Antiproliferative activity of some novel platinum complexes on C6 glioma and MCF-7 breast cancer cells

The anti-cancer chemotherapeutic potential of novel platinum(II) complexes of salicylate derivatives [Pt(dppe)(SA)2, Pt(dppm)(SA)2] and fumaric acid [Pt(dppe)(FU)2] were determined, using two cancer cell lines, breast cancer (MCF-7) and glioma cells (C6). IC50 values of the three compounds were lower in the cisplatin-resistant cell type C6 cell lines than in MCF-7 cells.Key words: Cisplatin, antiproliferative activity, breast cancer cells (MCF-7), glioma cells (C6), IC50

ASSESSING GENETIC DIVERSITY OF SOME POTATO (Solanum tuberosum L.) GENOTYPES GROWN IN TURKEY USING THE AFLP MARKER TECHNIQUE

ABSTRACT In the present study, the level of polymorphism and the genetic relationships among 26 potato genotypes were studied by means of molecular markers using the amplified fragment length polymorphism (AFLP) technique. DNA was extracted from fresh leaves of the seedlings. Selective amplification products revealed a total of 191 polymorphic bands ranging from 8 to 45 for each combination. Scoring results were used to generate a tree in JMP software. The 26 samples formed six clades with varying number of members between one and eleven. Genetic distances among genotypes were calculated according to Jaccard's formula, in Phylip 3.0 software. According to the results of genetic distance, dendrogram showed that genotypes 6/7-4 and 6/7-2 were the closest genotypes with a genetic distance of 0.13. On the other hand, genotypes Posof-10 and Marabel were the most distinct from each other with a genetic distance value of 0.55. The AFLP marker results showed a great consistency along with their pedigrees indicating the AFLP technique as a useful tool in the calculation of genetic distance of the potato genotypes

Baby with neonatal systemic juvenile xanthogranuloma born within a cross-cousin marriage

AbstractJuvenile xanthogranuloma is a non-Langerhans cell histiocytosis seen most commonly in childhood and adolescence. Extracutaneous involvement is rare. We report an interesting and extremely rare case of systemic (skin, lung, spleen, and colon) “juvenile xanthogranuloma” in the neonatal period. Our case was the first ever reported case born to a cross-cousin marriage

ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA

Background: Inflammatory mechanisms are reported to play important roles in the pathophysiology of schizophrenia. The neutrophil–lymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our goal was to investigate whether NLR was higher in patients with schizophrenia than in healthy comparison subjects similar in age, sex, and body mass index. Subjects and methods: In this multicenter cross-sectional study, we analyzed 156 non-obese patients with schizophrenia and 89 healthy control subjects for complete blood count. The Brief Psychiatric Rating Scale was used to determine the severity of clinical pathology. Results: The mean±SD NLR of patients with schizophrenia was significantly higher than that of healthy controls (2.6±1.1 vs. 1.9±0.6, respectively, p0.05). Conclusions: Our findings suggest that NLR levels are increased in physically healthy, non-obese, patients with schizophrenia when compared with physically and mentally healthy individuals. To our knowledge, this is the first study that demonstrated the association between NLR and schizophrenia

Актуальные вопросы развития правового регулирования арбитража (третейского разбирательства) в Российской Федерации

В магистерской диссертации ставились следующие цели и задачи: Целью работы является изучение теоретических и практических проблем, связанных с отдельными вопросами арбитрабельности споров в развитии законодательства и судебной практики. Актуальность вопроса вызвана произошедшей в 2015-2016 гг. в РФ реформой третейского разбирательства, связанной с принятием Федерального закона от 29.12.2015 № 382-ФЗ «Об арбитраже (третейском разбирательстве) в Российской Федерации» и Федерального закона от 29.12.2015 № 409-ФЗ «О внесении изменений в отдельные законодательные акты Российской Федерации и признании утратившим силу пункта 3 части 1 статьи 6 Федерального закона „О саморегулируемых организациях“ в связи с принятием Федерального закона „Об арбитраже (третейском разбирательстве) в Российской Федерации». В основу исследования легли правовые позиции, выраженные в Постановлении Президиума ВАС РФ от 11.02.2014 № 11059/13 по делу № А26-9592/2012, а также отдельных выводов, сформулированных в Определениях КС РФ от 15.01.2015 № 5-О и от 29.09.2015 № 2214-О, касающихся вопросов установления критериев, позволяющих сделать вывод о неарбитрабельности споров, возникающих из природоресурсных договоров, и, в частности, из такого основания для возникновения специального права лесопользования, как договор аренды лесного участка, заключенного в целях заготовки древесины. Помимо вышеуказанного, к задачам и целям исследования относятся: 1. Обзор существующих в доктрине права третейского разбирательства научных взглядов и представлений об институте арбитрабельности споров, их краткая характеристика. Изложение автором собственной позиции в отношении критериев арбитрабельности. 2. Характеристика лесных имущественных правоотношений, основанных на договорных основаниях возникновения права природопользования. Исследование вопроса арбитрабельности споров, возникающих из лесных имущественных правоотношений, с позиции материально-правового (позитивного) критерия установления арбитрабельности. Анализ стадий заключения, исполнения, расторжения договора аренды лесного участка, а также признания его недействительным. 3. Исследование вопроса о допустимости передачи гражданско-правового спора, возникшего из лесных имущественных правоотношений, на рассмотрение в третейский суд с позиции обеспечения необходимых гарантий прав участников юрисдикционного процесса в рамках процессуальной формы арбитража, в её соотношении с судопроизводством, осуществляемом по правилам АПК РФ и ГПК РФ. Выводы, сделанные по результатам исследования: • Изменения, внесенные в правовое регулирование арбитража в результате третейской реформы, позволяют расширить категории споров, относимых к компетенции третейского суда ввиду «юридизации» процедуры третейского разбирательства с одной стороны, и усиления диспозитивных начал в определении правил арбитража – с другой. • Ввиду особенностей третейского процесса, следует согласиться с позицией ВАС РФ о том, что споры, возникающие на стадии заключения договора аренды лесного участка, в настоящий момент являются неарбитрабельными по причине необходимости учёта законных интересов заведомо неопределённого круга лиц – потенциальных участников аукциона по продаже права на заключение договора аренды лесного участка. Представляется, что соответствующая позиция правомерна до принятия изменений в законодательном регулировании, обеспечивающих учет интересов широкого круга субъектов при обращении за юрисдикционной защитой в третейский суд – по аналогии с арбитражем корпоративных споров. • Публичный интерес РФ, субъектов РФ, выражающийся в необходимости соблюдения природоохранных требований, а также в администрировании неналоговых доходов бюджетов, не может являться аргументом в признании данной категории споров неарбитрабельными. Данный публичный интерес в конкретном деле, рассмотренном ВАС РФ, не сводим к содержанию «публичного порядка», либо «основополагающих принципов российского права», являющимися безусловными основаниями для отмены решения третейского суда. Аналогичный вывод следует и применительно к объекту лесного правоотношения – земельного участка лесного фонда. • Процессуальная форма арбитража как до проведения третейской реформы, так и после неё позволяет отнести к категории арбитрабельных споров, возникающих в связи с исполнением, изменением, расторжением договора аренды лесного участка, признания его недействительным, поскольку стороны третейского соглашения вправе предъявлять повышенные требования к механизму юрисдикционной защиты прав участника арендного правоотношения, а также приспособить процедуру третейского разбирательства к особенностям экономической деятельности в сфере лесного хозяйства. • С учетом судебной практики Европейского Суда по правам человека, заключение сторонами арбитражного соглашения рассматривается как допустимое в определенной степени ограничение права на судебную защиту. В связи с этим, стороны арбитражного соглашения, признавая компетенцию третейского суда по окончательному разрешению гражданско-правового спора, несут повышенный риск совершения, либо не совершения ими необходимых процессуальных действий, в том числе при выборе арбитра. Вынесенное третейским судом решение по существу обладает свойством обязательности для сторон, выражающейся, в том числе, в запрете последующего пересмотра данного решения по существу. По обстоятельствам дела, рассмотренного ВАС РФ, действия проигравшей арбитраж стороны были направлены на преодоление окончательного решения третейского суда и представляли собой злоупотребление правом. В свою очередь, ВАС РФ необоснованно не применил в отношении заявления проигравшей спор стороны правило эстоппель, применимое и в процессуальных правоотношениях.In the master's thesis, the following goals and tasks were set: The aim of the work is to study theoretical and practical problems related to specific issues of arbitrability in the development of legislation and judicial practice. The urgency of the issue is caused by happened in 2015-2016. in the Russian Federation the reform of arbitration proceedings related to the adoption of Federal Law No. 382-FZ of December 29, 2015 "On Arbitration (Arbitration) in the Russian Federation" and Federal Law No. 409-FZ of December 29, 2015 "On Amending Certain Legislative Acts of the Russian Federation and the invalidation of paragraph 3 of Part 1 of Article 6 of the Federal Law "On Self-Regulating Organizations" in connection with the adoption of the Federal Law "On Arbitration (Arbitration Proceedings) in the Russian Federation". The research was based on the legal positions expressed in the Resolution of the Presidium of the Supreme Arbitration Court of the Russian Federation of 11.02.2014 No. 11059/13 in the case No. A26-9592 / 2012, as well as certain conclusions formulated by Constitutional Court of RF, Decrees No. 5-O of 15.01.2015 and 09/29/2015 № 2214-О, concerning the issues of establishing criteria allowing to conclude, that the disputes, arising from nature resources contracts are not arbitrary, and in particular from such grounds for the emergence of a special forest use right, as a lease contract for a forest plot, concluded for the purpose of harvesting timber . Besides the above-mentioned, there are following goals and tasks of the research: 1. Review of existing in the doctrine of the right of arbitration proceedings of scientific views and representations about the institution of arbitrability of disputes, their brief description. The author's statement based on his own position with respect to the criteria of arbitrability. 2. Characteristics of forest proprietary relations, based on the contractual grounds for the emergence of the right to use nature. Investigation of the issue of arbitrability of disputes arising from forest proprietary relations, from the position of a substantive (positive) criterion for establishing arbitrability. Analysis of the stages of conclusion, execution, cancellation of the lease contract for the forest plot, and its recognition as invalid. 3. Investigation of the issue of the admissibility of the transfer of a civil dispute, arising out from a forest property relations to the arbitration court, for ensuring the necessary guarantees of the rights of participants in the jurisdictional process within the procedural form of arbitration, in its relation to legal proceedings, carried out per rules of Arbitrage Procedural Code and Civil Procedural Code of Russian Federation. Conclusions drawn from the study: • The changes made to the legal regulation of arbitration because of the arbitration reform make it possible to expand the categories of disputes falling within the competence of the arbitral tribunal due to the "legalization" (formalizing) of the arbitration procedure on the one hand, and the strengthening of the discretionary principles in determining arbitration rules, on the other. • Due to the peculiarities of the arbitrage, we should agree with the position of the Supreme Arbitration Court of RF, that the disputes, arising at the stage of concluding the lease contract for the forest plot are currently non-arbitrable, considering the legitimate interests of an uncertain circle of potential participants in the auction for the sale of the right to concluding a lease agreement for a forest plot. It seems, that the corresponding position is legitimate until be made changes in the legislative regulation, that ensure the consideration of the interests of a wide range of subjects, applying for jurisdictional protection in an arbitrage - by analogy with arbitration of corporate disputes. • The public interest of the RF, RF subjects, expressed in the propositions of complying by land plot leaser environmental requirements, as well as in the administration of non-tax revenues of budgets, cannot be an argument in recognizing this category of disputes as non-arbitrable. This public interest in a case, considered by the Supreme Arbitration Court of the Russian Federation is not reduced to the content of "public policy" or "fundamental principles of Russian law", which are unconditional grounds for canceling the decision of the arbitral tribunal. A similar conclusion follows also regarding to the object of the forest legal relationship - the land plot of the forest fund. • Remedial form of arbitration as before the arbitration reforms, and after them can be attributed to the category of arbitrability of disputes, arising about the execution, modification, cancellation of lease agreement, annulment; as for the parties of the arbitration agreement causes to demand higher mechanism jurisdictional protect the rights of parties, as well as to adapt the arbitration procedure to the peculiarities of the economic activity in the forestry. • Considering the judgment practice of the European Court of Human Rights, conclusion by the parties the arbitration agreement is considered as valid to some extent, restrictions on the right to judicial protection. In this regard, the parties of the arbitration agreement, recognizing the competence of the arbitral tribunal for the final settlement of a civil dispute, bear an increased risk of committing or not committing the necessary procedural actions, including choosing an arbitrator. The decision, made by the arbitrage has the property of binding on the parties, which is expressed, inter alia, in the prohibition of the subsequent revision of this decision on the merits. Due to the circumstances of the case, considered by the Supreme Arbitration Court of RF, the actions of the losing party were aimed at overcoming the final decision of the arbitration court and represented abuse of law. In turn, the Supreme Arbitration Court of the Russian Federation unreasonably denied to apply estoppel rule to the statement of the losing party of the dispute, which is also applicable in procedural legal relations

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/1/cen13732_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/2/cen13732.pd

Internet addiction, fatigue, and sleep problems among adolescent students: a large-scale study

Aim: The aim of the present study was to examine the association between Internet Addiction (IA), fatigue, and sleep problems among university students. Methods: A total of 3,000 Turkish students aged 18 to 25 years were approached and 2,350 students (78.3%) participated in this cross-sectional study from April 2017 to September 2017 in public and private universities in Istanbul. Data were collected via a structured questionnaire including socio-demographic details, lifestyle and dietary habits, Internet Addiction Test (IAT), Fatigue Scale, and Epworth Sleepiness Scale [ESS]. Descriptive statistics, multivariate and factorial analyses were performed. Results: The overall prevalence of IA among the studied population was 17.7%. There were significant differences between gender, family income, father’s occupation, school performance, frequency and duration of watching television, physical activity, internet use duration, and sleep duration (all p<0.001). Significant differences were also found between participants with IA and those without IA in having headaches, blurred vision, double vision, hurting eyes, hearing problems, and eating fast food frequently (all p<0.001). Using multivariate regression analysis, the duration of internet use, physical and mental symptoms, headache, hurting eyes, tired eyes, hearing problems and ESS scores were significantly associated with (and primary predictors of) IA. Conclusion: The present study demonstrated that IA was associated with poor dietary habits, sleep problems, and fatigue symptoms

Market power in CEE banking sectors and the impact of the global financial crisis

The aim of this study is to undertake an up-to-date assessment of market power in Central and Eastern European banking markets and explore how the global financial crisis has affected market power and what has been the impact of foreign ownership. Three main results emerge. First, while there is some convergence in country-level market power during the pre-crisis period, the onset of the global crisis has put an end to this process. Second, bank-level market power appears to vary significantly with respect to ownership characteristics. Third, asset quality and capitalization affect differently the margins in the pre-crisis and the crisis periods. While in the pre-crisis period the impacts are similar for all banks regardless of ownership status, in the crisis period non-performing loans have a negative effect and capitalization a positive effect only for domestically-owned banks