3,262 research outputs found
Cohomology for infinitesimal unipotent algebraic and quantum groups
In this paper we study the structure of cohomology spaces for the Frobenius
kernels of unipotent and parabolic algebraic group schemes and of their quantum
analogs. Given a simple algebraic group , a parabolic subgroup , and
its unipotent radical , we determine the ring structure of the cohomology
ring . We also obtain new results on computing
as an -module where is a
simple -module with high weight in the closure of the bottom
-alcove. Finally, we provide generalizations of all our results to the
quantum situation.Comment: 18 pages. Some proofs streamlined over previous version. Additional
details added to some proofs in Section
Late-type galaxies observed with SAURON. Two-dimensional stellar and emission-line kinematics of 18 spirals
We present the stellar and gas kinematics of a sample of 18 nearby late-type
spiral galaxies (Hubble types ranging from Sb to Sd), observed with the
integral-field spectrograph SAURON at the 4.2-m William Herschel Telescope.
SAURON covers the spectral range 4800-5380 A, allowing us to measure the Hbeta,
Fe, Mgb absorption features and the emission in the Hbeta line and the [OIII],
and [NI] doublets over a 33x41 arcsec field of view. The maps cover the nuclear
region of these late-type galaxies and in all cases include the entire bulge.
In many cases the stellar kinematics suggests the presence of a cold inner
region, as visible from a central drop in the stellar velocity dispersion. The
ionised gas is almost ubiquitous and behaves in a complicated fashion: the gas
velocity fields often display more features than the stellar ones, including
wiggles in the zero-velocity lines, irregular distributions, ring-like
structures. The line ratio [OIII]/Hbeta often takes on low values over most of
the field, probably indicating a wide-spread star formation.Comment: 34 pages, 24 figures. Accepted for publication in MNRAS. A version
with full resolution figures is available at
http://www.strw.leidenuniv.nl/sauron/papers/ganda2005_late_types.pd
Are environmental characteristics in the municipal eldercare, more closely associated with frequent short sick leave spells among employees than with total sick leave: a cross-sectional study
Background: It has been suggested that frequent-, short-term sick leave is associated with work environment
factors, whereas long-term sick leave is associated mainly with health factors. However, studies of the hypothesis of
an association between a poor working environment and frequent short spells of sick leave are few and results are
inconsistent. Therefore, we aimed to explore associations between self-reported psychosocial work factors and
workplace-registered frequency and length of sick leave in the eldercare sector.
Methods: Employees from the municipal eldercare in Aarhus (N = 2,534) were included. In 2005, they responded to
a work environment questionnaire. Sick leave records from 2005 were dichotomised into total sick leave days (0–14
and above 14 days) and into spell patterns (0–2 short, 3–9 short, and mixed spells and 1–3 long spells). Logistic
regression models were used to analyse associations; adjusted for age, gender, occupation, and number of spells or
sick leave length.
Results: The response rate was 76%; 96% of the respondents were women. Unfavourable mean scores in work
pace, demands for hiding emotions, poor quality of leadership and bullying were best indicated by more than 14
sick leave days compared with 0–14 sick leave days. For work pace, the best indicator was a long-term sick leave
pattern compared with a non-frequent short-term pattern. A frequent short-term sick leave pattern was a better
indicator of emotional demands (1.62; 95% CI: 1.1-2.5) and role conflict (1.50; 95% CI: 1.2-1.9) than a short-term
non-frequent pattern.
Age (= 40 years) statistically significantly modified the association between the 1–3 long-term sick leave
spell pattern and commitment to the workplace compared with the 3–9 frequent short-term pattern.
Conclusions: Total sick leave length and a long-term sick leave spell pattern were just as good or even better
indicators of unfavourable work factor scores than a frequent short-term sick leave pattern. Scores in commitment
to the workplace and quality of leadership varied with sick leave pattern and age. Thus, different sick leave
measures seem to be associated with different work environment factors. Further studies on these associations may
inform interventions to improve occupational health care
Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004
BACKGROUND. Phthalates are ubiquitous chemicals used in consumer products. Some phthalates are reproductive toxicants in experimental animals, but human data are limited. OBJECTIVE. We conducted a cross-sectional study of urinary phthalate metabolite concentrations in relation to self-reported history of endometriosis and uterine leiomyomata among 1,227 women 20-54 years of age from three cycles of the National Health and Nutrition Examination Survey (NHANES), 1999-2004. METHODS. We examined four phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBP), monoethyl phthalate (MEP), and monobenzyl phthalate (MBzP). From the last two NHANES cycles, we also examined mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders. RESULTS. Eighty-seven (7%) and 151 (12%) women reported diagnoses of endometriosis and leiomyomata, respectively. The ORs comparing the highest versus lowest three quartiles of urinary MBP were 1.36 (95% CI, 0.77-2.41) for endometriosis, 1.56 (95% CI, 0.93-2.61) for leiomyomata, and 1.71 (95% CI, 1.07-2.75) for both conditions combined. The corresponding ORs for MEHP were 0.44 (95% CI, 0.19-1.02) for endometriosis, 0.63 (95% CI, 0.35-1.12) for leiomyomata, and 0.59 (95% CI, 0.37-0.95) for both conditions combined. Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. We observed null associations for MEP and MBzP. Associations were similar when we excluded women diagnosed > 7 years before their NHANES evaluation. CONCLUSION. The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies
From Continent to Ocean: Investigating the Multi-Element and Precious Metal Geochemistry of the Paraná-Etendeka Large Igneous Province Using Machine Learning Tools
This is the final version. Available on open access from the Geological Society of London via the DOI in this recordData Availability Statement:
The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding author.Large Igneous Provinces, and by extension the mantle plumes that generate them, are frequently associated with platinum-group element (PGE) ore deposits, yet the processes controlling the metal budget in plume-derived magmas remains debated. In this paper, we present a new whole-rock geochemical data set from the 135 Ma Paraná-Etendeka Large Igneous Province (PELIP) in the South Atlantic, which includes major and trace elements, PGE, and Au concentrations for onshore and offshore lavas from different developmental stages in the province, which underwent significant syn-magmatic continental rifting from 134 Ma onwards. The PELIP presents an opportunity to observe magma geochemistry as the continent and sub-continental lithospheric mantle (SCLM) are progressively removed from a melting environment. Here, we use an unsupervised machine learning approach (featuring the PCA, t-SNE and k-means clustering algorithms) to investigate the geochemistry of a set of (primarily basaltic) onshore and offshore PELIP lavas. We test the hypothesis that plume-derived magmas can scavenge precious metals including PGE from the SCLM and explore how metal concentrations might change the metal content in intraplate magmas throughout rifting. Onshore lavas on the Etendeka side of the PELIP are classified as the products of deep partial melts of the mantle below the African craton but without significant PGE enrichment. Offshore lavas on both continents exhibit similarities through the multi-element space to their onshore equivalents, but they again lack PGE enrichment. Of the four onshore lava types on the Paraná side of the PELIP, the Type 1 (Southern) and Type 1 (Central-Northern) localities exhibit separate PGE-enriched assemblages (Ir-Ru-Rh and Pd-Au-Cu, respectively). It follows that there is a significant asymmetry to the metallogenic character of the PELIP, with enrichment focused specifically on lavas from the South American continent edge in Paraná. This asymmetry contrasts with the North Atlantic Igneous Province (NAIP), a similar geodynamic environment in which continent-edge lavas are also PGE-enriched, albeit on both sides of the plume-rift system. We conclude that, given the similarities in PGE studies of plume-rift environments, SCLM incorporation under progressively shallowing (i.e., rifting) asthenospheric conditions promotes the acquisition of metasomatic and residual PGE-bearing minerals, boosting the magma metal budget.University of Exete
A machine learning approach for regional geochemical data: Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province
This is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this recordWhilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation, by considering entire regional data sets on an objective basis using machine learning algorithms (MLA), we can highlight new facets within the broader data structure and significantly enhance previous geochemical interpretations. The platinum-group element (PGE) budget of lavas in the North Atlantic Igneous Province (NAIP) have been shown to vary systematically according to age, geographic location and geodynamic environment. Given the large multi-element geochemical data set available for the region, MLA was employed to explore the magmatic controls on these shifting concentrations. The key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional (i.e., multi-element) space. The NAIP data set is manipulated using Principal Component Analysis (PCA) and t-Distributed Stochastic Neighbour Embedding (t-SNE) techniques to increase separability in the data alongside clustering using the k-means MLA. The new multi-element classification is compared to the original geographic classification to assess the performance of both approaches. The workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the region. The techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input variables. These end-members are seen to fluctuate in prominence throughout the NAIP, which we propose reflects the changing geodynamic environment and melting source. Crucially, the variability of Pt and Pd are not reflected in MLA-based clustering trends, suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure (i.e., other proxies for magmatic differentiation). This data science approach thus highlights that PGE (here signalled by Pt/Pd ratio) may be used to identify otherwise localised or cryptic geochemical inputs from the subcontinental lithospheric mantle (SCLM) during the ascent of plume-derived magma, and thereby impact upon the resulting metallogenic basket.University of Exete
Etiological Profile and Treatment Outcome of Epistaxis at a Tertiary Care Hospital in Northwestern Tanzania: A Prospective Review of 104 Cases.
Epistaxis is the commonest otolaryngological emergency affecting up to 60% of the population in their lifetime, with 6% requiring medical attention. There is paucity of published data regarding the management of epistaxis in Tanzania, especially the study area. This study was conducted to describe the etiological profile and treatment outcome of epistaxis at Bugando Medical Centre, a tertiary care hospital in Northwestern Tanzania. This was a prospective descriptive study of the cases of epistaxis managed at Bugando Medical Centre from January 2008 to December 2010. Data collected were analyzed using SPSS computer software version 15. A total of 104 patients with epistaxis were studied. Males were affected twice more than the females (2.7:1). Their mean age was 32.24 ± 12.54 years (range 4 to 82 years). The modal age group was 31-40 years. The commonest cause of epistaxis was trauma (30.8%) followed by idiopathic (26.9%) and hypertension (17.3%). Anterior nasal bleeding was noted in majority of the patients (88.7%). Non surgical measures such as observation alone (40.4%) and anterior nasal packing (38.5%) were the main intervention methods in 98.1% of cases. Surgical measures mainly intranasal tumor resection was carried out in 1.9% of cases. Arterial ligation and endovascular embolization were not performed. Complication rate was 3.8%. The overall mean of hospital stay was 7.2 ± 1.6 days (range 1 to 24 days). Five patients died giving a mortality rate of 4.8%. Trauma resulting from road traffic crush (RTC) remains the most common etiological factor for epistaxis in our setting. Most cases were successfully managed with conservative (non-surgical) treatment alone and surgical intervention with its potential complications may not be necessary in most cases and should be the last resort. Reducing the incidence of trauma from RTC will reduce the incidence of emergency epistaxis in our centre
Noiseless Linear Amplification and Distillation of Entanglement
The idea of signal amplification is ubiquitous in the control of physical
systems, and the ultimate performance limit of amplifiers is set by quantum
physics. Increasing the amplitude of an unknown quantum optical field, or more
generally any harmonic oscillator state, must introduce noise. This linear
amplification noise prevents the perfect copying of the quantum state, enforces
quantum limits on communications and metrology, and is the physical mechanism
that prevents the increase of entanglement via local operations. It is known
that non-deterministic versions of ideal cloning and local entanglement
increase (distillation) are allowed, suggesting the possibility of
non-deterministic noiseless linear amplification. Here we introduce, and
experimentally demonstrate, such a noiseless linear amplifier for
continuous-variables states of the optical field, and use it to demonstrate
entanglement distillation of field-mode entanglement. This simple but powerful
circuit can form the basis of practical devices for enhancing quantum
technologies. The idea of noiseless amplification unifies approaches to cloning
and distillation, and will find applications in quantum metrology and
communications.Comment: Submitted 10 June 200
Diagnostic performance of tuberculosis-specific IgG antibody profiles in patients with presumptive tuberculosis from two continents
Background. Development of rapid diagnostic tests for tuberculosis is a global priority. A whole proteome screen identified Mycobacterium tuberculosis antigens associated with serological responses in tuberculosis patients. We used World Health Organization (WHO) target product profile (TPP) criteria for a detection test and triage test to evaluate these antigens. Methods. Consecutive patients presenting to microscopy centers and district hospitals in Peru and to outpatient clinics at a tuberculosis reference center in Vietnam were recruited. We tested blood samples from 755 HIV–uninfected adults with presumptive pulmonary tuberculosis to measure IgG antibody responses to 57 M. tuberculosis antigens using a field-based multiplexed serological assay and a 132-antigen bead-based reference assay. We evaluated single antigen performance and models of all possible 3-antigen combinations and multiantigen combinations. Results. Three-antigen and multiantigen models performed similarly and were superior to single antigens. With specificity set at 90% for a detection test, the best sensitivity of a 3-antigen model was 35% (95% confidence interval [CI], 31–40). With sensitivity set at 85% for a triage test, the specificity of the best 3-antigen model was 34% (95% CI, 29–40). The reference assay also did not meet study targets. Antigen performance differed significantly between the study sites for 7/22 of the best-performing antigens. Conclusions. Although M. tuberculosis antigens were recognized by the IgG response during tuberculosis, no single antigen or multiantigen set performance approached WHO TPP criteria for clinical utility among HIV-uninfected adults with presumed tuberculosis in high-volume, urban settings in tuberculosis-endemic countries
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