508 research outputs found
Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles
AbstractBeagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding colony Beagles had significantly different DLA haplotype frequencies in comparison with pet Beagles and both groups showed limited DLA diversity. Restricted DLA class II genetic variability within Beagles might result in selective antigen presentation and vaccine responses that are not necessarily representative of those seen in other dog breeds
Searching for "monogenic diabetes" in dogs using a candidate gene approach
BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. RESULTS: Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds. CONCLUSIONS: Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2052-6687-1-8) contains supplementary material, which is available to authorized users
The Detectability of Pair-Production Supernovae at z < 6
Nonrotating, zero metallicity stars with initial masses 140 < M < 260 solar
masses are expected to end their lives as pair-production supernovae (PPSNe),
in which an electron-positron pair-production instability triggers explosive
nuclear burning. Interest in such stars has been rekindled by recent
theoretical studies that suggest primordial molecular clouds preferentially
form stars with these masses. Since metal enrichment is a local process, the
resulting PPSNe could occur over a broad range of redshifts, in pockets of
metal-free gas. Using the implicit hydrodynamics code KEPLER, we have
calculated a set of PPSN light curves that addresses the theoretical
uncertainties and allows us to assess observational strategies for finding
these objects at intermediate redshifts. The peak luminosities of typical PPSNe
are only slightly greater than those of Type Ia, but they remain bright much
longer (~ 1 year) and have hydrogen lines. Ongoing supernova searches may soon
be able to limit the contribution of these very massive stars to < 1% of the
total star formation rate density out to z=2 which already provides useful
constraints for theoretical models. The planned Joint Dark Energy Mission
satellite will be able to extend these limits out to z=6.Comment: 12 pages, 6 figures, ApJ in press; slightly revised version, a few
typos correcte
Highly Reflective Dielectric Back Reflector for Improved Efficiency of Tandem Thin-Film Solar Cells
We report on the prototyping and development of a highly reflective dielectric back reflector for application in thin-film solar cells. The back reflector is fabricated by Snow Globe Coating (SGC), an innovative, simple, and cheap process to deposit a uniform layer of TiO2 particles which shows remarkably high reflectance over a broad spectrum (average reflectance of 99% from 500 nm to 1100 nm). We apply the highly reflective back reflector to tandem thin-film silicon solar cells and compare its performance with conventional ZnO:Al/Ag reflector. By using SGC back reflector, an enhancement of 0.5 mA/cm2 in external quantum efficiency of the bottom solar cell and an absolute value of 0.2% enhancement in overall power conversion efficiency are achieved. We also show that the increase in power conversion efficiency is due to the reduction of parasitic absorption at the back contact; that is, the use of the dielectric reflector avoids plasmonic losses at the reference ZnO:Al/Ag back reflector. The Snow Globe Coating process is compatible with other types of solar cells such as crystalline silicon, III–V, and organic photovoltaics. Due to its cost effectiveness, stability, and excellent reflectivity above a wavelength of 400 nm, it has high potential to be applied in industry
Finding Radio Pulsars in and Beyond the Galactic Center
Radio-wave scattering is enhanced dramatically for Galactic center sources in
a region with radius >~ 15 arc min. Using scattering from Sgr A* and other
sources, we show that pulse broadening for pulsars in the Galactic center is
{\em at least} 6.3 \nu^{-4} seconds (\nu = radio frequency in GHz) and is most
likely 50--200 times larger because the relevant scattering screen appears to
be within the Galactic center region itself. Pulsars beyond---but viewed
through---the Galactic center suffer even greater pulse broadening and are
angularly broadened by <~ 2 {\em arc min}. Periodicity searches at radio
frequencies are likely to find only long period pulsars and, then, only if
optimized by using frequencies >~ 7 GHz and by testing for small numbers of
harmonics in the power spectrum. The optimal frequency is where \Delta_{0.1} is the distance of the
scattering region from Sgr A* in units of 0.1 kpc, P is the period (seconds),
and \alpha is the spectral index. A search for compact sources using aperture
synthesis may be far more successful than searches for periodicities because
the angular broadening is not so large as to desensitize the survey. We
estimate that the number of {\em detectable} pulsars in the Galactic center may
range from <= 1 to 100, with the larger values resulting from recent, vigorous
starbursts. Such pulsars provide unique opportunities for probing the ionized
gas, gravitational potential, and stellar population near Sgr A*.Comment: 13 pages, 4 PS figures, LaTeX and requires AASTeX macro aas2pp4,
accepted by ApJ, also available as
http://astrosun.tn.cornell.edu/SPIGOT/papers/pulsar/gc_psr.web
‘O sibling, where art thou?’ – a review of avian sibling recognition with respect to the mammalian literature
Avian literature on sibling recognition is rare compared to that developed by mammalian researchers. We compare avian and mammalian research on sibling recognition to identify why avian work is rare, how approaches differ and what avian and mammalian researchers can learn from each other. Three factors: (1) biological differences between birds and mammals, (2) conceptual biases and (3) practical constraints, appear to influence our current understanding. Avian research focuses on colonial species because sibling recognition is considered adaptive where ‘mixing potential’ of dependent young is high; research on a wider range of species, breeding systems and ecological conditions is now needed. Studies of acoustic recognition cues dominate avian literature; other types of cues (e.g. visual, olfactory) deserve further attention. The effect of gender on avian sibling recognition has yet to be investigated; mammalian work shows that gender can have important influences. Most importantly, many researchers assume that birds recognise siblings through ‘direct familiarisation’ (commonly known as associative learning or familiarity); future experiments should also incorporate tests for ‘indirect familiarisation’ (commonly known as phenotype matching). If direct familiarisation proves crucial, avian research should investigate how periods of separation influence sibling discrimination. Mammalian researchers typically interpret sibling recognition in broad functional terms (nepotism, optimal outbreeding); some avian researchers more successfully identify specific and testable adaptive explanations, with greater relevance to natural contexts. We end by reporting exciting discoveries from recent studies of avian sibling recognition that inspire further interest in this topic
Hard X-ray Emission Associated with White Dwarfs
We have used the WGACAT to search for hard X-ray sources associated with
white dwarfs (WDs) from the catalog of McCook & Sion (1999). We find 17 X-ray
sources coincident with WDs showing significant hard X-ray emission at energies
>0.5 keV. Twelve of these WDs are in known binary systems, in two of which the
accretion of the close companion's material onto the white dwarf produces the
hard X-ray emission, and in the other ten of which the late-type companions'
coronal activity emits hard X-rays. One WD is projected near an AGN which is
responsible for the hard X-ray emission. The remaining four WDs and two
additional white dwarfs with hard X-ray emission appear single. The lack of
near-IR excess from the apparently single WDs suggests that either X-ray
observations are more effective than near-IR photometry in diagnosing faint
companions or a different emission mechanism is needed. It is intriguing that
50% of the six apparently single WDs with hard X-ray emission are among the
hottest WDs. We have compared X-ray properties of 11 hot WDs with different
spectral types, and conclude that stellar pulsation and fast stellar winds are
not likely the origin of the hard X-ray emission, but a leakage of the
high-energy Wien tail of emission from deep in the stellar atmosphere remains a
tantalizing source of hard X-ray emission from hot DO and DQZO WDs. (This
abstract is an abridged version.)Comment: 35 pages, 8 figures, 4 tables, accepted for publication in AJ, April
issu
The type IIb SN 2008ax: spectral and light curve evolution
We present spectroscopy and photometry of the He-rich supernova (SN) 2008ax.
The early-time spectra show prominent P-Cygni H lines, which decrease with time
and disappear completely about two months after the explosion. In the same
period He I lines become the most prominent spectral features. SN 2008ax
displays the ordinary spectral evolution of a type IIb supernova. A stringent
pre-discovery limit constrains the time of the shock breakout of SN 2008ax to
within only a few hours. Its light curve, which peaks in the B band about 20
days after the explosion, strongly resembles that of other He-rich
core-collapse supernovae. The observed evolution of SN 2008ax is consistent
with the explosion of a young Wolf-Rayet (of WNL type) star, which had retained
a thin, low-mass shell of its original H envelope. The overall characteristics
of SN 2008ax are reminiscent of those of SN 1993J, except for a likely smaller
H mass. This may account for the findings that the progenitor of SN 2008ax was
a WNL star and not a K supergiant as in the case of SN 1993J, that a prominent
early-time peak is missing in the light curve of SN 2008ax, and that Halpha is
observed at higher velocities in SN 2008ax than in SN 1993J.Comment: 10 pages, including 8 figures and 4 tables. Accepted for publication
in MNRA
Detailed Analysis of Nearby Bulgelike Dwarf Stars III. Alpha and Heavy-element abundances
The present sample of nearby bulgelike dwarf stars has kinematics and
metallicities characteristic of a probable inner disk or bulge origin. Ages
derived by using isochrones give 10-11 Gyr for these stars and metallicities
are in the range -0.80< [Fe/H]< +0.40. We calculate stellar parameters from
spectroscopic data, and chemical abundances of Mg, Si, Ca, Ti, La, Ba, Y, Zr
and Eu are derived by using spectrum synthesis.
We found that [alpha-elements/Fe] show different patterns depending on the
element. Si, Ca and Ti-to-iron ratios decline smoothly for increasing
metallicities, and follow essentially the disk pattern. O and Mg, products of
massive supernovae, and also the r-process element Eu, are overabundant
relative to disk stars, showing a steeper decline for metallicities [Fe/H] >
-0.3 dex. [s-elements/Fe] roughly track the solar values with no apparent trend
with metallicity for [Fe/H] < 0, showing subsolar values for the metal rich
stars. Both kinematical and chemical properties of the bulgelike stars indicate
a distinct identity of this population when compared to disk stars.Comment: 21 pages, 9 figures, to appear in Ap
Optical and infrared observations of the Type IIP SN2002hh from day 3 to 397
We present optical and infrared (IR) observations of the type IIP SN2002hh
from 3 to 397 days after explosion. The optical spectroscopic (4-397d) and
photometric (3-278d) data are complemented by spectroscopic (137-381d) and
photometric (137-314d) data acquired at IR wavelengths. This is the first time
L-band spectra have ever been successfully obtained for a supernova at a
distance beyond the Local Group. The VRI light curves in the first 40 days
reveal SN2002hh to be a SN IIP (plateau) - the most common of all core-collapse
supernovae. SN2002hh is one of the most highly extinguished supernovae ever
investigated. To provide a good match between its early-time spectrum and a
coeval spectrum of the Type IIP SN1999em, as well as maintaining consistency
with KI interstellar absorption, we invoke a 2-component extinction model. One
component is due to the combined effect of the interstellar medium of our Milky
Way Galaxy and the SN host galaxy, while the other component is due to a "dust
pocket" where the grains have a mean size smaller than in the interstellar
medium. The early-time optical light curves of SNe 1999em and 2002hh are
generally well-matched, as are the radioactive tails of these two SNe and
SN1987A. The late-time similarity of the SN2002hh optical light curves to those
of SN1987A, together with measurements of the optical/IR luminosity and [FeII]
1.257mu emission indicate that 0.07 +- 0.02 Msun of Ni 56 was ejected by
SN2002hh. [... ABRIDGED...] From the [OI] 6300,6364 A doublet luminosity we
infer a 16-18 Msun main-sequence progenitor star. The progenitor of SN2002hh
was probably a red supergiant with a substantial, dusty wind.Comment: 32 pages, 30 figures, accepted for publication in MNRA
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