Chromosome numbers of two Colchicum L. species, C. burttii and C. balansae, from Turkey

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Linear canonical transformations and quantum phase:a unified canonical and algebraic approach

The algebra of generalized linear quantum canonical transformations is examined in the prespective of Schwinger's unitary-canonical basis. Formulation of the quantum phase problem within the theory of quantum canonical transformations and in particular with the generalized quantum action-angle phase space formalism is established and it is shown that the conceptual foundation of the quantum phase problem lies within the algebraic properties of the quantum canonical transformations in the quantum phase space. The representations of the Wigner function in the generalized action-angle unitary operator pair for certain Hamiltonian systems with the dynamical symmetry are examined. This generalized canonical formalism is applied to the quantum harmonic oscillator to examine the properties of the unitary quantum phase operator as well as the action-angle Wigner function.Comment: 19 pages, no figure

Real-time interval type-2 fuzzy control of an unmanned aerial vehicle with flexible cable-connected payload

This study presents the design and real-time applications of an Interval Type-2 Fuzzy PID (IT2-FPID) control system on an unmanned aerial vehicle (UAV) with a flexible cable-connected payload in comparison to the PID and Type-1 Fuzzy PID (T1-FPID) counterparts. The IT2-FPID control has significant stability, disturbance rejection, and response time advantages. To prove and show these advantages, the DJI Tello, a commercial UAV, is used with a flexible cable-connected payload to test the robustness of PID, T1-FPID, and IT2-FPID controllers. First, the optimal coefficients of the compared controllers are found using the Big Bang–Big Crunch algorithm via the nonlinear UAV model without the payload. Second, once optimised, the controllers are tested using several scenarios, including disturbing the payload and the coverage path planning area to examine their robustness. Third, the controller performance results are evaluated according to reference achievement and point-based tracking under disturbances. Finally, the superiority of the IT2-FPID controller is shown via simulations and real-time experiments with a better overshoot, a faster settling time, and good properties of disturbance rejection compared with the PID and the T1-FPID controllers

Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study

Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients. Materials and Methods: Two hundred and sixteen treatment-naive CHC patients were enrolled from 32 locations across Turkey in this open-labelled, non-interventional prospective observational study. FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine aminotransferase ratio (AAR), fibrosis index based on four factors (FIB-4), Age-platelet(AP) index and Forns index were measured and compared with Metavir scores got from liver biopsies. Results: Data from 182 patients with baseline liver biopsy were suitable for analysis. One hundred and twenty patients (65.9%) had F0-F1 fibrosis and 62 patients (34.1%) had F2-F4 fibrosis. APRI 0.732 area under the curve(AUC) indicated advanced fibrosis with 69% sensitivity and 77% specificity. FIB-4 0.732 AUC and FibroTest 0.715 AUC indicated advanced fibrosis with 69% and 78.4% sensitivity, and 75% and 71.4% specificity, respectively. The combined use of tests also led to an increase in AUC and specificity. Combinations of FibroTest with APRI and/or FIB-4, and FIB-4 with APRI were optimal for the evaluation of liver fibrosis. Conclusion: Fibrotest, FIB-4, APRI, AP index and Forns index exhibit good diagnostic performance for determining liver fibrosis in CHC patients, and the use of at least two tests together will increase their diagnostic value still further. © Copyright 2018 by The Turkish Society of Gastroenterology

The discrete harmonic oscillator, Harper's equation, and the discrete fractional Fourier transform

Certain solutions to Harper's equation are discrete analogues of (and approximations to) the Hermite-Gaussian functions. They are the energy eigenfunctions of a discrete algebraic analogue of the harmonic oscillator, and they lead to a definition of a discrete fractional Fourier transform (FT). The discrete fractional FT is essentially the time-evolution operator of the discrete harmonic oscillator

Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism

ObjectiveParkinson's disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson's from atypical parkinsonian syndromes. We assessed the clinical utility of serum neuronal exosomes as biomarkers across the spectrum of Parkinson's disease, multiple system atrophy and other proteinopathies.MethodsWe performed a cross-sectional study of 664 serum samples from the Oxford, Kiel and Brescia cohorts consisting of individuals with rapid eye movement sleep behavioural disorder, Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, frontotemporal dementia, progressive supranuclear palsy, corticobasal syndrome and controls. Longitudinal samples were analysed from Parkinson's and control individuals. We developed poly(carboxybetaine-methacrylate) coated beads to isolate L1 cell adhesion molecule (L1CAM)-positive extracellular vesicles with characteristics of exosomes and used mass spectrometry or multiplexed electrochemiluminescence to measure exosomal proteins.ResultsMean neuron-derived exosomal α-synuclein was increased by twofold in prodromal and clinical Parkinson's disease when compared with multiple system atrophy, controls or other neurodegenerative diseases. With 314 subjects in the training group and 105 in the validation group, exosomal α-synuclein exhibited a consistent performance (AUC=0.86) in separating clinical Parkinson's disease from controls across populations. Exosomal clusterin was elevated in subjects with non-α-synuclein proteinopathies. Combined neuron-derived exosomal α-synuclein and clusterin measurement predicted Parkinson's disease from other proteinopathies with AUC=0.98 and from multiple system atrophy with AUC=0.94. Longitudinal sample analysis showed that exosomal α-synuclein remains stably elevated with Parkinson's disease progression.ConclusionsIncreased α-synuclein egress in serum neuronal exosomes precedes the diagnosis of Parkinson's disease, persists with disease progression and in combination with clusterin predicts and differentiates Parkinson's disease from atypical parkinsonism