Flight test of a decoupler pylon for wing/store flutter suppression

The decoupler pylon is a NASA concept of passive wing-store flutter suppression achieved by providing a low store-pylon pitch frequency. Flight tests were performed on an F-16 aircraft carrying on each wing an AIM-9J wingtip missile, a GBU-8 bomb near midspan, and an external fuel tank. Baseline flights with the GBU-8 mounted on a standard pylon established that this configuration is characterized by an antisymmetric limited amplitude flutter oscillation within the operational envelope. The airplane was then flown with the GBU-8 mounted on the decoupler pylon. The decoupler pylon successfully suppressed wing-store flutter throughout the flight envelope. A 37-percent increase in flutter velocity over the standard pylon was demonstrated. Maneuvers with load factors to 4g were performed. Although the static store displacements during maneuvers were not sufficiently large to be of concern, a store pitch alignment system was tested and performed successfully. One GBU-8 was ejected demonstrating that weapon separation from the decoupler pylon is normal. Experience with the present decoupler pylon design indicated that friction in the pivoting mechanism could affect its proper functioning as a flutter suppressor

Flight test of passive wing/store flutter suppression

Flight tests were performed on an F-16 airplane carrying on each wing an AIM-9J wingtip missile, a GBU-8 bomb near midspan, and an external fuel tank. Baseline flights with the GBU-8 mounted on a standard pylon established that this configuration is characterized by an antisymmetric limited amplitude flutter oscillation within the operational envelope. The airplane was then flown with GBU-8 mounted on the decoupler pylon. The decoupler pylon is a NASA concept of passive wing-store flutter suppression achieved by providing a low store-pylon pitch frequency. The decoupler pylon successfully suppressed wing-store flutter throughout the flight envelope. A 37 percent increase in flutter velocity over the standard pylon was demonstrated. Maneuvers with load factors to 4g were performed. Although the static store displacements during maneuvers were not sufficiently large to be of concern, a store pitch alignment system was tested and performed successfully. One GBU-8 was ejected demonstrating that weapon separation from the decoupler pylon is normal

Transonic steady- and unsteady-pressure measurements on a high-aspect-ratio supercritical-wing model with oscillating control surfaces

A supercritical wing with an aspect ratio of 10.76 and with two trailing-edge oscillating control surfaces is described. The semispan wing is instrumented with 252 static orifices and 164 in situ dynamic-pressure gages for studying the effects of control-surface position and motion on steady- and unsteady-pressures at transonic speeds. Results from initial tests conducted in the Langley Transonic Dynamics Tunnel at two Reynolds numbers are presented in tabular form

Transonic unsteady airloads on an energy efficient transport wing with oscillating control surfaces

An aspect ratio 10.8 supercritical wing with oscillating control surfaces is described. The wing is instrumental with 252 static orifices and 164 in situ dynamic pressure transducers for studying the effects of control surface deflection on steady and unsteady pressures at transonic speeds. Results from initial wind tunnel tests conducted in the Langley Transonic Dynamics Tunnel are discussed. Unsteady pressure results are presented for two trailing edge control surfaces oscillating separately at the design Mach number of 0.78. Some experimental results are compared with analytical results obtained by using linear lifting surface theory

Ground vibration test of an F-16 airplane with modified decoupler pylons

The decoupler pylon is a passive wing/store flutter suppression device. It was modified to reduce friction following initial flight tests. A ground vibration test was conducted on an F-16 aircraft loaded on each wing with a one-half-full (center bay empty) 370-gallon fuel tank mounted on a standard pylon, a GBU-8 store mounted on the decoupler pylon, and an AIM-9J missile mounted on a wingtip launcher. The test was conducted prior to flight tests with the modified pylon to determine modal frequencies, mode shapes, and structural damping coefficients. Data presented include frequency response plots, mode shape plots, and limited force-effect plots

Ground vibration test of the laminar flow control JStar airplane

A ground vibration test was conducted on a Lockheed JetStar airplane that had been modified for the purpose of conducting laminar flow control experiments. The test was performed prior to initial flight flutter tests. Both sine-dwell and single-point-random excitation methods were used. The data presented include frequency response functions and a comparison of mode frequencies and mode shapes from both methods

Flutter clearance of the horizontal tail of the Bellanca Skyrocket II airplane

The Skyrocket II is an all composite constructed experimental prototype airplane. A flutter clearance program was conducted on the horizontal tail so that the airplane could be safely flown to acquire natural laminar flow aerodynamic data. Ground vibration test data were used in a lifting surface flutter analysis to predict symmetric and antisymmetric flutter boundaries. Subcritical response data which were acquired during flight tests are compared with the analytical results. The final flutter clearance placard speed was based on flight test data

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

Common Variable Immunodeficiency Disorders (CVIDs) are the most prevalent cause of primary antibody failure. CVIDs are highly variable and a genetic causes have been identified in <5% of patients. Here, we performed whole genome sequencing (WGS) of 34 CVID patients (94% sporadic) and combined them with transcriptomic profiling (RNA-sequencing of B cells) from three patients and three healthy controls. We identified variants in CVID disease genes TNFRSF13B, TNFRSF13C, LRBA and NLRP12 and enrichment of variants in known and novel disease pathways. The pathways identified include B-cell receptor signalling, non-homologous end-joining, regulation of apoptosis, T cell regulation and ICOS signalling. Our data confirm the polygenic nature of CVID and suggest individual-specific aetiologies in many cases. Together our data show that WGS in combination with RNA-sequencing allows for a better understanding of CVIDs and the identification of novel disease associated pathways

Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

Breast and ovarian cancers now account for one in three cancers in Indian women and their incidence is rising. Major differences in the clinical presentation of breast and ovarian cancers exist between India and the United Kingdom. For example, Indian patients with breast cancer typically present a decade earlier than in the UK. Reasons for this could be multifactorial, including differences in underlying biology, environmental risks, and other systematic factors including access to screening. One possible explanation lies in variable incidence or penetrance of germline mutations in genes such as BRCA1 and BRCA2. We performed a methodical database and literature review to investigate the prevalence and spectrum of high-risk cancer susceptibility genes in Indian patients with breast and ovarian cancers. We identified 148 articles, but most studies were small, with inconsistent inclusion criteria and based on heterogeneous technologies, so that mutation frequency could not be reliably ascertained. Data were also often lacking on penetrance, histopathology, and survival outcomes. After filtering out unsuitable studies, only 13 remained, comprising 1028 patients. Large-scale research studies are urgently needed to determine mutation prevalence, spectra, and clinico-pathological features, and hence derive guidelines for screening, treatment, and prevention specific to the Indian population

Exposure to vancomycin causes a shift in the microbial community structure without affecting nitrate reduction rates in river sediments

International audienceAntibiotics and antibiotic resistance genes have shown to be omnipresent in the environment. In this study, we investigated the effect of vancomycin (VA) on denitrifying bacteria in river sediments of a Waste Water Treatment Plant, receiving both domestic and hospital waste. We exposed these sediments continuously in flow-through reactors to different VA concentrations under denitrifying conditions (nitrate addition and anoxia) in order to determine potential nitrate reduction rates and changes in sedimentary microbial community structures. The presence of VA had no effect on sedimentary nitrate reduction rates at environmental concentrations, whereas a change in bacterial (16S rDNA) and denitrifying (nosZ) community structures was observed (determined by polymerase chain reaction-denaturing gradient gel electrophoresis). The bacterial and denitrifying community structure within the sediment changed upon VA exposure indicating a selection of a non-susceptible VA population