Leguminous cover crops improve the profitability and the sustainability of rainfed olive (Olea europaea L.) orchards: from soil biology to physiology of yield determination

The olive sector has a crucial economic, social, cultural and ecological relevance in the Mediterranean region, where tillage and herbicides application still are generalized practices. However, these techniques oppose to the recommendations of UE policy. Thus, other methods are needed to reduce adverse environmental impacts and to improve biodiversity, soil carbon sink and fertility, to save fossil fuels and to increase yield and the safety and nutritional value of food products. Meanwhile, since Mediterranean basin is particularly vulnerable to climate change, including lower precipitation in summer, olive tree will experiment some hard changes, mainly under rainfed conditions. Therefore, we propose an adequate management of cover crops to shift tillage and herbicides, in order to minimize runoff and evaporation water losses, conserve soil moisture storage and promote the infiltration of water in soil. The experiment was carried out during 4 years on a commercial orchard (cv. Cobrançosa) in Northeast Portugal. The treatments laid out were: (1) ordinary tillage techniques (OT) used by local growers (two tillage trips per year); (2) cover crop with self-reseeding annual legume species (AL); (3) natural vegetation fertilized (NVF) with 60 kg N hm2 (as in OT); (4) natural vegetation (NV) left unfertilized. The results revealed that AL treatment is the best option, reaching 37, 53 and 95% higher cumulative yield than NVF, OT and NV, respectively, in a closely association with greater physiological performance during the summer, mainly evidenced by lower oxidative damage and by favourable changes in water status and net photosynthetic rate, due to lower stomatal and mesophyll limitations. Moreover, the AL covered soil presented considerable microbial diversity and enzymatic activities, which may contribute to promote and conserve soil quality and health, as well the stability of ecosystems. Thus, leguminous cover crops improve the profitability and the sustainability of rainfed olive orchards.info:eu-repo/semantics/publishedVersio

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362