Metastasis Suppressors and the Tumor Microenvironment

The most dangerous attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and extracellular molecules. This brief review explores how a new class of molecules – metastasis suppressors – regulate tumor cell–microenvironmental interactions. Data are presented which demonstrate that metastasis suppressors act at multiple steps of the metastatic cascade. A brief discussion for how metastasis suppressor regulation of cellular interactions might be exploited is presented

Laser-induced crystalline optical waveguide in glass fiber format

We report on the first fabrication of a glass fiber based laserinduced crystalline waveguide. The glass and crystal are based on the stoichiometric composition of (La,Yb)BGeO5. A laser induced waveguide has been fabricated on the surface of a ribbon glass fiber using milliwatt-level continuous wave UV laser radiation at a fast scanning speed. Evidence of crystallinity in the created structure was observed using micro-Raman spectroscopy and scanning electron microscopy. Preliminary investigations on the waveguiding behavior and the nonlinear performance in the crystalline waveguide are reported.<br/