interest (ROIs): ischemic zone (ROI 1), presumed viable margins (ROI 2a-2b), and vascularized areas (3a-3b). Capillary lactates were measured to compare clinical vs. FLER assessment. Basal (V 0 ) and maximal (V max) mitochondrial respiration rates were determined according to FLER. Lactates (mmol/L) at clinically identified resection lines were significantly higher when compared to those identified by FLER (2.43 ± 0.95 vs. 1.55 ± 0.33 p = 0.02) after 4 h of ischemia. Lactates at 2 h at ROI 1 were 5.45 ± 2.44 vs. 1.9 ± 0.6 (2a-2b; p &lt; 0.0001) vs. 1.2 ± 0.3 (3a-3b; p &lt; 0.0001). At 4 h, lactates were 4.36 ± 1.32 (ROI 1) vs. 1.83 ± 0.81 (2a-2b; p &lt; 0.0001) vs. 1.35 ± 0.67 (3a-3b; p &lt; 0.0001). At 6 h, lactates were 4.16 ± 2.55 vs. 1.8 ± 1.2 vs. 1.45 ± 0.83 at ROI 1 vs. 2a--2b (p = 0.013) vs. 3a-3b (p = 0.0035). Mean V 0 and V max (pmolO2/second/mg of tissue) were significantly impaired after 4 and 6 h at ROI 1 (V 0 (4h) = 34.83 ± 10.39; V max (4h) = 76.6 ± 29.09; V 0 (6h) = 44.1 ± 12.37 and V max (6h) = 116.1 ± 40.1) when compared to 2a--2b (V 0 (4h) = 67.1 ± 17.47 p = 0.00039; V max (4h) = 146.8 ± 55.47 p = 0.0054; V 0 (6h) = 63.9 ± 28.99 p = 0.03; V max (6h) = 167.2 ± 56.96 p = 0.01). V 0 and V max were significantly higher at 3a-3b. FLER may identify the future anastomotic site even after repetitive assessments and long-standing bowel ischemia

Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial.

BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamous NSCLC. We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.MethodsWe did an open-label, randomised, phase 3 trial of adult patients (aged ≥18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and who had completely resected stage IB (≥4 cm) to IIIA (defined by the American Joint Committee on Cancer 6th edition) NSCLC. We enrolled patients from across the US National Clinical Trials Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) affiliates in Europe and from the Canadian Cancer Trials Group, within 6-12 weeks of surgery. The chemotherapy regimen for each patient was selected before randomisation and administered intravenously; it consisted of four 21-day cycles of cisplatin (75 mg/m2 on day 1 in all regimens) in combination with investigator's choice of vinorelbine (30 mg/m2 on days 1 and 8), docetaxel (75 mg/m2 on day 1), gemcitabine (1200 mg/m2 on days 1 and 8), or pemetrexed (500 mg/m2 on day 1). Patients in the bevacizumab group received bevacizumab 15 mg/kg intravenously every 21 days starting with cycle 1 of chemotherapy and continuing for 1 year. We randomly allocated patients (1:1) to group A (chemotherapy alone) or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy regimen, stage of disease, histology, and sex. No one was masked to treatment assignment, except the Data Safety and Monitoring Committee. The primary endpoint was overall survival, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00324805.FindingsBetween June 1, 2007, and Sept 20, 2013, 1501 patients were enrolled and randomly assigned to the two treatment groups: 749 to group A (chemotherapy alone) and 752 to group B (chemotherapy plus bevacizumab). 383 (26%) of 1458 patients (with complete staging information) had stage IB, 636 (44%) had stage II, and 439 (30%) had stage IIIA disease (stage of disease data were missing for 43 patients). Squamous cell histology was reported for 422 (28%) of 1501 patients. All four cisplatin-based chemotherapy regimens were used: 377 (25%) patients received vinorelbine, 343 (23%) received docetaxel, 283 (19%) received gemcitabine, and 497 (33%) received pemetrexed. At a median follow-up of 50·3 months (IQR 32·9-68·0), the estimated median overall survival in group A has not been reached, and in group B was 85·8 months (95% CI 74·9 to not reached); hazard ratio (group B vs group A) 0·99 (95% CI 0·82-1·19; p=0·90). Grade 3-5 toxicities of note (all attributions) that were reported more frequently in group B (the bevacizumab group) than in group A (chemotherapy alone) were overall worst grade (ie, all grade 3-5 toxicities; 496 [67%] of 738 in group A vs 610 [83%] of 735 in group B), hypertension (60 [8%] vs 219 [30%]), and neutropenia (241 [33%] vs 275 [37%]). The number of deaths on treatment did not differ between the groups (15 deaths in group A vs 19 in group B). Of these deaths, three in group A and ten in group B were considered at least possibly related to treatment.InterpretationAddition of bevacizumab to adjuvant chemotherapy did not improve overall survival for patients with surgically resected early-stage NSCLC. Bevacizumab does not have a role in this setting and should not be considered as an adjuvant therapy for patients with resected early-stage NSCLC.FundingNational Cancer Institute of the National Institutes of Health

High concentration PV system

The aim of the European funded project HICON (High Concentration PV Power Systems) has been to develop, set up and test a new high concentration – 1000x or more – PV system. This system uses an actively cooled large-area receiver consisting of III-V solar cells. Two technology fields have been integrated: The high concentration of the sunlight has been obtained by using technologies experienced in solar thermal systems like parabolic dishes or tower systems. The high concentration photovoltaic receiver is based on the III-V solar cell technology. To deal with the high concentration, Monolithic Integrated Modules (MIMs) [1-3] have been further developed and assembled to Compact Concentrator Modules (CCM). The CCM prototypes have been tested in a solar furnace (PSA) and in a parabolic dish (BGU). The results of the project will be presented in this paper.peer-reviewe