Numerical simulations of the possible origin of the two sub-parsec scale and counter-rotating stellar disks around SgrA*

We present a high resolution simulation of an idealized model to explain the origin of the two young, counter-rotating, sub-parsec scale stellar disks around the supermassive black hole SgrA* at the Center of the Milky Way. In our model, the collision of a single molecular cloud with a circum-nuclear gas disk (similar to the one observed presently) leads to multiple streams of gas flowing towards the black hole and creating accretion disks with angular momentum depending on the ratio of cloud and circum-nuclear disk material. The infalling gas creates two inclined, counter-rotating sub-parsec scale accretion disks around the supermassive black hole with the first disk forming roughly 1 Myr earlier, allowing it to fragment into stars and get dispersed before the second, counter-rotating disk forms. Fragmentation of the second disk would lead to the two inclined, counter-rotating stellar disks which are observed at the Galactic Center. A similar event might be happening again right now at the Milky Way Galactic Center. Our model predicts that the collision event generates spiral-like filaments of gas, feeding the Galactic Center prior to disk formation with a geometry and inflow pattern that is in agreement with the structure of the so called mini-spiral that has been detected in the Galactic Center.Comment: 14 pages, 12 figures, submitted to Ap

Simulating the impact of the Smith Cloud

We investigate the future evolution of the Smith Cloud by performing hydrodynamical simulations of the cloud impact onto the gaseous Milky Way Galactic disk. We assume a local origin for the cloud and thus do not include a dark matter component to stabilize it. Our main focus is the cloud's influence on the local and global star formation rate (SFR) of the Galaxy and whether or not it leads to an observable event in the far future. Our model assumes two extremes for the mass of the Smith Cloud, an upper mass limit of 10$^7$ M$_{\odot}$ and a lower mass limit of 10$^6$ M$_{\odot}$, compared to the observational value of a few 10$^6$ M$_{\odot}$. In addition, we also make the conservative assumption that the entirety of the cloud mass of the extended Smith Cloud is concentrated within the tip of the cloud. We find that the impact of the low-mass cloud produces no noticeable change in neither the global SFR nor the local SFR at the cloud impact site within the galactic disk. For the high-mass cloud we find a short-term (roughly 5 Myr) increase of the global SFR of up to 1 M$_{\odot}$ yr$^{-1}$, which nearly doubles the normal Milky Way SFR. This highly localized starburst should be observable.Comment: 14 pages, 5 figure

The roles of stellar feedback and galactic environment in star-forming molecular clouds

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Feedback from massive stars is thought to play an important role in the evolution of molecular clouds. In this work we analyse the effects of stellar winds and supernovae (SNe) in the evolution of two massive (∼ 106 M ) giant molecular clouds (GMCs): one gravitationally bound collapsing cloud and one unbound cloud undergoing disruption by galactic shear. These two clouds have been extracted from a large scale galaxy model and are re-simulated at a spatial resolution of ∼ 0.01 pc, including feedback from winds, SNe, and the combined effect of both. We find that stellar winds stop accretion of gas onto sink particles, and can also trigger star formation in the shells formed by the winds, although the overall effect is to reduce the global star formation rate of both clouds. Furthermore, we observe that winds tend to escape through the corridors of diffuse gas. The effect of SNe is not so prominent and the star formation rate is similar to models neglecting stellar feedback. We find that most of the energy injected by the SNe is radiated away, but overdense areas are created by multiple and concurrent SN events especially in the most virialised cloud. Our results suggest that the impact of stellar feedback is sensitive to the morphology of star forming clouds, which is set by large scale galactic flows, being of greater importance in clouds undergoing gravitational collapse.The calculations for this paper were performed on the supercomputer at Exeter, which is jointly funded by STFC, the Large Facilities Capital Fund of BIS and the University of Exeter. RRR and CLD acknowledge funding from the European Research Council for the FP7 ERC starting grant project LOCALSTAR. OA and RRR would like to acknowledge support from STFC consolidated grant ST/M000990/1. Figs 1, 2, 5, and 3 were produced using SPLASH (Price 2007)

Design of An Improved Miniature Ion Neutral Mass Spectrometer for NASA Applications

The ion optics of NASA's Ion Neutral Mass Spectrometer (INMS) sensor was simulated with three dimensional models of the open source, the quadrupole deflector, the exit lens system and the quadrupole mass analyzer to design more compact models with lower weight. Comparison of calculated transmission with experimental results shows good agreement. Transmission analyses with varying geometrical parameters and voltages throw light on possible ways of reducing the size of the sensor. Trajectories of ions of mass 1-99 amu were simulated to analyze and optimize transmission. Analysis of open source transmission with varying angle of attack shows that the angular acceptance can be considerably increased by programming the voltages on the ion trap/ collimator. Analysis of transmission sensitivity to voltages and misalignments of the quadrupole deflector rods indicate that increased transmission is possible with a geometrically asymmetrical deflector and a deflector can be designed with much lower sensitivities of transmission. Bringing the disks closer together can decrease the size of the quadrupole deflector and also increase transmission. The exit lens system can be redesigned to be smaller by eliminating at least one electrode entirely without loss of transmission. Ceramic materials were investigated to find suitable candidates for use in the construction of lighter weight mass spectrometer. A high-sensitivity, high-resolution portable gas chromatograph mass spectrometer with a mass range of 2-700 amu has been built and will be commercialized in Phase 3

Simulations of the Origin and Fate of the Galactic Center Cloud G2

We investigate the origin and fate of the recently discovered gas cloud G2 close to the Galactic Center. Our hydrodynamical simulations focussing on the dynamical evolution of the cloud in combination with currently available observations favor two scenarios: a Compact Cloud which started around the year 1995 and a Spherical Shell of gas, with an apocenter distance within the disk(s) of young stars and a radius of a few times the size of the Compact Cloud. The former is able to explain the detected signal of G2 in the position-velocity diagram of the Br gamma emission of the year 2008.5 and 2011.5 data. The latter can account for both, G2's signal as well as the fainter extended tail-like structure G2t seen at larger distances from the black hole and smaller velocities. In contrast, gas stripped from a compact cloud by hydrodynamical interactions is not able to explain the location of the detected G2t emission in the observed position-velocity diagrams. This favors the Spherical Shell Scenario and might be a severe problem for the Compact Cloud as well as the so-called Compact Source Scenario. From these first idealized simulations we expect a roughly constant feeding of the supermassive black hole through a nozzle-like structure over a long period, starting shortly after the closest approach in 2013.51 for the Compact Cloud. If the matter accretes in the hot accretion mode, we do not expect a significant boost of the current activity of Sgr A* for the Compact Cloud model, but a boost of the average infrared and X-ray luminosity by roughly a factor of 80 for the Spherical Shell scenario with order of magnitude variations on a timescale of a few months. The near-future evolution of the cloud will be a sensitive probe of the conditions of the gas distribution in the milli-parsec environment of the massive black hole in the Galactic Center.Comment: 16 pages, 16 figures, accepted by Ap

Physics of the Galactic Center Cloud G2, on its Way towards the Super-Massive Black Hole

The origin, structure and evolution of the small gas cloud, G2, is investigated, that is on an orbit almost straight into the Galactic central supermassive black hole (SMBH). G2 is a sensitive probe of the hot accretion zone of Sgr A*, requiring gas temperatures and densities that agree well with models of captured shock-heated stellar winds. Its mass is equal to the critical mass below which cold clumps would be destroyed quickly by evaporation. Its mass is also constrained by the fact that at apocenter its sound crossing timescale was equal to its orbital timescale. Our numerical simulations show that the observed structure and evolution of G2 can be well reproduced if it formed in pressure equilibrium with the surrounding in 1995 at a distance from the SMBH of 7.6e16 cm. If the cloud would have formed at apocenter in the 'clockwise' stellar disk as expected from its orbit, it would be torn into a very elongated spaghetti-like filament by 2011 which is not observed. This problem can be solved if G2 is the head of a larger, shell-like structure that formed at apocenter. Our numerical simulations show that this scenario explains not only G2's observed kinematical and geometrical properties but also the Br_gamma observations of a low surface brightness gas tail that trails the cloud. In 2013, while passing the SMBH G2 will break up into a string of droplets that within the next 30 years mix with the surrounding hot gas and trigger cycles of AGN activity.Comment: 22 pages, 13 figures, submitted to Ap

Simulations of Direct Collisions of Gas Clouds with the Central Black Hole

We perform numerical simulations of clouds in the Galactic Centre (GC) engulfing the nuclear super-massive black hole and show that this mechanism leads to the formation of gaseous accretion discs with properties that are similar to the expected gaseous progenitor discs that fragmented into the observed stellar disc in the GC. As soon as the cloud hits the black hole, gas with opposite angular momentum relative to the black hole collides downstream. This process leads to redistribution of angular momentum and dissipation of kinetic energy, resulting in a compact gaseous accretion disc. A parameter study using thirteen high resolution simulations of homogeneous clouds falling onto the black hole and engulfing it in parts demonstrates that this mechanism is able to produce gaseous accretion discs that could potentially be the progenitor of the observed stellar disc in the GC. A comparison of simulations with different equations of state (adiabatic, isothermal and full cooling) demonstrates the importance of including a detailed thermodynamical description. However the simple isothermal approach already yields good results on the radial mass transfer and accretion rates, as well as disc eccentricities and sizes. We find that the cloud impact parameter strongly influences the accretion rate whereas the impact velocity has a small affect on the accretion rate.Comment: 21 pages, 18 figures, Accepted for publication in MNRA

Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

PURPOSE This pilot study aimed on generating insight on alterations in circulating immune cells during the use of FOLFIRINOX and gemcitabine/nab-paclitaxel in pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND METHODS Peripheral blood mononuclear cells were isolated before and 30~days after initiation of chemotherapy from 20 patients with advanced PDAC. Regulatory T cells (FoxP3+) and immune checkpoints (PD-1 and TIM-3) were analyzed by flow cytometry and immunological changes were correlated with clinical outcome. RESULTS Heterogeneous changes during chemotherapy were observed in circulating T-cell subpopulations with a pronounced effect on PD-1+ CD4+/CD8+ T cells. An increase in FoxP3+ or PD-1+ T cells had no significant effect on survival. An increase in TIM3+/CD8+ (but not TIM3+/CD4+) T cells was associated with a significant inferior outcome: median progression-free survival in the subgroup with an increase of TIM-3+/CD8+ T cells was 6.0 compared to 14.0~months in patients with a decrease/no change (p = 0.026); corresponding median overall survival was 13.0 and 20.0~months (p = 0.011), respectively. CONCLUSIONS Chemotherapy with FOLFIRNOX or gemcitabine/nab-paclitaxel induces variable changes in circulating T-cell populations that may provide prognostic information in PDAC

Probing dispersion and re-agglomeration phenomena upon melt-mixing of polymer-functionalized graphite nanoplates

A one-step melt-mixing method is proposed to study dispersion and re-agglomeration phenomena of the as-received and functionalized graphite nanoplates in polypropylene melts. Graphite nanoplates were chemically modified via 1,3-dipolar cycloaddition of an azomethine ylide and then grafted with polypropylene-graft-maleic anhydride. The effect of surface functionalization on the dispersion kinetics, nanoparticle re-agglomeration and interface bonding with the polymer is investigated. Nanocomposites with 2 or 10 wt% of as-received and functionalized graphite nanoplates were prepared in a small-scale prototype mixer coupled to a capillary rheometer. Samples were collected along the flow axis and characterized by optical microscopy, scanning electron microscopy and electrical conductivity measurements. The as-received graphite nanoplates tend to re-agglomerate upon stress relaxation of the polymer melt. The covalent attachment of a polymer to the nanoparticle surface enhances the stability of dispersion, delaying the re-agglomeration. Surface modification also improves interfacial interactions and the resulting composites presented improved electrical conductivity.The authors acknowledge the financial support to Project Matepro Optimizing Materials and Processes, with reference NORTE-07-0124-FEDER-000037 by the Programa Operacional Regional do Norte (ON.2) and Portuguese Foundation for the Science and Technology (FCT) for PEst-C/CTM/LA0025/2013. EC acknowledges FCT for a PhD grant SFRH/BD/87214/2012

Star Formation and Dynamics in the Galactic Centre

The centre of our Galaxy is one of the most studied and yet enigmatic places in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre (GC) is the ideal environment to study the extreme processes that take place in the vicinity of a supermassive black hole (SMBH). Despite the hostile environment, several tens of early-type stars populate the central parsec of our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The formation of such early-type stars has been a puzzle for a long time: molecular clouds should be tidally disrupted by the SMBH before they can fragment into stars. We review the main scenarios proposed to explain the formation and the dynamical evolution of the early-type stars in the GC. In particular, we discuss the most popular in situ scenarios (accretion disc fragmentation and molecular cloud disruption) and migration scenarios (star cluster inspiral and Hills mechanism). We focus on the most pressing challenges that must be faced to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A., 'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201