7,766 research outputs found
Derivation of the Planck Spectrum for Relativistic Classical Scalar Radiation from Thermal Equilibrium in an Accelerating Frame
The Planck spectrum of thermal scalar radiation is derived suggestively
within classical physics by the use of an accelerating coordinate frame. The
derivation has an analogue in Boltzmann's derivation of the Maxwell velocity
distribution for thermal particle velocities by considering the thermal
equilibrium of noninteracting particles in a uniform gravitational field. For
the case of radiation, the gravitational field is provided by the acceleration
of a Rindler frame through Minkowski spacetime. Classical zero-point radiation
and relativistic physics enter in an essential way in the derivation which is
based upon the behavior of free radiation fields and the assumption that the
field correlation functions contain but a single correlation time in thermal
equilibrium. The work has connections with the thermal effects of acceleration
found in relativistic quantum field theory.Comment: 23 page
Brownian Entanglement
We show that for two classical brownian particles there exists an analog of
continuous-variable quantum entanglement: The common probability distribution
of the two coordinates and the corresponding coarse-grained velocities cannot
be prepared via mixing of any factorized distributions referring to the two
particles in separate. This is possible for particles which interacted in the
past, but do not interact in the present. Three factors are crucial for the
effect: 1) separation of time-scales of coordinate and momentum which motivates
the definition of coarse-grained velocities; 2) the resulting uncertainty
relations between the coordinate of the brownian particle and the change of its
coarse-grained velocity; 3) the fact that the coarse-grained velocity, though
pertaining to a single brownian particle, is defined on a common context of two
particles. The brownian entanglement is a consequence of a coarse-grained
description and disappears for a finer resolution of the brownian motion. We
discuss possibilities of its experimental realizations in examples of
macroscopic brownian motion.Comment: 18 pages, no figure
Developing a Business Case for the Care Coordination and Transition Management Model: Need, Metrics, and Measures
In this descriptive qualitative study, nurse and healthcare leaders\u27 experiences, perceptions of care coordination and transition management (CCTM®), and insights as to how to foster adoption of the CCTM RN role in nursing education, practice across the continuum, and policy were explored. Twenty-five barriers to recognition and adoption of CCTM RN practice across the continuum were identified and categorized. Implications of these findings, recommendations for adoption of CCTM RN practice across the care continuum, and strategies for reimbursement policies are discussed
Bringing Earth-Abundant Plasmonic Catalysis to Light : Gram-Scale Mechanochemical Synthesis and Tuning of Activity by Dual Excitation of Antenna and Reactor Sites
The localized surface plasmon resonance (LSPR) excitation in plasmonic nanoparticles (NPs) in the visible and near-infrared ranges is currently at the forefront of improving photocatalytic performances via plasmonic photocatalysis. One bottleneck of this field is that the NPs that often display the best optical properties in the visible and near-infrared ranges are based on expensive noble metals such as silver (Ag) and gold (Au). While earth-abundant plasmonic materials have been proposed together with catalytic metals in antenna-reactor systems, their performances remain limited by their optical properties. Importantly, the synthesis of plasmonic photocatalysts remains challenging in terms of scalability while often requiring several steps, high temperatures, and special conditions. Herein, we address these challenges by developing a one-pot, gram-scale, room-temperature synthesis of earth-abundant plasmonic photocatalysts while improving their activities beyond what has been dictated by the LSPR excitation of the plasmonic component. We describe the mechanochemical synthesis of earth-abundant plasmonic photocatalysts by using MoO3 (antenna) and Au (reactor) NPs as a proof-of-concept example and demonstrate that the dual plasmonic excitation of antenna and reactor sites enables the tuning of plasmonic photocatalytic performances toward the reductive coupling of nitrobenzene to azobenzene as a model reaction. In addition to providing a pathway to the facile and gramscale synthesis of plasmonic photocatalysts, the results reported herein may open pathways to improved activities in plasmonic catalysis.Peer reviewe
Dna methylation changes in fibromyalgia suggest the role of the immune‐inflammatory response and central sensitization
Fibromyalgia (FM) has been explained as a result of gene‐environment interactions. The present study aims to verify DNA methylation differences in eleven candidate genome regions previously associated to FM, evaluating DNA methylation patterns as potential disease biomarkers. DNA methylation was analyzed through bisulfite sequencing, comparing 42 FM women and their 42 healthy sisters. The associations between the level of methylation in these regions were further explored through a network analysis. Lastly, a logistic regression model investigated the regions potentially associated with FM, when controlling for sociodemographic variables and depressive symptoms. The analysis highlighted significant differences in the GCSAML region methylation between patients and controls. Moreover, seventeen single CpGs, belonging to other genes, were significantly different, however, only one cytosine related to GCSAML survived the correction for multiple comparisons. The network structure of methylation sites was different for each group; GRM2 methylation represented a central node only for FM patients. Logistic regression revealed that depressive symptoms and DNA methylation in the GRM2 region were significantly associated with FM risk. Our study encourages better exploration of GCSAML and GRM2 functions and their possible role in FM affecting immune, inflammatory response, and central sensitization of pain
Simulating Hard Rigid Bodies
Several physical systems in condensed matter have been modeled approximating
their constituent particles as hard objects. The hard spheres model has been
indeed one of the cornerstones of the computational and theoretical description
in condensed matter. The next level of description is to consider particles as
rigid objects of generic shape, which would enrich the possible phenomenology
enormously. This kind of modeling will prove to be interesting in all those
situations in which steric effects play a relevant role. These include biology,
soft matter, granular materials and molecular systems. With a view to
developing a general recipe for event-driven Molecular Dynamics simulations of
hard rigid bodies, two algorithms for calculating the distance between two
convex hard rigid bodies and the contact time of two colliding hard rigid
bodies solving a non-linear set of equations will be described. Building on
these two methods, an event-driven molecular dynamics algorithm for simulating
systems of convex hard rigid bodies will be developed and illustrated in
details. In order to optimize the collision detection between very elongated
hard rigid bodies, a novel nearest-neighbor list method based on an oriented
bounding box will be introduced and fully explained. Efficiency and performance
of the new algorithm proposed will be extensively tested for uniaxial hard
ellipsoids and superquadrics. Finally applications in various scientific fields
will be reported and discussed.Comment: 36 pages, 17 figure
Schroedingers equation with gauge coupling derived from a continuity equation
We consider a statistical ensemble of particles of mass m, which can be
described by a probability density \rho and a probability current \vec{j} of
the form \rho \nabla S/m. The continuity equation for \rho and \vec{j} implies
a first differential equation for the basic variables \rho and S. We further
assume that this system may be described by a linear differential equation for
a complex state variable \chi. Using this assumptions and the simplest possible
Ansatz \chi(\rho,S) Schroedingers equation for a particle of mass m in an
external potential V(q,t) is deduced. All calculations are performed for a
single spatial dimension (variable q) Using a second Ansatz \chi(\rho,S,q,t)
which allows for an explict q,t-dependence of \chi, one obtains a generalized
Schroedinger equation with an unusual external influence described by a
time-dependent Planck constant. All other modifications of Schroeodingers
equation obtained within this Ansatz may be eliminated by means of a gauge
transformation. Thus, this second Ansatz may be considered as a generalized
gauging procedure. Finally, making a third Ansatz, which allows for an
non-unique external q,t-dependence of \chi, one obtains Schroedingers equation
with electromagnetic potentials \vec{A}, \phi in the familiar gauge coupling
form. A possible source of the non-uniqueness is pointed out.Comment: 25 pages, no figure
Structure of \u3ci\u3eClostridium difficile\u3c/i\u3e PilJ Exhibits Unprecedented Divergence from Known Type IV Pilins
Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, cellular adhesion, and colonization. Recently, there has been an increased appreciation of the ability of Gram-positive species, including Clostridium difficile, to produce Type IV pili. Here we report the first three-dimensional structure of a Grampositive Type IV pilin, PilJ, demonstrate its incorporation into Type IV pili, and offer insights into how the Type IV pili of C. difficile may assemble and function. PilJ has several unique structural features, including a dual-pilin fold and the incorporation of a structural zinc ion. We show that PilJ is incorporated into Type IV pili in C. difficile and present a model in which the incorporation of PilJ into pili exposes the C-terminal domain of PilJ to create a novel interaction surface
Structural and Evolutionary Analyses Show Unique Stabilization Strategies in the Type IV Pili of Clostridium difficile
Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, biofilm formation, cellular adhesion and horizontal gene transfer. However, many Gram-positive species, including C. difficile, also produce Type IV pili. Here, we identify the major subunit of the Type IV pili of C. difficile, PilA1, and describe multiple three-dimensional structures of PilA1, demonstrating the diversity found in three strains of C. difficile. We also model the incorporation of both PilA1 and a minor pilin, PilJ, into the pilus fiber. Although PilA1 contains no cysteine residues, and therefore cannot form the disulfide bonds found in all Gram-negative Type IV pilins, it adopts unique strategies to achieve a typical pilin fold. The structures of PilA1 and PilJ exhibit similarities with the Type IVb pilins from Gram-negative bacteria that suggest that the Type IV pili of C. difficile are involved in microcolony formation
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