Temporal Trends and Outcomes of Acute Myocardial Infarction in Patients With Cancer

Background: Data on outcomes of ST-elevation myocardial infarction (STEMI) in patients with cancer are scarce. We investigated the nationwide trends in admissions for STEMI, utilization of percutaneous coronary intervention (PCI), and in-hospital outcomes in patients with the three most common cancer diagnoses (lung, breast, and colon) compared to patients without cancer. Methods: We conducted an administrative database study using the Nationwide Inpatient Sample (NIS). All in-patient hospitalizations for STEMI from 2001 to 2011 were identified. Patients with concomitant diagnosis of lung, breast or colon cancer were identified using appropriate International classification of diagnosis (ICD 9-CM) codes. Primary outcome was utilization of PCI and in-hospital mortality in patients with cancer compared to those without cancer. Results: Utilization of PCI was 30.8% (1,191/3,871), 20.2% (4,541/22,480) and 17.3% (1,716/9,944) in patients with breast, lung and colon cancer, respectively. Among patients without any of these cancers, use of PCI was 49.6%. In-hospital mortality was highest in patients with lung cancer (57.1%) and lowest in patients without cancer (25.7%). Conclusions: Patients with cancer have significantly worse in-hospital mortality compared to those without cancer, partly due to a relatively lower rate of PCI utilization in cancer patients with STEMI

Early farmers from across Europe directly descended from Neolithic Aegeans

Farming and sedentism first appeared in southwestern Asia during the early Holocene and later spread to neighboring regions, including Europe, along multiple dispersal routes. Conspicuous uncertainties remain about the relative roles of migration, cultural diffusion, and admixture with local foragers in the early Neolithization of Europe. Here we present paleogenomic data for five Neolithic individuals from northern Greece and northwestern Turkey spanning the time and region of the earliest spread of farming into Europe. We use a novel approach to recalibrate raw reads and call genotypes from ancient DNA and observe striking genetic similarity both among Aegean early farmers and with those from across Europe. Our study demonstrates a direct genetic link between Mediterranean and Central European early farmers and those of Greece and Anatolia, extending the European Neolithic migratory chain all the way back to southwestern Asia

Coronary stent healing in cancer patients: an optical coherence tomography perspective

Objective: This study assessed stent healing patterns and cardiovascular outcomes by optical coherence tomography (OCT) in cancer patients after drug-eluting stent (DES) placement.Background: Cancer treatment, owing to its cytotoxic and antiproliferative effects, could delay stent healing and increase stent thrombosis risk, especially when dual antiplatelet therapy (DAPT) is discontinued early for oncological treatment. OCT can assess stent endothelialization and other healing parameters, which may provide clinical guidance in these challenging scenarios.Methods: This single-center retrospective study enrolled all cancer patients who underwent OCT for assessment of vascular healing patterns after prior DES placement from November 2009 to November 2018. Primary study endpoints were stent healing parameters, including stent coverage, apposition, degree of expansion, neointimal hyperplasia heterogeneity, in-stent restenosis, stent thrombosis, and overall survival (OS).Results: A total of 67 patients were included in this study. Mean time between DES placement and OCT evaluation was 154 +/- 82 days. Stent healing matched published values for DES in non-cancer patients (P >= 0.063). At 1 year, the OS was 86% (95% confidence interval [CI]: 78-96%) with 0% incidence of acute coronary syndrome. Advanced cancers and active chemotherapies were associated with inferior OS (P = 0.024, hazard ratio [HR]: 3.50, 95% CI: 1.18-10.42 and P = 0.026, HR: 2.65, 95% CI: 1.13-6.22, respectively), while stent healing parameters were unassociated with OS. Forty-one patients (61%) had DAPT duration <= 6 months.Conclusions: Stent healing of contemporary DES appears similar in cancer and non-cancer patients. Cardiovascular risk of cancer patients after DES placement can be managed to facilitate timely cancer therapies, as the underlying malignancy and active chemotherapy ultimately determine survival.Cardiovascular Aspects of Radiolog

Real-time Communication

Recent advances in networking technology has enabled new multimedia and process control applications. These applications require real-time communication services with stringent performance guarantees expressed in terms of delay, delay jitter, throughput and loss rate. Current network architectures and protocols are designed to support best-effort services and they are inefficient in supporting real-time services. In this paper, we survey real-time communication architectures and protocols both in packet-switching networks and in multiple-access networks. For each network a service model is presented as a general framework. Specifically, the service model for a packet-switching network is composed of a specification for traffic characterization and performance requirements, a routing protocol, a resource reservation protocol and a packet service discipline at switching nodes. The model for a multiple-access network, on the other hand, includes a basic traffic characterization and a MAC-layer real-time scheduling algorithm. This paper surveys the recent developments in each component of the service models with comparisons of alternative techniques. (Also cross-referenced as UMIACS-TR-97-04

The effect of scolicidal solutions on the biliary tracts (An experimental study in rats) SKOLISIDAL AJANLARIN SAFRA YOLLARI UZERINE ETKISI (DENEYSEL CALISMA)

Several cases of sclerosing cholangitis have been reported after surgical treatment of hepatic hydatid disease. In these patients, hypertonic saline of formaldehyde solutions had been given into the cysts. In our country, 3% hydrogen peroxide has been frequently injected into the cyst as a scolicidal agent and there have been no reported case of sclerosing cholangitis. In this experimental study, we showed that injection of 20% hypertonic saline solution, 2% formaldehyde solution, 3% hydrogen peroxide solution and 10% hydrogen peroxide solution into the biliary tract in rats caused lesions of the biliary epithelium. As compared with 20% hypertonic saline solution, 2% formaldehyde solution and 3% H2O2 resulted in more severe lesions in the biliary epithelium and in addition, induced the development of periductal fibrosis and pseudocirrhosis. This experimental study confirms the deleterious effect of all scolicidal solutions to the biliary epithelium and the liver

Between Anatolia and the Aegean:Epipalaeolithic and Mesolithic Foragers of the Karaburun Peninsula

Dincer, Berkay/0000-0001-8240-5973; TURAN, Didem/0000-0001-8375-1296WOS: 000555217700001The Epipalaeolithic and Mesolithic periods of Turkey are poorly understood. the discovery of two sites (Kocaman and Kayadibi) in the Karaburun Peninsula in coastal western Turkey opens a whole new window into our understanding of these periods in Turkey and beyond by providing the first solid evidence for pre-Neolithic foragers. This article presents typological and technological properties of the lithics from these two open-air sites in terms of raw material selection, tool types, and technological preferences and discusses the results in relation to contemporary Anatolian, Aegean, southwest Asian, and southeast European industries. Typological and technological analyses suggest that Kocaman lithics were part of the eastern Mediterranean and northern Aegean Epipalaeolithic traditions; the Kayadibi lithics, on the other hand, correspond well with the Aegean Mesolithic assemblages. the lack of any affinity between the Kayadibi and Initial Neolithic lithic assemblages from western Turkey has important implications about the Neolithization process of western Turkey and the Aegean.Ege University Research Projects Coordination Unit [EDB-16-018, EDB-15-005]; NCN (Polish National Research Center) [2015/19/B/H53/00477]; Groningen Institute of Archaeology; Municipality of KaraburunThis study was supported by Ege University Research Projects Coordination Unit (Projects No: EDB-16-018 and EDB-15-005) and by NCN (Polish National Research Center Grant No: 2015/19/B/H53/00477). Karaburun Archaeological Survey Project is supported by the Groningen Institute of Archaeology and the Municipality of Karaburun