Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms

This is a post-peer-review, pre-copyedit version of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at: https://doi.org/10.1007/s00216-019-02217-yMetal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have evolved tremendously due to the emergence of these hybrid inorganic–organic MOF-based materials. This is because these materials possess a series of key properties essential for bioapplications, such as minimal toxicity to living cells, intrinsic biodegradability, and possibility of synthesizing with nanoscale sizes. Additional properties of MOFs such as ultra-large surface-to-volume ratios, tunable pore size, high drug loading capacity, tunable structure and chemical composition, and potential for multiple postsynthetic modification make them ideal candidates for drug delivery. This review highlights recent research progress on MOF-based drug delivery systems (DDS), pointing out the evolution of these systems toward the development of theranostic nanoplatforms. Rather than a comprehensive review, representative recent examples are selected to illustrate such an evolution, and a critical discussion of the advantages and limitations of the different DDS types is given. Finally, the remaining challenges and future opportunities in this field are presented, highlighting that overcoming the current issues will pave the way toward the elusive dream of “personalized medicine.”C.C.C. thanks the financial support from the European Union under the H2020-MSCA-IF-2016 program (MSCA-IF-EF-ST Grant Agreement No. 749667)S

Analytical strategies based on quantum dots for heavy metal ions detection

Heavy metal contamination is one of the major concerns to human health because these substances are toxic and retained by the ecological system. Therefore, in recent years, there has been a pressing need for fast and reliable methods for the analysis of heavy metal ions in environmental and biological samples. Quantum dots (QDs) have facilitated the development of sensitive sensors over the past decade, due to their unique photophysical properties, versatile surface chemistry and ligand binding ability, and the possibility of the encapsulation in different materials or attachment to different functional materials, while retaining their native luminescence property. This paper comments on different sensing strategies with QD for the most toxic heavy metal ions (i.e., cadmium, Cd2+; mercury, Hg2+; and lead, Pb2+). Finally, the challenges and outlook for the QD-based sensors for heavy metals ions are discussedM.V.G. thanks the MICINN for the PhD grant (FPI, BES-2010-032652). C.C.C. acknowledges a postdoctoral fellowship from the Alexander von Humboldt FoundationS

Reintegro del IVA por exportaciones

La profesión de Contador Público tiene diversas y muy importantes incumbencias sociales que ponen de manifiesto los grandes cambios que se van produciendo a través del tiempo, por lo que continuamente el graduado debe estar informado y plenamente capacitado para llevar a cabo las tareas que se le presentan. Con la globalización, las exportaciones han ido creciendo notablemente, razón por la cual los “clientes-exportadores" cada vez son más y la primera inquietud que ellos manifiestan una vez que ya está en marcha su negocio es la temática del recupero de I.V.A (Impuesto al Valor Agregado) que disminuye notablemente el costo de la operatoria de poderse llevar a cabo tal recupero. Esta temática está muy poco explorada en las bibliografías existentes, por ser compleja y por el grado de dificultad que se presenta al querer llevarla a la práctica. Además, al ser medianamente nuevo este proceso de recupero, los profesionales contables innovan acerca de su uso práctico por lo que existen diversidad de criterios y opiniones, más aún si se tiene en cuenta la cantidad de “clientes-exportadores", cada cual con su operatoria muy propia. Como consecuencia de esto, orientamos nuestro trabajo a la investigación de este tema, para ver de qué manera podemos colaborar con el desarrollo profesional, no sólo de los estudiantes o profesionales en Ciencias Económicas sino también de la sociedad en su totalidad.Fil: Carrión, Guillermo Daniel. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Gili Carrillo, Renzo Omar. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

CdSe/ZnS Quantum Dots modificados con Calix[8]arenos como nanosensor de fullereno. Monitorización de aguad

II Encuentro sobre nanociencia y nanotecnología de investigadores y tecnólogos de la Universidad de Córdoba. NANOUC

μLC-SERS system using silver-quantum dots substrate for the separation and determination of nucleic acid bases

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

A novel silver-quantum dots "sponge" nanocomposite as sers-active substrate

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

Los efectos psicosociales generados por el COVID-19 en los trabajadores y sus familias. Sistematización de la experiencia de una empresa de Quito durante los meses de junio a agosto del 2020.

La pandemia del COVID-19 ha tenido un fuerte impacto en la vida de toda la población del Ecuador y el mundo, sin duda también afectó a los mercados laborales, la economía y las empresas, por tal razón el presente trabajo de sistematización de la experiencia fue desarrollado en una empresa de la ciudad de Quito mientras desarrollaba mi función profesional, la empresa preocupada por su responsabilidad laboral hacia sus colaboradores en los momentos más críticos de la pandemia decidió otorgar un beneficio adicional a cada uno brindando ayuda psicológica a través de varios programas de atención que se implementaron para cada uno de los trabajadores que necesitaban de asistencia profesional. El objetivo de esta sistematización fue relatar la experiencia de apoyo psicosocial brindada a los trabajadores y sus familias durante los meses de retorno al trabajo junio-agosto 2020, con el propósito de evidenciar y reconocer el rol de la empresa y de sus trabajadores en momentos de la crisis sanitaria del COVID-19. Está investigación se realizó desde una metodología cualitativa buscando comprender los fenómenos desde la perspectiva de los participantes, a través de la utilización de instrumentos como la observación y entrevista semiestructurada, el análisis de contenido se utilizó para el análisis de datos. Los participantes de la investigación estuvieron satisfechos en la entrevista recordaron momentos difíciles que vivieron junto a su familia, pero todos destacaron el trabajo que se realizó junto a ellos, el seguimiento permanente, la asesoría profesional, la escucha activa, los primeros auxilios psicológicos fueron parte de la estrategia que se utilizó para solventar los momentos de crisis de cada uno.The COVID-19 pandemic has had a strong impact on the lives of the entire population of Ecuador and the world, undoubtedly it also affected labor markets, the economy and companies, for this reason the present work of systematization of the experience was developed in a company in the city of Quito while I developed my professional function, The company, concerned about its labor responsibility towards its collaborators in the most critical moments of the pandemic, decided to grant an additional benefit to each of the collaborators, providing psychological help through various programs of attention that were implemented for each of the workers who needed professional assistance. The objective of this systematization was to relate the experience of psychosocial support provided to workers and their families during the months of return to work June-August 2020, with the purpose of evidencing and recognizing the role of the company and its workers at the time of the health crisis of COVID-19. This research was conducted from a qualitative methodology through the use of instruments such as observation and semi-structured interview, content analysis was used for data analysis. The participants of the research were satisfied in the interview, they recalled difficult moments they lived through with their family, but all of them highlighted the work that was done with them, the permanent follow-up, the professional counseling, the active listening, the psychological first aid were part of the strategy used to solve the moments of crisis of each one

Synthesis and Functionalization of Monodisperse Near-ultraviolet and Visible Excitable Multifunctional Eu3+, Bi3+:REVO4 Nanophosphors for Bioimaging and Biosensing Applications

Near-ultraviolet and visible excitable Eu- and Bi-doped NPs based on rare earth vanadates (REVO4, RE = Y, Gd) have been synthesized by a facile route from appropriate RE precursors, europium and bismuth nitrate, and sodium orthovanadate, by homogeneous precipitation in an ethylene glycol/water mixture at 120 °C. The NPs can be functionalized either by a one-pot synthesis with polyacrylic acid (PAA) or by a Layer-by-Layer approach with poly(allylamine hydrochloride) (PAH) and PAA. In the first case, the particle size can also be tuned by adjusting the amount of PAA. The Eu- Bi-doped REVO4 based nanophosphors show the typical red luminescence of Eu(III), which can be excited through an energy transfer process from the vanadate anions, resulting in a much higher luminescence intensity in comparison to the direct excitation of the europium cations. The incorporation of Bi into the REVO4 structure shifts the original absorption band of the vanadate anions towards longer wavelengths, giving rise to nanophosphors with an excitation maximum at 342 nm, which can also be excited in the visible range. The suitability of such nanophosphors for bioimaging and biosensing applications, as well as their colloidal stability in different buffer media of biological interest, their cytotoxicity, their degradability at low pH, and their uptake by HeLa cells have been evaluated. Their suitability for bioimaging and biosensing applications is also demonstrated.European Union 267226Ministerio de Economía y Competitividad MAT2014-54852-

Rare earth based nanostructured materials: Synthesis, functionalization, properties and bioimaging and biosensing applications

Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.European Union 267226Ministerio de Economía y Competitividad MAT2014-54852-

Adiciones a la flora vascular de Murcia

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