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New insights into the genetic etiology of Alzheimer's disease and related dementias

Author: Aaltonen L.
Aaltonen V.
Aarsland Dag
Aavikko M.
Abalos M.S.
Abdelnour Carla
Abner E.
Abraham R.
Adams H.
Adams P.M.
Adarmes-Gómez A.
Adarmes-Gómez A.D.
Aguilera N.
Aguilera N.
Aguirre A.
Ahmad S.
Akinyemi R.O.
Al-Chalabi A.
Alarcón-Martín Emilio
Albert M.S.
Albin R.L.
Alcolea Daniel
Alegret Montserrat
Ali M.
Allen M.
Allende I.R.
Alonso M.D.
Alonso M.D.
Alvarez I.
Alvarez L.
Amer-Ferrer G.
Amin N.
Amouyel Philippe
Anastasiou A.
Anastasiou C.
Andrade V.
Andreassen Ole A.
Andreoni S.
Antequera M.
Antikainen R.
Antonell A.
Anttonen V.
Antúnez C.
Aparicio H.J.
Apostolova L.G.
Appollonio I.
Arcaro M.
Archetti S.
Armstrong N.J.
Arnold S.E.
Arosio B.
Arvas M.
Assogna F.
Asthana S.
Athanasiu L.
Atwood C.S.
Auge F.
Auranen A.
Auvinen P.
Awaisa G.
Ayres G.
Bacha J.I.
Bahadori M.
Bahrami S.
Bailly H.
Baldwin C.T.
Banaj N.
Baquero M.
Barber R.C.
Barnes L.L.
Barral S.
Barral S.
Bass N.
Bass N.J.
Bastiani P.
Bayer A.
Beach T.G.
Becker J.T.
Becker J.T.
Becker T.
Beecham G.W.
Beekly D.
Behrens T.
Beiser A.
Belezhanska D.
Bellenguez Céline
Below J.E.
Below J.E.
Ben-Shlomo Y.
Benchek P.
Benchek P.
Benitez B.A.
Bennett D.
Benussi A.
Benussi L.
Bergh S.
Bernardo-Harrington M.
Berr Claudine
Bertelson J.
Besse C.
Bessi V.
Betts J.
Bhangale T.
Biessels G.J.
Binetti G.
Bing N.
Bird T.D.
Bis Joshua C
Biswas S.
Bizarro A.
Bjerke M.
Blacker D.
Blesa Rafael
Blomster T.
Boada M.
Boecker H.
Boerwinkle E.
Boeve B.F.
Boland A.
Borroni B.
Boschi S.
Bosnes I.
Bossù Paola
Bowen J.D.
Bowers N.
Boxer A.
Brauer M.
Brayne C.
Brein G.
Bresner C.
Bressler J.
Breteler M.
Brewer J.
Brice A.
Brodaty H.
Broeckhoven C.V.
Bronson P.
Brookes K.J.
Brown K.
Brown K.S.
Brusco L.I.
Bråthen G.
Buendia M.
Buiza-Rueda D.
Bullido M.J.
Burguera J.A.
Burholt V.
Burke J.R.
Burns J.M.
Bush W.S.
Bush W.S.
Buxbaum J.D.
Bûrger K.
Cairns N.J.
Calero M.
Caliskan M.
Call K.
Call K.
campion D.
Campos-Martin R.
Cano A.
Cantwell Laura B
Cao C.
Carlson C.S.
Carlsson C.M.
Carney R.M.
Carpén O.
Carracedo Ángel
Carrasquillo M.M.
Carrillo F.
Carrillo F.
Carrión-Claro M.
Carrión-Claro M.
Casajeros M.J.
Castaño E.M.
Cañabate P.
Cañabate P.
Cecchetti R.
Cervera-Carles L.
Challis B.
Chang D.
Chapuis J.
Charbonnier C.
Chasman D.
Chasse S.
Chatelain C.
Chauhan G.
Chen C.Y.
Chen H.
Chen H.
Chen H.H.
Chen X.
Chene G.
Chesi A.
Chesselet M.F.
Chhibber A.
Chillotti Caterina
Chin N.A.
Chipi E.
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Ciullo V.
Claassen J.A.H.R.
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Cribbs D.H.
Crocco E.A.
Crohns M.
Cruchaga C.
Cuccaro M.L.
Cuesta C.
Cullum M.
Cummings B.
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Custodero C.
Daian D.
Dalmasso Maria Carolina
Daly M.
Damotte V.
Daniele A.
Darby E.
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Dartigues J.F.
Davies C.
Davies G.
Davis B.
Davis J.W.
de Deyn P.P.
De Jager P.L.
de Mendonça A.
de Munain A.L.
de Paiva Lopes K.
de Rojas I.
de Witte L.D.
Debette Stéphanie
DeCarli C.
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Deckert J.
del Ser T.
Deleuze J.F.
della Briotta Parola P.
della Briotta Parolo P.
Deloukas P.
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Denning N.
Deramecourt V.
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Dickson D.W.
Diego S.
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Dongen J.V.
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Escuela R.
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Etchepareborda I.
Evans D.A.
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Faber K.M.
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Fallon K.B.
Fan F.
Fardo D.W.
Farlow M.R.
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Fenoglio C.
Fernandez-Hernandez V.
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Ferrarese C.
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Ferri E.
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Feulner T.
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Fin B.
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Gailhajenet A.
Galasko D.R.
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Galimberti D.
Gamboa A.
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Garcia-Ribas G.
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García-Alberca J.M.
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Garrote-Espina L.
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Gearing M.
Geerlings M.
Georgantas B.
George-Hyslop P.S.
Germani S.
Gerrish A.
Geschwind D.H.
Ghanbari M.
Ghetti B.
Ghidoni R.
Ghosh S.
Giedraitis Vilmantas
Giegling I.
Gilbert J.R.
Gill M.
Giorgio G.
Glatt S.J.
Goate A.M.
Goldhardt O.
Gomez-Fonseca D.
Gonzalez H.M.
González-Pérez A.
Gordillo J.E.
Gormley P.
Goss M.
Gossel M.
Grabe H.
Grabowski T.J.
Gracia-Tabuenca J.
Graff C.
Graff-Radford N.R.
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Grande G.
Grant S.F.A.
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Guerreiro R.
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Gwilliam R.
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Hartmann A.M.
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Hollingworth P.
Holmans Peter
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Huebinger R.M.
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Swerdlow R.H.
Sáez María Eugenia
Sánchez-Arjona M.B.
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Universitat Autònoma de Barcelona
Uphill J.
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Uusitalo H.
Uusitalo-Järvinen H.
Vacca A.
Vainio S.
Valero S.
Valladares O.
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Wiltfang J.
Windle G.
Wingo T.S.
Wisniewski T.
Wittfeld K.
Woltjer R.L.
Wong R.
Woods B.
Woon M.
Wright C.B.
Wu C.K.
Wu Y.
Xia T.h.
Xu E.
Xu F.
Yanek L.
Yang Q.
Yang Y.
Yannakoulia M.
Yaqub A.
Younkin S.G.
Yu C.E.
Yu L.
Zare H.
Zhang X.
Zhang Y.
Zhao Y.
Zhao Y.
Zhou W.
Zhu C.
Zhu X.
Ziemann A.
Zoia C.P.
Zompo M.D.
Zulaica M.
Álvarez V.
Publication venue
Publication date: 01/01/2022
Field of study

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Diposit Digital de Documents de la UAB

Search for gravitational-wave transients associated with magnetar bursts in advanced LIGO and advanced Virgo data from the third observing run

Author: Abbott R
Abe H
Acernese F
Ackley K
Adhikari N
Adhikari R.X
Adkins V.K
Adya V.B
Affeldt C
Agarwal D
Agathos M
Agatsuma K
Aggarwal N
Aguiar O.D
Aiello L
Ain A
Ajith P
Akutsu T
Albanesi S
Alfaidi R.A
Allocca A
Altin P.A
Amato A
Anand C
Anand S
Ananyeva A
Anderson S.B
Anderson W.G
Ando M
Andrade T
Andres N
Andrić T
Andrés-Carcasona M
Angelova S.V
Ansoldi S
Antelis J.M
Antier S
Apostolatos T
Appavuravther E.Z
Appert S
Apple S.K
Arai K
Araya A
Araya M.C
Areeda J.S
Arellano F.E. Peña
Aritomi N
Arnaud N
Arogeti M
Aronson S.M
Arène M
Asada H
Asali Y
Ashton G
Aso Y
Assiduo M
Aston S.M
Astone P
Aubin F
Aultoneal K
Austin C
Babak S
Badaracco F
Bader M.K. M
Badger C
Bae S
Bae Y
Baer A.M
Bagnasco S
Bai Y
Baird J
Bajpai R
Baka T
Ball M
Ballardin G
Ballmer S.W
Balsamo A
Baltus G
Banagiri S
Banerjee B
Bankar D
Barayoga J.C
Barbieri C
Barish B.C
Barker D
Barneo P
Barone F
Barr B
Barsotti L
Barsuglia M
Barta D
Bartlett J
Barton M.A
Bartos I
Basak S
Bassiri R
Basti A
Bawaj M
Bayley J.C
Bazzan M
Becher B.R
Bedakihale V.M
Beirnaert F
Bejger M
Belahcene I
Benedetto V
Beniwal D
Benjamin M.G
Bennett T.F
Bentley J.D
Benyaala M
Bera S
Berbel M
Bergamin F
Berger B.K
Bernuzzi S
Bersanetti D
Bertolini A
Betzwieser J
Beveridge D
Bhandare R
Bhandari A.V
Bhardwaj U
Bhatt R
Bhattacharjee D
Bhaumik S
Bianchi A
Bilenko I.A
Billingsley G
Bini S
Birney R
Birnholtz O
Biscans S
Bischi M
Biscoveanu S
Bisht A
Biswas B
Bitossi M
Bizouard M.-A
Blackburn J.K
Blair C.D
Blair D.G
Blair R.M
Bobba F
Bode N
Bogaert G
Boldrini M
Bolingbroke G.N
Bonavena L.D
Bondu F
Bonilla E
Bonnand R
Booker P
Boom B.A
Bork R
Boschi V
Bose N
Bose S
Bossilkov V
Boudart V
Bouffanais Y
Bozzi A
Boër M
Bradaschia C
Brady P.R
Bramley A
Branch A
Branchesi M
Brau J.E
Breschi M
Briant T
Briggs J.H
Brillet A
Brinkmann M
Brockill P
Brooks A.F
Brooks J
Brown D.D
Brunett S
Bruno G
Bruntz R
Bryant J
Bucci F
Bulik T
Bulten H.J
Buonanno A
Burtnyk K
Buscicchio R
Buskulic D
Buy C
Byer R.L
Bécsy B
Cabourn Davies G.S
Cabras G
Cabrita R
Cadonati L
Caesar M
Cagnoli G
Cahillane C
Calderón Bustillo J
Callaghan J.D
Callister T.A
Calloni E
Cameron J
Camp J.B
Canepa M
Canevarolo S
Cannavacciuolo M
Cannon K.C
Cao H
Cao Z
Capocasa E
Capote E
Carapella G
Carbognani F
Carlassara M
Carlin J.B
Carney M.F
Carpinelli M
Carrillo G
Carullo G
Carver T.L
Casentini C
Castaldi G
Caudill S
Cavaglià M
Cavalier F
Cavalieri R
Cella G
Cerdá-Durán P
Cesarini E
Chaibi W
Champion E
Chan C
Chan C.-H
Chan C.L
Chan K
Chan M
Chandra K
Chang I.P
Chanial P
Chao S
Chapman-Bird C
Charlton P
Chase E.A
Chassande-Mottin E
Chatterjee C
Chatterjee Debarati
Chatterjee Deep
Chaturvedi M
Chaty S
Chen C
Chen D
Chen H.Y
Chen J
Chen K
Chen X
Chen Y.-B
Chen Y.-R
Chen Z
Cheng H
Cheong C.K
Cheung H.Y
Chia H.Y
Chiadini F
Chiang C-Y
Chiarini G
Chierici R
Chincarini A
Chiofalo M.L
Chiummo A
Choudhary R.K
Choudhary S
Christensen N
Chu Q
Chu Y-K
Chua S.S. Y
Chung K.W
Ciani G
Ciecielag P
Cieślar M
Cifaldi M
Ciobanu A.A
Ciolfi R
Cipriano F
Clara F
Clark J.A
Clearwater P
Clesse S
Cleva F
Coccia E
Codazzo E
Cohadon P.-F
Cohen D.E
Colleoni M
Collette C.G
Colombo A
Colpi M
Compton C.M
Constancio M
Conti L
Cooper S.J
Corban P
Corbitt T.R
Cordero-Carrión I
Corezzi S
Corley K.R
Cornish N.J
Corre D
Corsi A
Cortese S
Costa C.A
Cotesta R
Cottingham R
Coughlin M.W
Coulon J.-P
Countryman S.T
Cousins B
Couvares P
Coward D.M
Cowart M.J
Coyne D.C
Coyne R
Creighton J.D. E
Creighton T.D
Criswell A.W
Croquette M
Crowder S.G
Cudell J.R
Cullen T.J
Cumming A
Cummings R
Cunningham L
Cuoco E
Curyło M
d'Angelo B
d'Antonio S
d'Emilio V
d'Onofrio L
d'Urso D
Dabadie P
Dal Canton T
Dall'Osso S
Dana A
Danilishin S
Danzmann K
Darsow-Fromm C
Dasgupta A
Datrier L.E. H
Datta Sayak
Datta Sayantani
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Dave I
Davier M
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Davis M.C
Daw E.J
de Laurentis M
de Lillo F
de Lillo N
de Matteis F
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de Rossi C
de Simone R
Dean R
Debra D
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del Favero V
del Pozzo W
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Dhurandhar S
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Di Giorgio C
Di Giovanni F
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Di Girolamo T
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Di Michele A
Di Pace S
Di Palma I
Di Renzo F
Diaz J. Casanueva
Didio N.A
Dietrich T
Ding B
Divakarla A.K
Dmitriev A
Doctor Z
Donahue L
Donovan F
Dooley K.L
Doravari S
Drago M
Driggers J.C
Drori Y
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Dupej P
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Durante O
Duverne P.-A
Dwyer S.E
Dálya G
Díaz M.C
Eassa C
Easter P.J
Ebersold M
Eckhardt T
Eddolls G
Edelman B
Edo T.B
Edy O
Effler A
Eguchi S
Eichholz J
Eikenberry S.S
Eisenmann M
Eisenstein R.A
Ejlli A
Engelby E
Enomoto Y
Errico L
Essick R.C
Estellés H
Estevez D
Etienne Z
Etzel T
Evans M
Evans T.M
Evstafyeva T
Ewing B.E
Fabrizi F
Faedi F
Fafone V
Fair H
Fairhurst S
Fan P.C
Farah A.M
Farinon S
Farr B
Farr W.M
Fauchon-Jones E.J
Favaro G
Favata M
Fays M
Fazio M
Feicht J
Fejer M.M
Fenyvesi E
Ferguson D.L
Fernandez-Galiana A
Ferrante I
Ferreira T.A
Fidecaro F
Figura P
Fiori A
Fiori I
Fishbach M
Fisher R.P
Fittipaldi R
Fiumara V
Flaminio R
Floden E
Fong H.K
Font J.A
Fornal B
Forsyth P.W. F
Franke A
Frasca S
Frasconi F
Freed J.P
Frei Z
Freise A
Freitas O
Frey R
Fritschel P
Frolov V.V
Fronzé G.G
Fujii Y
Fujikawa Y
Fujimoto Y
Fulda P
Fyffe M
Gabbard H.A
Gabella W.E
Gadre B.U
Gair J.R
Gais J
Galaudage S
Gamba R
Ganapathy D
Ganguly A
Gao D
Gaonkar S.G
Garaventa B
García-Quirós C
Garufi F
Gateley B
Gayathri V
Ge G.-G
Gemme G
Gennai A
George J
Gerberding O
Gergely L
Gewecke P
Ghonge S
Ghosh Abhirup
Ghosh Archisman
Ghosh Shaon
Ghosh Shrobana
Ghosh Tathagata
Giacomazzo B
Giacoppo L
Giaime J.A
Giardina K.D
Gibson D.R
Gier C
Giesler M
Giri P
Gissi F
Gkaitatzis S
Glanzer J
Gleckl A.E
Godwin P
Goetz E
Goetz R
Gohlke N
Golomb J
Goncharov B
González G
Gosselin M
Gouaty R
Gould D.W
Goyal S
Grace B
Grado A
Graham V
Granata M
Granata V
Grant A
Gras S
Grassia P
Gray C
Gray R
Greco G
Green A.C
Green R
Gretarsson A.M
Gretarsson E.M
Griffith D
Griffiths W.L
Griggs H.L
Grignani G
Grimaldi A
Grimes E
Grimm S.J
Grote H
Grunewald S
Gruning P
Gruson A.S
Guerra D
Guidi G.M
Guimaraes A.R
Guixé G
Gulati H.K
Gunny A.M
Guo H.-K
Guo Y
Gupta Anchal
Gupta Anuradha
Gupta I.M
Gupta P
Gupta S.K
Gustafson R
Guzman F
Ha S
Hadiputrawan I.P. W
Haegel L
Haino S
Halim O
Hall E.D
Hamilton E.Z
Hammond G
Han W.-B
Haney M
Hanks J
Hanna C
Hannam M.D
Hannuksela O
Hansen H
Hansen T.J
Hanson J
Harder T
Haris K
Harms J
Harry G.M
Harry I.W
Hartwig D
Hasegawa K
Haskell B
Haster C.-J
Hathaway J.S
Hattori K
Haughian K
Hayakawa H
Hayama K
Hayes F.J
Healy J
Heidmann A
Heidt A
Heintze M.C
Heinze J
Heinzel J
Heitmann H
Hellman F
Hello P
Helmling-Cornell A.F
Hemming G
Hendry M
Heng I.S
Hennes E
Hennig J
Hennig M.H
Henshaw C
Hernandez A.G
Hernandez I. Magaña
Heurs M
Hewitt A.L
Higginbotham S
Hild S
Hill P
Himemoto Y
Hines A.S
Hirata N
Hirose C
Ho T-C
Hochheim S
Hofman D
Hohmann J.N
Holcomb D.G
Holland N.A
Hollows I.J
Holmes Z.J
Holt K
Holz D.E
Hong Q
Hough J
Hourihane S
Howell E.J
Hoy C.G
Hoyland D
Hreibi A
Hsieh B-H
Hsieh H-F
Hsiung C
Hsu Y
Huang H-Y
Huang P
Huang Y-C
Huang Y.-J
Huang Yiting
Huang Yiwen
Huddart A.D
Hughey B
Hui D.C. Y
Hui V
Husa S
Huttner S.H
Huxford R
Huynh-Dinh T
Hübner M.T
Ide S
Idzkowski B
Iess A
Inayoshi K
Inoue Y
Iosif P
Isi M
Isleif K
Ito K
Itoh Y
Iyer B.R
Jaberianhamedan V
Jacqmin T
Jacquet P.-E
Jadhav S.J
Jadhav S.P
Jain T
James A.L
Jan A.Z
Jani K
Janquart J
Janssens K
Janthalur N.N
Jaranowski P
Jariwala D
Jaume R
Jenkins A.C
Jenner K
Jeon C
Jia W
Jiang J
Jin H.-B
Johns G.R
Johnston R
Jones A.W
Jones D.I
Jones P
Jones R
Joshi P
Ju L
Jue A
Jung K
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Junker J
Juste V
Kaihotsu K
Kajita T
Kakizaki M
Kalaghatgi C.V
Kalogera V
Kamai B
Kamiizumi M
Kanda N
Kandhasamy S
Kang G
Kanner J.B
Kao Y
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Kapasi D.P
Karathanasis C
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Kashyap R
Kasprzack M
Kastaun W
Kato T
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Katzman W
Kaur T
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Khadka S
Khalili F.Y
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Khanam T
Khazanov E.A
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Kirchhoff R
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Kringel V
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Lane B.B
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Legred I.N
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Leviton J.N
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Li T.G. F
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Lin E.T
Lin F-K
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Lin H.L
Lin L.C.-C
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Linker S.D
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Littenberg T.B
Liu G.C
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Llamas F
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London L.T
Longo A
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Loriette V
Lormand M
Losurdo G
Lott T.P
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Lousto C.O
Lovelace G
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Lumaca D
Lundgren A.P
Luo L.-W
Lynam J.E
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Machtinger J.B
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Macleod D.M
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Maksimovic I
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Mannix B.R
Mansell G.L
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Zhu X.J
Zhu Z.-H
Zucker M.E
Zweizig J
Publication venue: American Astronomical Society
Publication date: 01/01/2024
Field of study

Gravitational waves are expected to be produced from neutron star oscillations associated with magnetar giant f lares and short bursts. We present the results of a search for short-duration (milliseconds to seconds) and longduration (∼100 s) transient gravitational waves from 13 magnetar short bursts observed during Advanced LIGO, Advanced Virgo, and KAGRA’s third observation run. These 13 bursts come from two magnetars, SGR1935 +2154 and SwiftJ1818.0−1607. We also include three other electromagnetic burst events detected by FermiGBM which were identified as likely coming from one or more magnetars, but they have no association with a known magnetar. No magnetar giant flares were detected during the analysis period. We find no evidence of gravitational waves associated with any of these 16 bursts. We place upper limits on the rms of the integrated incident gravitational-wave strain that reach 3.6 × 10−²³ Hz at 100 Hz for the short-duration search and 1.1 ×10−²² Hz at 450 Hz for the long-duration search. For a ringdown signal at 1590 Hz targeted by the short-duration search the limit is set to 2.3 × 10−²² Hz. Using the estimated distance to each magnetar, we derive upper limits upper limits on the emitted gravitational-wave energy of 1.5 × 1044 erg (1.0 × 1044 erg) for SGR 1935+2154 and 9.4 × 10^43 erg (1.3 × 1044 erg) for Swift J1818.0−1607, for the short-duration (long-duration) search. Assuming isotropic emission of electromagnetic radiation of the burst ﬂuences, we constrain the ratio of gravitational-wave energy to electromagnetic energy for bursts from SGR 1935+2154 with the available ﬂuence information. The lowest of these ratios is 4.5 × 103

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