Report of the COSPAR Mars special regions colloquium

International audienceIn this paper we present the findings of a COSPAR Mars Special Regions Colloquium held in Rome in 2007. We review and discuss the definition of Mars Special Regions, the physical parameters used to define Mars Special Regions, and physical features on Mars that can be interpreted as Mars Special Regions. We conclude that any region experiencing temperatures > -25 degrees C for a few hours a year and a water activity > 0.5 can potentially allow the replication of terrestrial microorganisms. Physical features on Mars that can be interpreted as meeting these conditions constitute a Mars Special Region. Based on current knowledge of the martian environment and the conservative nature of planetary protection, the following features constitute Mars Special regions: Gullies and bright streaks associated with them, pasted-on terrain, deep subsurface, dark streaks only on a case-by-case basis, others to be determined. The parameter definition and the associated list of physical features should be re-evaluated on a regular basis

Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: Results from an international snapshot audit

Background: A right hemicolectomy is among the most commonly performed operations for colon cancer, but modern high-quality, multination data addressing the morbidity and mortality rates are lacking. Objective: This study reports the morbidity and mortality rates for right-sided colon cancer and identifies predictors for unfavorable short-term outcome after right hemicolectomy. Design: This was a snapshot observational prospective study. Setting: The study was conducted as a multicenter international study. Patients: The 2015 European Society of Coloproctology snapshot study was a prospective multicenter international series that included all patients undergoing elective or emergency right hemicolectomy or ileocecal resection over a 2-month period in early 2015. This is a subanalysis of the colon cancer cohort of patients. Main Outcome Measures: Predictors for anastomotic leak and 30-day postoperative morbidity and mortality were assessed using multivariable mixed-effect logistic regression models after variables selection with the Lasso method. Results: Of the 2515 included patients, an anastomosis was performed in 97.2% (n = 2444), handsewn in 38.5% (n = 940) and stapled in 61.5% (n = 1504) cases. The overall anastomotic leak rate was 7.4% (180/2444), 30-day morbidity was 38.0% (n = 956), and mortality was 2.6% (n = 66). Patients with anastomotic leak had a significantly increased mortality rate (10.6% vs 1.6% no-leak patients; p 65 0.001). At multivariable analysis the following variables were associated with anastomotic leak: longer duration of surgery (OR = 1.007 per min; p = 0.0037), open approach (OR = 1.9; p = 0.0037), and stapled anastomosis (OR = 1.5; p = 0.041). Limitations: This is an observational study, and therefore selection bias could be present. For this reason, a multivariable logistic regression model was performed, trying to correct possible confounding factors. Conclusions: Anastomotic leak after oncologic right hemicolectomy is a frequent complication, and it is associated with increased mortality. The key contributing surgical factors for anastomotic leak were anastomotic technique, surgical approach, and duration of surgery