950 research outputs found
Correlation Redistribution by Causal Horizons
The Minkowski vacuum , which for an inertial observer is devoid
of particles, is treated as a thermal bath by Rindler observers living in a
single Rindler wedge, as a result of the discrepancy in the definition of
positive frequency between the two classes of observers and a strong
entanglement between degrees of freedom in the left and right Rindler wedges.
We revisit, in the context of a free scalar Klein-Gordon field, the problem of
quantification of the correlations between an inertial observer Alice and
left/right Rindler observes Rob/AntiRob. We emphasize the analysis of
informational quantities, like the locally accessible and locally inaccessible
information, and a closely associated entanglement measure, the entanglement of
formation. We conclude that, with respect to the correlation structure probed
by inertial observers alone, the introduction of a Rindler observer gives rise
to a correlation redistribution which can be quantified by the entanglement of
formation.Comment: 9 pages, 7 figure
Mass accretion rates of clusters of galaxies: CIRS and HeCS
We use a new spherical accretion recipe tested on N-body simulations to
measure the observed mass accretion rate (MAR) of 129 clusters in the Cluster
Infall Regions in the Sloan Digital Sky Survey (CIRS) and in the Hectospec
Cluster Survey (HeCS). The observed clusters cover the redshift range of
and the mass range of . Based on three-dimensional mass profiles of simulated
clusters reaching beyond the virial radius, our recipe returns MARs that agree
with MARs based on merger trees. We adopt this recipe to estimate the MAR of
real clusters based on measurements of the mass profile out to .
We use the caustic method to measure the mass profiles to these large radii. We
demonstrate the validity of our estimates by applying the same approach to a
set of mock redshift surveys of a sample of 2000 simulated clusters with a
median mass of as well as a sample
of 50 simulated clusters with a median mass of : the median MARs based on the caustic mass profiles of
the simulated clusters are unbiased and agree within with the median
MARs based on the real mass profile of the clusters. The MAR of the CIRS and
HeCS clusters increases with the mass and the redshift of the accreting
cluster, which is in excellent agreement with the growth of clusters in the
CDM model.Comment: 25 pages, 19 figures, 7 table
Fornecimento de água dentro do comedouro e efeitos no desempenho, carcaça e efluentes da produção de suÃnos.
bitstream/CNPSA/8520/1/cot231.pd
New insights into the structure of early-type galaxies: the Photometric Plane at z~0.3
We study the Photometric Plane (PHP), namely the relation between the
effective radius re, the mean surface brightness within that radius e, and
the Sersic index n, in optical (R and I) and near-infrared (K) bands for a
large sample of early-type galaxies (ETGs) in the rich cluster MS1008-1224 at
z=0.306. The PHP relation has an intrinsic dispersion of ~32% in re, and turns
out to be independent of waveband. This result is consistent with the fact that
internal colour gradients of ETGs can have only a mild dependence on galaxy
luminosity (mass). There is no evidence for a significant curvature in the PHP.
We show that this can be explained if this relation origins from a systematic
variation of the specific entropy of ETGs along the galaxy sequence, as was
suggested from previous works. The intrinsic scatter of the PHP is
significantly smaller than for other purely photometric relations, such as the
Kormendy relation and the photometric Fundamental Plane, which is constructed
by using colours in place of velocity dispersions. The scatter does not depend
on the waveband and the residuals about the plane do not correlate with
residuals of the colour-magnitude relation. Finally, we compare the
coefficients of the PHP at z~0.3 with those of ETGs at z~0, showing that the
PHP is a valuable tool to constrain the luminosity evolution of ETGs with
redshift. The slopes of the PHP do not change significantly with redshift,
while the zero-point is consistent with cosmological dimming of the surface
brightness in an expanding universe plus the passive fading of galaxy stellar
populations with a high formation redshift (z_f >1-2).Comment: 21 pages, 10 figures, MNRAS in pres
Autopsy in adults with congenital heart disease (ACHD).
The adult congenital heart diseases (ACHD) population is exceeding the pediatric congenital heart diseases (CHD) population and is progressively expanding each year, representing more than 90% of patients with CHD. Of these, about 75% have undergone surgical and/or percutaneous intervention for palliation or correction. Autopsy can be a very challenging procedure in ACHD patients. The approach and protocol to be used may vary depending on whether the pathologists are facing native disease without surgical or percutaneous interventions, but with various degrees of cardiac remodeling, or previously palliated or corrected CHD. Moreover, interventions for the same condition have evolved over the last decades, as has perioperative myocardial preservations and postoperative care, with different long-term sequelae depending on the era in which patients were operated on. Careful clinicopathological correlation is, thus, required to assist the pathologist in performing the autopsy and reaching a diagnosis regarding the cause of death. Due to the heterogeneity of the structural abnormalities, and the wide variety of surgical and interventional procedures, there are no standard methods for dissecting the heart at autopsy. In this paper, we describe the most common types of CHDs that a pathologist could encounter at autopsy, including the various types of surgical and percutaneous procedures and major pathological manifestations. We also propose a practical systematic approach to the autopsy of ACHD patients
Effect of axial coordination on the kinetics of assembly and folding of the two halves of horse heart cytochrome c
The kinetics of the assembly of two complementary fragments of oxidized horse heart cytochrome c (cyt c), namely the heme-containing fragment-(1-56) and the fragment-(57-104), have been characterized at different pH values. At neutral pH the fragment-(1-56) is hexacoordinated and has two histidines axially ligated to the heme-Fe(III) (Santucci, R., Fiorucci, L., Sinibaldi, F., Polizio, F., Desideri, A., and Ascoli, F. (2000) Arch. Biochem. Biophys. 379, 331-336), thus mimicking what occurs in the folding intermediate of cyt c. The kinetics of the formation of the complex between the two fragments are characterized at pH 7.0 by a slow rate constant that is independent of the concentration of the reactants; conversely, at a low pH the kinetics are much faster and depend on the concentration of the fragments. This behavior suggests that the rate-limiting step observed in the recombination process of the fragments at neutral pH (that leads to the final coordination of Met-80) has to be ascribed to the detachment of the "misligated" histidine. Thus, the faster recombination rate at a low pH can be related to the fact that histidine is protonated and not able to coordinate to the metal. Furthermore, the independence of the rate constant on the concentration of the reactants observed at pH 7.0 can be accounted for by the occurrence of a conformational transition, which takes place immediately after the two fragments collapse together, likely simulating what induces the detachment of the misligated histidine during cytochrome folding
GMRT 333 MHz observations of 6 nearby normal galaxies
We report Giant Meterwave Radio Telescope (GMRT) continuum observations of
six nearby normal galaxies at 333 MHz. The galaxies are observed with angular
resolutions better than ~20" (corresponding to a linear scale of about 0.4 - 1
kpc). These observations are sensitive to all the angular scales of interest,
since the resolution of the shortest baseline in GMRT is greater than the
angular size of the galaxies. Further, for five of these galaxies we show that
at 333 MHz, the mean thermal fraction is less than 5%. Using archival data at
about 1 GHz, we estimate the mean thermal fraction to be about 10% at that
frequency. We also find that the nonthermal spectral index is generally steeper
in regions with low thermal fraction and/or located in the outer parts of the
galaxy. In regions of high thermal fraction, the nonthermal spectral index is
flatter, and has a narrow distribution peaking at ~ -0.78 with a spread of
0.16, putting stringent constraints on the physical conditions for generation,
diffusion and energy losses of cosmic ray electrons at scales of ~ 1 kpc.Comment: 18 pages, 11 figures, Accepted for publication in MNRA
DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions
Binding-induced conformational changes of a protein at regions distant from the binding site may play crucial roles in protein function and regulation. The p53 tumour suppressor is an example of such an allosterically regulated protein. Little is known, however, about how DNA binding can affect distal sites for transcription factors. Furthermore, the molecular details of how a local perturbation is transmitted through a protein structure are generally elusive and occur on timescales hard to explore by simulations. Thus, we employed state-of-the-art enhanced sampling atomistic simulations to unveil DNA-induced effects on p53 structure and dynamics that modulate the recruitment of cofactors and the impact of phosphorylation at Ser215. We show that DNA interaction promotes a conformational change in a region 3 nm away from the DNA binding site. Specifically, binding to DNA increases the population of an occluded minor state at this distal site by more than 4-fold, whereas phosphorylation traps the protein in its major state. In the minor conformation, the interface of p53 that binds biological partners related to p53 transcription-independent functions is not accessible. Significantly, our study reveals a mechanism of DNA-mediated protection of p53 from interactions with partners involved in the p53 transcription-independent signalling. This also suggests that conformational dynamics is tightly related to p53 signalling
Study on a fermented whole wheat: Phenolic content, activity on PTP1B enzyme and in vitro prebiotic properties
Study on a fermented whole wheat: Phenolic content, activity on PTP1B enzyme and in vitro prebiotic properties
Fermented cereals, staple foods in Asia and Africa, are recently receiving a growing interest in Western countries. The object of this work is the characterization of a fermented wheat used as a food ingredient and dietary supplement. To this aim, the phenolic composition, the activity on protein tyrosine phosphatase 1B (PTP1B), an enzyme overexpressed in type-II diabetes, the in vitro prebiotic properties on Lactobacillus reuteri and the microbial composition were investigated. Basic and acidic hydrolysis were tested for an exhaustive recovery of bound phenols: the acidic hydrolysis gave best yields. Methyl ferulate and neocarlinoside were identified for the first time in wheat. The inhibitory power of the extracts of several batches were investigated on PTP1B enzyme. The product was not able to inhibit the enzyme, otherwise, for the first time, a complete inhibition was observed for schaftoside, a major C-flavonoid of wheat. The microbial composition was assessed identifying Lactobacillus, Enterococcus, and Pediococcus as the main bacterial species. The fermented wheat was a suitable substrate for the grown of L. reuteri, recognized for its health properties in the human gut. The proposed method for phenols is easier compared to those based on strong basic hydrolysis; our results assessed the bound phenols as the major fraction, differently from that suggested by the literature for fermented cereals
- …