4,319 research outputs found
Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis
STUDY QUESTION: Are low or high plasma mannose-binding lectin (p-MBL) levels associated with recurrent pregnancy loss (RPL) and the reproductive and perinatal outcomes before and after RPL? SUMMARY ANSWER: The prevalence of low p-MBL levels was significantly higher in RPL patients, while high levels were significantly less prevalent. No association was found between p-MBL level and reproductive and perinatal outcomes before and after RPL. WHAT IS KNOWN ALREADY: Mannose-binding lectin (MBL) is an important component in the innate immune system. Low p-MBL levels have been associated with RPL, while the correlation with high levels has been poorly studied. Adverse perinatal outcomes are generally more frequent among RPL patients, but reports concerning the association between maternal p-MBL levels and perinatal outcomes, including birth weight (BW) and gestational age (GA), are conflicting. STUDY DESIGN, SIZE, DURATION: This study was a combined cross-sectional and cohort study of 267 RPL patients admitted to the RPL Center of Western Denmark between January 2016 and March 2020. RPL patients were followed until birth of a liveborn child or until end of follow-up, March 2021. A sample of 185 healthy female blood donors of reproductive age was used as a MBL reference group. PARTICIPANTS/MATERIALS, SETTING, METHODS: All RPL patients had ≥3 consecutive pregnancy losses, a regular menstrual cycle and no known significant chromosomal or uterine malformations. At the first consultation, routine blood samples including p-MBL measurement and detailed obstetrical and perinatal information were collected. p-MBL levels in RPL patients were compared to the MBL reference group. A logistic regression analysis adjusted for relevant confounders assessed the association between low p-MBL levels and an unsuccessful reproductive outcome in RPL patients in first pregnancy after admission. Perinatal outcomes before and after RPL were compared between RPL subgroups according to low (≤500 µg/l), intermediate (501–3000 µg/l) and high (>3000 µg/l) p-MBL levels. MAIN RESULTS AND THE ROLE OF CHANCE: Significantly more RPL patients had low p-MBL levels (prevalence proportion ratio (PPR): 1.79, 95% CI: 1.34–2.38) and fewer had high p-MBL levels (PPR: 0.56, 95% CI: 0.40–0.79) compared to the reference group, while the prevalence of intermediate p-MBL level was not different between the groups (PPR: 0.86, 95% CI: 0.69–1.08). In the prospective study, low p-MBL level was not a significant risk factor for a pregnancy loss in the first pregnancy after admission after adjustment for age, BMI and smoking. Neither before nor after the RPL diagnosis were maternal p-MBL levels significantly associated with BW or GA. LIMITATIONS, REASONS FOR CAUTION: Only 161 (60.3%) patients had given birth after RPL during the follow-up period, which limited the possibility to detect clear associations between p-MBL levels and perinatal outcomes after RPL. WIDER IMPLICATIONS OF THE FINDINGS: In agreement with several previous studies, low p-MBL levels are strongly associated with RPL, while this study for the first time documents that high levels may play a protective role, which suggests a causal relationship. We suggest that larger prospective studies evaluate the association between p-MBL levels and RPL prognosis. STUDY FUNDING/COMPETING INTEREST(S): No external funding was received. We acknowledge the Department of Obstetrics and Gynaecology at Aalborg University Hospital for financial support. U.S.K. has reported personal fees from Merck, consulting fees from IBSA Nordic, and a grant from Gedeon Richter, Merck and IBSA Nordic outside of the submitted work. TRIAL REGISTRATION NUMBER: ID from clinicaltrials.gov is NCT04017754
Effect of Plastic Pre-straining on Residual Stress and Composition Profiles in Low-Temperature Surface-Hardened Austenitic Stainless Steel
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures
Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with follow-up in 10,091 subjects of European and East-Asian descent, we found a new BMD locus that harbours the PTCH1 gene, represented by rs28377268 (freq. 11.4–22.6%) that associates with reduced spine BMD (P=1.0 × 10−11, β=−0.09). We also identified a new spine BMD signal in RSPO3, rs577721086 (freq. 6.8%), that associates with increased spine BMD (P=6.6 × 10−10, β=0.14). Importantly, both variants associate with osteoporotic fractures and affect expression of the PTCH1 and RSPO3 genes that is in line with their influence on BMD and known biological function of these genes. Additional new BMD signals were also found at the AXIN1 and SOST loci and a new lead SNP at the EN1 locus
Self-trapping and stable localized modes in nonlinear photonic crystals
We predict the existence of stable nonlinear localized modes near the band
edge of a two-dimensional reduced-symmetry photonic crystal with a Kerr
nonlinearity. Employing the technique based on the Green function, we reveal a
physical mechanism of the mode stabilization associated with the effective
nonlinear dispersion and long-range interaction in the photonic crystals.Comment: 4 pages (RevTex) with 5 figures (EPS
Risks, alternative knowledge strategies and democratic legitimacy: the conflict over co-incineration of hazardous industrial waste in Portugal.
The decision to incinerate hazardous industrial waste in cement plants (the socalled
‘co-incineration’ process) gave rise to one of the most heated environmental
conflicts ever to take place in Portugal. The bitterest period was between 1997 and
2002, after the government had made a decision. Strong protests by residents,
environmental organizations, opposition parties, and some members of the
scientific community forced the government to backtrack and to seek scientific
legitimacy for the process through scientific expertise. The experts ratified the
government’s decision, stating that the risks involved were socially acceptable.
The conflict persisted over a decade and ended up clearing the way for a more
sustainable method over which there was broad social consensus – a multifunctional
method which makes it possible to treat, recover and regenerate most
wastes. Focusing the analysis on this conflict, this paper has three aims: (1) to
discuss the implications of the fact that expertise was ‘confiscated’ after the
government had committed itself to the decision to implement co-incineration and
by way of a reaction to the atmosphere of tension and protest; (2) to analyse the
uses of the notions of ‘risk’ and ‘uncertainty’ in scientific reports from both
experts and counter-experts’ committees, and their different assumptions about
controllability and criteria for considering certain practices to be sufficiently safe
for the public; and (3) to show how the existence of different technical scientific
and political attitudes (one more closely tied to government and the corporate
interests of the cement plants, the other closer to the environmental values of reuse
and recycling and respect for the risk perception of residents who challenged
the facilities) is closely bound up with problems of democratic legitimacy. This
conflict showed how adopting more sustainable and lower-risk policies implies a
broader view of democratic legitimacy, one which involves both civic movements
and citizens themselves
Two-kaon correlations in central Pb + Pb collisions at 158 A GeV/c
Two-particle interferometry of positive kaons is studied in Pb + Pb
collisions at mean transverse momenta and 0.91 GeV/c. A
three-dimensional analysis was applied to the lower data, while a
two-dimensional analysis was used for the higher data. We find that the
source size parameters are consistent with the scaling curve observed in
pion correlation measurements in the same collisions, and that the duration
time of kaon emission is consistent with zero within the experimental
sensitivity.Comment: 4 pages incl. 1 table and 3 fig's; RevTeX; accepted for publication
in PR
Wave decay on convex co-compact hyperbolic manifolds
For convex co-compact hyperbolic quotients X=\Gamma\backslash\hh^{n+1}, we
analyze the long-time asymptotic of the solution of the wave equation
with smooth compactly supported initial data . We show that, if
the Hausdorff dimension of the limit set is less than , then
u(t) = C_\delta(f) e^{(\delta-\ndemi)t} / \Gamma(\delta-n/2+1) +
e^{(\delta-\ndemi)t} R(t) where and
||R(t)||=\mc{O}(t^{-\infty}). We explain, in terms of conformal theory of the
conformal infinity of , the special cases \delta\in n/2-\nn where the
leading asymptotic term vanishes. In a second part, we show for all \eps>0
the existence of an infinite number of resonances (and thus zeros of Selberg
zeta function) in the strip \{-n\delta-\eps<\Re(\la)<\delta\}. As a byproduct
we obtain a lower bound on the remainder for generic initial data .Comment: 18 page
The ALICE TPC, a large 3-dimensional tracking device with fast readout for ultra-high multiplicity events
The design, construction, and commissioning of the ALICE Time-Projection
Chamber (TPC) is described. It is the main device for pattern recognition,
tracking, and identification of charged particles in the ALICE experiment at
the CERN LHC. The TPC is cylindrical in shape with a volume close to 90 m^3 and
is operated in a 0.5 T solenoidal magnetic field parallel to its axis.
In this paper we describe in detail the design considerations for this
detector for operation in the extreme multiplicity environment of central
Pb--Pb collisions at LHC energy. The implementation of the resulting
requirements into hardware (field cage, read-out chambers, electronics),
infrastructure (gas and cooling system, laser-calibration system), and software
led to many technical innovations which are described along with a presentation
of all the major components of the detector, as currently realized. We also
report on the performance achieved after completion of the first round of
stand-alone calibration runs and demonstrate results close to those specified
in the TPC Technical Design Report.Comment: 55 pages, 82 figure
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