Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

The position of reporting guidelines in qualitative nursing research

Editorial

Transparency in the reporting of nursing research

Editorial

The experiences of people with liver disease of palliative and end-of-life care in the United Kingdom – a systematic literature review and metasynthesis

Background Liver disease is a growing health concern and a major cause of death. It causes multiple symptoms, including financial, psychological and social issues. To address these challenges, palliative care can support people alongside active treatment, and towards the end of life, but little is known about the care experiences of individuals with liver disease in the United Kingdom. This review aimed to explore the palliative and end-of-life care experiences of people with liver disease in the United Kingdom. Method A systematic review was conducted using a five-stage process and following Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines. Searches were across Web of Science, Scopus, EBSCO and grey literature until 10 May 2023. The review was registered through International Prospective Register of Systematic Reviews (PROSPERO). NVivo 12.5 was used to facilitate data analysis (systematic review registration: PROSPERO CRD42022382649). Results Of 6035 papers (excluding duplicates) found from searches, five met the inclusion criteria of primary research related to adults with liver disease receiving palliative and/or end-of-life care in the United Kingdom, published in English. Reflexive thematic analysis of the data was conducted. The themes identified were the experiences of people with liver disease of relating to healthcare professionals, using services, receiving support, and experiences of information and communication. These were connected by an overarching concept of disempowerment versus empowerment, with the notion of person-centred care as an important feature. Conclusion This review has found variations in the care experiences of people with advanced liver disease towards the end of life and an overall lack of access to specialist palliative care services. Where services are designed to be person-centred, experiences are more empowering. Further research is needed but with recognition that it is often unclear when care for people with liver disease is palliative or end-of-life. Patient and Public Contribution An online public involvement workshop was held on 18 April 2023 through Voice (2023). This included four people with liver disease and four carers to discuss the review findings and to design a qualitative research study to further explore the topic

Still dreaming: service users' employment, education & training goals

Background: Enabling service users to find and keep real jobs is a significant strand of UK mental health policy. An evidence-based approach to employment support is well documented, but is not widely implemented in the UK. Aim: To inform the development of vocational services in South Essex by ascertaining service users' employment, education and training goals. Method: Face-to-face interviews with a randomly selected sample of service users on enhanced CPA carried out by a team of service user researchers using an adapted version of a questionnaire developed for a previous similar survey. A postal survey of a further randomly selected sample of service users on enhanced CPA using a brief version of the questionnaire was also carried out. Results: Interviews were carried out with 82 service users. A further 159 returned a postal questionnaire. 42.7% had no regular day time activity. Only 15% were in paid work. 60.6% were definitely interested in finding work. Seventy-seven percent of respondents to the interviews who were interested in work were not currently receiving support to achieve this. The main help wanted was support in work, help with mental health problems and benefits advice. The main barriers identified were employers' attitudes and threat to benefits. Service user researchers reported benefits from undertaking the work. Conclusions: High numbers of mental health service users are interested in pursuing employment, education or training goals but currently lack the support they need to do so. Implementation of an evidence-based approach to employment support has the potential to enable service users to achieve their goals. Service users are well able to undertake research with considerable benefits for themselves and other stakeholders

Mitochondrial and plastidial COG0354 proteins have folate-dependent functions in iron–sulphur cluster metabolism

COG0354 proteins have been implicated in synthesis or repair of iron/sulfur (Fe/S) clusters in all domains of life, and those of bacteria, animals, and protists have been shown to require a tetrahydrofolate to function. Two COG0354 proteins were identified in Arabidopsis and many other plants, one (At4g12130) related to those of α-proteobacteria and predicted to be mitochondrial, the other (At1g60990) related to those of cyanobacteria and predicted to be plastidial. Grasses and poplar appear to lack the latter. The predicted subcellular locations of the Arabidopsis proteins were validated by in vitro import assays with purified pea organelles and by targeting assays in Arabidopsis and tobacco protoplasts using green fluorescent protein fusions. The At4g12130 protein was shown to be expressed mainly in flowers, siliques, and seeds, whereas the At1g60990 protein was expressed mainly in young leaves. The folate dependence of both Arabidopsis proteins was established by functional complementation of an Escherichia coli COG0354 (ygfZ) deletant; both plant genes restored in vivo activity of the Fe/S enzyme MiaB but restoration was abrogated when folates were eliminated by deleting folP. Insertional inactivation of At4g12130 was embryo lethal; this phenotype was reversed by genetic complementation of the mutant. These data establish that COG0354 proteins have a folate-dependent function in mitochondria and plastids, and that the mitochondrial protein is essential. That plants retain mitochondrial and plastidial COG0354 proteins with distinct phylogenetic origins emphasizes how deeply the extant Fe/S cluster assembly machinery still reflects the ancient endosymbioses that gave rise to plants