330 research outputs found
A Rare Second Year - Lake Ice Cover in the Canadian High Arctic
Colour Lake, Axel Heiberg Island, N.W.T. (79 25 N; 90 45 W), remained largely ice covered from autumn 1985 to summer 1987. This is a relatively rare event. Observations and measurements of the thickness and specific conductance of the lake ice cover were made at the end of the 1986 summer and again in the following spring. The residual ice cover (second-year ice with first-year ice beneath it) was significantly thicker and had a lower specific conductance than first-year ice formed in marginal leads (moat) that had been ice free in 1986. The first-year ice that grew beneath the residual ice cover had the lowest specific conductance. Distribution of snow on the lake was affected by the roughness of the second-year ice (as compared to the smoother moat ice) and differences in elevation between second-year (high) and moat ice.Key words: High Arctic, specific conductance, residual ice cover, snow distributionMots clés: Extrême-Arctique, conductivité spécifique, couverture de glace résiduelle, répartition de la neig
ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the central nervous system (CNS). ADAMTS-1 is also known to exhibit anti-angiogenic activity. Their main endogenous inhibitor is tissue inhibitor of metalloproteinases (TIMP)-3.
The present study was designed to investigate ADAMTS-1, -4 and -5 and TIMP-3 expression after experimental cerebral ischaemia and to examine whether cytokines known to be up-regulated in stroke could alter their expression by astrocytes in vitro. Focal cerebral ischaemia was induced by transient middle cerebral artery occlusion in the rat using the filament method.
Our results demonstrate a significant increase in expression of ADAMTS-1 and -4 in the occluded hemisphere but no significant change in TIMP-3. This was accompanied by an increase in mRNA levels for interleukin (IL)-1, IL-1 receptor antagonist (IL-1ra) and tumour necrosis factor (TNF). ADAMTS-4 mRNA and protein was up-regulated by TNF in primary human astrocyte cultures. The increased ADAMTS-1 and -4 in experimental stroke, together with no change in TIMP-3, may promote ECM breakdown after stroke, enabling infiltration of inflammatory cells and contribute to brain injury. In vitro studies suggest that the in vivo modulation of ADAMTS-1 and -4 may be controlled in part by TNF.</p
Size-dependent wet removal of black carbon in Canadian biomass burning plumes
Wet deposition is the dominant mechanism for removing black carbon (BC) from the atmosphere and is key in determining its atmospheric lifetime, vertical gradient and global transport. Despite the importance of BC in the climate system, especially in terms of its ability to modulate the radiative energy budget, there are few quantitative case studies of wet removal in ambient environments. We present a case study of BC wet removal by examining aerosol size distributions and BC coating properties sampled in three Canadian boreal biomass burning plumes, one of which passed through a precipitating cloud. This depleted the majority of the plume’s BC mass, and the largest and most coated BCcontaining particles were found to be preferentially removed, suggesting that nucleation scavenging was likely the dominant mechanism. Calculated single-scattering albedo (SSA) showed little variation, as a large number of non-BC particles were also present in the precipitation-affected plume. The remaining BC cores were smaller than those observed in previous studies of BC in post-precipitation outflow over Asia, possibly due to the thick coating by hydrophilic compounds associated with the Canadian biomass burning particles. This study provides measurements of BC size, mixing state and removal efficiency to constrain model parameterisations of BC wet removal in biomass burning regions, which will help to reduce uncertainty in radiative forcing calculations
Competition between decay and dissociation of core-excited OCS studied by X-ray scattering
We show the first evidence of dissociation during resonant inelastic soft
X-ray scattering. Carbon and oxygen K-shell and sulfur L-shell resonant and
non-resonant X-ray emission spectra were measured using monochromatic
synchrotron radiation for excitation and ionization. After sulfur, L2,3 ->
{\pi}*, {\sigma}* excitation, atomic lines are observed in the emission spectra
as a consequence of competition between de-excitation and dissociation. In
contrast the carbon and oxygen spectra show weaker line shape variations and no
atomic lines. The spectra are compared to results from ab initio calculations
and the discussion of the dissociation paths is based on calculated potential
energy surfaces and atomic transition energies.Comment: 12 pages, 6 pictures, 2 tables,
http://link.aps.org/doi/10.1103/PhysRevA.59.428
Of Bounces, Branes and Bounds
Some recent studies have considered a Randall-Sundrum-like brane world
evolving in the background of an anti-de Sitter Reissner-Nordstrom black hole.
For this scenario, it has been shown that, when the bulk charge is
non-vanishing, a singularity-free ``bounce'' universe will always be obtained.
However, for the physically relevant case of a de Sitter brane world, we have
recently argued that, from a holographic (c-theorem) perspective, such brane
worlds may not be physically viable. In the current paper, we reconsider the
validity of such models by appealing to the so-called ``causal entropy bound''.
In this framework, a paradoxical outcome is obtained: these brane worlds are
indeed holographically viable, provided that the bulk charge is not too small.
We go on to argue that this new finding is likely the more reliable one.Comment: 15 pages, Revtex; references added and very minor change
Corneal Biomechanics in Ectatic Diseases: Refractive Surgery Implications.
BACKGROUND: Ectasia development occurs due to a chronic corneal biomechanical decompensation or weakness, resulting in stromal thinning and corneal protrusion. This leads to corneal steepening, increase in astigmatism, and irregularity. In corneal refractive surgery, the detection of mild forms of ectasia pre-operatively is essential to avoid post-operative progressive ectasia, which also depends on the impact of the procedure on the cornea.
METHOD: The advent of 3D tomography is proven as a significant advancement to further characterize corneal shape beyond front surface topography, which is still relevant. While screening tests for ectasia had been limited to corneal shape (geometry) assessment, clinical biomechanical assessment has been possible since the introduction of the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Buffalo, USA) in 2005 and the Corvis ST (Oculus Optikgerate GmbH, Wetzlar, Germany) in 2010. Direct clinical biomechanical evaluation is recognized as paramount, especially in detection of mild ectatic cases and characterization of the susceptibility for ectasia progression for any cornea.
CONCLUSIONS: The purpose of this review is to describe the current state of clinical evaluation of corneal biomechanics, focusing on the most recent advances of commercially available instruments and also on future developments, such as Brillouin microscopy.(undefined)info:eu-repo/semantics/publishedVersio
Global extent and drivers of mammal population declines in protected areas under illegal hunting pressure
Illegal hunting is a persistent problem in many protected areas, but an overview of the extent of this problem and its impact on wildlife is lacking. We reviewed 40 years (1980–2020) of global research to examine the spatial distribution of research and socio-ecological factors influencing population decline within protected areas under illegal hunting pressure. From 81 papers reporting 988 species/site combinations, 294 mammal species were reported to have been illegally hunted from 155 protected areas across 48 countries. Research in illegal hunting has increased substantially during the review period and showed biases towards strictly protected areas and the African continent. Population declines were most frequent in countries with a low human development index, particularly in strict protected areas and for species with a body mass over 100 kg. Our results provide evidence that illegal hunting is most likely to cause declines of large-bodied species in protected areas of resource-poor countries regardless of protected area conservation status. Given the growing pressures of illegal hunting, increased investments in people’s development and additional conservation efforts such as improving anti-poaching strategies and conservation resources in terms of improving funding and personnel directed at this problem are a growing priority
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