Análisis temporal de la sostenibilidad a través de indicadores sintéticos. Una aplicación a las empresas de aguas portuguesas

En este trabajo proponemos evaluar la evolución de la sostenibilidad a través de un nuevo indicador sintético dinámico basado en la programación por metas. Dicho indicador permite cuantificar, para cada observación, si los cambios son debidos a factores externos o internos. Para ilustrar su funcionamiento, lo aplicamos a la evaluación de la sostenibilidad, entre 2012 y 2015, de 129 empresas de aguas portuguesas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Assessing changes in eco-productivity of wastewater treatment plants: The role of costs, pollutant removal efficiency, and greenhouse gas emissions

Improving eco-efficiency of wastewater treatment plants (WWTPs) has been identified as being essential for achieving urban sustainability. Several previous papers have evaluated the eco-efficiency of WWTPs using data envelopment analysis (DEA) models. However, those models provided only a static assessment in that they ignored possible fluctuations over time within each plant. To overcome this temporal limitation, this paper evaluates dynamic eco-efficiency (changes in eco-productivity over time) of WWTPs using the dynamic weighted Russell directional distance model (WRDDM). This approach allows one to obtain an eco-productivity change index for each major component of the WRDDM model (costs, pollutants removal, and greenhouse gas emissions). Our results illustrate that although eco-productivity improved in half of the WWTPs we assessed, there was still potential for improving some eco-efficiency components. Moreover, operational costs and greenhouse gases emissions were the main drivers reducing eco-productivity. This paper demonstrates the importance of evaluating change in eco-productivity over time and in identifying the drivers associated with those changes, both of which can be used to support decision-making focused on the sustainability of WWTPsThis work was supported by the Spanish Ministry of Education [ECO2016-76567-C4-4-R]; the Junta de Andalucía [SEJ417]; and Conicyt [Fondecyt (11160031)]

Transexualidad y transgénero desde una visión de género

Presentamos el diseño y los primeros resultados de una investigación que desde una perspectiva antropológica y con metodología cualitativa, estamos realizando para conocer aspectos psicosociales de la construcción de género de las personas transexuales. De este modo pretendemos abarcar la problemática del colectivo transexual de manera global. Para seleccionar la muestra para la realización de las entrevistas en profundidad hemos tenido en cuenta: Un marco de edad suficientemente amplio; El nivel de estudios ;Lugar de nacimiento ; Tipo de transexualidad ; La ocupación ; Haber sido víctima o no de malos tratos. El análisis de las entrevistas a transexuales nos está permitiendo conocer que entre las transexuales de hombre a mujer existen diferencias significativas con los de mujer a hombre. Además entre el colectivo hay una gran heterogeneidad tanto en sus vivencias como en sus objetivos de vida, aunque hay que resaltar el alto grado de sufrimiento que ambos grupos padecen

Evaluación dinámica de la sostenibilidad de empresas de aguas portuguesas

En este trabajo se pretende realizar una evaluación mediante indicadores sintéticos, de la sostenibilidad de empresas de aguas portuguesas a lo largo de dos periodos de tiempo. Para ello se utilizarán los datos públicos de dichas empresas en 2012 y 2015 y se analizará el cambio producido en el indicador por el comportamiento de las mismas, intentando mostrar aquellas que tienen un buen comportamiento temporal y a que es debido el mismo.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Evaluating the eco-efficiency of wastewater treatment plants: comparison of optimistic and pessimistic approaches

The assessment of wastewater treatment plant (WWTP) performance has gained the interest of water utilities and water regulators. Eco-efficiency has been identified as a powerful indicator, as it integrates economic and environmental variables into a single index. Most previous studies have employed traditional data envelopment analysis (DEA) for the evaluation of WWTP eco-efficiency. However, DEA allows the selection of input and output weights for individual WWTPs for the calculation of eco-efficiency scores. To overcome this limitation, we employed the double-frontier and common set of weights methods to evaluate the eco-efficiency of a sample of 30 WWTPs in Spain. The WWTPs were ranked based on eco-efficiency scores derived under several scenarios including best- and worst-case scenarios; this approach to performance assessment is reliable and robust. Twenty-six of the 30 WWTPs were not classified as eco-efficient, even under the most favorable scenario, indicating that these facilities have substantial room for the reduction of costs and greenhouse gas emissions. The ranking of WWTPs varied according to the scenario used for evaluation, which has notable consequences when eco-efficiency scores are used for regulatory purposes. The findings of this study are relevant for water regulators and water utilities, as they demonstrate the importance of weight allocation for eco-efficiency score estimation

Kinematic Parameters That Can Discriminate in Levels of Functionality in the Six-Minute Walk Test in Patients with Heart Failure with a Preserved Ejection Fraction

It is a challenge to manage and assess heart failure with preserved left ventricular ejection fraction (HFpEF) patients. Six-Minute Walk Test (6MWT) is used in this clinical population as a functional test. The objective of the study was to assess gait and kinematic parameters in HFpEF patients during the 6MWT with an inertial sensor and to discriminate patients according to their performance in the 6MWT: (1) walk more or less than 300 m, (2) finish or stop the test, (3) women or men and (4) fallen or did not fall in the last year. A cross-sectional study was performed in patients with HFpEF older than 70 years. 6MWT was carried out in a closed corridor larger than 30 m. Two Shimmer3 inertial sensors were used in the chest and lumbar region. Pure kinematic parameters analysed were angular velocity and linear acceleration in the three axes. Using these data, an algorithm calculated gait kinematic parameters: total distance, lap time, gait speed and step and stride variables. Two analyses were done according to the performance. Student’s t-test measured differences between groups and receiver operating characteristic assessed discriminant ability. Seventy patients performed the 6MWT. Step time, step symmetry, stride time and stride symmetry in both analyses showed high AUC values (>0.75). More significant differences in velocity and acceleration in the maximum Y axis or vertical movements. Three pure kinematic parameters obtained good discriminant capacity (AUC > 0.75). The new methodology proved differences in gait and pure kinematic parameters that can distinguish two groups according to the performance in the 6MWT and they had discriminant capacity.This work was supported by the Spanish Foundation of Internal Medicine, through the call “Prof. Dr. Miguel Vilardell 2019 research project”, grant number: FEMI-PB-PI-MV-2019. Partial funding for open access charge: Universidad de Málaga

Echocardiographic Changes with Positive Airway Pressure Therapy in Obesity Hypoventilation Syndrome. Long-Term Pickwick Randomized Controlled Clinical Trial

Spanish Sleep Network.[Rationale] Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on cardiac structure and function assessed by echocardiography are lacking. Rationale: Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on cardiac structure and function assessed by echocardiography are lacking.[Objectives] In a prespecified secondary analysis of the largest multicenter randomized controlled trial of OHS (Pickwick Project; N = 221 patients with OHS and coexistent severe obstructive sleep apnea), we compared the effectiveness of three years of NIV and CPAP on structural and functional echocardiographic changes.[Methods] At baseline and annually during three sequential years, patients underwent transthoracic two-dimensional and Doppler echocardiography. Echocardiographers at each site were blinded to the treatment allocation. Statistical analysis was performed using a linear mixed-effects model with a treatment group and repeated measures interaction to determine the differential effect between CPAP and NIV. Measurements and Main Results: A total of 196 patients were analyzed: 102 were treated with CPAP and 94 were treated with NIV. Systolic pulmonary artery pressure decreased from 40.5 ± 1.47 mm Hg at baseline to 35.3 ± 1.33 mm Hg at three years with CPAP, and from 41.5 ± 1.56 mm Hg to 35.5 ± 1.42 with NIV (P < 0.0001 for longitudinal intragroup changes for both treatment arms). However, there were no significant differences between groups. NIV and CPAP therapies similarly improved left ventricular diastolic dysfunction and reduced left atrial diameter. Both NIV and CPAP improved respiratory function and dyspnea.[Conclusions] In patients with OHS who have concomitant severe obstructive sleep apnea, long-term treatment with NIV and CPAP led to similar degrees of improvement in pulmonary hypertension and left ventricular diastolic dysfunction

PARP inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia

We test the hypothesis that PARP inhibition can decrease acute tubular necrosis (ATN) and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of Wisconsin (UW) solution. Material and Methods. We used 30 male Parp1+/+ wild-type and 15 male Parp10/0 knockout C57BL/6 mice. Fifteen of these wild-type mice were pretreated with 3,4-dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) at a concentration of 15 mg/kg body weight, used as PARP inhibitor. Subgroups of mice were established (A: IR 45 min/6 h; B: IR + 48 h in UW solution; and C: IR + 48 h in UW solution plus DPQ). We processed samples for morphological, immunohistochemical, ultrastructural, and western-blotting studies. Results. Prolonged cold ischemia time in UW solution increased PARP-1 expression and kidney injury. Preconditioning with PARP inhibitor DPQ plus DPQ supplementation in UW solution decreased PARP-1 nuclear expression in renal tubules and renal damage. Parp10/0 knockout mice were more resistant to IR-induced renal lesion. In conclusion, PARP inhibition attenuates ATN and other IR-related renal lesions in mouse kidneys under prolonged cold storage in UW solution. If confirmed, these data suggest that pharmacological manipulation of PARP activity may have salutary effects in cold-stored organs at transplantation.Funding: This research was supported by CTS no. 138 Research Group and from the Carlos III Health Institute of the Spanish Ministery of Health and Consumer Affairs (Red de Investigación Renal, REDinREN 012/0021/0025). “FEDER una manera de hacer Europa”

Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome

Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.Peer reviewe

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489