Variations of foF2 and GPS total electron content over the Antarctic sector

This paper presents a preliminary analysis of the variations of the critical frequency of the F2 region (foF2) and the total electron content (TEC) derived from Global Positioning System (GPS) data. Hourly foF2 values were scaled from ionograms recorded at San Martin (68.1°S, 293.0°E) and the TEC values were derived from GPS observations at O'Higgins (63.3°S, 302.5 °E). The database includes measurements obtained under different seasonal and solar activity conditions. The study shows that the daily peak of foF2 occurs around local noon in winter and fall, and in spring a secondary peak is observed around midnight. In summer (January) foF2 reaches its minimum value around the noon sector while the maximum in the diurnal variation of foF2 is located in a time sector close to midnight. This behaviour is observed at low and high solar activity. The semiannual anomaly appears around noon at high and low solar activity and the winter anomaly is not observed. The effect of the solar activity is generally observed in every season. The analysis of the GPS TEC measurements in the same region indicates that the diurnal, seasonal and solar activity variations are similar to those observed in the foF2 values. An analysis of the performance of the IRI model to predict foF2 is also shown using the two IRI options (URSI and CCIR). The comparisons between the experimental values and the IRI predictions show some discrepancies.Facultad de Ciencias Astronómicas y Geofísica

Very high quality factor measured in annealed fused silica

We present the results of quality factor measurements for rod samples made of fused silica. To decrease the dissipation we annealed our samples. The highest quality factor that we observed was $Q=(2.03\pm0.01)\times10^8$ for a mode at 384 Hz. This is the highest published value of $Q$ in fused silica measured to date.Comment: 8 pages, 2 figure

Medición de la inclusión financiera en México a través de un índice multidimensional

Dada la importancia de la inclusión financiera, es necesario contar con información que ayude a medirla y evaluarla, por lo que el objetivo de esta investigación es elaborar un índice compuesto, utilizando la técnica multivariada del análisis de componentes principales (ACP), que permita medir el nivel de inclusión financiera individual. La ventaja de construir el índice a partir de las características de los individuos permite, por un lado, analizar la relación que guardan las dimensiones consideradas de la inclusión financiera con rasgos individuales como el sexo, la escolaridad, o el lugar de residencia, lo que en principio permite mejorar el diseño de políticas públicas para incrementar la inclusión. Por otra parte, el índice permite medir el grado de inclusión financiera de segmentos específicos de la población, facilitando su contraste con otros segmentos poblacionales, así como su evolución a través del tiempo. El índice se diferencia de otros índices disponibles porque utiliza una técnica estadística multivariada para el cálculo, así como los datos más recientes disponibles sobre inclusión financiera en México. Además, la utilización de las técnicas multivariadas permite resumir una gran cantidad de información para elaborar índice. Este documento se divide de la siguiente manera: en el capítulo I se explora el concepto de inclusión financiera y las múltiples fuentes de datos existentes y fiables sobre la inclusión financiera. También se examinan los indicadores planteados y conocidos basados en distintas técnicas, así como sus fortalezas y debilidades. En el capítulo II se expone la elección de la metodología para construir un indicador compuesto y sus ventajas. También se muestra el tratamiento que se les dio a las variables, así como la elaboración de índices simples que pudieran medir e incorporar más información a las dimensiones de uso y calidad. En el capítulo III se describen los datos que se utilizaron para la estimación. En el capítulo IV se presenta la estimación y los resultados de la investigación, mientras que en el V se muestra la validación y los posibles usos del índice. Finalmente, en el capítulo VI se presentan las conclusiones y las recomendaciones de política pública que se pueden desprender del cálculo de este indicador compuesto.Resumen .-- Introducción .-- I. Inclusión financiera .-- II. Estrategia empírica .-- III. Datos y estadística descriptiva .-- IV. Estimación y resultados .-- V. Validación y usos del IIFI .-- VI. Conclusiones

A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level

BACKGROUND: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude. METHODS: We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. Participants completed a 6-min walk test, answered a sociodemographics and clinical questionnaire, underwent spirometry, and a blood test. RESULTS: Average age was 54.0 vs. 53.8 years, 48% vs. 43% were male, average height was 155 vs. 158 cm, average blood oxygen saturation was 98% vs. 90%, and average resting heart rate was 67 vs. 72 beats/min in Lima vs. Puno. In multivariable regression, participants in Puno walked 47.6 m less (95% CI -81.7 to -13.6 m; p < 0.01) than those in Lima. Other variables besides age and height that were associated with 6MWD include change in heart rate (4.0 m per beats/min increase above resting heart rate; p < 0.001) and percent body fat (-1.4 m per % increase; p = 0.02). CONCLUSIONS: The 6-min walk test predicted a lowered functional capacity among Andean high altitude vs. sea level natives at their altitude of residence, which could be explained by an incomplete adaptation or a protective mechanism favoring neuro- and cardioprotection over psychomotor activity

Variations of foF2 and GPS total electron content over the Antarctic sector

This paper presents a preliminary analysis of the variations of the critical frequency of the F2 region (foF2) and the total electron content (TEC) derived from Global Positioning System (GPS) data. Hourly foF2 values were scaled from ionograms recorded at San Martin (68.1°S, 293.0°E) and the TEC values were derived from GPS observations at O'Higgins (63.3°S, 302.5 °E). The database includes measurements obtained under different seasonal and solar activity conditions. The study shows that the daily peak of foF2 occurs around local noon in winter and fall, and in spring a secondary peak is observed around midnight. In summer (January) foF2 reaches its minimum value around the noon sector while the maximum in the diurnal variation of foF2 is located in a time sector close to midnight. This behaviour is observed at low and high solar activity. The semiannual anomaly appears around noon at high and low solar activity and the winter anomaly is not observed. The effect of the solar activity is generally observed in every season. The analysis of the GPS TEC measurements in the same region indicates that the diurnal, seasonal and solar activity variations are similar to those observed in the foF2 values. An analysis of the performance of the IRI model to predict foF2 is also shown using the two IRI options (URSI and CCIR). The comparisons between the experimental values and the IRI predictions show some discrepancies.Facultad de Ciencias Astronómicas y Geofísica

Analysis of noise temperature sensitivity for the design of a broadband thermal noise primary standard

A broadband primary standard for thermal noise measurements is presented and its thermal and electromagnetic behaviour is analysed by means of a novel hybrid analytical?numerical simulation methodology. The standard consists of a broadband termination connected to a 3.5mm coaxial airline partially immersed in liquid nitrogen and is designed in order to obtain a low reflectivity and a low uncertainty in the noise temperature. A detailed sensitivity analysis is made in order to highlight the critical characteristics that mostly affect the uncertainty in the noise temperature, and also to determine the manufacturing and operation tolerances for a proper performance in the range 10MHz to 26.5 GHz. Aspects such as the thermal bead design, the level of liquid nitrogen or the uncertainties associated with the temperatures, the physical properties of the materials in the standard and the simulation techniques are discussed

Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer:A Population-Based Case-Control Study and Meta-Analysis

In this study, we have evaluated whether 57 genome-wide association studies (GWAS)-identified common variants for type 2 diabetes (T2D) influence the risk of developing prostate cancer (PCa) in a population of 304 Caucasian PCa patients and 686 controls. The association of selected single nucleotide polymorphisms (SNPs) with the risk of PCa was validated through meta-analysis of our data with those from the UKBiobank and FinnGen cohorts, but also previously published genetic studies. We also evaluated whether T2D SNPs associated with PCa risk could influence host immune responses by analysing their correlation with absolute numbers of 91 blood-derived cell populations and circulating levels of 103 immunological proteins and 7 steroid hormones. We also investigated the correlation of the most interesting SNPs with cytokine levels after in vitro stimulation of whole blood, peripheral mononuclear cells (PBMCs), and monocyte-derived macrophages with LPS, PHA, Pam3Cys, and Staphylococcus Aureus. The meta-analysis of our data with those from six large cohorts confirmed that each copy of the FTOrs9939609A, HNF1Brs7501939T, HNF1Brs757210T, HNF1Brs4430796G, and JAZF1rs10486567A alleles significantly decreased risk of developing PCa (p = 3.70 × 10−5, p = 9.39 × 10−54, p = 5.04 × 10−54, p = 1.19 × 10−71, and p = 1.66 × 10−18, respectively). Although it was not statistically significant after correction for multiple testing, we also found that the NOTCH2rs10923931T and RBMS1rs7593730 SNPs associated with the risk of developing PCa (p = 8.49 × 10−4 and 0.004). Interestingly, we found that the protective effect attributed to the HFN1B locus could be mediated by the SULT1A1 protein (p = 0.00030), an arylsulfotransferase that catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic com-pounds. In addition to these results, eQTL analysis revealed that the HNF1Brs7501939, HNF1Brs757210, HNF1Brs4430796, NOTCH2rs10923931, and RBMS1rs7593730 SNPs influence the risk of PCa through the modulation of mRNA levels of their respective genes in whole blood and/or liver. These results confirm that functional TD2-related variants influence the risk of developing PCa, but also highlight the need of additional experiments to validate our functional results in a tumoral tissue context

Usefulness of two independent DNA and rna tissue-based multiplex assays for the routine care of advanced NSCLC patients

Personalized medicine is nowadays a paradigm in lung cancer management, offering important benefits to patients. This study aimed to test the feasibility and utility of embedding two multiplexed genomic platforms as the routine workup of advanced non-squamous non-small cell lung cancer (NSCLC) patients. Two parallel multiplexed approaches were performed based on DNA sequencing and direct digital detection of RNA with nCounter® technology to evaluate gene mutations and fusions. The results were used to guide genotype-directed therapies and patient outcomes were collected. A total of 224 advanced non-squamous NSCLC patients were prospectively included in the study. Overall, 85% of samples were successfully characterized at DNA and RNA levels and oncogenic drivers were found in 68% of patients, with KRAS, EGFR, MET∆ex14, BRAF, and ALK being the most frequent (31%, 19%, 5%, 4%, and 4%, respectively). Among all patients with complete genotyping results and follow-up data (n = 156), the median overall survival (OS) was 1.90 years (confidence interval (CI) 95% 1.69-2.10) for individuals harbouring an actionable driver treated with a matched therapy, compared with 0.59 years (CI 95% 0.39-0.79) in those not eligible for any targeted therapy and 0.61 years (CI 95% 0.12-1.10) in patients with no drivers identified (p < 0.001). Integrating DNA and RNA multiplexing technologies into the routine molecular testing of advanced NSCLC patients is feasible and useful and highlights the necessity of widespread integrating comprehensive molecular diagnosis into lung cancer care

APICAMPUS, a project on Urban beekeeping developed at the University of Malaga

Urban beekeeping has ourished in the last years, with many institutions interested in creating colonies on their roofs. Bees and other animal pollinators contribute to increase food production, making bees essential for agriculture and plant life, in general. And, as bee populations decline, the need for secondary sources of pollinators for agricultural production grows. The Vice-rectorate of Smart-Campus of the University of Malaga focuses on two fundamen tal aspects: understanding the UMA campus as a Smart City in itself and marking new lines of action at the academic level that will make the UMA an international benchmark in Sustainability. Framed in the program above mentioned, APICAMPUS is a pilot and interdisciplinary project that involves researchers and students belonging to 4 departments of 2 university faculties together with Bee Garden Malaga, a multi-disciplinary environmental company with thematic areas on beekeeping. The project aims to promote the development of beekeeping in urban environments, raising awareness about the importance of the bees as pollinating insects, as well as the use of the beehive products. For the above mentioned, two beehives Langstroth type, were installed at the roof of the Faculty of Science, a traditional wooden one, and another made of polystyrene. The main interest of this project lies in the monitoring of the hives by means of temperature and humidity sensors, electronic scales for weight control, video cameras located inside and outside of them, together with the use of bee-marking systems. Additionally, analysis for characterizing and study the origin and the properties of the beehive products will be carried out, as well as field monitoring to highlight the situation of pollinators at the University Campus of Teatinos. Although the samplings have barely begun, this communication intends to be the offcial presentation of the project APICAMPUS to the scientific community.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Measurement of the Lifetime Difference Between B_s Mass Eigenstates

We present measurements of the lifetimes and polarization amplitudes for B_s --> J/psi phi and B_d --> J/psi K*0 decays. Lifetimes of the heavy (H) and light (L) mass eigenstates in the B_s system are separately measured for the first time by determining the relative contributions of amplitudes with definite CP as a function of the decay time. Using 203 +/- 15 B_s decays, we obtain tau_L = (1.05 +{0.16}/-{0.13} +/- 0.02) ps and tau_H = (2.07 +{0.58}/-{0.46} +/- 0.03) ps. Expressed in terms of the difference DeltaGamma_s and average Gamma_s, of the decay rates of the two eigenstates, the results are DeltaGamma_s/Gamma_s = (65 +{25}/-{33} +/- 1)%, and DeltaGamma_s = (0.47 +{0.19}/-{0.24} +/- 0.01) inverse ps.Comment: 8 pages, 3 figures, 2 tables; as published in Physical Review Letters on 16 March 2005; revisions are for length and typesetting only, no changes in results or conclusion