78 research outputs found
Public Resource Allocation, Strategic Behavior, and Status Quo Bias in Choice Experiments
Choice experiments, a survey methodology in which consumers face a series of choice tasks requiring them to indicate their most preferred option from a choice set containing two or more options, are used to generate estimates of consumer preferences to determine the appropriate allocation of public resources to competing projects or programs. The analysis of choice experiment data typically relies on the assumptions that choices of the non-status quo option are demand-revealing and choices of the status quo option are not demand-revealing, but rather, reflect an underlying behavioral bias in favor of the status quo. This paper reports the results of an experiment which demonstrates that both of these assumptions are likely to be invalid. We demonstrates that choice experiments for a public good are vulnerable to the same types of strategic voting that affect other types of multiple-choice voting mechanisms. We show that due to the mathematics of choice set design, what is actually strategic voting is often interpreted as a behavioral bias for the status quo option. Therefore, we caution against using current choice experiment methodologies to inform policy making about public goods
Limits on spin-dependent WIMP-nucleon cross-sections from the first ZEPLIN-II data
The first underground data run of the ZEPLIN-II experiment has set a limit on
the nuclear recoil rate in the two-phase xenon detector for direct dark matter
searches. In this paper the results from this run are converted into the limits
on spin-dependent WIMP-proton and WIMP-neutron cross-sections. The minimum of
the curve for WIMP-neutron cross-section corresponds to 0.07 pb at a WIMP mass
of around 65 GeV.Comment: 12 pages, 2 figures, to be published in Physics Letters
The ZEPLIN II dark matter detector: data acquisition system and data reduction
ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching
for WIMP-nucleon interactions. In this paper we describe the data acquisition
system used to record the data from ZEPLIN-II and the reduction procedures
which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure
The ZEPLIN II dark matter detector: data acquisition system and data reduction
ZEPLIN-II is a two-phase (liquid/gas) xenon dark matter detector searching
for WIMP-nucleon interactions. In this paper we describe the data acquisition
system used to record the data from ZEPLIN-II and the reduction procedures
which parameterise the data for subsequent analysis.Comment: 11 pages, 10 figure
The ZEPLIN-III dark matter detector: performance study using an end-to-end simulation tool
We present results from a GEANT4-based Monte Carlo tool for end-to-end
simulations of the ZEPLIN-III dark matter experiment. ZEPLIN-III is a two-phase
detector which measures both the scintillation light and the ionisation charge
generated in liquid xenon by interacting particles and radiation. The software
models the instrument response to radioactive backgrounds and calibration
sources, including the generation, ray-tracing and detection of the primary and
secondary scintillations in liquid and gaseous xenon, and subsequent processing
by data acquisition electronics. A flexible user interface allows easy
modification of detector parameters at run time. Realistic datasets can be
produced to help with data analysis, an example of which is the position
reconstruction algorithm developed from simulated data. We present a range of
simulation results confirming the original design sensitivity of a few times
pb to the WIMP-nucleon cross-section.Comment: Submitted to Astroparticle Physic
Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort
Background
Individuals with rare kidney diseases account for 5–10% of people with chronic kidney disease, but constitute more than 25% of patients receiving kidney replacement therapy. The National Registry of Rare Kidney Diseases (RaDaR) gathers longitudinal data from patients with these conditions, which we used to study disease progression and outcomes of death and kidney failure.
Methods
People aged 0–96 years living with 28 types of rare kidney diseases were recruited from 108 UK renal care facilities. The primary outcomes were cumulative incidence of mortality and kidney failure in individuals with rare kidney diseases, which were calculated and compared with that of unselected patients with chronic kidney disease. Cumulative incidence and Kaplan–Meier survival estimates were calculated for the following outcomes: median age at kidney failure; median age at death; time from start of dialysis to death; and time from diagnosis to estimated glomerular filtration rate (eGFR) thresholds, allowing calculation of time from last eGFR of 75 mL/min per 1·73 m2 or more to first eGFR of less than 30 mL/min per 1·73 m2 (the therapeutic trial window).
Findings
Between Jan 18, 2010, and July 25, 2022, 27 285 participants were recruited to RaDaR. Median follow-up time from diagnosis was 9·6 years (IQR 5·9–16·7). RaDaR participants had significantly higher 5-year cumulative incidence of kidney failure than 2·81 million UK patients with all-cause chronic kidney disease (28% vs 1%; p<0·0001), but better survival rates (standardised mortality ratio 0·42 [95% CI 0·32–0·52]; p<0·0001). Median age at kidney failure, median age at death, time from start of dialysis to death, time from diagnosis to eGFR thresholds, and therapeutic trial window all varied substantially between rare diseases.
Interpretation
Patients with rare kidney diseases differ from the general population of individuals with chronic kidney disease: they have higher 5-year rates of kidney failure but higher survival than other patients with chronic kidney disease stages 3–5, and so are over-represented in the cohort of patients requiring kidney replacement therapy. Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney replacement therapy demand.
Funding
RaDaR is funded by the Medical Research Council, Kidney Research UK, Kidney Care UK, and the Polycystic Kidney Disease Charity
The Old Destroyerman\u27s Trivia Quiz
If you served in destroyers in the 1940s, 50s or 60s, you\u27ll find that this quiz triggers long dormant memories. Many of the items were essential to the skills and training necessary to get through the daily business of the fleet, but haven\u27t been used now in a decade or more, Even if you have never served in destroyers, you\u27ll probably find things here that will tickle your memory if you are older, or amuse you if you are younger
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