Editorial

Revista Saúde.co

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.

ABSTRACT: A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome Project (EBP), which plans to sequence and assemble high-quality reference genomes for all ∼1.5 million recognized eukaryotic species through a stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are to be sequenced in just four years, worldwide participation in the project will be fundamental to success. As the European node of the EBP, the European Reference Genome Atlas (ERGA) seeks to implement a new decentralised, accessible, equitable and inclusive model for producing high-quality reference genomes, which will inform EBP as it scales. To embark on this mission, ERGA launched a Pilot Project to establish a network across Europe to develop and test the first infrastructure of its kind for the coordinated and distributed reference genome production on 98 European eukaryotic species from sample providers across 33 European countries. Here we outline the process and challenges faced during the development of a pilot infrastructure for the production of reference genome resources, and explore the effectiveness of this approach in terms of high-quality reference genome production, considering also equity and inclusion. The outcomes and lessons learned during this pilot provide a solid foundation for ERGA while offering key learnings to other transnational and national genomic resource projects.info:eu-repo/semantics/publishedVersio

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Risk assessment of balance and falls in elderly patients due to stroke

The aim of this study was to evaluate the balance and risk of falls in elderly patients with Stroke treated at the Municipal Center for Prevention and Rehabilitation Physics of the Municipality of Jequié (NUPREJ), (Bahia). Instruments were used as the Mini Mental State Examination, a social demographic questionnaire and the Berg Balance Scale. The results showed a decrease in balance, indicating that this was a risk factor for falls

FATORES ASSOCIADOS À INATIVIDADE FÍSICA ENTRE IDOSOS ASILARES

resumo   Este estudo teve como objetivo analisar os fatores associados ao nível de atividade física em idosos asilares. Trata-se de um estudo transversal, de caráter descritivo, realizado com 16 idosos de uma instituição asilar no município de Jequié-BA. Na coleta de dados, realizou-se uma entrevista sobre informações sociodemográficas, sendo aplicado questionário sobre perfil do estado de saúde e nível de atividade física. Utilizaram-se procedimentos da estatística descritiva, através de medidas de tendência central, (média e mediana) e de dispersão (desvio-padrão), para variáveis numéricas e frequência simples, para variáveis categóricas. Calculou-se o nível de atividade física (NAF) segundo características sociodemográficas e estado de saúde. Nos resultados, observou-se que, 12,5% dos idosos foram classificados como ativos fisicamente e 87,5%, como inativos fisicamente. Indivíduos com idade mais avançada (com 80 ou mais) (14,3%), do sexo masculino (16,7%), com estado civil solteiro/separado (25,0%), não alfabetizado (14,3%) e de raça/cor branca (25,0%) apresentaram maior frequência de atividade física habitual. Um maior nível de independência (15,4%), percepção positiva da qualidade de vida (20,0%) e do estado de saúde (20,0%) e maior risco coronariano (20,0%) foram verificados nos indivíduos ativos fisicamente. O conhecimento sobre os fatores associados ao nível de atividade física habitual favorece o melhor direcionamento dos programas de atenção à saúde dos idosos residentes em instituições de longa permanência. Faz-se necessário a realização de outros estudos no intuito de compreender melhor esta associação.   palavras-chave Atividade Física. Qualidade de Vida. Asilo.   abstract   This study aimed to analyze the factors associated with physical activity in elderly nursing homes. This is a descriptive cross-sectional study, which was conducted with 16 individuals from a nursing home in Jequié-BA. To collect data, the following instruments were used: a questionnaire applied in the form of individual interviews with information sociodemographic profile of health status and physical activity level. We used descriptive statistics procedures to trace the profile of elderly subjects according to sociodemographic characteristics and health status. Physical activity level (PAL) was calculated according to sociodemographic characteristics and health status. The results showed that 12.5% of the elderly were classified as physically active and 87.5% as physically inactive. Individuals with more advanced age (80 or older) (14.3%), male (16.7%), with being single / separated (25.0%), illiterate (14.3%) and race / white (25.0%) had higher frequency of physical activity. A higher level of independence (15.4%), positive perceptions of quality of life (20.0%) and health (20.0%) and higher coronary risk (20.0%) were found for active individuals physically. Knowledge about the factors associated with level of habitual physical activity promotes improved targeting of programs for health care to elderly residents in long-stay institutions. It is necessary to conduct further studies in order to better understand this association.  keywords Physical Inactivity. Quality of Life. Asylum

Nível de atividade física entre funcionários de uma instituição de ensino superior da bahia

The aim of this study was to evaluate the physical activity level (PAL) employee of an institution of higher education. We conducted a cross-sectional study with descriptive and administrative servers and general services headcount from the State University of Southwest Bahia (UESB) Jequié campus, in the period from March to December 2009. After meeting the criteria were included 81 patients, representing 79.4% of the population. We used a standardized questionnaire containing the International Physical Activity Questionnaire, short version (IPAQ-C), and sociodemographic and occupational issues. In the data analysis procedures were used descriptive statistics and measures of association for categorical variables by using the chi-square and Fisher exact Pearson, adopting a significance level of 5% (p = 0.05). Among respondents, 50.6% of the subjects are physically active most active Subjects were men and those who have no partner (p <0.005). The prevalence of physical inactivity was higher among respondents and had a higher frequency among individuals with characteristics specific demographic. In this sense, it is recommended to implement physical activity programs and adopting an active lifestyle within the university, in order to promote change in this scenario.O objetivo do presente estudo foi avaliar o nível de atividade física (NAF) de funcionários de uma instituição de ensino superior. Foi realizado um estudo de corte transversal e caráter descritivo com servidores administrativos e de serviços gerais do quadro efetivo da Universidade Estadual do Sudoeste da Bahia (UESB), campus de Jequié, no período de março a dezembro de 2009. Após atender aos critérios estabelecidos foram incluídos 81 sujeitos, representando 79,4% da população. Utilizou-se um questionário padronizado contendo o International Physical Activity Questionnaire, versão curta (IPAQ-C), além de questões sociodemograficas e ocupacionais. Na análise dos dados foram utilizados procedimentos da estatística descritiva e medidas de associação para variáveis categóricas por meio do teste Qui-Quadrado de Pearson e Exato de Fischer, adotando-se nível de significância de 5% (p=0,05). Entre os entrevistados, 50,6% dos sujeitos são ativos fisicamente Os sujeitos mais ativos foram os homens e aqueles que não possuem companheira (p<0,005).A prevalência de inatividade física foi elevada entre os entrevistados e apresentou maior freqüências entre indivíduos com características sociodemográficas específicas. Neste sentido, recomenda-se a implementação de programas de atividade física e adoção de estilo de vida ativo no âmbito da universidade, no intuito de favorecer a mudança desse quadro

Physical activity level and back pain among workers of a higher education institution in Northeast of Brazil

Objective: To investigate the association between level of physical activity and prevalence of low back pain among employees of a higher education institution in Jequié-BA, Brazil. Methods: A cross-sectional census study, which included 83 of the 102 employees of the State University of Southwest Bahia, Jequié-Campus, obtaining a response rate of 81.37%. We used a data collection instrument containing eight blocks of information, in which were included social-demographic variables, habitual physical activity and musculoskeletal symptoms (back pain). Data collection was conducted through individual interviews at the working sector of the participant. Data were tabulated with EpiData, version 3.5 and analyzed using Statistical Package for Social Sciences - SPSS, version 9.0. Results: Among employees, 50.6% were physically active (practicing at least 150 minutes per week of physical activity). The prevalence of low back pain in the last twelve months was 48.1%. We observed that 22 (59.5%) employees considered physically active presented more complaints of back pain compared with 15 (40.5%) who were inactive. Despite the presence of low back pain among active individuals has shown to be higher, we understand that the percentage of back pain among physically inactive was also significant. Conclusion: There was no statistical significant association between the level of physical activity and the presence of back pain

Nível de atividade física e lombalgia entre funcionários de uma instituição de ensino superior no Nordeste do Brasil - doi:10.5020/18061230.2011.p199

Objective: To investigate the association between level of physical activity and prevalence of low back pain among employees of a higher education institution in Jequié-BA, Brazil. Methods: A cross-sectional census study, which included 83 of the 102 employees of the State University of Southwest Bahia, Jequié-Campus, obtaining a response rate of 81.37%. We used a data collection instrument containing eight blocks of information, in which were included social-demographic variables, habitual physical activity and musculoskeletal symptoms (back pain). Data collection was conducted through individual interviews at the working sector of the participant. Data were tabulated with EpiData, version 3.5 and analyzed using Statistical Package for Social Sciences - SPSS, version 9.0. Results: Among employees, 50.6% were physically active (practicing at least 150 minutes per week of physical activity). The prevalence of low back pain in the last twelve months was 48.1%. We observed that 22 (59.5%) employees considered physically active presented more complaints of back pain compared with 15 (40.5%) who were inactive. Despite the presence of low back pain among active individuals has shown to be higher, we understand that the percentage of back pain among physically inactive was also significant. Conclusion: There was no statistical significant association between the level of physical activity and the presence of back painObjetivo: Verificar a associação entre o nível de atividade física habitual e a prevalência de lombalgia entre profissionais de uma instituição de ensino superior em Jequié-BA, Brasil. Métodos: Estudo transversal, censitário, que incluiu 83 dos 102 funcionários da Universidade Estadual do Sudoeste da Bahia - Campus Jequié, obtendo uma taxa resposta de 81,37%. Utilizou-se um instrumento de coleta de dados contendo oito blocos de informações, nos quais foram incluídas variáveis sociodemográficas, de atividade física habitual e sintomas musculoesqueléticos (dor lombar). A coleta de dados foi realizada por meio de entrevista individual no setor de trabalho do participante. Os dados foram tabulados com EpiData, versão 3.5 e analisados através do programa estatístico Statistical Package for Social Sciences – SPSS, versão 9.0. Resultados: Entre os funcionários, 41 (50,6%) são ativos fisicamente (praticam pelo menos 150 minutos/semana de atividades físicas). A prevalência de lombalgia nos últimos doze meses foi de 48,1%. Observou-se que 22 (59,5%) funcionários considerados fisicamente ativos apresentaram mais queixas de dores lombares quando comparados com os 15 (40,5%) funcionários inativos. Apesar da presença de lombalgia entre os indivíduos ativos ter sido maior, entende-se que o percentual de dores lombares entre os inativos fisicamente também foi significante. Conclusão: Não foi encontrada associação estatisticamente significante entre o nível de atividade física habitual e a presença de dores lombares

NÍVEL DE ATIVIDADE FÍSICA ENTRE FUNCIONÁRIOS DE UMA INSTITUIÇÃO DE ENSINO SUPERIOR DA BAHIA

O objetivo do presente estudo foi avaliar o nível de atividade física (NAF) de funcionários de uma instituição de ensino superior. Foi realizado um estudo de corte transversal e caráter descritivo com servidores administrativos e de serviços gerais do quadro efetivo da Universidade Estadual do Sudoeste da Bahia (UESB), campus de Jequié, no período de março a dezembro de 2009. Após atender aos critérios estabelecidos foram incluídos 81 sujeitos, representando 79,4% da população. Utilizou-se um questionário padronizado contendo o International Physical Activity Questionnaire, versão curta (IPAQ-C), além de questões sociodemograficas e ocupacionais. Na análise dos dados foram utilizados procedimentos da estatística descritiva e medidas de associação para variáveis categóricas por meio do teste Qui-Quadrado de Pearson e Exato de Fischer, adotando-se nível de significância de 5% (p0,05). Entre os entrevistados, 50,6% dos sujeitos são ativos fisicamente Os sujeitos mais ativos foram os homens e aqueles que não possuem companheira (p0,005).A prevalência de inatividade física foi elevada entre os entrevistados e apresentou maior freqüências entre indivíduos com características sociodemográficas específicas. Neste sentido, recomenda-se a implementação de programas de atividade física e adoção de estilo de vida ativo no âmbito da universidade, no intuito de favorecer a mudança desse quadro