Land cover analysis in wildland-urban interfaces according to wildfire risk: a case study in the South of France

Each year, forest fires destroy about 500,000 ha of vegetation in Europe, predominantly in the Mediterranean region. Many large fires are linked to the land transformations that have taken place in the Mediterranean region in recent decades that have increased the risk of forest fires. On the one hand, agricultural fallows and orchards are slowly being colonized by vegetation, and on the other hand, the forest is not sufficiently used, both of which result in increased accumulation of fuel. In addition, urbanization combined with forest extension results in new spatial configurations called wildland-urban interfaces (WUI). WUI are commonly defined as areas where urban areas meet and interact with rural lands, wildland vegetation and forests. Spatial analyses were performed using a WUI typology based on two intertwined elements, the spatial organization of homes and the structure of fuel vegetation. The organisation of the land cover in terms of representativeness, complexity or road density was evaluated for each type of WUI. Results showed that there were significant differences between the types of WUI in the study area. Three indicators (i) fire ignition density, derived from the distribution of fire ignition points, (ii) wildfire density, derived from the distribution of wildfire area and (iii) burned area ratio, derived from the proportion of the burned area to the total study area were then compared with each type of WUI. Assuming that the three indicators correspond to important aspects of fire risk, we showed that, at least in the south of France, WUI are at high risk of wildfire, and that of the different types of wildland-urban interfaces, isolated and scattered WUI were the most at risk. Their main land cover characteristics, i.e. low housing and road densities but a high density of country roads, and the availability of burnable vegetation such as forested stands and shrubland (garrigue) explain the high fire risk. Improving our knowledge of relationships between WUI environments and fire risk should increase the efficiency of wildfire prevention: to this end, suitable prevention actions and communication campaigns targeting the types of WUI at the highest risk are recommended

Segmentation 3D d'hologrammes numériques de particules par palpage morphologique : application à l'analyse d'un jet diesel haute-pression

Dans cette article, nous nous intéressons à l'holographie numérique pour l'étude d'un champ volumique de particules. L'holographie numérique offre de nouvelles possibilités par rapport à l'holographie sur plaque photosensible, notamment du point de vue de sa facilité de mise en oeuvre. L'hologramme d'un champ de particules enregistré sur un capteur matriciel, est restitué numériquement plan par plan afin de pouvoir localiser les particules dans le volume d'étude. Nous introduisons pour cela une méthode de détection des particules par palpage morphologique. Nous avons appliqué cette technique à l'obtention d'un champ tridimensionnel de particules en volume, et nous présentons les résultats pour un jet issu d'un injecteur diesel haute-pression

Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study

Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and simultaneous radiotherapy. Patients and Methods: Previously untreated patients with stage IIIB NSCLC received concurrent chemoradiotherapy with 66 Gy and 2 cycles of cisplatin and oral vinorelbine which was administered at 3 different levels (40, 50 and 60 mg/m(2)). This was to be followed by 2 cycles of cisplatin/vinorelbine oral consolidation chemotherapy. The study goal was to determine the maximal recommended dose of oral vinorelbine during concurrent treatment. Results: 11 stage IIIB patients were entered into the study. The median radiotherapy dose was 66 Gy. Grade 3-4 toxicity included neutropenia, esophagitis, gastritis and febrile neutropenia. The dose-limiting toxicity for concurrent chemoradiotherapy was esophagitis. 9 patients received consolidation chemotherapy, with neutropenia and anemia/thrombocytopenia grade 3 being the only toxicities. The overall response was 73%. Conclusion: Oral vinorelbine 50 mg/m(2) (days 1, 8, 15 over 4 weeks) in combination with cisplatin 20 mg/m2 (days 1-4) is the recommended dose in combination with radiotherapy (66 Gy) and will be used for concurrent chemoradiotherapy in a forthcoming phase III trial testing the efficacy of consolidation chemotherapy in patients not progressing after chemoradiotherapy

Manufacturing and Installation of the Compound Cryogenic Distribution Line for the Large Hadron Collider

The Large Hadron Collider (LHC) [1] currently under construction at CERN will make use of superconducting magnets operating in superfluid helium below 2 K. A compound cryogenic distribution line (QRL) will feed with helium at different temperatures and pressures the local elementary cooling loops in the cryomagnet strings. Low heat inleak to all temperature levels is essential for the overall LHC cryogenic performance. Following a competitive tendering, CERN adjudicated in 2001 the contract for the series line to Air Liquide (France). This paper recalls the main features of the technical specification and shows the project status. The basic choices and achievements for the industrialization phase of the series production are also presented, as well as the installation issues and status

On the origin of the A1g_{1g} and B1g_{1g} electronic Raman scattering peaks in the superconducting state of YBa2_{2}Cu3_{3}O7−δ_{7-\delta}

The electronic Raman scattering has been investigated in optimally oxygen doped YBa$_{2}$Cu$_{3}$O$_{7-\delta}$ single crystals as well as in crystals with non-magnetic, Zn, and magnetic, Ni, impurities. We found that the intensity of the A$_{1g}$ peak is impurity independent and their energy to $T_{c}$ ratio is almost constant ($2\Delta/k_{B}T_{c}\sim5$). Moreover, the signal at the B$_{1g}$ channel is completely smeared out when non-magnetic Zn impurities are present. These results are qualitatively interpreted in terms of the Zeyher and Greco's theory that relates the electronic Raman scattering in the A$_{1g}$ and B$_{1g}$ channels to \textit{d}-CDW and superconducting order parameters fluctuations, respectively.Comment: Submited to Phys. Rev. Let

Temporally ordered collective creep and dynamic transition in the charge-density-wave conductor NbSe3

We have observed an unusual form of creep at low temperatures in the charge-density-wave (CDW) conductor NbSe$_3$. This creep develops when CDW motion becomes limited by thermally-activated phase advance past individual impurities, demonstrating the importance of local pinning and related short-length-scale dynamics. Unlike in vortex lattices, elastic collective dynamics on longer length scales results in temporally ordered motion and a finite threshold field. A first-order dynamic phase transition from creep to high-velocity sliding produces "switching" in the velocity-field characteristic.Comment: 4 pages, 4 eps figures; minor clarifications To be published in Phys. Rev. Let

The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer

International audienceHeparan sulfate (HS) proteoglycan chains are key components of the breast tumor microenvironment that critically influence the behavior of cancer cells. It is established that abnormal synthesis and processing of HS play a prominent role in tumorigenesis, albeit mechanisms remain mostly obscure. HS function is mainly controlled by sulfotransferases, and here we report a novel cellular and pathophysiological significance for the 3-O-sulfotransferase 3-OST3A (HS3ST3A), catalyzing the final maturation step of HS, in breast cancer. We show that 3-OST3A is epigenetically repressed in all breast cancer cell lines of a panel representative of distinct molecular subgroups, except in human epidermal growth factor receptor 2-positive (HER2+) sloan-kettering breast cancer (SKBR3) cells. Epigenetic mechanisms involved both DNA methylation and histone modifications, producing different repressive chromatin environments depending on the cell molecular signature. Gain and loss of function experiments by cDNA and siRNA transfection revealed profound effects of 3-OST3A expression on cell behavior including apoptosis, proliferation, response to trastuzumab in vitro and tumor growth in xenografted mice. 3-OST3A exerted dual activities acting as tumor-suppressor in lumA-michigan cancer foundation (MCF)-7 and triple negative-MD Anderson (MDA) metastatic breast (MB)-231 cells, or as an oncogenic factor in HER2+-SKBR3 cells. Mechanistically, fluorescence-resonance energy transfer-fluorescence-lifetime imaging microscopy experiments indicated that the effects of 3-OST3A in MCF-7 cells were mediated by altered interactions between HS and fibroblast growth factor-7 (FGF-7). Further, this interplay between HS and FGF-7 modulated downstream ERK, AKT and p38 cascades, suggesting that altering 3-O-sulfation affects FGFR2IIIb-mediated signaling. Corroborating our cellular data, a clinical study conducted in a cohort of breast cancer patients uncovered that, in HER2+ patients, high level expression of 3-OST3A in tumors was associated with reduced relapse-free survival. Our findings define 3-OST3A as a novel regulator of breast cancer pathogenicity, displaying tumor-suppressive or oncogenic activities in a cell-and tumor-dependent context, and demonstrate the clinical value of the HS-O-sulfotransferase 3-OST3A as a prognostic marker in HER2+ patients

Community structure of woody plants on islands along a bioclimatic gradient

Peer reviewe

Status of a European Standard for the protection of helium cryostats against excessive pressure

The overpressure protection of various types of cryogenic vessels is covered by a number of International Standards. Helium cryostats, however, include additional components such as superconducting magnets and cavities, electrical heaters and control valves with associated piping, which significantly influence the potential risk. At the European Committee for Standardization CEN, a new working group was hence founded as CEN/TC 268/WG6, dealing with ‘Specific helium technology applications’. Its aim is to develop a European Standard for the protection of helium cryostats against excessive pressure that is harmonized with the European Pressure Equipment Directive. It will cover the typical conditions in accidental scenarios in order to harmonize the risk assessment as well as design practices for the pressure relieving systems. We report about the general concept of this new Standard, its structure and content, and the actual status of the project

Toll-Like Receptor Agonists Synergize with CD40L to Induce Either Proliferation or Plasma Cell Differentiation of Mouse B Cells

In a classical dogma, pathogens are sensed (via recognition of Pathogen Associated Molecular Patterns (PAMPs)) by innate immune cells that in turn activate adaptive immune cells. However, recent data showed that TLRs (Toll Like Receptors), the most characterized class of Pattern Recognition Receptors, are also expressed by adaptive immune B cells. B cells play an important role in protective immunity essentially by differentiating into antibody-secreting cells (ASC). This differentiation requires at least two signals: the recognition of an antigen by the B cell specific receptor (BCR) and a T cell co-stimulatory signal provided mainly by CD154/CD40L acting on CD40. In order to better understand interactions of innate and adaptive B cell stimulatory signals, we evaluated the outcome of combinations of TLRs, BCR and/or CD40 stimulation. For this purpose, mouse spleen B cells were activated with synthetic TLR agonists, recombinant mouse CD40L and agonist anti-BCR antibodies. As expected, TLR agonists induced mouse B cell proliferation and activation or differentiation into ASC. Interestingly, addition of CD40 signal to TLR agonists stimulated either B cell proliferation and activation (TLR3, TLR4, and TLR9) or differentiation into ASC (TLR1/2, TLR2/6, TLR4 and TLR7). Addition of a BCR signal to CD40L and either TLR3 or TLR9 agonists did not induce differentiation into ASC, which could be interpreted as an entrance into the memory pathway. In conclusion, our results suggest that PAMPs synergize with signals from adaptive immunity to regulate B lymphocyte fate during humoral immune response