The relationship between Mathematical Utility Theory and the Integrability Problem: some arguments in favour

The resort to utility-theoretical issues will permit us to propose a constructive procedure for deriving a homogeneous of degree one, continuous function that gives raise to a primitive demand function under suitably mild conditions. This constitutes the first elementary proof of a necessary and sufficient condition for an integrability problem to have a solution by continuous (subjective utility) functions. Such achievement reinforces the relevance of a technique that was succesfully formalized in Alcantud and Rodríguez-Palmero (2001). The analysis of these two works exposes deep relationships between two apparently separate fields: mathematical utility theory and the revealed preference approach to the integrability problem.Strong Axiom of Homothetic Revelation; revealed preference; continuous homogeneous of degree one utility; integrability of demand.

Existence and uniqueness of solutions to the Bellman equation in the unbounded case

We study the problem of the existence and uniqueness of solutions to the Bellman equation in the presence of unbounded returns. We introduce a new approach based both on consideration of a metric on the space of all continuous functions over the state space, and on the application of some metric fixed point theorems. With appropriate conditions we prove uniqueness of solutions with respect to the whole space of continuous functions. Furthermore, the paper provides new sufficient conditions for the existence of solutions that can be applied to fairly general models. It is also proven that the fixed point coincides with the value function and that it can be approached by successive iterations of the Bellman operator.The research of J. P. Rincón-Zapatero was supported by Project VA108/01 of Junta de Castilla y León and Project BFM2002–00425 (FEDER) of Ministerio de Ciencia y Tecnología, Spain. C. Rodríguez-Palmero gratefully acknowledges financial support from Junta de Castilla y León, Project VA31/01.Publicad

Una aproximación a las representaciones del alumnado sobre el Universo

This study explains how the children from secondary school (age 14-18) represent the structure of the universe and the way it may be useful in daily teaching. The results obtained describe the same conceptualization difficulties that the younger students already have, as well as the need for studying deeply the process for learning of those students as far as, having dealt with those contents before, they have not reached the expected scientific knowledge concerning the topic

Fungal microbiota from rain water and pathogenicity of Fusarium species isolated from atmospheric dust and rainfall dust

In order to determine the presence of Fusarium spp. in atmospheric dust and rainfall dust, samples were collected during September 2007, and July, August, and October 2008. The results reveal the prevalence of airborne Fusarium species coming from the atmosphere of the South East coast of Spain. Five different Fusarium species were isolated from the settling dust: Fusarium oxysporum, F. solani, F. equiseti, F. dimerum, and F. proliferatum. Moreover, rainwater samples were obtained during significant rainfall events in January and February 2009. Using the dilution-plate method, 12 fungal genera were identified from these rainwater samples. Specific analyses of the rainwater revealed the presence of three species of Fusarium: F. oxysporum, F. proliferatum and F. equiseti. A total of 57 isolates of Fusarium spp. obtained from both rainwater and atmospheric rainfall dust sampling were inoculated onto melon (Cucumis melo L.) cv. Piñonet and tomato (Lycopersicon esculentum Mill.) cv. San Pedro. These species were chosen because they are the main herbaceous crops in Almeria province. The results presented in this work indicate strongly that spores or propagules of Fusarium are able to cross the continental barrier carried by winds from the Sahara (Africa) to crop or coastal lands in Europe. Results show differences in the pathogenicity of the isolates tested. Both hosts showed root rot when inoculated with different species of Fusarium, although fresh weight measurements did not bring any information about the pathogenicity. The findings presented above are strong indications that long-distance transmission of Fusarium propagules may occur. Diseases caused by species of Fusarium are common in these areas. They were in the past, and are still today, a problem for greenhouses crops in Almería, and many species have been listed as pathogens on agricultural crops in this region. Saharan air masses dominate the Mediterranean regions. The evidence of long distance dispersal of Fusarium spp. by atmospheric dust and rainwater together with their proved pathogenicity must be taken into account in epidemiological studies

Hippocampal neurogenesis and Arc expression are enhanced in high-fat fed prepubertal female pigs by a diet including omega-3 fatty acids and Bifidobacterium breve CECT8242

Obesity during childhood has become a pandemic disease, mainly caused by a diet rich in sugars and fatty acids. Among other negative effects, these diets can induce cognitive impairment and reduce neuroplasticity. It is well known that omega-3 and probiotics have a beneficial impact on health and cognition, and we have hypothesized that a diet enriched with Bifidobacterium breve and omega-3 could potentiate neuroplasticity in prepubertal pigs on a high-fat diet.info:eu-repo/semantics/publishedVersio

Contenidos, metodología y alumnado : una valoración crítica de la enseñanza en BUP y COU

The aim of this study was to compare the interest of the students in Natural Science in front of three other subjects such as Mathematics, Literature and Geography & History. The selected items of the contents of every subject, and the importance of teaching as an influential factor on students were also studied. The results showed that both the selection of the contents and the methods should have been modified

On the structure of acyclic binary relations

We investigate the structure of acyclic binary relations from different points of view. On the one hand, given a nonempty set we study real-valued bivariate maps that satisfy suitable functional equations, in a way that their associated binary relation is acyclic. On the other hand, we consider acyclic directed graphs as well as their representation by means of incidence matrices. Acyclic binary relations can be extended to the asymmetric part of a linear order, so that, in particular, any directed acyclic graph has a topological sorting.This work has been partially supported by the research projects MTM2012-37894-C02-02, TIN2013-47605-P, ECO2015-65031-R, MTM2015-63608-P (MINECO/FEDER), TIN2016-77356-P and the Research Services of the Public University of Navarre (Spain)

Direct observation of transverse and vortex metastable magnetic domains in cylindrical nanowires

We present experimental evidence of transverse magnetic domains, previously observed only in nanostrips, in CoNi cylindrical nanowires with designed crystal symmetry and tailored magnetic anisotropy. The transverse domains are found together with more conventional vortex domains along the same cylindrical nanowire, denoting a bistable system with similar energies. The surface and the inner magnetization distribution in both types of domains are analyzed by photoemission electron microscopy with x-ray magnetic circular dichroism contrast, and hysteresis loop in individual nanowires are measured by magneto-optical Kerr effect. These experimental data are understood and compared with complementary micromagnetic simulations

Análisis de los trabajos académicos del área de geriatría y gerontología en la escuela de enfermería de Zamora, Universidad de Salamanca

In Nursing Degree studies, the student must know the most frequent health problems in the elderly and know how to select the most appropriate interventions. In a transversal way, the student must acquire the competence to investigate in the different nursing subjects studied. To contribute to achieve these competencies, in the EUE of Zamora, a group work of bibliographic review in the subject of Geriatrics and Gerontology Nursing is programmed, with 15 works carried out since the 2019/20 academic year. In addition, one of the research lines of the Final Degree Project (TFG) corresponds to this subject. There are 442 students who have presented their TFG since the 2013/14 academic year; 24 of them are related to the theme of Geriatrics. Most of the works (60%) are bibliographic reviews, followed by clinical cases, descriptive works and research projects. With this observational study, it is perceived that the typology of the bibliographic review predominates and that the works have been published in journals: INFAD, in the Gredos USAL repository, in the TFG Grupo Paradigma repository, in addition to being presented at conferences and congresses, highlighting the Congress Silver Economy, where all the works of the Geriatric and Gerontological Nursing subject have been presented. We mustencourageresearch in thefield ofageing, taking into account demographics and the very reasons on which the specialty is based.En los estudios de Grado en Enfermería, el alumno debe conocer los problemas de salud más frecuentes en las personas mayores y saber seleccionar las intervenciones más adecuadas. De forma transversal, el estudiante debe adquirir la competencia de investigar en las diferentes materias de enfermería estudiadas. Para contribuir a alcanzar dichas competencias, en la EUE de Zamora, se programa, desde el curso 2019/20, un trabajo grupal de revisión bibliográfica en la asignatura de Enfermería Geriatría y Gerontología, siendo 15 los trabajos realizados. Además, una de las líneas de investigación del Trabajo Fin de Grado (TFG) corresponde a esta materia. Son 442 los alumnos que han presentado sus TFG desde el curso 2013/14; 24 de ellos están relacionados con la temática de Geriatría. La mayoría de los trabajos (60 %) son revisiones bibliográficas, seguido de los casos clínicos, trabajos descriptivos y proyectos de investigación. Con este estudio observacional se percibe que predomina la tipología de la revisión bibliográfica y que los trabajos han sido publicados en revistas: INFAD, en el repositorio Gredos USAL, en el repositorio TFG Grupo Paradigma, además de presentarse en jornadas y congresos, destacando el Congreso Silver Economy, donde se han presentado todos los trabajos de la asignatura de Enfermería Geriátrica y Gerontológica. Debemos fomentar la investigación en el campo del envejecimiento, teniendo en cuenta la demografía y las propias razones en las que se sustenta la especialidad.

Alectinib after failure to crizotinib in patients with ALK-positive non-small cell lung cancer : results from the Spanish early access program

Altres ajuts: Roche Farma, S.A.This retrospective observational study analyzed the clinical characteristics, treatment patterns and outcomes of 120 patients with advanced ALK-positive nonsmall-cell lung cancer (ALK+ NSCLC) according to data collected between November 2019 and October 2020 in 38 Spanish hospitals. Patients had progressed after 1-5 prior treatment lines (which included crizotinib in any prior line) and received subsequent therapy with alectinib in a local expanded access program. Median age was 58.7 years, 50% of patients were female, 64.1% had ECOG PS of 0-1, 85% presented stage IV, 95% had adenocarcinoma histology and 20.8% had brain metastases. After a median 9.6 months of alectinib treatment, objective response rate (ORR) was 54.5%, disease control rate (DCR) was 80%, median progression-free survival (PFS) was 9.4 months and median overall survival (OS) was 24.1 months. Patients with brain metastases achieved an intracranial DCR of 71.4%. Adverse events (AEs) were reported in 35.8% of patients (14.2% of AEs were grade ≥3). Over 40% of patients received some treatment after alectinib, most frequently lorlatinib (65.2%) and brigatinib (32.6%). This study provides information on real-world treatment patterns and confirms the tolerability and prolonged PFS and OS observed with alectinib in clinical trials, in unselected pretreated patients with advanced ALK+ NSCLC