7 research outputs found
¿Existieron vicios del razonamiento práctico en cuanto a la precipitación e inconsideración en el caso de la sentencia 01294 de 2018 del Consejo de Estado, analizado desde la prudencia política y jurídica?
- Author
- Ambrosio-Ramos Natalia Camila
- Barreto-Cifuentes Paula Andrea
- Calvo-Parra Karen Daniela
- Cermeño-Ramírez Paula Alejandra
- Jiménez-Ávila Fernando
- Maldonado-Fonseca Diana Vannesa
- Moreno-Salazar Astrid Viviana
- Muñoz-Muñoz Ingrid Katherine
- Rivera-Ibáñez Dayan Lorena
- Silva-Espitia María Camila
- Solano-Avella Juan José
- Publication venue
- Bogotá: Facultad de Derecho, 2019
- Publication date
- 01/01/2019
- Field of study
13 p.A continuación, se planteará el caso de la ex representante a la cámara y senadora electa por el partido conservador colombiano Aida Merlano Rebolledo, quien perdió la investidura de su cargo en el año 2018 como consecuencia de la violación de los topes máximos de financiación de su campaña electoral, y se realizará un análisis detallado de los vicios del razonamiento prudencial de precipitación e inconsideración que se manifestaron tanto en su actuar como en el procedimiento judicial que se le realizó respectivamente. De esta manera, (y con los conceptos de los vicios del razonamiento ya entendidos) se aplicará lo establecido por prudencia jurídica y política en el caso en concreto para poder plantear una conclusión interpretativa objetiva sobre el actuar ético- moral de dicha mujer, y el por qué se expone que no fue el correcto, lo cual se espera de un jurista en el cual, los ciudadanos depositan su confianza para la buena administración de su país.Introducción
Prudencia jurídica
Prudencia política
Resumen sentencia
Vicios del razonamiento
Conclusión
Referencia
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
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- Alawneh Yazan
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- Alegbeleye Bamidele
- Alekberli Tural
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- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
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- Alharmi Rawan A. Rahman
- Alharthi Mohammed
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- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
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- Aljiffry Murad
- Aljirdabi Noof
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- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
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- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
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- Alonso Jesús Aarón Martínez
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- Dawson Jonathon
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- Fadalla Tarig
- Fadel Zahir T
- Fahim Margo Medhat Fouad
- Fahmy Ali
- Faiz Javaria
- Fajardo Rafael Torres
- Fakhradiyev Ildar
- Fallah Jean-Michel
- Familiari Pietro
- Fang Clarissa Ern Hui
- Faponle Folayemi
- Farhan-Alanie Muhamed
- Farid Shahzaib
- Farooq Muhammad
- Fatima Mishal
- Fayad Elsayed A.
- Federer Simon
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- Gananadha Sivakumar
- Garas George
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- Garcia Sean
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- Vincent Elizabeth
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- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
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- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
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- Wiesinger Clemens Georg
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- Wilkins Alex
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- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Make EU trade with Brazil sustainable
- Author
- Aalders Inge
- Aavik Tsipe
- Addison Prue
- af Segerstad Louise Hard
- Aguilee Robin
- Aguilera Eduardo
- Albanito Fabrizio
- Alexanderson Helena
- Alonso Juan C.
- Alonso-Alvarez Carlos
- Altringham John
- Alvarez Matheus Rodriguez
- Ammer Christian
- Amo Luisa
- Andresen Louise C.
- Ange Olivia
- Antal Miklos
- Antonelli Alexandre
- Antwis Rachael
- Aragon Pedro
- Arlidge William
- Arlt Debora
- Ascensao Fernando
- Ascoli Davide
- Bacon Christine D.
- Bager Simon L.
- Bagneres Anne-Genevieve
- Balmford Andrew
- Balmford Andrew
- Banks-Leite Cristina
- Barlow Jos
- Barrientos Rafael
- Bastos Araujo Miguel
- Batsleer Femke
- Battisti Corrado
- Battiston Roberto
- Bauer Barbara
- Baumann Matthias
- Benavides Lucia
- Bennett Dominic J.
- Benyei Petra
- Berenguer Erika
- Bernardo-Madrid Ruben
- Bhan Manan
- Biedermann Peter
- Billen Gilles
- Bjoersne Anna-Karin
- Bjorck Svante
- Bjorklund Heidi
- Blanco Moreno Jose M.
- Bleyhl Benjamin
- Bocquillon Pierre
- Boehnert Tim
- Bongalov Boris
- Boonstra Wiebren
- Booth Hollie
- Borges Paulo A. V.
- Borregaard Michael Krabbe
- Borrell Asuncion
- Boto Luis
- Brambach Fabian
- Briens Francois
- Brown Calum
- Brumelis Guntis
- Bruna Josef
- Buckley David
- Buckley Yvonne
- Buzzetti Filippo Maria
- Cabello Javier
- Cabeza Mar
- Cabral Juliano Sarmento
- Cahen-Fourot Louison
- Caillon Sophie
- Canals Oriol
- Canteri Elisabetta
- Caprio Enrico
- Cardoso Pedro
- Carmenta Rachel
- Carnicer Jofre
- Carrillo Juan D.
- Carvalho Joana
- Casazza Marco
- Cassar Louis F.
- Cathy Vet Gibault
- Cattaneo Claudio
- Celine Bellard
- Cesarz Simone
- Challender Dan
- Chenet Hugues
- Chobanov Dragan Petrov
- Christie Alec Philip
- Christophe Piquet Julien
- Chuine Isabelle
- Chvatalova Veronika
- Clark Mike
- Coenen Johanna
- Colino Rabanal Victor
- Collalti Alessio
- Comandulli Carolina
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- Cooper Conor
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- Cordero Ana Maria Araujo
- Cornell Sarah
- Cotta Benedetta
- Cottyn Hanne
- Crona Beatrice
- Csergo Anna Maria
- Curtis David
- D'Amico Marcello
- da Fonte Luis Fernando Marin
- da Silva Jessica Fonseca
- da Silva Sven
- Danet Alain
- Daniel-Ferreira Juliana
- Dara Andrey
- Darras Kevin
- Dauriach Alice
- Davoli Marco
- Daw Tim
- de Agua Luis Borda
- de Castro Fabio
- de Castro Paula Drummond
- de Freitas Flavio Luiz Mazzaro
- de Frutos Angel
- De Knijf Geert
- de la Pena Eduardo
- De la Riva Ignacio
- De Marzo Teresa
- De Smedt Pallieter
- De Smedt Sebastian
- de Waroux Yann le Polain
- Deguines Nicolas
- Dengler Juergen
- Di Gregorio Monica
- Diaz Mario
- Doherty Anya
- Domingos Tiago
- Duran Paz
- Durieux Laurent
- Edler Daniel
- Eiro Flavio
- Eisenhauer Nico
- Elias Marianne
- Emperaire Laure
- Engel Thore
- Engert Manuela
- Engl Tobias
- Engler Jan Oliver
- Englund Oskar
- Enqvist Johan
- Enseroth Tanja
- Erb Karlheinz
- Eriksson K. Martin
- Ernst Stefan
- Escobar Neus
- Esculier Fabien
- Essl Franz
- Evans Amy Louise
- Faberova Tamara
- Fandos Guillermo
- Fargallo Juan A.
- Farrell Katharine N.
- Felipe-Lucia Maria
- Felix Rob
- Fernandez-Llamazares Alvaro
- Figueiredo Ludmilla
- Fischer Joern
- Fischer-Kowalski Marina
- Fitton Nuala
- Fleischer Katrin
- Florencio Margarita
- Florez Laura V.
- Fraixedas Sara
- Franco Aldina
- Frantz David
- Friis Cecilie
- Frossard Carolina M.
- Fuchs Richard
- Gambin Belinda
- Garcia del Amo David
- Garcia Maria Mancilla
- Garnett Emma
- Garnett Tara
- Garnier Josette
- Gebara Maria Fernanda
- Geldmann Jonas
- Gerlach Justin
- Geschke Jonas
- Ghazoul Jaboury
- Gherghel Iulian
- Ghoddousi Arash
- Gil Diego
- Gledhill John
- Godde Cecile
- Goepel Jan
- Goerg Christoph
- Golland Ami
- Gollnow Florian
- Gomes Carmen Bessa
- Gonzalez Adriana Trompetero
- Goula Marta
- Granda Elena
- Grass Ingo
- Greenfield Michael
- Gremillet David
- Grieco Elisa
- Grilo Clara
- Gruychev Gradimir Valentinov
- Guedes Thais
- Gueldner Dino
- Guerrero Mayra Daniela Pena
- Guth Miriam Karen
- Haberl Helmut
- Hacket-Pain Andrew
- Hadjichambis Andreas
- Hahn Thomas
- Haklay Muki
- Hankerson Brett
- Heikkinen Anna
- Heikkurinen Pasi
- Heinen Julia Helena
- Heller Klaus-Gerhard
- Helm Aveliina
- Henders Sabine
- Henriksson Patrik J. G.
- Henrique Faria Sergio
- Henriques Sergio
- Hernandez Miguel
- Heylen Brigitte
- Hide Geoff
- Hinsley Amy
- Hinton Jennifer
- Hissa Leticia B. V.
- Hochkirch Axel
- Holzschuh Andrea
- Hortal Joaquin
- Hosner Peter A.
- Hurtado Fernando
- Infante-Amate Juan
- Islar Mine
- Ivkovic Slobodan
- Jacobs Sander
- Janke Rebekka
- Jarcuska Benjamin
- Johanisova Nadia
- Johansson Maria
- Johnson Mark D.
- Jones Julia Patricia Gordon
- Jucker Tommaso
- Juergensen Jonathan
- Jung Martin
- Junginger Martin
- Kallis Giorgos
- Kaltenpoth Martin
- Kanka Robert
- Karagouni Niki
- Kasimir Asa
- Kastner Thomas
- Kati Vassiliki
- Kechev Mihail Ognianov
- Kehoe Laura
- Kehoe Laura
- Keil Petr
- Keller Alexander
- Kerner Janika
- Kessner-Beierlein Daniela
- Kipson Marina
- Knohl Alexander
- Koh Niak
- Koster Martijn
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- Krause Torsten
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- Kristin Anton
- Krofel Miha
- Krueger Tobias
- Kuemmerle Tobias
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- Kurdikova Vendula
- Langerwisch Fanny
- Lapka Miloslav
- Larson Sven Ake
- Lassaletta Luis
- Latella Leonardo
- Lavorel Sandra
- Lehikoinen Aleksi
- Leidinger Ludwig
- Leijten Floris
- Leitao Pedro J.
- Lena Philippe
- Lens Luc
- Leonhardt Sara Diana
- Leroy Boris
- Leve Marine
- Levers Christian
- Lewerentz Anne
- Lewis Jerome
- Libbrecht Romain
- Lindkvist Emilie
- Lipsky Zdenek
- Ljubomirov Toshko
- Llusia Diego
- Lobmann Michael
- Lobo Jorge M.
- Loetters Stefan
- Londo Marc
- Lopez Baucells Adria
- Lopez Bosch David
- Lopez Hernandez Heriberto D.
- Lopez-Marquez Violeta
- Lorrilliere Romain
- Louis Deharveng
- Lukic Marko
- Lutter Stephan
- Macdiarmid Jennie
- Mace Georgina
- Machordom Annie
- Macia Manuel J.
- Mairota Paola
- Malecore Eva
- Marescaux Audrey
- Marselle Melissa
- Martin Arnaud
- Martin Jean-Louis
- Martin Philip
- Martins Andrea Damacena
- Marull Joan
- Mas Navarro Maria
- Mascarenhas Andre
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- Matenaar Daniela
- Mateos David Moreno
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- Mayer Andreas
- Mayer Martin
- McKay David Armstrong
- Mckeon Caroline
- McPhearson Timon
- Medvedovic Jasna
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- Mempel Finn
- Menzel Florian
- Mertz Ole
- Meseguer Andrea S.
- Meyer Carsten
- Meyer Christoph
- Meyfroidt Patrick
- Milchev Boyan Petrov
- Monserand Antoine
- Montade Vincent
- Morales Manuel B.
- Moreira Francisco
- Morelli Federico
- Moreta Lys Sanz
- Morin Xavier
- Motivans Elena
- Motta Renzo
- Moyano Fernando Esteban
- Mueller Daniel
- Mueller Joerg
- Mumby Hannah S.
- Munteanu Catalina
- Murtough Katie L.
- Mutke Jens
- Newig Jens
- Nielsen Jonas O.
- Nieto Roman Alejandra
- Nikolov Boris Petrov
- Noe Julia Le
- Noguera Jose C.
- Noll Domink
- Novoa Ana
- Nuernberger Fabian
- Nuissl Henning
- Nunes Matheus Henrique
- Nygren Michelle
- Ochu Erinma
- Oddie Melissa
- Ohrling Christian
- Oliveira Eduardo
- Olsson Gunilla Almered
- Olsson Urban
- Oppel Steffen
- Orach Kirill
- Orland Chloe
- Ostapowicz Katarzyna
- Ostermann Ole
- Oyanedel Rodrigo
- Padro Caminal Roc
- Paitan Claudia Parra
- Palm Celinda
- Palmeirim Jorge
- Panferov Oleg
- Partel Meelis
- Pascual Unai
- Pe'er Guy
- Peco Begona
- Pedersen Anna Frohn
- Pendrill Florence
- Penone Caterina
- Pereira Laura
- Peres Carlos A.
- Perez-Ortega Sergio
- Pergl Jan
- Perrigo Allison
- Persson Joel
- Persson Martin
- Peters Marcell K.
- Peterson Garry
- Peterson Gustaf
- Petridis Panos
- Petrik Petr
- Petrovan Silviu
- Petter Gunnar
- Phalan Ben
- Pichler Melanie
- Piemontese Luigi
- Pienkowski Thomas
- Pilo Francesca
- Piotrowski Jan A.
- Piquer-Rodriguez Maria
- Polaina Ester
- Pollet Marc
- Prat Narcis
- Presa Asencio Juan Jose
- Prevel Leonie
- Prince Karine
- Pucetaite Milda
- Pueyo Salvador
- Pynegar Edwin L.
- Pysek Petr
- Qin Siyu
- Rammig Anja
- Rands Mike
- Razanajatovo Mialy
- Rebelo Hugo
- Redlich Sarah
- Reis Tiago
- Renaud Pierre-Cyril
- Revilla Eloy
- Reyes-Garcia Victoria
- Rhee Howon
- Richardson Vanessa A.
- Riede Klaus
- Riggi Laura
- Rilovic Andro
- Ringsmuth Andrew
- Ritter Camila Duarte
- Robillard Tony
- Rocha Juan Carlos
- Rocha Ricardo
- Rodrigues Ana
- Rodriguez-Labajos Beatriz
- Roeder Achim
- Roemer Charlotte
- Roessler Daniela C.
- Romero-Munoz Alfredo
- Rosalino Luis Miguel
- Rothhaupt Karl-Otto
- Roturier Samuel
- Rounsevell Mark
- Roux Nicolas
- Rozylowicz Laurentiu
- Ruedenauer Fabian
- Rufin Philippe
- Rugani Benedetto
- Rust Niki
- Rutschmann Benjamin
- Rutting Tobias
- Salaseviciene Alvija
- Salek Martin
- Sanchez-Fernandez David
- Santagata Remo
- Santos Ana M. C.
- Sanz-Cobena Alberto
- Savaget Paulo
- Sayol Ferran
- Schilthuizen Menno
- Schindler Stefan
- Schleicher Judith
- Schlerf Martin
- Schmelzer Stefan
- Schmoll Tim
- Schneider Christoph
- Schnitzler Jan
- Schroeder Heike
- Schuenzel Julia
- Schug Franz
- Schumacher Kim
- Schwieder Marcel
- Seebens Hanno
- Sekerka Lukas
- Selva Nuria
- Semper-Pascual Asuncion
- Seppelt Ralf
- Seufert Verena
- Sieger Charlotte Sophie
- Silvestro Daniele
- Simaika John P.
- Simon Judy
- Sinare Hanna
- Sindicic Magda
- Singh Chandrakant
- Sjoberg Sissel
- Skejo Josip
- Smetschka Barbara
- Smith Annabel
- Smith Pete
- Smith Rebecca
- Snell Katherine
- Sober Virve
- Somma Francesca
- Souza Queiroz Allan
- Sovova Lucie
- Sperfeld Erik
- Staal Arie
- Stajerova Katerina
- Stanek Nicola
- Staude Ingmar
- Stein Anke
- Steinberger Julia K.
- Stenseke Marie
- Stibral Karel
- Strubbe Diederik
- Strugariu Alexandru
- Suarez Manuela Gonzalez
- Sullivan Martin
- Sutherland William J.
- Swinfield Tom
- Taiti Stefano
- Tatin Laurent
- Taylor Astrid
- Tello Enric
- Tengo Maria
- Teplitsky Celine
- Theurl Michaela C.
- Thieu Vincent
- Thonicke Kirsten
- Tiralla Nina
- Toledo-Hernandez Manuel
- Torre Ignasi
- Torres Aurora
- Traba Diaz Juan
- Trogisch Stefan
- Truong Minh-Xuan A.
- Tscharntke Teja
- Uddling Johan
- Ulgiati Sergio
- Vacchiano Giorgio
- Vaclavik Tomas
- Vajda Vivi
- Valdecasas Antonio G.
- Valentini Riccardo
- Valladares Fernando
- van den Burg Matthijs P.
- van der Ent Ruud J.
- van der Linden Sebastian
- van Kleunen Mark
- Vasconcelos Sasha
- Vavra Jan
- Verburg Peter
- Vieites David
- Vighi Morgana
- Vila Traver Jaime
- Villen-Perez Sara
- Vira Bhaskar
- Virah-Sawmy Malika
- Vlahos George
- Voigt Christian C.
- Voigt Maria
- Volaire Florence
- von Doehren Peer
- Wagner Norman
- Wandl Marie-Theres
- Wang-Erlandsson Lan
- Wanger Thomas Cherico
- Wassen M. J.
- Weigelt Patrick
- Weigend Maximilian
- Whittaker Robert J.
- Wiegand Kerstin
- Wieringa Jan J.
- Willemse Luc
- Winiwarter Verena
- Winter Marten
- Wong Grace
- Wordley Claire
- Worthington Thomas
- Yates Katherine
- Yin Fang
- Zafra-Calvo Noelia
- Zang Christian
- Zemp Delphine Clara
- Zhang Zhijie
- Zirion Maria
- Zobel Martin
- zu Ermgassen Erasmus
- Zucaro A.
- Zurell Damaris
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2019
- Field of study
Brazil, home to one of the planet's last great forests, is currently in trade negotiations with its second largest trading partner, the European Union (EU). We urge the EU to seize this critical opportunity to ensure that Brazil protects human rights and the environment
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- Abbasciano Isabella
- Abrantes Catarina
- Accarino Simone
- Adler Sharon
- Adoberg Annika
- Afsari Rouzbeh
- Ahmad Syeda
- Ahmed Jafar
- Ahn Wooin
- Ajayi Bamidele
- Aksamit Dariusz
- Al Chalabi Saif
- Alamartine Eric
- Alchi Bassam
- Ali Mohammad
- Aliotta Roberta
- Almaani Salem
- Almeida Catarina
- Almeida Edgar
- Alpers Charles E
- Alvarez Francisco de la Prada
- Alves Patricia
- Annese Francesca
- Appel Gerald
- Arduan Alberto Ortiz
- Arena Maria
- Arevalo Marta Calvo
- Arfaania Dariush
- Arias Carlos
- Aristoy Emma Calatayud
- Asakiene Egle
- Ashley Sarah
- Assefi Ali
- Atenza Alba
- Auerbach Asta
- Augustyniak-Bartosik Hanna
- Avella Monroy
- Ayling-Smith Jonathan
- Ayoub Isabelle
- Ayvazyan Christine
- Baccaro Rocco
- Bailey Asha
- Baker Bruce
- Balamuthusamy Saravanan
- Ballarin Jose
- Barata Rui
- Barbic Jerko
- Barisic Dunja
- Barratt Jonathan
- Barreto Jose Carlos de Jesus
- Barrios Clara
- Belingheri Mirco
- Benesova Anna
- Bernabeu Ana Avila
- Bernhardt Wanja
- Bhadra Shamik
- Biancone Luigi
- Bieler Stewart
- Blanchard Anne
- Boaglio Elena
- Bolignano Davide
- Bomback Andrew
- Bonilla Gustavo Andres Useche
- Bordoli Monica
- Bose Bhadran
- Boudville Neil
- Brandon Donald
- Brown Karen
- Broyet Christian
- Bucknall Thomas
- Buffet Alexandre
- Bumblyte' Inga Arune
- Burdese Manuel
- Burgos Natalia Allende
- Burguet Laure
- Burtey Stephane
- Busch Martin
- Cakiroglu Figen
- Campbell Victoria
- Canetta Pietro
- Capaccio Flavia
- Carbonell Juan
- Cardoso Filipa
- Carro Clara Garcia
- Carroll Robert
- Carron Pierre-Louis
- Carullo Nazareno
- Cassia Matthias
- Caster Dawn
- Castillo Belen Vizcaino
- Catucci Davide
- Cavalli Andrea
- Chae Dong-Wan
- Chakera Aron
- Chan Anthony Ting Pong
- Chan Doris
- Chan Gary Chi Wang
- Chan Lai Wan
- Chang Jae Hyun
- Chang Ming-Shan
- Chapman Fiona
- Charytan Chaim
- Chaudhry Asghar
- Cheetham Melissa
- Chen Cheng-Hsu
- Chen Chien-Liang
- Chen Hsin-Yu
- Chen Hung-Chun
- Chen Hung-Yuan
- Chenine Leila
- Cheung Chee Kay
- Cheung Siu Fai
- Chiche-Jourde Noemie
- Chiu Hsien-Fu
- Chiu Ian
- Chiu Yen-Ling
- Chiu Yi-Wen
- Choi Hoon Young
- Chou Kang-Ju
- Chowdhury Paramit
- Chowdhury Pradip
- Chrysochou Constantina
- Chukwu Chukwuma
- Chun Ka Yeong
- Chung Wookyung
- Cieniawski Dominik
- Claisse Guillaume
- Clayton Philip
- Cleary Catalina Martín
- Clement Nisha
- Coates Toby
- Cogno Chiara
- Colla Loredana
- Collins Michael
- Colucci Marco
- Combe Christian
- Comi Nicolino
- Comunale Roderick
- Contreras Gabriel
- Cooper Bruce
- Coppock Gaia
- Costa Ana Cortesão
- Costanzi Stefano
- Cozzolino Mario
- Crail Susan
- Cunha Liliana
- Curry Elizabeth
- Dai Tiane
- Daina Erica
- Daneshvari Sam
- Dasgupta Indranil
- DaSilva Louise
- Davidson Robert
- De Bhailis Aine Maire
- de Précigout Valérie
- Decupere Marc
- Delmas Yahsou
- Deodato Francesca
- Dhaun Neeraj
- Dhaygude Ajay
- Dhelaria Ranjit
- Di Maio Federica
- Diezhandino Maria Angeles Goicoechea
- Dika Zivka
- Dinic Miriana
- Dittmer Ian
- Diva Ulysses A
- Dobre Mirela
- Doctor Gabriel
- Donati Gabriele
- Doubel Peter
- Douthit Nicole
- Draganova Diliana
- Drexler Yelena
- Drinkovic Martin
- Drinovska Klara
- Dudreuilh Caroline
- Dumond Clement
- Durlen Ivan
- Dussol Bertrand
- Encarnacion Montserrat Diaz
- Endre Zoltan
- Enrique Jorge
- Eqbal Yusuf
- Erlich Jonathan
- Esposito Ciro
- Esposito Vittoria
- Fakih Faisal
- Fang Hua-Chang
- Farinha Ana
- Fearday Aaron
- Felgueiras Joana de Sousa Soares
- Felicjanczuk Elzbieta
- Fernandes Adriana
- Fernandes João Carlos
- Fernandes Sara
- Fernandez Jose Luño
- Fernandez Victor
- Fernando Mangalee
- Figueiredo Ana Carolina
- Firre Eric
- Floege Jürgen
- Flossmann Oliver
- Floyd Lauren
- Fonseca Jose Nuno de Almeida Agapito
- Fonseca Nuno
- Foote Celine
- Forbes Suzanne
- Forcen Angel
- Fornoni Alessia
- Fouassier David
- Fraser Ian
- Fung Ka Shun Samuel
- Furlano Monica
- Furtado Teresa
- Gadh Rajdeep
- Gaisset Roxane
- Gallagher Martin
- Gameiro Joana
- Gangadharan Muralikrishna
- Garcia Fabiola Alonso
- Garcia Olga Gracia
- Garg Gunjan
- Garrouste Cyril
- Gautam Archana
- Geara Abdallah
- Geddes Colin
- Gellineo Lana
- Germain Michael
- Gesualdo Loreto
- Ghalli Farid
- Giaroni Francesco
- Giles Harold
- Gillies Alastair
- Gimeno Ana Vilar
- Girardet Annette
- Glaze Jeffrey
- Goh Tze
- Gois Mario
- Goldsmith Christopher
- Goma Elena
- Gomes Ana Marta
- Goncalves Luis Pedro Falcao
- Goncalves Sara
- Gontarek-Kacprzak Julita
- Gonzalez Carlos
- Gopu Arun
- Gowda Nayan
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- Green Heather
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- Guldris Secundino Cigarran
- Guzman Ursula Verdalles
- Ha Jeffrey Tsun Kit
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- Hamilton Patrick
- Han Seung Hyeok
- Haws Robert
- Hayat Ashik
- Heath Lauren
- Heerspink Hiddo J L
- Heinrichs Sven
- Henderson Amy
- Henderson Andrew
- Hendren Elizabeth
- Heng Anne-Elisabeth
- Heres Salia Virxinia Pol
- Herfurth Johann Konstantin
- Herrero Evangelina Merida
- Ho Tzung-Yo
- Hogan Jonathan
- Hohenstein Bernd
- Hollett Peter
- Horvatic Ivica
- Hsu Bang-Gee
- Hsu Chia-Tien
- Hsu Chih-Yang
- Hsu Shih-Ping
- Huang Chien-Wei
- Hudson Amy
- Hung Chi-Chih
- Hwang Daw-Yang
- Hwang Shang-Jyh
- Hyun Young Youl
- Ilmoja Madis
- Inrig Jula K
- Irish Georgina
- Jacob Radu
- Jahan Sadia
- Jain Arunima
- Jamar Sofie
- Jander Anna
- Jang Hye Ryoun
- Janko Catherine
- Jardine Meg
- Jaskowski Piotr
- Jeantet Guillaume
- Jelakovic Bojan
- Jeon Junseok
- Jeong Jong Cheol
- Jesudason Shilpanjali
- Jittirat Arksarapuk
- Jo Sang-Kyung
- Jones Rachel
- Joo Narae
- Jorge Sofia
- Julian Bruce
- Jung JiYong
- Jyothinagaram Praveena
- Kadakia Jigar
- Kamal Fahameedah
- Kanigicherla Durga
- Karanovic Sandra
- Karras Alexandre
- Kasimatis Theodoros
- Kassem Mohamad
- Kattamanchi Siddhartha
- Keller Christopher
- Kentric Dubravka Trajbar
- Kettner Christiane
- Khalil Kassem
- Kim Aejin
- Kim Dana
- Kim Hyung Wook
- Kim Jwa-Kyung
- Kim Myung-Gyu
- Kim Se Joong
- Kim Sunggyun
- Kim Yeong Hoon
- Kim Yunmi
- Kimber Cassandra
- Klamm Kathryn
- Koch Annegret
- Koester Eric
- Kohan Donald E
- Kolvald Kulli
- Komers Radko
- Kon Sui
- Kooienga Laura Ann
- Kotwal Sradha
- Krajewska Magdalena
- Kratka Karolina
- Krishnan Anoushka
- Krishnasamy Rathika
- Krueger Thilo
- Kruljac Ivan
- Kulka Simone
- Kunzendorf Ulrich
- Kuo Hung-Tien
- Kuo Mei-Chuan
- Kuo Sheng
- Kwan Lorraine Pui Yuen
- Kwella Bogna
- Kwella Norbert
- Kyaw Kay
- Labat Aurore
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- Lagatta Mark
- Lam Chi Kwan Darwin
- Lambie Mark
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- Latif Farah
- Laute Margo
- Law Wai Ping
- Lawman Sarah
- Lazo Mercedes Salgueira
- Lee Hajeong
- Lee Hyun Hee
- Lee Hyung-seok
- Lee JungEun
- Lee Kyu-Beck
- Lee Moon Hyoung
- Lee Po-Tsang
- Leis Liisi
- Lemahieu Wim
- Leung Janson
- Li Yan
- Lie Davina Ngoi Wah
- Lifland Howard
- Lilienthal Kadri
- Lim Wai
- Limardo Monica
- Livrozet Marine
- Longhi Selena
- Lopes Daniela
- Lopes Jose Antonio
- Lorde Nathan
- Luxton Grant
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- Madhrira Machaiah
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- Maes Bart
- Mahadevan Kumaradevan
- Mahdi Amar
- Mahdi Eamon
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- Maixnerova Dita
- Majstorovic Barac Karolina
- Malecki Robert
- Malfait Thomas
- Malvica Silvia
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- Manley Paul
- Mansfield Nick
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- Mariat Christophe
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- Martinez Eduardo Gutierrez
- Martinez Stacy
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- Masson Ingrid
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- Mayet Valentin
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- Messa Piergiorgio
- Messias Ana
- Miarka Przemyslaw
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- Mikhail Ashraf
- Milicevic Martina
- Minasian Raffi
- Moeller Marcus
- Mohey Hesham
- Mojarrab Javad
- Mok Maggie Ming Yee
- Moncasi Eduardo Parra
- Moonen Martial
- Morales Wenceslao Adrian Aguilera
- Moreno Antolina
- Moreno Eduardo Verde
- Morris Adam
- Moutzouris Dimitrios
- Moya Mercedes Gonzalez
- Mucha Simon
- Musolino Michela
- Napodano Pietro
- Natario Ana
- Negrea Lavinia
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- Neuen Brendon
- Newsome Britt
- Ng Kit Chung Jack
- Nguyen Thu
- Nguyen Viet
- Nicolo Clementine
- Nitschke Martin
- Noble Euan
- Nolasco Fernando
- Noronha Irene L
- O'Lone Emma
- O'Shaughnessy Michelle
- Ochoa Adriana Sierra
- Oh Kook-Hwan
- Oh Se Won
- Oh SeWon
- Okoh Pedro
- Ombelet Sara
- Ou Shih-Hsiang
- Packham David
- Padiyar Aparna
- Pai Mei-Fen
- Pamplona Irene Agraz
- Pan Szu-Yu
- Pandya Bhavna
- Papadia Federica
- Pardinhas Clara
- Parikh Nishita
- Parikh Samir
- Park Hyeong Cheon
- Park Jung Tak
- Parreira Lucia
- Passerini Patrizia
- Patak Ramachandra
- Patecki Margret
- Patel Suthar Meera
- Patel Jusmin
- Patel Rajan
- Patella Gemma
- Patrikyan Artashes
- Pavlovic Drasko
- Paxton William
- Peh Chen
- Peh Chen Au
- Peleg Yonatan
- Pelicano Josep Miquel Blasco
- Peng Yu-Sen
- Pereira de Vicente Manuel
- Perez de Jose Ana
- Perez Lluna Leticia
- Perez Erika
- Perez Jonay Pantoja
- Peri Usha
- Perico Norberto
- Perkovic Vlado
- Philipponnet Carole
- Phua Elaine
- Piel Julia
- Pillai Unnikrishnan
- Pilmore Helen
- Plavljanic Djuro
- Plaza Mercedes Velo
- Pollock Carol
- Ponnusamy Arvind
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- Powell Thomas
- Pradhan Nishigandha
- Prado Raul Fernandez
- Praga Manuel
- Preciado Priscila
- Prkacin Ingrid
- Pruthi Rishi
- Pugh Dan
- Pérez Gómez María Vanessa
- Quinn Sarah
- Quintana Luis F
- Raakesh Lathika
- Rabindranath Kannaiyan
- Radermacher Luc
- Radhakrishnan Jai
- Ragy Omar Sherin Ibrahim
- Raichoudhury Ritesh
- Raimundo Mario
- Randone Paolo
- Razavian Mona
- Reichel Helmut
- Reis Marina
- Remuzzi Giuseppe
- Reynolds Annie
- Rheault Michelle N
- Ricchiuto Anna
- Rico Ivon Maritza Bobadilla
- Rigothier Claire
- Ritchie Angus
- Rivero Maria Antonieta Azancot
- Rizk Dana
- Ro Han
- Rodriguez Garcia Eva
- Rodriguez Alfred
- Roger Simon
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- Rosenberg Mai
- Rote William E
- Roueff Stephane
- Rovin Brad
- Rovin Brad H
- Roxburgh Sarah
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- Salehi Tania
- Sanden Silja
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- Santos Patricia Valerio
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- Savuk Ana
- Sayer Matthew
- Schlieper Georg
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- Schmidt-Guertler Hans
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- Schulte Kevin
- Schulz Lisa
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- Serrano Antonio Galan
- Serre Jean-Emmanuel
- Sevillano Angel
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- Shen Yvonne
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- Silva Sónia
- Sinha Smeeta
- Siriwardana Amanda
- Sitas Zvonimir
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- Soares Elsa Sofia Quadrado
- Solazzo Andrea
- Solis Elena Gutierrez
- Solomon Laurence
- Song Young Rim
- Sousa Helena
- Spinowitz Bruce
- Stallworthy Elizabeth
- Stamellou Eleni
- Stanczyk Malgorzata
- Stangenberg Stefanie
- Stankovic Marija
- Stankuviene Asta
- Stea Emma Diletta
- Stompor Tomasz
- Storrar Joshua
- Sullivan James
- Sulowicz Wladyslaw
- Suyumova Irina
- Szeto Cheuk Chun
- Sá Helena
- Sánchez de la Nieta Maria Dolores
- Tamarit Esther
- Tan Eddie
- Tan May
- Tang Hon
- Tang Sydney C W
- Tang Sydney Chi Wai
- Teixeira Catarina
- Telling Kadri
- Terrades Natalia Ramos
- Tesar Vladimir
- Tez Didem
- Thervet Eric
- Thibaudin Damien
- Thomas Mark
- Thyagarajan Nikhil
- Tkaczyk Marcin
- Torreggiani Massimo
- Trachtman Howard
- Trillini Matias
- Trimarchi Hernán
- Tsai Jer-Chia
- Tsai Shang-Feng
- Tsai Wan-Chuan
- Tseng Po-Yu
- Tumlin James
- Tumlin James A
- Tung Kuei-Ting
- Turnbull Angus
- Udani Suneel
- Uhlinova Jana
- Unt Kristin
- Urciuolo Federica
- Vanacker An
- Vandewiele Bert
- Vaz Alvaro
- Veermae Kristi
- Viaene Liesbeth
- Vickiene Alvita
- Vigano Sara
- Vila Maria Antonia Munar
- Vilayur Eswari
- Villanueva Caridad Martinez
- Villarroya Cristina Medrano
- Villen Alejandro Soria
- Viramontes Veronica
- Vita Caterina
- Vujcic Dunja
- Wahba Mona
- Wan Susan
- Wang Chih-Hsien
- Warling Xavier
- Waters Gerald
- Waugh Jane
- Weiland Lea
- Weiner Stefan
- Weinreich Thomas
- Werth Stephan Christian
- Wickens Olivia
- Wijeratne Vidu
- Wilder Karen
- Willcocks Lisa
- Williams Allister
- Winiarska Agata
- Wirtz Nikolaus
- Wolf Gunter
- Wolf Lothar
- Wong Muh Geot
- Wong Sze Ho Sunny
- Wong Yick Hei
- Workeneh Biruh
- Wu Hon-Yen
- Wu Ming-Ju
- Wyndham Roger
- Yang Jihyun
- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
- Bassam Alchi
- Belen Vizcaino Castillo
- Bernd Hohenstein
- Bert Vandewiele
- Bertrand Dussol
- Bhadran Bose
- Bhavna Pandya
- Biruh Workeneh
- Bogna Kwella
- Bojan Jelakovic
- Brad Rovin
- Bradley Nelson
- Brendon Neuen
- Brian Snow
- Britt Newsome
- Brittany Sheridan
- Bruce Baker
- Bruce Cooper
- Bruce Julian
- Bruce Spinowitz
- Camille Lanaret
- Caridad Martinez Villanueva
- Carlos Arias
- Carlos Gonzalez
- Carlotta Federica Zizzi
- Carmelita Marcantoni
- Carmen Sivo
- Carol Pollock
- Carole Philipponnet
- Caroline Dudreuilh
- Cassandra Kimber
- Catalina Martín Cleary
- Catarina Abrantes
- Catarina Almeida
- Catarina Teixeira
- Caterina Vita
- Catherine Janko
- Catherine Masset
- Cathylee Sly
- Celine Foote
- Chaim Charytan
- Chee Kay Cheung
- Chen Peh
- Cheng-Hsu Chen
- Cheuk Chun Szeto
- Chi Kwan Darwin Lam
- Chi-Chih Hung
- Chia-Tien Hsu
- Chiara Cogno
- Chien-Liang Chen
- Chien-Wei Huang
- Chih-Hsien Wang
- Chih-Yang Hsu
- Chii Yeap
- Christian Broyet
- Christian Combe
- Christiane Kettner
- Christine Ayvazyan
- Christophe Mariat
- Christopher Goldsmith
- Christopher Keller
- Chukwuma Chukwu
- Ciro Esposito
- Claire Rigothier
- Clara Barrios
- Clara Garcia Carro
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- Cristina Medrano Villarroya
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- Dana Kim
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- Mei-Fen Pai
- Melissa Cheetham
- Mercedes Gonzalez Moya
- Mercedes Salgueira Lazo
- Mercedes Velo Plaza
- Michael Collins
- Michael Germain
- Michel Zakari
- Michela Musolino
- Michelle N Rheault MD i
- Michelle O'Shaughnessy
- Ming-Ju Wu
- Ming-Shan Chang
- Mingyao Ma
- Mirco Belingheri
- Mirela Dobre
- Miriana Dinic
- Mohamad Kassem
- Mohammad Ali
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- Nicolino Comi
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- Nisha Clement
- Nishigandha Pradhan
- Nishita Parikh
- Noemie Chiche-Jourde
- Norbert Kwella
- Norberto Perico
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- Olga Gracia Garcia
- Oliver Flossmann
- Olivia Wickens
- Olivier Schockaert
- Omar Sherin Ibrahim Ragy
- Paolo Randone
- Paramit Chowdhury
- Patricia Alves
- Patricia Valerio Santos
- Patrick Hamilton
- Patrick Mark
- Patrizia Passerini
- Paul Manley
- Pedro Okoh
- Peter Doubel
- Peter Hollett
- Peter Hollett
- Peter Sizeland
- Philip Clayton
- Philippe Zaoui
- Phillip Madonia
- Piergiorgio Messa
- Pierre-Louis Carron
- Pietro Canetta
- Pietro Napodano
- Piotr Jaskowski
- Po-Tsang Lee
- Po-Yu Tseng
- Pradip Chowdhury
- Praveena Jyothinagaram
- Priscilla Smith
- Prof Brad Rovin MD j
- Prof Charles E Alpers MD d
- Prof Hiddo J L Heerspink PhD a b
- Prof Howard Trachtman MD k
- Prof Irene L Noronha MD h
- Prof Jai Radhakrishnan MD c
- Prof Jonathan Barratt PhD e
- Prof Vlado Perkovic MD b ofor the PROTECT Investigators† Author links open overlay panelEric Alarmartine
- Przemyslaw Miarka
- Rachel Jones
- Radko Komers MD f
- Radu Jacob
- Raffi Minasian
- Rajan Patel
- Rajdeep Gadh
- Ramachandra Patak
- Ranjit Dhelaria
- Rathika Krishnasamy
- Rathika Krishnasamy
- Raul Fernandez Prado
- Richard Lafayette
- Rishi Pruthi
- Ritesh Raichoudhury
- Robert Carroll
- Robert Davidson
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- Roderick Comunale
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- Rouzbeh Afsari
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- Sadia Jahan
- Saif Al Chalabi
- Salem Almaani
- Salia Virxinia Pol Heres
- Sam Daneshvari
- Samir Parikh
- Sandra Karanovic
- Sang-Kyung Jo
- Sapna Shah
- Sara Fernandes
- Sara Goncalves
- Sara Ombelet
- Sara Vigano
- Sarah Ashley Ford Sightler
- Sarah Lawman
- Sarah Quinn
- Sarah Roxburgh
- Saravanan Balamuthusamy
- Se Joong Kim
- Sebahat Sat
- Secundino Cigarran Guldris
- Selena Longhi
- Serena Ponti
- Seung Hyeok Han
- SeWon Oh
- Shamik Bhadra
- Shang-Feng Tsai
- Shang-Jyh Hwang
- Sharon Adler
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- Shih-Hsiang Ou
- Shih-Ping Hsu
- Shilpanjali Jesudason
- Sian Griffin
- Siddhartha Kattamanchi
- Silja Sanden
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- Sradha Kotwal
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- Stacy Martinez
- Stefan Weiner
- Stefanie Stangenberg
- Stefano Costanzi
- Stephan Christian Werth
- Stephane Burtey
- Stephane Roueff
- Stephen McDonald
- Stewart Bieler BA a
- Sui Kon
- Suneel Udani
- Sunggyun Kim
- Susan Crail
- Susan Wan
- Suzanne Forbes
- Sven Heinrichs
- Sydney Chi Wai Tang
- Syeda Ahmad
- Sze Ho Sunny Wong
- Szu-Yu Pan
- Sónia Silva
- Tae-Hyun Yoo
- Tak Tai Andrew Yue
- Tamara Malek Marin
- Tania Salehi
- Teresa Furtado
- Theodoros Kasimatis
- Thida Maung Maung Myint
- Thilo Krueger
- Thomas Bucknall
- Thomas Malfait
- Thomas Powell
- Thomas Weinreich
- Thu Nguyen
- Tiane Dai
- Toby Coates
- Tomasz Stompor
- Tung-Min Yu
- Tze Goh
- Tzung-Yo Ho
- Ulrich Kunzendorf
- Ulysses Diva PhD f
- Unnikrishnan Pillai
- Unnikrishnan Pillai
- Ursula Verdalles Guzman
- Urte Zakauskiene
- Usha Peri
- Valentin Mayet
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- Veronica Viramontes
- Victor Fernandez
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- Victoria Campbell
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- Viet Nguyen
- Viet Nguyen
- Vittoria Esposito
- Vladmir Tesar
- Wai Lim
- Wai Ping Law
- Wan-Chuan Tsai
- Wanja Bernhardt
- Wenceslao Adrian Aguilera Morales
- William Paxton
- William Rote PhD f
- Wim Lemahieu
- Wladyslaw Sulowicz
- Wooin Ahn
- Wookyung Chung
- Xavier Warling
- Yahsou Delmas
- Yan Li
- Yelena Drexler
- Yen-Ling Chiu
- Yeong Hoon Kim
- Yi-Wen Chiu
- Yick Hei Wong
- Yonatan Peleg
- Young Rim Song
- YoungYoul Hyun
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- Yusuf Eqbal
- Yvonne Shen
- Zivka Dika
- Zoltan Endre
- Zvonimir Sitas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Aaron Fearday (17386231)
- Abdallah Geara (17386297)
- Adam Morris (2043517)
- Adriana Fernandes (8856416)
- Adriana Sierra Ochoa (17386699)
- Aejin Kim (2175798)
- Agata Winiarska (17387086)
- Aine Maire De Bhailis (17386168)
- Ajay Dhaygude (10682946)
- Alastair Gillies (17386309)
- Alba Atenza (17385991)
- Alberto Ortiz Arduan (17385973)
- Alejandro Soria Villen (17387041)
- Alessia Fornoni (519467)
- Alex Mercer (59669)
- Alexandre Buffet (14930766)
- Alexandre Karras (506611)
- Alfred Rodriguez (17386840)
- Ali Assefi (17385988)
- Allister Williams (17387083)
- Allyson Medina (17386612)
- Alvaro Vaz (17387023)
- Alvita Vickiene (6473255)
- Amanda Hall (210816)
- Amanda Mather (285324)
- Amanda Siriwardana (17386933)
- Amar Mahdi (10295868)
- Amy Henderson (17386369)
- Amy Hudson (8412594)
- An Vanacker (17387017)
- Ana Avila Bernabeu (17386036)
- Ana Carolina Figueiredo (17386246)
- Ana Cortesão Costa (5670833)
- Ana Farinha (17386228)
- Ana Marta Gomes (2851424)
- Ana Messias (17386621)
- Ana Natario (17386672)
- Ana Perez de Jose (17386768)
- Ana Savuk (17386891)
- Ana Vilar Gimeno (17386312)
- Andrea Cavalli (102196)
- Andrea Solazzo (4768362)
- Andrew Bomback (17386042)
- Andrew Henderson (2641108)
- Andrew McNally (1982641)
- Angel Forcen (17386264)
- Angel Sevillano (17386918)
- Angus Ritchie (9950267)
- Angus Turnbull (17387002)
- Anna Benesova (17386033)
- Anna Jander (17386405)
- Anna Ricchiuto (17386831)
- Anne Blanchard (480536)
- Anne-Elisabeth Heng (4164625)
- Annegret Koch (17386468)
- Annette Girardet (17386315)
- Annie Reynolds (8204301)
- Annika Adoberg (17385931)
- Anoushka Krishnan (12896624)
- Anthony Ting Pong Chan (17386099)
- Antolina Moreno (17386657)
- Antonio Galan Serrano (17386915)
- Aparna Padiyar (17386714)
- Archana Gautam (402849)
- Arksarapuk Jittirat (17386420)
- Arnold Silva (17386930)
- Aron Chakera (239959)
- Artashes Patrikyan (17386744)
- Arun Gopu (17386342)
- Arunima Jain (17386402)
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- Vlado Perkovic (141532)
- Wai Lim (3583598)
- Wai Ping Law (12288571)
- Wan-Chuan Tsai (5476856)
- Wanja Bernhardt (245782)
- Wenceslao Adrian Aguilera Morales (17386651)
- William E Rote (17385919)
- William Paxton (17386750)
- Wim Lemahieu (3547811)
- Wladyslaw Sulowicz (17386969)
- Wooin Ahn (17385943)
- Wookyung Chung (610342)
- Xavier Warling (17387056)
- Yahsou Delmas (4034183)
- Yan Li (23143)
- Yelena Drexler (12365018)
- Yen-Ling Chiu (442530)
- Yeong Hoon Kim (8962688)
- Yi-Wen Chiu (106535)
- Yick Hei Wong (12288568)
- Yonatan Peleg (9922071)
- Young Rim Song (13242926)
- Young Youl Hyun (13016397)
- Yu-Sen Peng (315725)
- Yunmi Kim (3040866)
- Yusuf Eqbal (17386222)
- Yvonne Shen (17386921)
- Zivka Dika (10281479)
- Zoltan Endre (714028)
- Zvonimir Sitas (17386936)
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.
Findings
Between Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.
Interpretation
Over 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function.</p
Delayed colorectal cancer care during covid-19 pandemic (decor-19). Global perspective from an international survey
- Author
- Abary Ryan Rainiel A
- Abdelwahab Khaled M Egypt
- Abellán Antonio M Spain
- Abraham Ned Australia
- Achkasov Sergey I Russia
- Adamina Michel Switzerland
- Adamo Vincenzo Italy
- Agapov Mikhail Russia
- Agarwal Amit USA
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- Aguilar Werner Chile
- AguilarMartínez María Del Mar AM Spain
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- Ahmed Jamil UK
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- Alapati Kishore India
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- Albastaki Sara UAE
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- Alconchel Felipe Spain
- Alerta-Torre Andrea J Philippines
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- Alexander Herold Germany
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- Zuhdy Mohammad
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background
The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic.
Methods
The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) ‘delay’ group: CRC care affected by the pandemic; 2) ‘no delay’ group: unaltered CRC practice.
Results
A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the ‘delay’ (745, 70.9%) and ‘no delay’ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the ‘delay’ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the ‘no delay’ group, while the geographical distribution was not.
Conclusions
Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care