Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors.Sexual dimorphism of this axis has been described in different species under physiological conditions and it hasbeen proposed that sexual hormones could have an effect on it. There are only a few reports about sex-linkedvariations in HPA axis hormones in the dog. Thus, studying the impact of sexual hormones on the HPA axis wouldbroaden the knowledge about its function in this species. Therefore, the objective of this study was to determinewhether there are variations in HPA plasma hormones (ACTH, alfa-melanocyte-stimulating hormone [α-MSH]and cortisol) according to the sex and photoperiod (positive or negative photoperiod were considered when theduration of the light hours of the day was more than 12 or less than 12, respectively) under basal conditions (likeanoestrus) and throughout the oestrous cycle in the female dog. The population under study consisted of 11 intactfemale and 14 intact male dogs. Under basal conditions neither ACTH nor α-MSH concentrations showed differencesbetween sexes and different photoperiods. Cortisol showed greater values in the negative photoperiod thanin the positive, both in females and males (P = 0.03 and P = 0.015, respectively). Throughout the oestrous cycle,all the studied hormones showed variations (P < 0.0001). The greatest concentrations of ACTH were observed atproestrus, while α-MSH and cortisol showed their greatest concentrations at oestrus. The three hormones decreasedin diestrus. ACTH and cortisol concentrations were higher in the negative photoperiod (P = 0.04 and P < 0.0001,respectively), while α-MSH concentrations were higher in the positive photoperiod (P = 0.012). In the group offemales oestradiol and progesterone correlated with ACTH (r = 0.75, P < 0.0001; r = 0.34, P < 0.01, respectively),α-MSH (r = 0.49, P < 0.0001; r = 0.52, P < 0.0001, respectively) and cortisol (r = 0.33, P < 0.01; r = 0.5, P < 0.0001,respectively). These results show that in females, HPA axis hormones vary during the oestrous cycle in relation tooestradiol and progesterone fluctuations. The ACTH, α-MSH and cortisol concentrations also showed differencesbetween photoperiods in females, but only cortisol did so in males. These findings suggest that sexual hormonescould have an effect on the HPA axis. Further research needs to be done to fully understand this interaction andthe mechanisms involved.Fil: Gallelli, María Florencia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Monachesi, N.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Cabrera Battler, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Gomez, N. V.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Meikle, A.. Universidad de Montevideo; UruguayFil: Castillo, V, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentin

Vibrational Characterization of Active Drug to the Treatment of Chagas Disease, Benznidazole by Using Force Fields and Internal Coordinates

Two experimental structures of benznidazole active drug used to the treatment of Chagas disease have been structurally characterized and its vibrational spectra completely assigned combining B3LYP/6-311++G** calculations with the experimental FT-IR and FT-Raman spectra and the SQMFF methodology. The most stable conformer of benznidazole found in the study of the potential energy surface is in agreement with that experimentally observed by X-ray diffraction at room temperature while the other one was observed with the heating up to 195 ºC. Both differs in the positions of CH2 groups of acetamide fragment. Their structural properties in gas phase and ethanol solution were computed by using natural bond orbital (NBO), atoms in molecules (AIM), Merz-Kollman (MK) charges, molecular electrostatic potentials (MEP) and frontier orbitals calculations by using the hybrid B3LYP method and the 6-31G* and 6-311++G** basis sets. Additional WB97XD/6-311++G** calculations show that the energy values optimized for the most stable species in both media present lower values than the obtained with the B3LYP/6-31G* method. The vibrational assignments for those two conformers in both media were obtained from their corresponding harmonic force fields together with the scaled force constants

Theoretical Investigation on Monomer and Dimers of Inhibitor of Cytochrome P450 Enzymes: 1-Aminobenzotriazole

In this research, structures and properties of monomer and two dimers (1 and 2) of inhibitor of cytochrome P450 enzymes, 1-Aminobenzotriazole (ABT) have been studied by using functional hybrid B3LYP/6-311++G** calculations. The very good correlations observed between theoretical and experimental 1H-, 13C-NMR, FT-IR and FT-Raman spectra suggest that C-H···N interactions of dimeric species should be expected in the solid phase, as was observed in the experimental crystalline structure of a quinolin benzotriazole derivative. NBO and AIM calculations suggest that dimer 2 with inverted positions of its monomers could be present in the solid phase because it evidence higher stabilities in both media. On the other hand, frontier orbitals studies support a higher reactivity of dimer 2 of ABT higher than the monomer and dimer 1, for which, the presence of dimer 2 containing N-NH2 groups in ABT could justify the biological activities observed for this species with gap values between 4.5933 and 4.8164 eV different from antiviral agents containing the C-NH2 moiety, as amantadine and chloroquine whose gap values are around 4.3012-4.1116 eV. Finally, the presence of bands of monomer and of both dimers are predicted in the vibrational spectra and, hence, its completes assignments have been performed. The scaled force constants for the three studied species are also reported

Propuesta para la enseñanza de las normas de higiene y bioseguridad en la Facultad de Odontología

Ponencia presentada en la II Muestra Nacional de Innovaciones en la Enseñanza de la Odontología y IV Muestra Institucional de Innovaciones en la Enseñanza de la Odontología. Córdoba, 13 y 14 de septiembre de 2012.La investigación llevada a cabo por el Equipo corrobora que la Bioseguridad debe ocupar un lugar central en la formación de los estudiantes de Odontología por el impacto social de dichos saberes y es en la formación de grado, cuando el futuro profesional debe adquirir sólidos conocimientos de esta disciplina en sus aspectos biológicos, técnicos, jurídicos, sociales y éticos. Sin embargo los resultados de esta investigación han puesto en evidencia que la enseñanza de la Bioseguridad no ha sido sistemática ni transversal en el Currículum de la Carrera.Fil: Castillo, Beatriz del Carmen. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Irazusta, María Laura. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Castillo, Graciela del V. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Priotto, Elba G. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Bregains, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Castillo, María Cristina. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina.Fil: Rezzónico, María Silvina. Universidad Nacional de Córdoba. Facultad de Odontología. Centro de Bioseguridad. Equipo de Investigación Normas de Higiene y Bioseguridad en la Formación de Odontólogos; Argentina

Gestión del Departamento de Enfermería frente al abordaje del ausentismo, Centro Médico Paitilla, 2016-2019.

El siguiente proyecto se realizó en el Centro Médico Paitilla. con el objetivo de fortalecer la gestión del Departamento de Enfermería de dicha institución, para el abordaje del ausentismo laboral. mediante la aplicación de un plan operativo. La población de estudio se concretó con el personal de Enfermería del Centro Médico Paitilla: Enfermeras gerentes y rotadoras, y Técnicos en Enfermería con un total de 213. Cabe señalar que este tema del proyecto fue sugerido por el Departamento de Enfermería del Centro Médico Paitilla. tomando en cuenta la necesidad de sensibilizar al personal de Enfermería de la importancia en la asistencia para lograr el balance entre las actividades laborales y la vida familiar. Como resultado de la aplicación de las estrategias para disminuir el ausentismo Laboral, se pudo conocer que el mismo disminuyó positivamente en un 20.5% para las Enfermeras y un 16,6% en los Técnicos en Enfermería

The Future of Micro-grids in Ecuador

An analysis is made on the development of power lines worldwide and that offer the approaches of the impacts that are generated in the economic and environmental, which justify the application of smart grids in Ecuador, as an effective way to raise the efficiency of the electric power service and to achieve a more efficient use of the energy that is generated by showing the different technologies used in electricity generation where renewable energy sources are incorporated. A comparative analysis of how the installed generation power has been increasing until 2016 is shown

INCIDENCIA DE POSTLARVAS DE CAMARONES PENEIDOS EN EL ESTERO CATÉ, GOLFO DE MONTIJO, PACÍFICO PANAMEÑO.

This study was carried out for a term of six months in 2014. It took two seasons per two-month intervals during the dry and rainy seasons. Later, ten samples were taken and segmented during two monthly collections which were carried out during the new and full moon phases in the low tide; however, the last month collection omitted just one capture sample. In addition, for hauling was used a chayo-type handwork net with a 0.45 m mouth and 1.16 mm light mesh; as a result, salinity, temperature, and dissolved oxygen were the physical-chemical parameters measured.&nbsp; Furthermore, 12003 postlarvae gathered through this research contained Litopenaeus occidentalis, Litopenaeus stylirostris, Litopenaeus vannamei, and Farfantepenaeus californiensis, obtaining the last ones in a restricted way. For their part, salinity and the dissolved oxygen exhibited a significant relationship to postlarval wealth, but not in temperature. &nbsp;In this way, this study concluded that "El Estero Cate" formed a natural area as an important hatchery of penaeid shrimp growth, in special to L. occidentalis, L. stylirostris y L. vannamei species. &nbsp; In this way we highlight that the Estero Caté constitutes a natural breeding area important for the development of penaeid shrimp, particularly for the species L. occidentalis, L. stylirostris and L. vannamei.El estudio se llevó a cabo durante 6 meses en el año 2014 distribuidos 3 meses en temporada seca y 3 meses en temporada lluviosa. Se hizo un total de 10 muestreos divididos en 2 colectas mensuales (a excepción del último mes de cada temporada en donde sólo se realizó una colecta al mes) que incluyeron los períodos de luna nueva y luna llena en marea baja, para el arrastre se utilizó una red de mano tipo “chayo” con una boca de 0.45 m y 1.16 mm de luz de malla. Los parámetros físico-químicos, medidos fueron salinidad, temperatura y oxígeno disuelto. Durante el período de estudio, se colectaron 12 003 postlarvas pertenecientes a las especies Litopenaeus occidentalis, Litopenaeus stylirostris, Litopenaeus vannamei y Farfantepenaeus californiensis, esta última encontrándose de manera restringida. Por su parte, la salinidad y el oxígeno disuelto presentaron correlación significativa con la abundancia de postlarvas, lo que no sucedió con la temperatura. De esta manera destacamos que el Estero Caté constituye un área natural de crianza importante para el desarrollo de camarones peneidos, particularmente para las especies L. occidentalis, L. stylirostris y L. vannamei

Nonlinear Acoustic Spectroscopy and Frequency Sweep Ultrasonics: Case on Thermal Damage Assessment in Mortar

[EN] An exhaustive study on thermal damage of Portland cement-based materials is addressed. Damage carried out at different temperatures on concrete between 40 and 525 degrees C were assessed by means of microstructural, physical and nondestructive tests. Microstructural analysis (thermogravimetry and scanning electron microscopy) showed the principal changes of the Portland cement hydrated products for the different analysed temperatures. Compressive and flexural strengths remained constant or even increased at a low heating temperature range, while the mass loss increases. Dilatometry analysis revealed important information about deformation incompatibilities between the paste and the aggregate. These results have been correlated with nondestructive tests: nonlinear impact resonance acoustic spectroscopy (NIRAS) and ultrasonic measures. The dynamic modulus and ultrasonic pulse velocity have closely predicted the linear stiffness decay of the specimens. However, hysteretic parameter from NIRAS analysis exhibited a different trend from stiffness-related parameters, keeping constant until 250>degrees C and suffering a huge increasing for 400 and 525 degrees C. Ultrasonic attenuation computed with a broadband ultrasonic signal (chirp) revealed interesting information about scattering components inside the material, and is sensitive to interfacial transition zone between aggregate and paste in a large range of frequencies. The correlation between microstructural, mechanical and nondestructive techniques were carried out successfully. Nonlinear vibration and ultrasonic attenuation are non-conventional parameters that gave specific information about a complex damage process, such as a thermal attack in highly heterogeneous materials (e.g. Portland cement composites).This work has been supported by the Spanish Administration under Grants, BES2015-071469, under the ONDATEST coordinated project, BIA2014-55311-C2-1-P and BIA2014-55311-C2-2-P. Thanks are given to FEDER funds for co-funding.Genovés, V.; Carrión García, A.; Escobar, D.; Gosálbez Castillo, J.; Monzó Balbuena, JM.; Borrachero Rosado, MV.; Paya Bernabeu, JJ. (2019). Nonlinear Acoustic Spectroscopy and Frequency Sweep Ultrasonics: Case on Thermal Damage Assessment in Mortar. Journal of Nondestructive Evaluation. 38(3):1-14. https://doi.org/10.1007/s10921-019-0599-0S114383Aïtcin, P.C.: Binders for Durable and Sustainable Concrete. Taylor & Francis, London (2008)Ma, Q., Guo, R., Zhao, Z., Lin, Z., He, K.: Mechanical properties of concrete at high temperature—a review. Constr. Build. Mater. 93, 371 (2015)Schneider, U.: Concrete at high temperatures—a general review. Fire Saf. J. 13(1), 55 (1988)Cruz, C.R., Gilien, M.: Thermal expansion of Portland cement paste, mortar and concrete at high temperatures. Fire Mater. 4(2), 66 (1980)Jay, A.H.: The thermal expansion of quartz by X-ray measurements. Proc. R. Soc. Lond. 142(846), 237 (1933)Malhotra, V., Carino, N.: Handbook on Nondestructive Testing of Concrete. Civil Engineering. CRC Press, Boca Raton (2004)Van Den Abeele, K., Carmeliet, J., Ten Cate, J.A., Johnson, P.: Nonlinear elasticwave spectroscopy (NEWS) techniques to discern material damage. Part I: nonlinear wave modulation spectroscopy (NWMS). Res. Nondestruct. Eval. 12(1), 17 (2000)Johnson, P.A., Sutin, A.: Nonlinear elastic wave NDE I. Nonlinear resonant ultrasound spectroscopy and slow dynamics diagnostics. In: AIP Conference Proceedings (2005)Leśnicki, K.J., Kim, J.Y., Kurtis, K.E., Jacobs, L.J.: Characterization of ASR damage in concrete using nonlinear impact resonance acoustic spectroscopy technique. NDT & E Int. 44(8), 721 (2011)Park, S.J., Yim, H.J., Kwak, H.G.: Nonlinear resonance vibration method to estimate the damage level on heat-exposed concrete. Fire Saf. J. 69, 36 (2014)Dahlen, U., Ryden, N., Jakobsson, A.: Damage identification in concrete using impact non-linear reverberation spectroscopy. NDT & E Int. 75, 15 (2015)Genovés, V., Carrión, A., Gosálbez, J., Bosch, I., Borrachero, M.V., Payá, J.J.: Optimized ultrasonic attenuation measures for internal sulphate attack monitoring in Portland cement mortars (1)Genovés, V., Gosálbez, J., Carrión, A., Miralles, R., Payá, J.: Optimized ultrasonic attenuation measures for non-homogeneous materials. Ultrasonics 65, 345 (2016)Philippidis, T.P., Aggelis, D.G.: Experimental study of wave dispersion and attenuation in concrete. Ultrasonics 43(7), 584 (2005)Molero, M., Segura, I., Aparicio, S., Hernández, M.G., Izquierdo, MaG: On the measurement of frequency-dependent ultrasonic attenuation in strongly heterogeneous materials. Ultrasonics 50(8), 824 (2010)Genovés, V., Vargas, F., Gosálbez, J., Carrión, A., Borrachero, M., Payá, J.: Ultrasonic and impact spectroscopy monitoring on internal sulphate attack of cement-based materials. Mater. Design 125(Suppl C), 46 (2017)Park, G.K., Yim, H.J.: Evaluation of fire-damaged concrete: an experimental analysis based on destructive and nondestructive methods. Int. J. Concr. Struct. Mater. 11(3), 447 (2017)Payan, C., Ulrich, T., Le Bas, P., Griffa, M., Schuetz, P., Remillieux, M., Saleh, T.: Probing material nonlinearity at various depths by time reversal mirrors. Appl. Phys. Lett. 104(14), 144102 (2014)Payan, C., Ulrich, T.J., Le Bas, P.Y., Saleh, T., Guimaraes, M.: Quantitative linear and nonlinear resonance inspection techniques and analysis for material characterization: application to concrete thermal damage. J. Acoust. Soc. Am. 136(2), 537 (2014)Payan, C., Garnier, V., Moysan, J., Johnson, P.: Applying nonlinear resonant ultrasound spectroscopy to improving thermal damage assessment in concrete. J. Acoust. Soc. Am. 121(4), EL125 (2007)Yim, H.J., Kim, J.H., Park, S.J., Kwak, H.G.: Characterization of thermally damaged concrete using a nonlinear ultrasonic method. Cem. Concr. Res. 42(11), 1438 (2012)Borrachero, M.V., Payá, J., Bonilla, M., Monzó, J.: The use of thermogravimetric analysis technique for the characterization of construction materials. J. Therm. Anal. Calorim. 91, 503–509 (2008)Genovés, V., Soriano, L., Borrachero, M., Eiras, J., Payá, J.: Preliminary study on short-term sulphate attack evaluation by non-linear impact resonance acoustic spectroscopy technique. Constr. Build. Mater. 78, 295 (2015)Krautkrämer, J., Krautkrämer, H.: Ultrasonic Testing of Materials. Springer, New York (1983)Gaydecki, P.A., Burdekin, F.M., Damaj, W., John, D.G.: The propagation and attenuation of medium-frequency ultrasonic waves in concrete: a signal analytical approach. Meas. Sci. Technol. 3(1), 126 (1992

Arqueología Virtual en Dispositivos Móviles. Un Caso Práctico: Patrimonio Defensivo Medieval

[ES] La arqueología virtual es un interesante canal de promoción del patrimonio con fines turísticos. En este trabajo proponemos aplicar técnicas de realidad virtual en dispositivos móviles a fin de aprovechar las ventajas únicas que brindan dichas plataformas: ubiquidad y localización. Primeramente, describimos una arquitectura cliente-servidor capaz de proporcionar mapas 3D realistas en dispositivos móviles en función de la localización del usuario. A continuación, describimos un caso de estudio que consiste en aplicar dicha arquitectura para implementar una guía turística en 3D. El objetivo de esta guía es divulgar y promocionar la organización territorial y las edificaciones defensivas existentes en el “Concejo de Baeza” (España) durante la baja Edad Media. Si bien, la guía se puede extrapolar fácilmente a otros periodos y áreas geográficas.[EN] Virtual archaeology is an interesting way to promote cultural heritage with touristic purposes. This paper proposes to apply virtual reality techniques on mobile devices in order to exploit the unique features provided by these devices: ubiquity and location-awareness. Firstly, we propose a client-server framework that provides realistic 3D maps on mobile devices according to the user’s location. Following, we describe a study case that applies this technology to implement a 3D touristic guide. This guide aims at promoting the territorial organization and defensive buildings during the low Middle Ages in the “Council of Baeza”, Spain. However, the proposed guide can be easily expanded to cover any geographic area and historic age.Este trabajo ha sido parcialmente financiado por la Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía y la Unión Europea (fondos FEDER) mediante el proyecto de investigación P07-TIC-02773.Noguera, JM.; Gutiérrez, MV.; Castillo, JC.; Segura Sánchez, RJ. (2012). Arqueología Virtual en Dispositivos Móviles. Un Caso Práctico: Patrimonio Defensivo Medieval. Virtual Archaeology Review. 3(7):109-115. https://doi.org/10.4995/var.2012.4403OJS10911537BAEZA, U. (2011): "Realidad Virtual para la dinamización de entornos rurales. Un caso práctico: Red Parque Cultural", en Virtual Archaeology Review, Volumen 2, Número 3, Abril 2011, pp. 105-108.CAPIN, T., PULLI, K., AKENINE-MÖLLER, T. (2008): "The state of the art in mobile graphics research", en IEEE Computer Graphics and Applications, 28 (4) pp. 74-84. doi:10.1109/MCG.2008.83.CASTILLO ARMENTEROS, JC; GUTIÉRREZ CALDERÓN, MV. (2010): "El Control del Territorio en la Comunidad de Villa y Tierra de Baeza (Jaén). Apuntes desde la Arqueología Espacial", en II Simposio Internacional sobre Castelos. Fortificaçoes e territorio na península Iberica e no Magreb. Séculos VI-XVI. Óbidos (Portugal), 2010.GARCÍA FITZ, F. (2008): Las Navas de Tolosa. Editorial Ariel.GUTIÉRREZ CALDERÓN, MV; CASTILLO ARMENTEROS, JC. (2011): "Los sistemas de Información Geográfica como herramienta arqueológica: La aplicación en el Concejo de Villa y Tierra de Baeza en la Baja Edad Media", en I Congreso Internacional "El patrimonio Cultural y Natural como motor de desarrollo: investigación e innovación". Jaén, 2011.INTERNATIONAL TELECOMMUNICATION UNION (2011): "Measuring the Information Society". ISBN 92-61-13801-2. Disponible en World Wide Web: http://www.itu.int/ITU-D/ict/publications/idi/index.html [último acceso: 17-Mayo-2012].JUNTA DE ANDALUCÍA (2005): "Modelo Digital del Terreno de Andalucía: Relieve y Orografía a resolución 10 m". Consejería de Obras Públicas y Transportes, Consejería de Agricultura y Pesca, Consejería de Medio Ambiente. DVD.NOGUERA, J.M., SEGURA, R.J., OGÁYAR, C.J., JOAN-ARINYO, R. (2011): "Navigating large terrains using commodity mobile devices", en Computers & Geosciences , Volume 37, Issue 9, September 2011, pp. 1218-1233. doi: 10.1016/j.cageo.2010.08.007.NURMINEN, A. et al. (2008): "Designing interactions for navigation in 3D mobile maps", en Map-based Mobile Services, Lecture Notes in Geoinformation and Cartography, Springer Berlin Heidelberg, 2008, pp. 198-227.PAJAROLA, R. (1998): "Large scale terrain visualization using the restricted quadtree triangulation", en VIS '98: Proceedings of the conference on Visualization '98, IEEE Computer Society Press, Los Alamitos, CA, USA, 1998, pp. 19-26. http://dx.doi.org/10.1109/visual.1998.745280RODRIGUEZ MOLINA, J. (1978): El reino de Jaén, en la Baja Edad Media. Aspectos demográficos y económicos. Editorial Universidad de Granada.SAMET, H. (1984): "The quadtree and related hierarchical data structures", en ACM Computing Surveys 16 (2), pp 187-260. doi:http://doi.acm.org/10.1145/356924.356930