Gamma-ray Spectral Evolution of NGC1275 Observed with Fermi-LAT

We report on a detailed investigation of the high-energy gamma-ray emission from NGC\,1275, a well-known radio galaxy hosted by a giant elliptical located at the center of the nearby Perseus cluster. With the increased photon statistics, the center of the gamma-ray emitting region is now measured to be separated by only 0.46' from the nucleus of NGC1275, well within the 95% confidence error circle with radius ~1.5'. Early Fermi-LAT observations revealed a significant decade-timescale brightening of NGC1275 at GeV photon energies, with a flux about seven times higher than the one implied by the upper limit from previous EGRET observations. With the accumulation of one-year of Fermi-LAT all-sky-survey exposure, we now detect flux and spectral variations of this source on month timescales, as reported in this paper. The average >100 MeV gamma-ray spectrum of NGC1275 shows a possible deviation from a simple power-law shape, indicating a spectral cut-off around an observed photon energy of E = 42.2+-19.6 GeV, with an average flux of F = (2.31+-0.13) X 10^{-7} ph/cm^2/s and a power-law photon index, Gamma = 2.13+-0.02. The largest gamma-ray flaring event was observed in April--May 2009 and was accompanied by significant spectral variability above E > 1-2 GeV. The gamma-ray activity of NGC1275 during this flare can be described by a hysteresis behavior in the flux versus photon index plane. The highest energy photon associated with the gamma-ray source was detected at the very end of the observation, with the observed energy of E = 67.4GeV and an angular separation of about 2.4' from the nucleus. In this paper we present the details of the Fermi-LAT data analysis, and briefly discuss the implications of the observed gamma-ray spectral evolution of NGC1275 in the context of gamma-ray blazar sources in general.Comment: 20 pages, 6 figures, accepted for publication in the Ap

A strontium isoscape of Italy for provenance studies

We present a novel database of biological and geological 87Sr/86Sr values (n = 1920) from Italy, using literature data and newly analysed samples, for provenance purposes. We collected both bioavailable and non-bioavailable (i.e. rocks and bulk soils) data to attain a broader view of the Sr isotope variability of the Italian territory. These data were used to build isotope variability maps, namely isoscapes, through Kriging interpolations. We employed two different Kriging models, namely Ordinary Kriging and Universal Kriging, with a geolithological map of Italy categorized in isotope classes as external predictor. Model performances were evaluated through a 10-fold cross validation, yielding accurate 87Sr/86Sr predictions with root mean squared errors (RMSE) ranging between 0.0020 and 0.0024, dependent on the Kriging model and the sample class. Overall, the produced maps highlight a heterogeneous distribution of the 87Sr/86Sr across Italy, with the highest radiogenic values (>0.71) mainly localized in three areas, namely the Alps (Northern Italy), the Tuscany/Latium (Central Italy) and Calabria/Sicily (Southern Italy) magmatic/metamorphic terrains. The rest of the peninsula is characterized by values ranging between 0.707 and 0.710, mostly linked to sedimentary geological units of mixed nature. Finally, we took advantage of the case study of Fratta Polesine, to underscore the importance of choosing appropriate samples when building the local isoscape and of exploring different end-members when interpreting the local Sr isotope variability in mobility and provenance studies. Our user-friendly maps and database are freely accessible through the Geonode platform and will be updated over time to offer a state-of-the-art reference in mobility and provenance studies across the Italian landscape

Tomba celtica della fase di romanizzazione dalla località Casona di Nogara (Verona)

The present paper focuses on a Celtic grave from the Romanization phase in Casona di Nogara (Verona). The grave, partially damaged by agricultural works, represents an important funerary documentation in the Verona plain and is thought to belong to the Cenomani culture. The funeral rite is cremation. Among the gravegoods, there remain the weapons, personal tools and elements from the funeral banquet and symposium. The grave is to be dated to the end of the second century BC and the beginning of the first century BC (LT D1)

Flows of people in villages and large centres in Bronze Age Italy through strontium and oxygen isotopes

This study investigates to what extent Bronze Age societies in Northern Italy were permeable accepting and integrating non-local individuals, as well as importing a wide range of raw materials, commodities, and ideas from networks spanning continental Europe and the Mediterranean. During the second millennium BC, the communities of Northern Italy engaged in a progressive stabilization of settlements, culminating in the large polities of the end of the Middle/beginning of the Late Bronze Age pivoted around large defended centres (the Terramare). Although a wide range of exotic archaeological materials indicates that the inhabitants of the Po plain increasingly took part in the networks of Continental European and the Eastern Mediterranean, we should not overlook the fact that the dynamics of interaction were also extremely active on local and regional levels. Mobility patterns have been explored for three key-sites, spanning the Early to Late Bronze Age (1900–1100 BC), namely Sant’Eurosia, Casinalbo and Fondo Paviani, through strontium and oxygen isotope analysis on a large sample size (more than 100 individuals). The results, integrated with osteological and archaeological data, document for the first time in this area that movements of people occurred mostly within a territorial radius of 50 km, but also that larger nodes in the settlement system (such as Fondo Paviani) included individuals from more distant areas. This suggests that, from a demographic perspective, the process towards a more complex socio-political system in Bronze Age Northern Italy was triggered by a largely, but not completely, internal process, stemming from the dynamics of intra-polity networks and local/regional power relationships

High Momentum Probes of Nuclear Matter

We discuss how the chemical composition of QCD jets is altered by final state interactions in surrounding nuclear matter. We describe this process through conversions of leading jet particles. We find that conversions lead to an enhancement of kaons at high transverse momentum in Au+Au collisions at RHIC, while their azimuthal asymmetry v_2 is suppressed.Comment: Contribution to the 4th international workshop High-pT physics at LHC 09, Prague; 6 pages, 6 figure

Assessment of cadmium levels in serum, toenails and diet: A cross sectional study in Modena, Northern Italy.

Assessment of cadmium levels in serum, toenails and diet: A cross sectional study in Modena, Northern Italy

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

The LOFT Ground Segment

LOFT, the Large Observatory For X-ray Timing, was one of the ESA M3 mission candidates that completed their assessment phase at the end of 2013. LOFT is equipped with two instruments, the Large Area Detector (LAD) and the Wide Field Monitor (WFM). The LAD performs pointed observations of several targets per orbit (~90 minutes), providing roughly ~80 GB of proprietary data per day (the proprietary period will be 12 months). The WFM continuously monitors about 1/3 of the sky at a time and provides data for about ~100 sources a day, resulting in a total of ~20 GB of additional telemetry. The LOFT Burst alert System additionally identifies on-board bright impulsive events (e.g., Gamma-ray Bursts, GRBs) and broadcasts the corresponding position and trigger time to the ground using a dedicated system of ~15 VHF receivers. All WFM data are planned to be made public immediately. In this contribution we summarize the planned organization of the LOFT ground segment (GS), as established in the mission Yellow Book 1 . We describe the expected GS contributions from ESA and the LOFT consortium. A review is provided of the planned LOFT data products and the details of the data flow, archiving and distribution. Despite LOFT was not selected for launch within the M3 call, its long assessment phase (> 2 years) led to a very solid mission design and an efficient planning of its ground operations.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91446