Synthesis, characterization of a new carbonylated zirconium metallocene using a dichloro-zirconocene derived from partially alkylated s-indacene

Indexación: ScieloThis work describes the synthesis and characterization of new organometallic species, an unprecedented mononuclear zirconium complex bearing a tetraalkylated s-indacene ligand, and secondly, its respective dicarbonyl complex obtained by reduction with Mg/HgCl2. Theoretical calculations of these two compounds were carried out to gain further understanding of these novel molecular systems.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300014&lng=es&nrm=is

Mechanical alterations in airway smooth muscle after interaction with indoor pollutant - A\ud mathematical model

The viscoelasticity of mammalian lung is determined by the mechanical properties and structural regulation of the airway smooth muscle (ASM). The exposure to polluted air may deteriorate these properties with harmful consequences to individual health. Formaldehyde (FA) is an important indoor pollutant found among volatile organic compounds. This pollutant permeates through the smooth muscle tissue forming covalent bonds between proteins in the extracellular matrix and intracellular protein structure changing mechanical properties of ASM and inducing asthma symptoms, such as airway hyperresponsiveness, even at low concentrations. In the experimental scenario, the mechanical effect of FA is the stiffening of the tissue, but the mechanism behind this effect is not fully w1derstood. Thus, the aim of this study is to reproduce the mechanical behavior of the ASM, such as contraction and stretching, under FA action or not. For this, it was created a two-dimensional viscoelastic network model based on Voronoi tessellation solved using Runge-Kutta method of fourth order. The equilibrium configuration was reached when the forces in different parts of the network were equal. This model simulates the mechanical behavior of ASM through of a network of dashpots and springs. This dashpot-spring mechanical coupling mimics the composition of the actomyosin machinery of ASM through the contraction of springs to a minimum length. We hypothesized that formation of covalent bonds, due to the FA action, can be represented in the model by a simple change in the elastic constant of the springs, while the action of methacholinc (MCh) reduce the equilibrium length of the spring. A sigmoid curve of tension as a function of MCh doses was obtained, showing increased tension when the muscle strip was exposed to FA. Our simulations suggest that FA, at a concentration of 0.1 ppm, can affect the elastic properties of the smooth muscle fibers by a factor of 120%. We also analyze the dynamic mechanical properties, observing the viscous and elastic behavior of the network. Finally, the proposed model, although simple, ir1corporates the phenomenology of both MCh and FA and reproduces experirnental results observed with ir1 vitro exposure of smooth muscle to .FA. Thus, this new mechanical approach incorporates several well know features of the contractile system of the cells ir1 a tissue level model. The model can also be used in different biological scales.CNPqFAPES

Mechanical Alterations in airway smooth muscle after interaction with indoor pollutant – A mathematical model.

The viscoelasticity of mammalian lung is determined by the mechanical properties and structural regulation of the airway smooth muscle (ASM). The exposure to polluted air may deteriorate these properties with harmful consequences to individual health. Formaldehyde (FA) is an important indoor pollutant found among volatile organic compounds. This pollutant permeates through the smooth muscle tissue forming covalent bonds between proteins in the extracellular matrix and intracellular protein structure changing mechanical properties of ASM and inducing asthma symptoms, such as airway hyperresponsiveness, even at low concentrations. In the experimental scenario, the mechanical effect of FA is the stiffening of the tissue, but the mechanism behind this effect is not fully understood. Thus, the aim of this study is to reproduce the mechanical behavior of the ASM, such as contraction and stretching, under FA action or not. For this, it was created a two-dimensional viscoelastic network model based on Voronoi tessellation solved using Runge-Kutta method of fourth order. The equilibrium configuration was reached when the forces in different parts of the network were equal. This model simulates the mechanical behavior of ASM through of a network of dashpots and springs. This dashpot-spring mechanical coupling mimics the composition of the actomyosin machinery of ASM through the contraction of springs to a minimum length. We hypothesized that formation of covalent bonds, due to the FA action, can be represented in the model by a simple change in the elastic constant of the springs, while the action of methacholine (MCh) reduce the equilibrium length of the spring. A sigmoid curve of tension as a function of MCh doses was obtained, showing increased tension when the muscle strip was exposed to FA. Our simulations suggest that FA, at a concentration of 0.1 ppm, can affect the elastic properties of the smooth muscle ¯bers by a factor of 120%. We also analyze the dynamic mechanical properties, observing the viscous and elastic behavior of the network. Finally, the proposed model, although simple, incorporates the phenomenology of both MCh and FA and reproduces experimental results observed with in vitro exposure of smooth muscle to FA. Thus, this new mechanical approach incorporates several well know features of the contractile system of the cells in a tissue level model. The model can also be used in different biological scales.CNPqFAPES

Near-Infrared Imaging Polarimetry of the Serpens Cloud Core: Magnetic Field Structure, Outflows, and Inflows in A Cluster Forming Clump

We made deep NIR imaging polarimetry toward the Serpens cloud core. The polarization vector maps enable us to newly detect 24 small IR reflection nebulae with YSOs. Polarization measurements of NIR point sources indicate an hourglass-shaped magnetic field, of which symmetry axis is nearly perpendicular to the elongation of the C18O (J=1-0) or submillimeter continuum emission. The bright part of C18O (J=1-0), submillimeter continuum cores as well as many class 0/I objects are located just toward the constriction region of the hourglass-shaped magnetic field. Applying the CF method, the magnetic field strength was estimated to be ~100 muG, suggesting that the ambient region of the Serpens cloud core is moderately magnetically supercritical. These suggest that the Serpens cloud core first contracted along the magnetic field to be an elongated cloud, which is perpendicular to the magnetic field, and that then the central part contracted cross the magnetic field due to the high density in the central region of the cloud core, where star formation is actively continuing. Comparison of this magnetic field with the previous observations of molecular gas and large-scale outflows suggests a possibility that the cloud dynamics is controlled by the magnetic field, protostellar outflows and gravitational inflows. This appears to be in good agreement with the outflow-driven turbulence model and implies the importance of the magnetic field to continuous star formation in the center region of the cluster forming region.Comment: 36 pages, 11 figures, 2 tables, accepted for publication in the Astrophysical Journa

Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

Major Depression is a severe psychiatric condition with a still poorly understood etiology. In the last years, evidence supporting the neuroinflammatory hypothesis of depression has increased. In the current clinical scenario, in which the available treatments for depression is far from optimal, there is an urgent need to develop fast-acting drugs with fewer side effects. In this regard, recent pieces of evidence suggest that cannabidiol (CBD), the major non-psychotropic component of Cannabis sativa with anti-inflammatory properties, appears as a drug with antidepressant properties. In this work, CBD 30 mg/kg was administered systemically to mice 30 min before lipopolysaccharide (LPS; 0.83 mg/kg) administration as a neuroinflammatory model, and behavioral tests for depressive-, anhedonic- and anxious-like behavior were performed. NF-?B, I?B? and PPAR? levels were analyzed by western blot in nuclear and cytosolic fractions of cortical samples. IL-6 and TNF? levels were determined in plasma and prefrontal cortex using ELISA and qPCR techniques, respectively. The precursor tryptophan (TRP), and its metabolites kynurenine (KYN) and serotonin (5-HT) were measured in hippocampus and cortex by HPLC. The ratios KYN/TRP and KYN/5-HT were used to estimate indoleamine 2,3-dioxygenase (IDO) activity and the balance of both metabolic pathways, respectively. CBD reduced the immobility time in the tail suspension test and increased sucrose preference in the LPS model, without affecting locomotion and central activity in the open-field test. CBD diminished cortical NF-?B activation, IL-6 levels in plasma and brain, and the increased KYN/TRP and KYN/5-HT ratios in hippocampus and cortex in the LPS model. Our results demonstrate that CBD produced antidepressant-like effects in the LPS neuroinflammatory model, associated to a reduction in the kynurenine pathway activation, IL-6 levels and NF-?B activation. As CBD stands out as a promising antidepressant drug, more research is needed to completely understand its mechanisms of action in depression linked to inflammation.FUNDING AND ACKNOWLEDGMENTS: This research was supported by the Ministerio de Economía y Competitividad (SAF2015-67457-R MINECO/FEDER), the Ministerio de Ciencia, Innovación y Universidades (RTI2018-097534-B-I00), the Instituto de Salud Carlos III (PI19/00170), and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). E F-Z was supported by a predoctoral fellowship from the Universidad de Cantabria (Spain). We acknowledge the technical assistance of Annamaria Architravo and Deborah Vasturzo, and Dr Rebeca Vidal for her scientific advice

Interés legítimo en amparo. un instrumento procesal “Comunitarista”**Agradezco mucho la revisión crítica de este texto al profesor Rodolfo Vázquez Cardozo (ITAM).

ResumenParte importante de la interpretación constitucional se origina como producto del juicio de amparo; sin embargo, ello no implica que la Suprema Corte de Justicia de la Nación haya construido una teoría constitucional uniforme sobre los derechos y libertades. Este texto tiene tres propósitos: a) mostrar que el discurso justificatorio de la Corte sobre los derechos se ha elaborado a partir de un enfoque de justicia comunitarista o, en ocasiones, utilitarista; b) subrayar que la interpretación del interés legítimo en amparo sigue la misma suerte, y c) destacar que la incorporación de dicha herramienta procesal con un enfoque distinto puede proyectar la inclusión de una visión liberal igualitaria en la justicia constitucional.AbstractAn important part of the constitutional interpretation arises as a result of the trial of amparo, however this does not imply that the Supreme Court of Justice has built a uniform theory of constitutional rights and freedoms. This text has three purposes: (a) show that speech rights court only has foundation on communitarianism justice or utilitarianism, (b) emphasize that the interpretation of legitimate interest in amparo follows the same fate and (c) noted that the incorporation of that procedural tool in the new model of amparo, can include of an egalitarian liberal view on constitutional justice

Trace semantics via determinization

This paper takes a fresh look at the topic of trace semantics in the theory of coalgebras. The first development of coalgebraic trace semantics used final coalgebras in Kleisli categories, stemming from an initial algebra in the underlying category (see notably~\cite{HasuoJS07}). This approach requires some non-trivial assumptions, like dcpo enrichment, which do not always hold, even in cases where one can reasonably speak of traces (like for weighted automata). More recently, it has been noticed (see~\cite{SBBR10}) that trace semantics can also arise by first performing a determinization construction. In this paper, we develop a systematic approach, in which the two approaches correspond to different orders of composing a functor and a monad, and accordingly, to different distributive laws. The relevant final coalgebra that gives rise to trace semantics does not live in a Kleisli category, but more generally, in a category of Eilenberg-Moore algebras. In order to exploit its finality, we identify an extension operation, that changes the state space of a coalgebra into a free algebra, which abstractly captures determinization of automata. Notably, we show that the two different views on trace semantics are equivalent, in the examples where both approaches are applicable.We are grateful to the anonymous referees for valuable comments. The work of Alexandra Silva is partially funded by the ERDF through the Programme COMPETE and by the Portuguese Foundation for Science and Technology, project Ref. FCOMP-01-0124-FEDER-020537 and SFRH/BPD/71956/2010

Registro Provincial de Antecedentes de Tránsito: Gobierno de la Provincia de Córdoba

El Sistema de Información que se presenta se denomina RePAT y es el actual Registro Provincial de Antecedentes de Tránsito de la Provincia de Córdoba. Se trata de un proyecto de desarrollo de un sistema de información, con el software asociado, realizado en la Facultad Regional Córdoba, de la Universidad Tecnológica Nacional, que incursiona en la atención de la problemática de la seguridad vial en tanto es el instrumento informático que permite la implementación en el territorio provincial de la Ley Provincial de Tránsito Nº 8560. El desarrollo contempla dos funcionalidades integradas, por un lado la gestión del otorgamiento de licencias de conducir atento al cumplimiento de los aspectos establecidos en la ley en cuanto a exámenes, pruebas y habilitaciones para conducir, y por otro lado la gestión de la sanción y el registro efectivo de las infracciones y antecedentes de tránsito. Esta última funcionalidad abarca todos los aspectos propios de las actividades administrativas asociadas al juzgamiento, la notificación, y la inhabilitación y gestión de puntos, en caso de ser pertinente. El sistema se encuentra actualmente habilitado e instalado, para el otorgamiento de licencias de conducir, en 270 municipios del ámbito provincial.Sociedad Argentina de Informática e Investigación Operativ

Registro Provincial de Antecedentes de Tránsito: Gobierno de la Provincia de Córdoba

El Sistema de Información que se presenta se denomina RePAT y es el actual Registro Provincial de Antecedentes de Tránsito de la Provincia de Córdoba. Se trata de un proyecto de desarrollo de un sistema de información, con el software asociado, realizado en la Facultad Regional Córdoba, de la Universidad Tecnológica Nacional, que incursiona en la atención de la problemática de la seguridad vial en tanto es el instrumento informático que permite la implementación en el territorio provincial de la Ley Provincial de Tránsito Nº 8560. El desarrollo contempla dos funcionalidades integradas, por un lado la gestión del otorgamiento de licencias de conducir atento al cumplimiento de los aspectos establecidos en la ley en cuanto a exámenes, pruebas y habilitaciones para conducir, y por otro lado la gestión de la sanción y el registro efectivo de las infracciones y antecedentes de tránsito. Esta última funcionalidad abarca todos los aspectos propios de las actividades administrativas asociadas al juzgamiento, la notificación, y la inhabilitación y gestión de puntos, en caso de ser pertinente. El sistema se encuentra actualmente habilitado e instalado, para el otorgamiento de licencias de conducir, en 270 municipios del ámbito provincial.Sociedad Argentina de Informática e Investigación Operativ

Registro Provincial de Antecedentes de Tránsito: Gobierno de la Provincia de Córdoba

El Sistema de Información que se presenta se denomina RePAT y es el actual Registro Provincial de Antecedentes de Tránsito de la Provincia de Córdoba. Se trata de un proyecto de desarrollo de un sistema de información, con el software asociado, realizado en la Facultad Regional Córdoba, de la Universidad Tecnológica Nacional, que incursiona en la atención de la problemática de la seguridad vial en tanto es el instrumento informático que permite la implementación en el territorio provincial de la Ley Provincial de Tránsito Nº 8560. El desarrollo contempla dos funcionalidades integradas, por un lado la gestión del otorgamiento de licencias de conducir atento al cumplimiento de los aspectos establecidos en la ley en cuanto a exámenes, pruebas y habilitaciones para conducir, y por otro lado la gestión de la sanción y el registro efectivo de las infracciones y antecedentes de tránsito. Esta última funcionalidad abarca todos los aspectos propios de las actividades administrativas asociadas al juzgamiento, la notificación, y la inhabilitación y gestión de puntos, en caso de ser pertinente. El sistema se encuentra actualmente habilitado e instalado, para el otorgamiento de licencias de conducir, en 270 municipios del ámbito provincial.Sociedad Argentina de Informática e Investigación Operativ