Molecular dynamics simulations of the dipolar-induced formation of magnetic nanochains and nanorings

Iron, cobalt and nickel nanoparticles, grown in the gas phase, are known to arrange in chains and bracelet-like rings due to the long-range dipolar interaction between the ferromagnetic (or super-paramagnetic) particles. We investigate the dynamics and thermodynamics of such magnetic dipolar nanoparticles for low densities using molecular dynamics simulations and analyze the influence of temperature and external magnetic fields on two- and three-dimensional systems. The obtained phase diagrams can be understood by using simple energetic arguments.Comment: 6 pages, 6 figure

Low calcium levels in serum-free media maintain chondrocyte phenotype in monolayer culture and reduce chondrocyte aggregation in suspension culture

SummaryObjectiveExtracellular calcium influences chondrocyte differentiation and synthesis of extracellular matrix. Previously, calcium concentrations ranging from 0.1mM to 2mM have been used in vitro and these studies indicated that low calcium concentrations were generally favorable for chondrocyte culture. Our objective was to extend these findings to yet lower calcium concentrations and to comprehensively examine effects on morphology and phenotype in two culture systems.MethodsSerum-free media containing 1mM, 50μM or 15μM of calcium and a serum-containing medium were used to culture chondrocytes in suspension and in monolayer, at high and low inoculation density.ResultsIn monolayer, at low and high density, removing serum and decreasing calcium concentration decreased cell spreading and lowered collagen type I expression whereas collagen type II expression remained stable. In suspension, cells aggregated for all media tested; however, aggregates were smaller and looser in the absence of serum.ConclusionThe serum-free 50μM and 1mM calcium media provide good alternatives to classical media for monolayer culture since both growth and chondrocyte phenotype were maintained. In suspension culture, the serum-free 1mM calcium medium also possesses the beneficial properties of limiting aggregate size while maintaining growth and phenotype

Short term effects of irradiance on the growth of Pterocladiella capillacea (Gelidiales, Rhodophyta)

Pterocladiella capillacea has been economically exploited for agar extraction in the Azores for many years. Harvesting dropped to a full stop in the early 1990s due to a population collapse, but restarted in 2013. Since then it has been intensively harvested and overexploitation must be prevented, with both sustainable harvesting and effective cultivation practices. This study represents the first attempt to determine optimal conditions for P. capillacea production in the Azores, and evaluates its vegetative growth in two experiments using von Stosch’s medium designed to test entire thallus and tips portions response to different irradiances (30, 70 and 150 μmol photons m¯² s¯¹). The best relative growth rate (RGR) was recorded at 150 μmol photons m¯² s¯¹ for the entire thalli and tips after two-weeks and three-weeks, respectively, indicating that an acclimation period is necessary to assure the growth of this alga under experimental conditions. Higher RGR was obtained at higher irradiance (3.98 ± 2.10% fm day¯¹), but overall, growth rates were low or negative. Epiphytes were a serious problem towards the end of the entire thallus experiments, where Feldmannia irregularis proliferate at all irradiances. Future cultivation approaches complemented with other relevant environmental factors (e.g. pH, photoperiod, salinity), are recommended.FCT – Fundação para a Ciência e Tecnologia projects UID/BIA/00329/2013, 2015 - 2018 and UID/BIA/00329/2019, CIRN (Centro de Investigação de Recursos Naturais, University of the Azores), and CIIMAR (Interdisciplinary Centre of Marine and Environmental Research, Porto, Portugal). RFP was supported by a doctoral grant M3.1.2/F/024/2011, Fundo Regional para a Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Lepton jets from radiating dark matter

Journal of High Energy Physics 2015.7 (2015): 045 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)The idea that dark matter forms part of a larger dark sector is very intriguing, given the high degree of complexity of the visible sector. In this paper, we discuss lepton jets as a promising signature of an extended dark sector. As a simple toy model, we consider an O(GeV) DM fermion coupled to a new U(1)´ gauge boson (dark photon) with a mass of order GeV and kinetically mixed with the Standard Model photon. Dark matter production at the LHC in this model is typically accompanied by collinear radiation of dark photons whose decay products can form lepton jets. We analyze the dynamics of collinear dark photon emission both analytically and numerically. In particular, we derive the dark photon energy spectrum using recursive analytic expressions, using Monte Carlo simulations in Pythia, and using an inverse Mellin transform to obtain the spectrum from its moments. In the second part of the paper, we simulate the expected lepton jet signatures from radiating dark matter at the LHC, carefully taking into account the various dark photon decay modes and allowing for both prompt and displaced decays. Using these simulations, we recast two existing ATLAS lepton jet searches to significantly restrict the parameter space of extended dark sector models, and we compute the expected sensitivity of future LHC searchesJK and JL are supported by the German Research Foundation (DFG) under Grant No. KO 4820/1–1. PANM acknowledges partial support from the European Union FP7 ITN INVISIBLES (Marie Curie Actions, PITN-GA-2011-289442) and from the Spanish MINECO’s “Centro de Excelencia Severo Ochoa” Programme under grant SEV-2012-024

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe

Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host. To address this issue we have examined by immunohistochemistry (IHC) and Western blotting (WB) for the disease-associated form of the prion protein (PrPd), the brains of 23 sheep from five European countries, all of which were of the same ARQ/ARQ genotype. As a result of IHC examinations, sheep were distributed into five groups with different phenotypes and the groups were the same regardless of the scoring method used, ‘long’ or ‘short’ PrPd profiling. The groups made did not respond to the geographical origin of the cases and did not correlate with the vacuolar lesion profiles, which showed a high individual variability. Discriminatory IHC and WB methods coincided to detect a ‘CH1641-like’ case but otherwise correlated poorly in the classification of disease phenotypes. No other polymorphisms of the PRNP gene were found that could account for the pathological differences, except perhaps for a sheep from Spain with a mutation at codon 103 and a unique pathological phenotype. Preliminary evidence indicates that those different IHC phenotypes correlate with distinct biological properties on bioassay, suggesting that they are indicative of strain diversity. We therefore conclude that natural scrapie strains exist and that they can be revealed by detailed pathological examinations, which can be harmonized between laboratories to produce comparable results

Multi-Channel-Handel:eine kostenspezifische Betrachtung differenzierter Strategieoptionen der Handelsdistribution in einer Einkaufswelt mit multioptionalen Kundenpräferenzen

Der Autor greift die Frage auf, ob die verschiedenen Kanäle in einer Multi-Channel-Strategie komplett miteinander integriert betrieben werden sollten um mögliche Vorteile zu generieren oder ob eine möglichst den Kundenwünschen entsprechende Ausgestaltung der einzelnen Kanäle einer integrierten Ausgestaltung überlegen ist. Herr Buschmann rückt dabei insbesondere die distributiven Aspekte der Umsetzung in den Fokus, die bisher im Rahmen der existierenden Forschung verhältnismäßig geringe Beachtung fanden. Allerdings sind sie im Rahmen der Umsetzung vielfach der zentrale Kostentreiber. Zur Erarbeitung seiner Argumentation greift der Autor auf einen Mixed-Method-Ansatz zurück. Nach einer umfassenden Literaturanalyse aus der drei zentrale Ziele einer Multi-Channel-Strategie abgeleitet werden, werden anschließend die tatsächlichen Kundenpräferenzen den daraus resultierenden Kosten, insb. der Distribution, gegenübergestellt. Für seine Analyse fokussiert sich der Autor primär auf den Modehandel. Allerdings können die Erkenntnisse durchaus auf den Handel allgemein übertragen werden

Spectral averaging techniques for Jacobi matrices

Spectral averaging techniques for one-dimensional discrete Schroedinger operators are revisited and extended. In particular, simultaneous averaging over several parameters is discussed. Special focus is put on proving lower bounds on the density of the averaged spectral measures. These Wegner type estimates are used to analyze stability properties for the spectral types of Jacobi matrices under local perturbations

Step-wise development of resilient ambient campus scenarios

This paper puts forward a new approach to developing resilient ambient applications. In its core is a novel rigorous development method supported by a formal theory that enables us to produce a well-structured step-wise design and to ensure disciplined integration of error recovery measures into the resulting implementation. The development method, called AgentB, uses the idea of modelling database to support a coherent development of and reasoning about several model views, including the variable, event, role, agent and protocol views. This helps system developers in separating various modelling concerns and makes it easier for future tool developers to design a toolset supporting this development. Fault tolerance is systematically introduced during the development of various model views. The approach is demonstrated through the development of several application scenarios within an ambient campus case study conducted at Newcastle University (UK) as part of the FP6 RODIN project. © 2009 Springer Berlin Heidelberg