API de Google maps para un mapa de conocimiento de los asesores especializados de un centro de desarrollo empresarial

Existen sitios dedicados a asesorar a emprendedores y micro empresarios en temas de compras, producción, innovación, ventas, finanzas, etc. Tanto en México, como en otros países, existen los CDE (Centros de Desarrollo Empresarial) otros denominados Incubadoras de Empresas, donde se brinda apoyo a los emprendedores que inician una nueva empresa. En la Universidad Autónoma del Estado de México, se creó una red de Incubadoras de Empresas en los Centros Universitarios, Una de estas unidades se encuentra en el Centro Universitario UAEM Texcoco, donde se enfocó este proyecto. Una de las misiones de los CDE es ofrecer y llevar a cabo asesorías ante los problemas y retos de las empresas nacientes. Para lo anterior se creó una aplicación Web para administrar el conocimiento a través de un Mapa de Conocimiento. Los usuarios pueden consultar la existencia de conocimiento requerido; si existe, lo podrán visualizar en un mapa con ayuda de la API (Interfaz de Programación de Aplicaciones) de Google Maps. Para su uso, basta un dispositivo con conexión a internet. Esta aplicación busca apoyar a emprendedores y empresarios que tiene las preguntas: ¿El CDE Tiene el conocimiento qué requiero? ¿Quién tiene el conocimiento? ¿Dónde están los portadores del conocimiento? ¿Cómo y dónde los contacto? De existir el conocimiento en el mapa bastará contactar a algún portador y establecer una modalidad para la asesoría requerida. Se parte, de la búsqueda de conocimiento, su existencia, ubicación y forma de contactar al portador del conocimiento. Para lo anterior se logró una aplicación capaz de filtrar un tipo de conocimiento y el mapeo sobre la plataforma de la API de Google Maps

Interspecific interactions among functionally diverse frugivores and their outcomes for plant reproduction: a new approach based on camera-trap data and tailored null models

Research ArticleThe study of plant-frugivore interactions is essential to understand the ecology and evolution of many plant communities. However, very little is known about how interactions among frugivores indirectly affect plant reproductive success. In this study, we examined direct interactions among vertebrate frugivores sharing the same fruit resources. Then, we inferred how the revealed direct interspecific interactions could lead to indirect (positive or negative) effects on reproductive success of fleshy fruited plants. To do so, we developed a new analytical approach that combines camera trap data (spatial location, visitor species, date and time, activity) and tailored null models that allowed us to infer spatial-temporal interactions (attraction, avoidance or indifference) between pairs of frugivore species. To illustrate our approach, we chose to study the system composed by the Mediterranean dwarf palm, Chamaerops humilis, the Iberian pear tree, Pyrus bourgaeana, and their shared functionally diverse assemblages of vertebrate frugivores in a Mediterranean area of SW Spain. We first assessed the extent to which different pairs of frugivore species tend to visit the same or different fruiting individual plants. Then, for pairs of species that used the same individual plants, we evaluated their spatial-temporal relationship. Our first step showed, for instance, that some prey frugivore species (e.g. lagomorphs) tend to avoid those C. humilis individuals that were most visited by their predators (e.g. red foxes). Also, the second step revealed temporal attraction between large wild and domestic frugivore ungulates (e.g. red deer, cows) and medium-sized frugivores (e.g. red foxes) suggesting that large mammals could facilitate the C. humilis and P. bourgaeana exploitation to other smaller frugivores by making fruits more easily accessible. Finally, our results allowed us to identify direct interaction pathways, that revealed how the mutualistic and antagonistic relations between animal associates derived into indirect effects on both plants seed dispersal success. For instance, we found that large-sized seed predators (e.g. ungulates) had a direct positive effect on the likelihood of visits by legitimate seed dispersers (e.g. red foxes) to both fleshy fruited plants. Then, seed predators showed an indirect positive effect on the plants’ reproductive Our new analytical approach provides a widely applicable framework for further studies on multispecies interactions in different systems beyond plant-frugivore interactions, including plant-pollinator interactions, the exploitation of plants by herbivores, and the use of carcasses by vertebrate scavengersinfo:eu-repo/semantics/publishedVersio

Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus

Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of metabolic waste products. Here we studied in the hyh mouse, an animal model of congenital hydrocephalus, the role of reactive astrocytes in this clinical degenerative condition. Materials and Methods Wild type and hydrocephalic hyh mice at 30 days of postnatal age were used. Three metabolites related to the oxidative and neurotoxic conditions were analysed in ex vivo samples (glutathione, glutamine and taurine) using High Resolution Magic Angle Spinning (HR-MAS). Glutathione synthetase and peroxidase, glutamine synthetase, kidney-type glutaminase (KGA), and taurine/taurine transporter were immunolocated in brain sections. Results Levels of the metabolites were remarkably higher in hydrocephalic conditions. Glutathione peroxidase and synthetase were both detected in the periventricular reactive astrocytes and neurons. Taurine was mostly found free in the periventricular parenchyma and in the reactive astrocytes, and the taurine transporter was mainly present in the neurons located in such regions. Glutamine synthetase was found in reactive astrocytes. Glutaminase was also detected in the reactive astrocytes and in periventricular neurons. These results suggest a possible protective response of reactive astrocytes against oxidative stress and neurotoxic conditions. Conclusions Astrocyte reaction seems to trigger an anti-oxidative and anti-neurotoxic response in order to ameliorate pathological damage in periventricular areas of the hydrocephalic mice.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PI15-00619 to AJJ

Effect of monotherapy with darunavir/ cobicistat on viral load and semen quality of HIV-1 patients

Many patients previously using darunavir/ritonavir (DRV/r) (800/100mg) have switched to darunavir/cobicistat (DRV/C) (800/150 mg) either as part of triple therapy (ART) or as monotherapy with DRV (mDRV). The latter approach continues to be used in some countries for patients receiving long-term treatment. However, to date, the behaviour of DRV/C in the seminal compartment has not been analysed. This study explores how the combination behaves in monotherapy, with respect to the control of viral load and seminal quality. To this end, we studied 20 patients who were treated with mDRV/C after previous treatment with mDRV/r for at least 24 weeks. A viral load control in seminal plasma similar to that published in the literature was observed after 24 weeks of treatment with mDRV/C (viral load positivity in 20% of patients). Similarly, semen quality was confirmed (70% normozoospermic) in patients treated with this formulation, as has previously been reported for ART and mDRV/r. The DRV levels measured in seminal plasma were above EC50, regardless of whether the seminal viral load was positive or negative. We conclude that this mDRV/C co-formulation behaves like mDRV/r in seminal plasma in terms of viral load control and semen quality

DETERMINATION OF ENVIRONMENTAL PARAMETERS BASED ON ARDUINO BASED LOW-COST SENSORS

Taking into account that the age of structures is closely connected to their energy consumption, the monitoring of structures is a crucial task for engineers. This article deals with application of Arduino based low-cost sensors for environmental monitoring of buildings. To do so, open source platform Arduino as well as four environmental sensors, DHT22, have been used for measuring variation of temperature and humidity. In order to check accuracy of the utilized data acquisition system, statistical approach was used to check the repeatability and discrepancy of the recorded data. Statistical calculations indicate that the sensor is more accurate in terms of measuring temperature rather than humidity one since discrepancy of the temperature parameter is less than the humidity one. The maximum range of standard deviation derived for temperature and humidity parameters are less than 0.13 and 1.33 respectively.Teniendo en cuenta que la edad de las estructuras está estrechamente relacionada con su consumo energético, la supervisión de las estructuras es una tarea crucial para los ingenieros. Este artículo trata de la aplicación de sensores de bajo coste basados en Arduino para la ambiental de los edificios. Para ello, se ha utilizado la plataforma de código abierto Arduino, así como cuatro sensores ambientales, DHT22 para medir la variación de la temperatura y la humedad. Para comprobar la precisión del sistema de adquisición de datos utilizado de datos utilizado, se utilizó un enfoque estadístico para comprobar la repetibilidad y la discrepancia de los datos registrados. Los cálculos estadísticos indican que el sensor es más preciso en la medición de la temperatura que en la de la humedad, ya que la discrepancia de de la temperatura es menor que la de la humedad. El rango máximo de desviación estándar obtenido para los parámetros de temperatura y humedad son inferiores a 0,13 y 1,33 respectivamente

Interoperabilidad de sensores de bajo coste con modelos BIM mediante programación visual paramétrica

The current advances in Smart Cities technology trend towards the creation of complex and interconnected systems, through the application of new software tools and devices based on the Internet of Things, Big Data and so on. However, the cost of certain elements and devices (such as monitoring of environmental and confort parameters) is oftenly very high, leading to exclusive procedures and being used only in relatively singular works or in those in which they have been found, or is foreseeable, to find pathologies. From this point emerges the need for proposing the development of versatile and reliable monitoring protocols from open source digital prototyping platforms and the use of low-cost sensors, in order to lay aside that exclusivity. Thus, it could be possible to contribute to the expansion of the field of application to get greater efficiency and sustainability together. This paper demosnstrates and shows the most effective options of interoperability of low-cost sensors with BIM models to make possible the development of BIM 7D stage, by monitoring thermal data and synchronizing and live updating in a virtual model. This will make possible more accurate simulations, as well as the improving decision-making process over the entire lifecycle of the infrastructure.La coyuntura tecnológica actual de las ciudades Inteligentes se orienta hacia la creación de sistemas complejos e interconectados, con aplicación de nuevas herramientas y dispositivos basados en Internet de las Cosas (IoT), Big Data, etc. Sin embargo, el coste de determinados elementos (como los de monitorización de parámetros de confort ambiental en edificios) suele ser elevado, lo que conlleva a su exclusividad y a utilizarse únicamente en obras relativamente singulares o en aquellas en las que se han encontrado, o es previsible, encontrar patologías. De ello surge la necesidad de plantear el desarrollo de protocolos de monitorización versátiles y económicos a partir de plataformas de prototipado digital de código abierto y la utilización de sensores de bajo coste, a fin de dejar a un lado la antedicha exclusividad y poder, así, contribuir a la ampliación de su campo de aplicación en pos de una lograr una mayor eficiencia y sostenibilidad en conjunto. Este trabajo estudia y muestra las alternativas más viables de interoperabilidad de sensores de bajo coste con modelos BIM para posibilitar el desarrollo de la fase BIM 7D, mediante la monitorización de datos térmicos y sincronización en tiempo real para su visualización en un modelo virtual. Esto permitirá la calibración de simulaciones más precisas, así como la mejora del proceso de toma de decisiones durante el ciclo de vida de la infraestructur

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good