Carbon fiber plume sampling for large scale fire tests at Dugway Proving Ground

Carbon fiber sampling instruments were developed: passive collectors made of sticky bridal veil mesh, and active instruments using a light emitting diode (LED) source. These instruments measured the number or number rate of carbon fibers released from carbon/graphite composite material when the material was burned in a 10.7 m (35 ft) dia JP-4 pool fire for approximately 20 minutes. The instruments were placed in an array suspended from a 305 m by 305 m (1000 ft by 1000 ft) Jacob's Ladder net held vertically aloft by balloons and oriented crosswind approximately 140 meters downwind of the pool fire. Three tests were conducted during which released carbon fiber data were acquired. These data were reduced and analyzed to obtain the characteristics of the released fibers including their spatial and size distributions and estimates of the number and total mass of fibers released. The results of the data analyses showed that 2.5 to 3.5 x 10 to the 8th power single carbon fibers were released during the 20 minute burn of 30 to 50 kg mass of initial, unburned carbon fiber material. The mass released as single carbon fibers was estimated to be between 0.1 and 0.2% of the initial, unburned fiber mass

Beyond the Death of Linear Response: 1/f optimal information transport

Non-ergodic renewal processes have recently been shown by several authors to be insensitive to periodic perturbations, thereby apparently sanctioning the death of linear response, a building block of nonequilibrium statistical physics. We show that it is possible to go beyond the ``death of linear response" and establish a permanent correlation between an external stimulus and the response of a complex network generating non-ergodic renewal processes, by taking as stimulus a similar non-ergodic process. The ideal condition of 1/f-noise corresponds to a singularity that is expected to be relevant in several experimental conditions.Comment: 4 pages, 2 figures, 1 table, in press on Phys. Rev. Let

Airborne Transmission of SARS-CoV-2: The Contrast between Indoors and Outdoors

COVID-19 is an airborne disease, with the vast majority of infections occurring indoors. In comparison, little transmission occurs outdoors. Here, we investigate the airborne transmission pathways that differentiate the indoors from outdoors and conclude that profound differences exist, which help to explain why SARS-CoV-2 transmission is much more prevalent indoors. Near- and far-field transmission pathways are discussed along with factors that affect infection risk, with aerosol concentration, air entrainment, thermal plumes, and occupancy duration all identified as being influential. In particular, we present the fundamental equations that underpin the Wells–Riley model and show the mathematical relationship between inhaled virus particles and quanta of infection. A simple model is also presented for assessing infection risk in spaces with incomplete air mixing. Transmission risk is assessed in terms of aerosol concentration using simple 1D equations, followed by a description of thermal plume–ceiling interactions. With respect to this, we present new experimental results using Schlieren visualisation and computational fluid dynamics (CFD) based on the Eulerian–Lagrangian approach. Pathways of airborne infection are discussed, with the key differences identified between indoors and outdoors. In particular, the contribution of thermal and exhalation plumes is evaluated, and the presence of a near-field/far-field feedback loop is postulated, which is absent outdoors

Is trunk strength associated with functional mobility in older women?

BACKGROUND AND AIM:Age-related declines in muscle strength have been associated with reduced functional capacity, postural instability and increased risk of falls in older adults. Studies have generally focussed on the significance of lower limb strength, however more recently the importance of trunk muscle strength has been explored, which may have been previously overlooked (Granacher et al., 2013). A limited number of studies have investigated the relationship between trunk strength and function, but this was tested under isometric contractions(Shahtahmassebi et al., 2017). Therefore, the purpose of this study was to investigate the relationship between dynamic (concentric) trunk strength and functional mobility in older women. METHODS:A sample of 40 older women (age: 68.9±3.73 years) participated in this study. To assess functional mobility, participants completed the timed up and go (TUG), 30 second chair stand test (CST), and a timed stair climb task (ascent and descent). Both self-selected normal and fast gait speed (GS) were also recorded. Concentric trunk flexion and extension strength data were collected using an isokinetic dynamometer (Biodex, USA). Measurements were conducted in the seated-compressed position in line with the manufacturer's guidelines. Following five sub-maximal trials, peak torque was recorded during three maximal flexion and extension trials at two testing speeds (20°/s and 45°/s). Peak torque was then normalised to body mass. Pearson's correlations were performed to investigate relationships between trunk strength and functional mobility measures. The level of significance was set at p≤0.05. RESULTS:A number of associations between trunk strength and functional mobility measures were revealed. Greater trunk extension strength was correlated with superior performance in the CST (45°/s: r=0.33, p=0.037), stair ascent (20°/s: r=-0.32, p=0.043; 45°/s: r=-0.56, p=<.001) and stair descent tasks (45°/s: r=-0.47, p=0.002). Trunk extension strength was also associated with GS during normal (20°/s: r=0.37, p=0.019; 45°/s: r=0.48, p=0.004) and fast trials (45°/s: r=0.34, p=0.034). Trunk flexion strength was correlated with TUG (45°/s: r=-0.42, p=0.007), stair ascent (20°/s: r=-0.41, p=0.008; 45°/s: r=-0.47, p=0.002) and stair descent times (20°/s: r=-0.44, p=0.005; 45°/s: r=-0.42, p=0.007). Trunk flexion strength was also associated with normal (20°/s: r=0.55, p=<.001; 45°/s: r=0.56, p=<.001) and fast GS (20°/s: r=0.32, p=0.047; 45°/s: r=0.34, p=0.031). CONCLUSIONS: These findings suggest that there is a moderate-strong relationship between muscle strength in the trunk area and a range of functional mobility measures in older women. These results have important practical implications which could be used to inform the inclusion of trunk exercises in interventions targeting functional mobility for older adults

Near-infrared spectroscopic cathodoluminescence imaging polarimetry on silicon photonic crystal waveguides

We measure polarization- and wavelength-resolved spectra and spatial emission intensity distributions from silicon photonic crystal waveguides in the near-infrared spectral range using spectroscopic cathodoluminescence imaging polarimetry. A 30 keV electron beam, incident along the surface normal of the sample, acts as an ultrabroadband and deeply subwavelength excitation source. For photonic crystal waveguides with a broad range of design parameters, we observe a dominant emission intensity distribution that is strongly confined to the waveguide. For a period of 420 nm and a hole radius of 120 nm, this occurs at a wavelength of 1425 nm. The polarization-resolved measurements demonstrate that this feature is fully linearly polarized along the waveguide axis. Comparing the modal pattern and polarization to calculations of the electric field profiles confirms that we measure the odd TE waveguide mode of the system. This result demonstrates that the electron beam can couple to modes dominated by in-plane field components in addition to the more commonly observed modes dominated by out-of-plane field components. From the emission directionality, we conclude that we sample a leaky portion of the odd waveguide mode

Scaling law for the transient behavior of type-II neuron models

We study the transient regime of type-II biophysical neuron models and determine the scaling behavior of relaxation times $\tau$ near but below the repetitive firing critical current, $\tau \simeq C (I_c-I)^{-\Delta}$. For both the Hodgkin-Huxley and Morris-Lecar models we find that the critical exponent is independent of the numerical integration time step and that both systems belong to the same universality class, with $\Delta = 1/2$. For appropriately chosen parameters, the FitzHugh-Nagumo model presents the same generic transient behavior, but the critical region is significantly smaller. We propose an experiment that may reveal nontrivial critical exponents in the squid axon.Comment: 6 pages, 9 figures, accepted for publication in Phys. Rev.

Alternative job search strategies in remote rural and peri-urban labour markets: the role of social networks

This paper examines the importance of informal methods (especially social networking) to the job search strategies used by unemployed people. It compares three areas: a small rural town; a larger, more sparsely populated, remote rural area; and a centrally-located, peri-urban labour market. The analysis is based first on survey research undertaken with 490 job seekers across the study areas. Emerging issues were then followed up during a series of twelve focus groups. The survey research showed that job seekers in the rural study areas were significantly more likely to use social networks to look for work. However, those who had experienced repeated or long-term periods out of work, the unskilled and young people were significantly less likely to use such networks. Focus groups confirmed the perceived importance of social networking to the job search process in rural areas, in contrast to the more marginal role such methods appear to play in peri-urban settings. For many rural job seekers, formal job search activities conducted through Jobcentres were seen as largely symbolic, lacking the practical value of social networking. These results suggest that service providers seeking to assist unemployed people in rural areas need to address the problems faced by many disadvantaged job seekers who are currently caught between their lack of social network relations and the absence of local public employment service facilities in more remote communities

The detection of airborne transmission of tuberculosis from HIV-infected patients, using an in vivo air sampling model

Background. Nosocomial transmission of tuberculosis remains an important public health problem. We created an in vivo air sampling model to study airborne transmission of tuberculosis from patients coinfected with human immunodeficiency virus (HIV) and to evaluate environmental control measures. Methods. An animal facility was built above a mechanically ventilated HIV‐tuberculosis ward in Lima, Peru. A mean of 92 guinea pigs were continuously exposed to all ward exhaust air for 16 months. Animals had tuberculin skin tests performed at monthly intervals, and those with positive reactions were removed for autopsy and culture for tuberculosis. Results. Over 505 consecutive days, there were 118 ward admissions by 97 patients with pulmonary tuberculosis, with a median duration of hospitalization of 11 days. All patients were infected with HIV and constituted a heterogeneous group with both new and existing diagnoses of tuberculosis. There was a wide variation in monthly rates of guinea pigs developing positive tuberculin test results (0%–53%). Of 292 animals exposed to ward air, 159 developed positive tuberculin skin test results, of which 129 had laboratory confirmation of tuberculosis. The HIV‐positive patients with pulmonary tuberculosis produced a mean of 8.2 infectious quanta per hour, compared with 1.25 for HIV‐negative patients with tuberculosis in similar studies from the 1950s. The mean monthly patient infectiousness varied greatly, from production of 0–44 infectious quanta per hour, as did the theoretical risk for a health care worker to acquire tuberculosis by breathing ward air. Conclusions. HIV‐positive patients with tuberculosis varied greatly in their infectiousness, and some were highly infectious. Use of environmental control strategies for nosocomial tuberculosis is therefore a priority, especially in areas with a high prevalence of both tuberculosis and HIV infection

Dagger Categories of Tame Relations

Within the context of an involutive monoidal category the notion of a comparison relation is identified. Instances are equality on sets, inequality on posets, orthogonality on orthomodular lattices, non-empty intersection on powersets, and inner product on vector or Hilbert spaces. Associated with a collection of such (symmetric) comparison relations a dagger category is defined with "tame" relations as morphisms. Examples include familiar categories in the foundations of quantum mechanics, such as sets with partial injections, or with locally bifinite relations, or with formal distributions between them, or Hilbert spaces with bounded (continuous) linear maps. Of one particular example of such a dagger category of tame relations, involving sets and bifinite multirelations between them, the categorical structure is investigated in some detail. It turns out to involve symmetric monoidal dagger structure, with biproducts, and dagger kernels. This category may form an appropriate universe for discrete quantum computations, just like Hilbert spaces form a universe for continuous computation

NCAM140 Interacts with the Focal Adhesion Kinase p125 fak and the SRC-related Tyrosine Kinase p59 fyn

Axonal growth cones respond to adhesion molecules and extracellular matrix components by rapid morphological changes and growth rate modification. Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this interaction has not been defined. The NCAM140 isoform, which is found in migrating growth cones, selectively co-immunoprecipitated with p59(fyn) from nonionic detergent (Brij 96) extracts of early postnatal mouse cerebellum and transfected rat B35 neuroblastoma and COS-7 cells. p59(fyn) did not associate significantly with the NCAM180 isoform, which is found at sites of stable neural cell contacts, or with the glycophosphatidylinositol-linked NCAM120 isoform. pp60(c-)src, a tyrosine kinase that promotes neurite growth on the neuronal cell adhesion molecule L1, did not interact with any NCAM isoform. Whereas p59(fyn) was constitutively associated with NCAM140, the focal adhesion kinase p125(fak), a nonreceptor tyrosine kinase known to mediate integrin-dependent signaling, became recruited to the NCAM140-p59(fyn) complex when cells were reacted with antibodies against the extracellular region of NCAM. Treatment of cells with a soluble NCAM fusion protein or with NCAM antibodies caused a rapid and transient increase in tyrosine phosphorylation of p125(fak) and p59(fyn). These results suggest that NCAM140 binding interactions at the cell surface induce the assembly of a molecular complex of NCAM140, p125(fak), and p59(fyn) and activate the catalytic function of these tyrosine kinases, initiating a signaling cascade that may modulate growth cone migration