280 research outputs found
Thermal conductivity of amorphous polymers and its dependence on molecular weight
Thermal conductivity is an important transport property governing the performance of polymers in non-isothermal conditions. Nevertheless, its dependence on molecular weight M has not been the subject of as much attention as other properties of polymeric materials. We determine the thermal conductivity of polystyrene and polyisobutylene for a wide range of molecular weight by measuring the density, heat capacity and thermal diffusivity. Using coarse-graining and reverse mapping methods, we were able to produce molecular melts to study the thermal conductivity of polystyrene using molecular dynamics simulations over a similar range of molecular weight. We find satisfactory agreement between the experimental and simulation results. However, all of our results show that thermal conductivity depends only slightly on molecular weight up the entanglement limit and it is independent thereafter. Our results put into question the few previous experimental studies on this topic by showing that the previously accepted proportionality to does not hold. Our findings could have significant implications for the understanding of complex phenomena such as anisotropic thermal conductivity in polymers subjected to flow.Marie Skłodowska-Curie IF MTCIATTP 750985
Energetic Particle Observations and Propagation in the Three-Dimensional Heliosphere During the 2006 December Events
We report observations of solar energetic particles obtained by the HI-SCALE and COSPIN/LET instruments onboard Ulysses during the period of isolated but intense solar activity in 2006 December, in the declining phase of the solar activity cycle. We present measurements of particle intensities and also discuss observations of particle anisotropies and composition in selected energy ranges. Active Region 10930 produced a series of major solar flares with the strongest one (X9.0) recorded on December 5 after it rotated into view on the solar east limb. Located over the South Pole of the Sun, at >72°S heliographic latitude and 2.8 AU radial distance, Ulysses provided unique measurements for assessing the nature of particle propagation to high latitudes under near-minimum solar activity conditions, in a relatively undisturbed heliosphere. The observations seem to exclude the possibility that magnetic field lines originating at low latitudes reached Ulysses, suggesting either that the energetic particles observed as large solar energetic particle (SEP) events over the South Pole of the Sun in 2006 December were released when propagating coronal waves reached high-latitude field lines connected to Ulysses, or underwent perpendicular diffusion. We also discuss comparisons with energetic particle data acquired by the STEREO and Advanced Composition Explorer in the ecliptic plane near 1 AU during this period
Simulation Analysis of Air Flow and Turbulence Statistics in a Rib Grit Roughened Duct
The implementation of variable artificial roughness patterns on a surface is an effective technique to enhance the rate of heat transfer to fluid flow in the ducts of solar air heaters. Different geometries of roughness elements investigated have demonstrated the pivotal role that vortices and associated turbulence have on the heat transfer characteristics of solar air heater ducts by increasing the convective heat transfer coefficient. In this paper we investigate the two-dimensional, turbulent, unsteady flow around rectangular ribs of variable aspect ratios by directly solving the transient Navier-Stokes and continuity equations using the finite elements method. Flow characteristics and several aspects of turbulent flow are presented and discussed including velocity components and statistics of turbulence. The results reveal the impact that different rib lengths have on the computed mean quantities and turbulence statistics of the flow. The computed turbulence parameters show a clear tendency to diminish downstream with increasing rib length. Furthermore, the applied numerical method is capable of capturing small-scale flow structures resulting from the direct solution of Navier-Stokes and continuity equations
Inter-familial and intra-familial phenotypic variability in three Sicilian families with Anderson-Fabry disease.
Abstract
BACKGROUND:
Anderson-Fabry disease (AFD) is an inborn lysosomal enzymopathy resulting from the deficient or absent activity of the lysosomal exogalactohydrolase, α-galactosidase A. This deficiency, results in the altered metabolism of glycosphingolipids which leads to their accumulation in lysosomes, thus to cellular and vascular dysfunction. To date, numerous mutations (according to recent data more than 1000 mutations) have been reported in the GLA intronic and exonic mutations. Traditionally, clinical manifestations are more severe in affected hemizygous males than in females. Nevertheless, recent studies have described severe organ dysfunction in women.
THE AIM OF THE STUDY:
This study reports clinical, biochemical, and molecular findings of the members of three Sicilian families. The clinical history of these patients highlights a remarkable interfamilial and intrafamilial phenotypic variability which characterizes Fabry disease relative to target organs and severity of clinical manifestations.
DISCUSSION:
Our findings, in agreement with previous data, report a little genotype-phenotype correlation for the disease, suggesting that the wide phenotypic variability of Anderson-Fabry disease is not completely ascribable to different gene mutations but other factors and mechanisms seem to be involved in the pathogenesis and clinical expression of the disease. Moreover, this study emphasies the importance of pedigree analysis in the family of each proband for identifying other possibly affected relatives
Comparative study of corrosion performance of HVOF-sprayed coatings produced using conventional and suspension WC-Co feedstock.
Corrosion properties of nanostructured coatings deposited by suspension high-velocity oxy-fuel (S-HVOF) via an aqueous suspension of milled WC-Co powder were compared with conventional HVOF-sprayed coatings. Microstructural evaluations of these coatings included x-ray diffraction and scanning electron microscopy equipped with an energy-dispersive x-ray spectroscopy. The corrosion performance of AISI440C stainless steel substrate and the coatings was evaluated in a 3.5 wt.% NaCl aqueous solution at ~25 °C. The electrochemical properties of the samples were assessed experimentally, employing potentiodynamic polarization and electrochemical impedance spectroscopy. The potentiodynamic polarization results indicated that coatings produced by S-HVOF technique show lower corrosion resistance compared with the coatings produced by HVOF-JK (HVOF Jet Kote) and HVOF-JP (HVOF JP5000) techniques. Results are discussed in terms of corrosion mechanism, Bode and Nyquist plots, as well as equivalent circuit models of the coating–substrate system
ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly
It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of the laboratory-based science, clinical trials and qualitative research that were presented during the 2022 European Respiratory Society International Congress within the sessions from the five groups of Assembly 1 (Respiratory Clinical Care and Physiology). Selected presentations are summarised from a wide range of topics: clinical problems, rehabilitation and chronic care, general practice and primary care, mobile/electronic health (m-health/e-health), clinical respiratory physiology, exercise and functional imaging
Physical activity is increased by a 12 week semi-automated telecoaching program in patients with COPD, a multicenter randomized controlled trial
Rationale
Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group.
Objectives
To investigate the effectiveness of a 12 week semi-automated telecoaching intervention on PA in COPD patients in a multicenter European RCT.
Methods
343 patients from 6 centers, encompassing a widespectrum of disease severity, were randomly allocated to either a usual care group (UCG) or a telecoaching intervention group (IG) between June and December 2014. This 12 weeks intervention included an exercise booklet and a step counter providing feedback both directly and via a dedicated smartphone application. The latter provided an individualized daily activity goal (steps) revised weekly and text messages as well as allowing occasional telephone contacts with investigators. Physical activity was measured using accelerometry during 1 week preceding randomization and during week 12. Secondary outcomes included exercise capacity and health status. Analyses were based on modified intention-to-treat.
Main results
Both groups were comparable at baseline in terms of factors influencing PA. At 12 weeks, the intervention yielded a between group difference of mean, 95% CI [ll-ul] +1469, 95% CI [971 – 1965] steps.day-1 and +10.4, 95% CI [6.1 - 14.7] min.day-1 moderate physical activity; favoring the IG (all p≤0.001). The change in six minute walk distance was significantly different (13.4, 95% CI [3.40 - 23.5]m, p<0.01), favoring the IG. In IG patients an improvement could be observed in the functional state domain of the CCQ (p=0.03), when compared to UCG. Other health status outcomes did not differ.
Conclusions
The amount and intensity of PA can be significantly increased in COPD patients using a 12 week semi-automated telecoaching intervention including a step counter and an application installed on a smartphone.
Trial registration
NCT02158065 (clinicaltrials.gov
The major geoeffective solar eruptions of 2012 March 7: comprehensive Sun-to-Earth analysis
During the interval 2012 March 7-11 the geospace experienced a barrage of intense space weather phenomena including the second largest geomagnetic storm of solar cycle 24 so far. Significant ultra-low-frequency wave enhancements and relativistic-electron dropouts in the radiation belts, as well as strong energetic-electron injection events in the magnetosphere were observed. These phenomena were ultimately associated with two ultra-fast (>2000 kms-1) coronal mass ejections (CMEs), linked to two X-class flares launched on early 2012 March 7. Given that both powerful events originated from solar active region NOAA 11429 and their onsets were separated by less than an hour, the analysis of the two events and the determination of solar causes and geospace effects are rather challenging. Using satellite data from a flotilla of solar, heliospheric and magnetospheric missions a synergistic Sun-to-Earth study of diverse observational solar, interplanetary and magnetospheric data sets was performed. It was found that only the second CME was Earth-directed. Using a novel method, we estimated its near-Sun magnetic field at 13R⊙ to be in the range [0.01, 0.16] G. Steep radial fall-offs of the near-Sun CME magnetic field are required to match the magnetic fields of the corresponding interplanetary CME (ICME) at 1 AU. Perturbed upstream solar-wind conditions, as resulting from the shock associated with the Earth-directed CME, offer a decent description of its kinematics. The magnetospheric compression caused by the arrival at 1 AU of the shock associated with the ICME was a key factor for radiation-belt dynamics.Publisher PDFPeer reviewe
Physical Activity Characteristics across GOLD Quadrants Depend on the Questionnaire Used
BACKGROUND:The GOLD multidimensional classification of COPD severity combines the exacerbation risk with the symptom experience, for which 3 different questionnaires are permitted. This study investigated differences in physical activity (PA) in the different GOLD quadrants and patient's distribution in relation to the questionnaire used. METHODS:136 COPD patients (58±21% FEV1 predicted, 34F/102M) completed COPD assessment test (CAT), clinical COPD questionnaire (CCQ) and modified Medical Research Council (mMRC) questionnaire. Exacerbation history, spirometry and 6MWD were collected. PA was objectively measured for 2 periods of 1 week, 6 months apart, in 5 European centres; to minimise seasonal and clinical variation the average of these two periods was used for analysis. RESULTS:GOLD quadrants C+D had reduced PA compared with A+B (3824 [2976] vs. 5508 [4671] steps.d-1, p<0.0001). The choice of questionnaire yielded different patient distributions (agreement mMRC-CAT κ = 0.57; CCQ-mMRC κ = 0.71; CCQ-CAT κ = 0.72) with different clinical characteristics. PA was notably lower in patients with an mMRC score ≥2 (3430 [2537] vs. 5443 [3776] steps.d-1, p <0.001) in both the low and high risk quadrants. CONCLUSIONS:Using different questionnaires changes the patient distribution and results in different clinical characteristics. Therefore, standardization of the questionnaire used for classification is critical to allow comparison of different studies using this as an entry criterion. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov NCT01388218
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