30 research outputs found
Volume I. Introduction to DUNE
- Author
- Abi B.
- Acciarri R.
- Acero M.A.
- Adamov G.
- Adams D.
- Adinolfi M.
- Ahmad Z.
- Ahmed J.
- Alba J. Bazo
- Alion T.
- Almeida R.M. De
- Alonso M. Rodriguez
- Alt C.
- Anderson J.
- Andreopoulos C.
- Andrews M.
- Andrianala F.
- Andringa S.
- Ankowski A.
- Antonova M.
- Antusch S.
- Aranda-Fernandez A.
- Ariga A.
- Arnold L.O.
- Arroyave M.A.
- Asaadi J.
- Astiz I.L. De Icaza
- Aurisano A.
- Aushev V.
- Autiero D.
- Azfar F.
- Back H.
- Back J.J.
- Backhouse C.
- Baesso P.
- Bagby L.
- Bajou R.
- Balasubramanian S.
- Baldi P.
- Bambah B.
- Barao F.
- Barenboim G.
- Barker G.
- Barkhouse Wayne A.
- Barnes C.
- Barr G.
- Barros N.
- Barrow J.L.
- Bashyal A.
- Basque V.
- Bay F.
- Beacom J.F.
- Bechetoille E.
- Behera B.
- Bellantoni L.
- Bellettini G.
- Bellini V.
- Beltramello O.
- Belver D.
- Benekos N.
- Berg R. Van
- Berger J.
- Berkman S.
- Bermeo L. Gomez
- Bernardini P.
- Berner R.M.
- Berns H.
- Bertolucci S.
- Betancourt M.
- Bezawada Y.
- Bhattacharjee M.
- Bhuyan B.
- Biagi S.
- Bian J.
- Biassoni M.
- Biery K.
- Bilki B.
- Bishai M.
- Bitadze A.
- Blake A.
- Blaszczyk F.
- Blazey G.
- Blucher E.
- Boissevain J.
- Bolognesi S.
- Bolton T.
- Bonesini M.
- Bongrand M.
- Bonini F.
- Bonis I. De
- Booth A.
- Booth C.
- Bordoni S.
- Borkum A.
- Boschi T.
- Bostan N.
- Bour P.
- Boyd S.
- Boyden D.
- Bracinik J.
- Braga D.
- Brailsford D.
- Brandt A.
- Bremer J.
- Brew C.
- Brianne E.
- Brice S.J.
- Brizzolari C.
- Bromberg C.
- Brooijmans G.
- Brooke J.
- Bross A.
- Brunetti G.
- Buchanan N.
- Budd H.
- Bueno L. Molina
- Caicedo D.A. Martinez
- Caiulo D.
- Calafiura P.
- Calcutt J.
- Calin M.
- Calvez S.
- Calvo E.
- Camilleri L.
- Caminata A.
- Campanelli M.
- Campo A. Olivares Del
- Caratelli D.
- Carini G.
- Carlus B.
- Carniti P.
- Carranza H.
- Castillo A.
- Castromonte C.
- Cattadori C.
- Cavalier F.
- Cavanna F.
- Centro S.
- Cerati G.
- Cervelli A.
- Chalifour M.
- Chang C.
- Chardonnet E.
- Chatterjee A.
- Chattopadhyay S.
- Chaves J.
- Chen H.
- Chen M.
- Chen Y.
- Cherdack D.
- Chi C.
- Childress S.
- Chiriacescu A.
- Cho K.
- Choubey S.
- Christensen A.
- Christian D.
- Christodoulou G.
- Church E.
- Clarke P.
- Coan T.E.
- Cocco A.G.
- Coelho J.
- Conley E.
- Conrad J.
- Convery M.
- Corwin L.
- Cotte P.
- Cremaldi L.
- Cremonesi L.
- Crespo-Anad J.I.
- Cristaldo E.
- Cross R.
- Cuesta C.
- Cui Y.
- Cussans D.
- Dabrowski M.
- David Q.
- Davies G.S.
- Davini S.
- Dawson J.
- de Oliveira M. Leigui
- de Souza H. Vieira
- de Water R.G. Van
- De K.
- Debbins P.
- Decowski M.
- Deisting A.
- Delbart A.
- Delepine D.
- Delgado M.
- Delgado M. Ramirez
- Dell\u27Acqua A.
- DeMuth D.M.
- Dennis S.
- Densham C.
- Deptuch G.
- Dharmapalan R.
- Dias M.
- Diaz F.
- Diaz J.
- Ding P.
- Distefano C.
- Diurba R.
- Diwan M.
- Djurcic Z.
- Dokania N.
- Dolinski M.
- Domine L.
- Domizio S. Di
- Douglas D.
- Drielsma F.
- Duchesneau D.
- Duffy K.
- Dunne P.
- Durkin T.
- Duyang H.
- Dvornikov O.
- Dwyer D.
- Dyshkant A.
- Eads M.
- Edmunds D.
- Eisch J.
- Emery S.
- Ereditato A.
- Escobar C.
- Evans J.J.
- Ewart E.
- Ezeribe A.C.
- Fahey K.
- Fajardo L.S. Gomez
- Falcone A.
- Farnese C.
- Farzan Y.
- Felix J.
- Fernandez-Martinez E.
- Ferraro F.
- Fields L.
- Filkins A.
- Filthaut F.
- Fitzpatrick R.S.
- Flanagan W.
- Fleming B.
- Flight R.
- Forero D. Vanegas
- Fowler J.
- Fox W.
- Franc J.
- Francis K.
- Franco D.
- Freeman J.
- Freestone J.
- Fried J.
- Friedland A.
- Fuess S.
- Furic I.
- Furmanski A.P.
- Gago A.
- Gallagher H.
- Gallego-Ros A.
- Gallice N.
- Galymov V.
- Gamberini E.
- Gamble T.
- Gandhi R.
- Gandrajula R.
- Gao S.
- Garceris M.Á.
- Garcia-Gamez D.
- Gardiner S.
- Gastler D.
- Ge G.
- Gelli B.
- Gendotti A.
- Gent S.
- Ghorbani-Moghaddam Z.
- Gibin D.
- Gil-Botella I.
- Girerd C.
- Giri A.
- Giulio L. Di
- Gnani D.
- Gogota O.
- Gold M.
- Gollapinni S.
- Gollwitzer K.
- Gomes R.A.
- Gonnella F.
- Gonzalez-Cuevas J.
- Goodman M.C.
- Goodwin O.
- Goswami S.
- Gotti C.
- Goudzovski E.
- Gouvea A. De
- Grace C.
- Graham M.
- Gramellini E.
- Gran R.
- Granados E.
- Grant A.
- Grant C.
- Gratieri D.
- Green P.
- Green S.
- Greenler L.
- Greenwood M.
- Greer J.
- Griffith C.
- Groh M.
- Grudzinski J.
- Grzelak K.
- Gu W.
- Guarino V.
- Guenette R.
- Guglielmi A.
- Guo B.
- Guthikonda K.
- Gutierrez R.
- Guzowski P.
- Guzzo M.M.
- Gwon S.
- Habig A.
- Hackenburg A.
- Hadavand H.
- Haenni R.
- Hahn A.
- Haigh J.
- Haiston J.
- Hamernik T.
- Hamilton P.
- Han J.
- Harder K.
- Harris D.A.
- Hartnell J.
- Hasegawa T.
- Hatcher R.
- Hazen E.
- Heavey A.
- Heeger K.M.
- Hennessy K.
- Henry S.
- Herner K.
- Hertel L.
- Hesam A.S.
- Hewes J.
- Hill T.
- Hillier S.J.
- Himmel A.
- Hoff J.
- Hohl C.
- Holanda P.C. De
- Holin A.
- Hoppe E.
- Horton-Smith G.A.
- Hostert M.
- Hourlier A.
- Howard B.
- Howell R.
- Huang J.
- Huang J.
- Hugon J.
- Iles G.
- Iliescu A.M.
- Illingworth R.
- Ioannisian A.
- Itay R.
- Izmaylov A.
- James E.
- Jargowsky B.
- Jediny F.
- Jesús-Valls C.
- Ji X.
- Jiang L.
- Jiménez S.
- Jipa A.
- Joglekar A.
- Johnson C.
- Johnson R.
- Jones B.
- Jones S.
- Jong P. De
- Jung C.
- Junk T.
- Jwa Y.
- Kabirnezhad M.
- Kaboth A.
- Kadenko I.
- Kamiya F.
- Karagiorgi G.
- Karcher A.
- Karolak M.
- Karyotakis Y.
- Kasai S.
- Kasetti S.P.
- Kashur L.
- Kazaryan N.
- Kearns E.
- Keener P.
- Kelly K.J.
- Kemp E.
- Ketchum W.
- Kettell S.
- Khabibullin M.
- Khotjantsev A.
- Khvedelidze A.
- Kim D.
- King B.
- Kirby B.
- Kirby M.
- Klein J.
- Koehler K.
- Koerner L.W.
- Kohn S.
- Koller P.P.
- Kordosky M.
- Kosc T.
- Kose U.
- Kostelecky V.
- Kothekar K.
- Krennrich F.
- Kreslo I.
- Kudenko Y.
- Kudryavtsev V.
- Kulagin S.
- Kumar J.
- Kumar R.
- Kuruppu C.
- Kus V.
- Kutter T.
- Lambert A.
- Lande K.
- Lane C.E.
- Lang K.
- Langford T.
- Lasorak P.
- Last D.
- Lastoria C.
- Laundrie A.
- Lawrence A.
- Lazanu I.
- LaZur R.
- Le T.
- Learned J.
- LeBrun P.
- Lehnert R.
- Leitner M.
- Leyton M.
- Li L.
- Li S.
- Li S.
- Li T.
- Li Y.
- Liao H.
- Lin C.
- Lin S.
- Lister A.
- Littlejohn B.R.
- Liu J.
- Lockwitz S.
- Loew T.
- Lokajicek M.
- Lomidze I.
- Long K.
- Loo K.
- Lorca D.
- Lord T.
- LoSecco J.
- Louis W.C.
- Luk K.
- Luo X.
- Lurgio P. De
- Lurkin N.
- Lux T.
- Luzio V.P.
- MacFarland D.
- Machado A.
- Machado P.
- Macias C.
- Macier J.
- Maddalena A.
- Madigan P.
- Magill S.
- Mahn K.
- Maio A.
- Maloney J.A.
- Mandrioli G.
- Maneira J.C.
- Manenti L.
- Manly S.
- Mann A.
- Manolopoulos K.
- Marchionni A.
- Marciano W.
- Marfatia D.
- Mariani C.
- Maricic J.
- Marinho F.
- Marino A.D.
- Marshak M.
- Marshall C.
- Marshall J.
- Marteau J.
- Martin-Albo J.
- Martinez N.
- Martynenko S.
- Mason K.
- Mastbaum A.
- Masud M.
- Matsuno S.
- Matthews J.
- Mauger C.
- Mauri N.
- Mavrokoridis K.
- Mazza R.
- Mazzacane A.
- Mazzucato E.
- McCluskey E.
- McConkey N.
- McFarland K.S.
- McGrew C.
- McNab A.
- Mefodiev A.
- Mehta P.
- Melas P.
- Mellinato M.
- Mena O.
- Menary S.
- Mendez H.
- Menegolli A.
- Menendez P. Fernandez
- Meng G.
- Messier M.
- Metcalf W.
- Mewes M.
- Meyer H.
- Miao T.
- Michna G.
- Miedema T.
- Migenda J.
- Milincic R.
- Miller W.
- Mills J.
- Milne C.
- Mineev O.
- Miotto G. Lehmann
- Miranda O.G.
- Miryala S.
- Mishra C.
- Mishra S.
- Mislivec A.
- Mladenov D.
- Mocioiu I.
- Moffat K.
- Moggi N.
- Mohanta R.
- Mohayai T.A.
- Mokhov N.
- Molina J.A.
- Monarca J. Barranco
- Monsalve S. Alonso
- Montanari A.
- Montanari C.
- Montanari D.
- Moon J.
- Mooney M.
- Moor A.
- Moreno D.
- Morgan B.
- Morquecho M. Hernandez
- Morris C.
- Mossey C.
- Motta H. Da
- Motuk E.
- Moura C.A.
- Mousseau J.
- Mu W.
- Mualem L.
- Mueller J.
- Muether M.
- Mufson S.
- Muheim F.
- Muir A.
- Mulhearn M.
- Muramatsu H.
- Murphy S.
- Musser J.
- Nachtman J.
- Nagu S.
- Nalbandyan M.
- Nandakumar R.
- Naples D.
- Narita S.
- Navas-Nicolas D.
- Nayak N.
- Nebot-Guinot M.
- Necib L.
- Negishi K.
- Nelson J.K.
- Nesbit J.
- Nessi M.
- Neto J.R. De Mello
- Neves F. Bento
- Newbold D.
- Newcomer M.
- Newhart D.
- Nichol R.
- Niner E.
- Nishimura K.
- Norman A.
- Northrop R.
- Noto L. Di
- Novella P.
- Nowak J.A.
- Nunes M. Soares
- Oberling M.
- Olivier A.
- Onel Y.
- Onishchuk Y.
- Oregui B. Tapia
- Ott J.
- Pagani L.
- Pakvasa S.
- Palamara O.
- Palestini S.
- Paley J.M.
- Pallavicini M.
- Palomares C.
- Pantic E.
- Paolone V.
- Papadimitriou V.
- Papaleo R.
- Papanestis A.
- Paramesvaran S.
- Parke S.
- Parsa Z.
- Parvu M.
- Pascoli S.
- Pasqualini L.
- Pasternak J.
- Pater J.
- Patrick C.
- Patrizii L.
- Patterson R.B.
- Patton S.
- Patzak T.
- Paudel A.
- Paulos B.
- Paulucci L.
- Pavlovic Z.
- Pawloski G.
- Payne D.
- Pec V.
- Peeters S.J.
- Penichot Y.
- Pennacchio E.
- Penzo A.
- Peres L. Da Silva
- Peres O.L.
- Perry J.
- Pershey D.
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- Pickering L.
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- Pillow J.
- Plata M. Manrique
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- Potenza R.
- Potukuchi B.V.
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- Prakash S.
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- Prince S.
- Prior G.
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- Qian X.
- Raaf J.
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- Radics B.
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- Roeth A.
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- Rondon J. Rodriguez
- Rosauro-Alcaraz S.
- Rossella M.
- Rout J.
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- Russell J.
- Ruterbories D.
- Saakyan R.
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- Safford T.
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- Sala P.
- Salinas C.J. Solano
- Samios N.
- Sanchez L. Escudero
- Sanchez M.
- Sanders D.A.
- Sankey D.
- Santana S.
- Santos-Maldonado M.
- Saoulidou N.
- Sapienza P.
- Sarasty C.
- Sarcevic I.
- Savage G.
- Savinov V.
- Scaramelli A.
- Scarff A.
- Scarpelli A.
- Schaffer T.
- Schellman H.
- Schlabach P.
- Schmitz D.
- Scholberg K.
- Schukraft A.
- Segreto E.
- Sensenig J.
- Seong I.
- Sergi A.
- Sergiampietri F.
- Sgalaberna D.
- Shaevitz M.
- Shafaq S.
- Shamma M.
- Sharma H.R.
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- Shepherd-Themistocleous C.
- Shin S.
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- Siffert B. Blanco
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- Sutera C.
- Svoboda R.
- Szczerbinska B.
- Szelc A.
- Söldner-Rembold S.
- Talaga R.
- Tanaka H.
- Tapper A.
- Tariq S.
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- Tenti M.
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- Terranova F.
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- Thea A.
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- Uchida M.A.
- Urheim J.
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- Vaziri K.
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- Vermeulen M.A.
- Verzocchi M.
- Vignoli C.
- Vilela C.
- Villanueva A. Cervera
- Viren B.
- Vrba T.
- Vries J. De
- Wachala T.
- Waldron A.V.
- Wallbank M.
- Wang H.
- Wang J.
- Wang Y.
- Wang Y.
- Warburton K.
- Warner D.
- Wascko M.
- Waters D.
- Watson A.
- Weatherly P.
- Weber A.
- Weber M.
- Wei H.
- Weinstein A.
- Wenman D.
- Wetstein M.
- While M.R.
- White A.
- Whitehead L.H.
- Whittington D.
- Wilking M.J.
- Wilkinson C.
- Williams Z.
- Wilson F.
- Wilson R.J.
- Wolcott J.
- Wongjirad T.
- Wood K.
- Wood L.
- Worcester E.
- Worcester M.
- Wret C.
- Wu W.
- Wu W.
- Xiao Y.
- Yang G.
- Yang T.
- Yershov N.
- Yonehara K.
- Young Tim
- Yu B.
- Yu J.
- Zalesak J.
- Zambelli L.
- Zamorano B.
- Zani A.
- Zazueta L.
- Zeller G.
- Zennamo J.
- Zetina L.M. Montano
- Zeug K.
- Zhang C.
- Zhao M.
- Zhivun E.
- Zhu G.
- Zimmerman E.D.
- Zito M.
- Zucchelli S.
- Zuklin J.
- Zutshi V.
- Zwaska R.
- Publication venue
- UND Scholarly Commons
- Publication date
- 01/08/2020
- Field of study
Get PDFThe preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology
Highly-parallelized simulation of a pixelated LArTPC on a GPU
- Author
- Abed Abud A.
- Abi B.
- Acciarri R.
- Acero M.A.
- Adames M.R.
- Adamov G.
- Adamowski M.
- Adams D.
- Adinolfi M.
- Adriano C.
- Aduszkiewicz A.
- Aguilar J.
- Ahmad Z.
- Ahmed J.
- Aimard B.
- Akbar F.
- Allison K.
- Alonso Monsalve S.
- Alrashed M.
- Alt C.
- Alton A.
- Alvarez R.
- Amedo P.
- Anderson J.
- Andrade D.A.
- Andreopoulos C.
- Andreotti M.
- Andrews M.P.
- Andrianala F.
- Andringa S.
- Anfimov N.
- Anicézio Campanelli W.L.
- Ankowski A.
- Antoniassi M.
- Antonova M.
- Antoshkin A.
- Antusch S.
- Aranda-Fernandez A.
- Arellano L.
- Arnold L.O.
- Arroyave M.A.
- Asaadi J.
- Ashkenazi A.
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2023
- Field of study
Get PDFThe rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype
Deep Underground Neutrino Experiment (DUNE), far detector technical design report, volume III: DUNE far detector technical coordination
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- A. Ankowski
- A. Aranda-Fernandez
- A. Ariga
- A. Aurisano
- A. Bashyal
- A. Bitadze
- A. Blake
- A. Booth
- A. Borkum
- A. Brandt
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- A. Castillo
- A. Cervelli
- A. Cervera Villanueva
- A. Cervera Villanueva
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- A. Chiriacescu
- A. Christensen
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Get PDFThe preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module
Exploring Differences of Consumers’ Perceived Factors in Shopping Online: The Effects of Shopping Experience and Gender
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No full textDNA Photonics — Probing Light-Induced Dynamics in DNA on the Femtosecond Timescale
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- A. Ajayaghosh
- A. Brodeur
- A. Cuppoletti
- A.L. Gaeta
- A.S. Davydov
- B. Giese
- B.A. Armitage
- C.E. Crespo-Hernandez
- C.E. Crespo-Hernandez
- C.J. Murphy
- C.S.M. Olsthoorn
- C.V. Sonntag
- C.Z. Wan
- C.Z. Wan
- D. Markovitsi
- D. Markovitsi
- D. Porath
- D.D. Eley
- E.M. Conwell
- F.D. Lewis
- F.D. Lewis
- F.D. Lewis
- F.D. Lewis
- F.J.M. Hoeben
- G. Kokkinidis
- H. Simpkins
- H.A. Wagenknecth
- H.J. Gao
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- P. Kaden
- P. Tinnefeld
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- R. Huber
- R.J. Sension
- R.N. Barnett
- R.R. Alfano
- S.O. Kelley
- S.O. Kelley
- T. Carell
- T. Fiebig
- T. Fiebig
- T. Förster
- T.M. Nordlund
- V.A. Bloomfield
- Y. Cho
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
No full textElectronic Structure Calculations for Nanomolecular Systems
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- A. Broo
- A. Calzolari
- A. Calzolari
- A. Calzolari
- A. Calzolari
- A. Carlo Di
- A. García-Martin
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- Publication date
- 01/01/2006
- Field of study
No full textWeaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
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- Zhang Weixin
- Zhao H.
- Zheng Jia
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- Çukurova Z.
- Öveges Nándo
- Publication venue
- Elsevier
- Publication date
- 01/01/2023
- Field of study
No full textInternational audienceBackground: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2–6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
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- Publication venue
- Publication date
- 01/08/2018
- Field of study
No full textAim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Doping Liquid Argon with Xenon in ProtoDUNE Single-Phase: Effects on Scintillation Light
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- Publication venue
- HAL CCSD
- Publication date
- 08/02/2024
- Field of study
No full textInternational audienceDoping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 770 t of total liquid argon mass with 410 t of fiducial mass. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of non-uniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen
Doping Liquid Argon with Xenon in ProtoDUNE Single-Phase: Effects on Scintillation Light
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- Zimmerman E.D
- Zucchelli S
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- Zutshi V
- Publication venue
- HAL CCSD
- Publication date
- 08/02/2024
- Field of study
No full textInternational audienceDoping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 770 t of total liquid argon mass with 410 t of fiducial mass. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of non-uniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen
