THE SENSITIVITY TO NEW PHYSICS OF A LEP SCAN IN 1995

We study the implications of possible off-peak measurements in the 1995 LEP run, in regard to probing physics beyond the Standard Model. To do so, we determine the accuracy with which various nonstandard couplings can be expected to be measured in the three different scan scenarios recently discussed by Clarke and Wyatt. We find that each scan scenario allows greater sensitivity to a different set of new physics couplings. Oblique parameters are best measured with the longest scan, while nonstandard fermion couplings to the Z tend to be better constrained (albeit only marginally) if all of the 1995 LEP measurements are taken on the Z peak.Comment: Plain TeX, 9 pages, no figures. We have streamlined our presentation by omitting observables of our Class B. All else is completely unchanged

Tracing Ghost Cavities with Low Frequency Radio Observations

We present X-ray and multi-frequency radio observations of the central radio sources in several X-ray cavity systems. We show that targeted radio observations are key to determining if the lobes are being actively fed by the central AGN. Low frequency observations provide a unique way to study both the lifecycle of the central radio source as well as its energy input into the ICM over several outburst episodes.Comment: 6 pages, 4 figures, To appear in the Proceedings of "Heating vs. Cooling in Galaxies and Clusters of Galaxies", eds. H. Boehringer, P. Schuecker, G. W. Pratt & A. Finoguenov (ESO Astrophysics Symposia, Springer-Verlag), Garching (Germany), August 200

Probe-configuration dependent dephasing in a mesoscopic interferometer

Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge and voltage fluctuations is investigated. Treating two terminals as voltage probes, we find a strong dependence of the dephasing rate on the probe configuration in agreement with a recent experiment by Kobayashi et al. (J. Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure

The Standard Model as a noncommutative geometry: the low energy regime

We render a thorough, physicist's account of the formulation of the Standard Model (SM) of particle physics within the framework of noncommutative differential geometry (NCG). We work in Minkowski spacetime rather than in Euclidean space. We lay the stress on the physical ideas both underlying and coming out of the noncommutative derivation of the SM, while we provide the necessary mathematical tools. Postdiction of most of the main characteristics of the SM is shown within the NCG framework. This framework, plus standard renormalization technique at the one-loop level, suggest that the Higgs and top masses should verify 1.3 m_top \lesssim m_H \lesssim 1.73 m_top.Comment: 44 pages, Plain TeX with AMS fonts, mass formulae readjusted, some references added, to appear in Physics Report

An improved lumped parameter method for building thermal modelling

In this work an improved method for the simplified modelling of the thermal response of building elements has been developed based on a 5-parameter second-order lumped parameter model. Previous methods generate the parameters of these models either analytically or by using single objective function optimisation with respect to a reference model. The analytical methods can be complex and inflexible and the single objective function method lacks generality. In this work, a multiple objective function optimisation method is used with a reference model. Error functions are defined at both internal and external surfaces of the construction element whose model is to be fitted and the resistance and capacitance distributions are adjusted until the error functions reach a minimum. Parametric results for a wide range (45) of construction element types have been presented. Tests have been carried out using a range of both random and periodic excitations in weather and internal heat flux variables resulting in a comparison between the simplified model and the reference model. Results show that the simplified model provides an excellent approximation to the reference model whilst also providing a reduction in computational cost of at least 30%

A developmental analysis of communication between mothers and infants with Down's syndrome

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68850/2/10.1177_027112148300300110.pd

A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.

Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial potency of pleurocidin, an AMP from Winter Flounder, is linked to its ability to cross bacterial plasma membranes and seek intracellular targets while also causing membrane damage. Here we describe modification strategies that generate pleurocidin analogues with substantially improved, broad spectrum, antibacterial properties, which are effective in murine models of bacterial lung infection. Increasing peptide-lipid intermolecular hydrogen bonding capabilities enhances conformational flexibility, associated with membrane translocation, but also membrane damage and potency, most notably against Gram-positive bacteria. This negates their ability to metabolically adapt to the AMP threat. An analogue comprising D-amino acids was well tolerated at an intravenous dose of 15 mg/kg and similarly effective as vancomycin in reducing EMRSA-15 lung CFU. This highlights the therapeutic potential of systemically delivered, bactericidal AMPs

Mucolipidosis II presenting as severe neonatal hyperparathyroidism.

UNLABELLED: Mucolipidosis II (ML II or I-cell disease ) (OMIM 252500) is an autosomal recessive lysosomal enzyme targeting disorder that usually presents between 6 and 12 months of age with a clinical phenotype resembling Hurler syndrome and a radiological picture of dysostosis multiplex. When ML II is severe enough to be detected in the newborn period, the radiological changes have been described as similar to hyperparathyroidism or rickets. The biological basis of these findings has not been explored and few biochemical measurements have been recorded. We describe three unrelated infants with ML II who had radiological features of intrauterine hyperparathyroidism and biochemical findings consistent with severe secondary neonatal hyperparathyroidism (marked elevation of serum parathyroid hormone and alkaline phosphatase levels). The vitamin D metabolites were not substantially different from normal and repeatedly normal calcium concentrations excluded vitamin D deficiency rickets and neonatal severe hyperparathyroidism secondary to calcium-sensing receptor gene mutations (OMIM 239200). The pathogenesis of severe hyperparathyroidism in the fetus and newborn with ML II is unexplained. We hypothesize that the enzyme targeting defect of ML II interferes with transplacental calcium transport leading to a calcium starved fetus and activation of the parathyroid response to maintain extracellular calcium concentrations within the normal range. CONCLUSION: Newborns with mucolipidosis II can present with radiological and biochemical signs of hyperparathyroidism. Awareness of this phenomenon may help in avoiding diagnostic pitfalls and establishing a proper diagnosis and therapy

Induction of antibodies by Staphylococcus aureus nasal colonization in young children

AbstractIn order to develop novel antlstaphylococcal strategies, understanding the determinants of carriage and how humans respond to Staphylococcus aureus exposure is essential. Here, the primary S. aureus-specific humoral immune response and its association with nasal colonization was studied in young children. Sera from 57 colonized or non-colonized children, serially collected at birth and at 6, 14 and 24 months, were analysed for IgG, IgA and IgM binding to 19 staphylococcal proteins, using flow cytometry-based technology. The antibody responses showed extensive inter-individual variability. On average, the levels of antistaphylococcal IgA and IgM increased from birth until the age of 2 years (p <0.05), whereas the levels of IgG decreased (p <0.001). Placentally transferred maternal IgG did not protect against colonization. In colonized children, IgG and IgA levels for a number of proteins were higher than in non-colonized children. At both 14 and 24 months, the levels of IgG against chemotaxis inhibitory protein of S. aureus (at 24 months; median fluorescence intensity, 4928 vs. 24, p <0.05), extracellular fibrinogen-binding protein (987 vs. 604, p <0.05), and iron-responsive surface determinant H (62 vs. 5, p <0.05) were significantly higher in colonized children. The levels of IgA against CHIPS, IsdH and IsdA were higher (p <0.05). Therefore, CHIPS, Efb, IsdA and IsdH seem to play a role in nasal colonization of young children