Assessment of cadmium levels in serum, toenails and diet: A cross sectional study in Modena, Northern Italy

Arcolin, Elisa

Bottecchi, Iliaria

Cavazzuti, L

Ferrari, Angela

Filippini, Tommaso

Iacuzio, Laura

Krogh, V

Malagoli, Carlotta

Malavolti, Marcella

Martino, Antonio

Michalke, B

Sieri, S

Vescovi, L

Vinceti, Marco

English

FILIPPINI, TOMMASO

BOTTECCHI, ILIARIA

IACUZIO, LAURA

MALAGOLI, Carlotta

FERRARI, Angela

MARTINO, Antonio

MALAVOLTI, Marcella

VINCETI, Marco

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

1 ICS 2015     International  Cadmium Symposium 2015        ICS 2015 Congress Proceedings   	-27, 2015    P-10 _ ASSESSMENT OF CADMIUM LEVELS IN SERUM, TOENAILS AND DIET: A CROSS SECTIONAL STUDY IN MODENA, NORTHERN ITALY  Filippini Tommaso1, Bottecchi Ilaria1, Arcolin Elisa1, Iacuzio Laura1, Malagoli Carlotta1, Vescovi Luciano2, Ferrari Angela1, Martino Antonio1, Malavolti Marcella1, Cavazzuti Lucia3, Sieri Sabina4, Krogh Vittorio4, Michalke Bernard5, Vinceti Marco1  1Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Reggio Emilia, Italy 2IREN, Reggio Emilia and Piacenza, Italy 3Local Health Unit of Modena, Modena, Italy 4Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy 5Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Munich, Germany   Cadmium (Cd) is a heavy metal that poses serious environmental health hazards to humans. Cigarette smoking and some occupations are major sources of exposure, while for non-smokers and subjects unexposed in the workplace, ingestion through food is the most important source, mainly due to vegetables and cereals, but also to fish, offal, wild mushrooms and chocolate. Blood Cd concentration represents both short and long-term exposures, while toenails Cd reflects medium-term exposure. The aim of the study was to assess Cd exposure and its determinants in fifty adults randomly drawn from the municipal population of Modena, by determining Cd levels in plasma and toenails, as well as its dietary intake using a semi-quantitative food frequency questionnaire. Median (25th-75th) values were 40.85 (30.05-53.50) ng/l, 5.66 (0.50-11.39) ng/g and 13.36 (10.45-16.63) μg/die in serum, toenail and diet, respectively. In stratified analyses for gender, age and smoking habits, males shown higher serum Cd content than females, as did current smokers versus never-smokers, while age shown an inverse correlation. Pearson’s correlations were 0.028 (95%CI -0.252, 0.304; P=0.845) between serum and dietary Cd, 0.001 (-0.277, 0.280; P=0.993) between toenail and dietary Cd, and -0.075 (-0.346, 0.208; P=0.606) between serum and toenail Cd, with little gender-related differences. When we excluded current smokers from analysis, only the correlation between serum and dietary Cd changed, slightly increasing (r=0.068, 95% CI -0.245,0.367; P=0.675).    

Assessment of cadmium levels in serum, toenails and diet: A cross sectional study in Modena, Northern Italy.

https://iris.unimore.it/bitstream/11380/1069867/2/abs_11_CDSYM2015poster_filippini.pdf

Assessment of cadmium levels in serum, toenails and diet: A cross sectional study in Modena, Northern Italy.

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Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia