18 research outputs found

    Strengthening and stretching for rheumatoid arthritis of the hand (SARAH). A randomised controlled trial and economic evaluation

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    Study registration: Current Controlled Trials ISRCTN 89936343.Background - The effectiveness of exercise for improving hand and wrist function in people with rheumatoid arthritis (RA) is uncertain. Objectives - The study aims were (1) to estimate the clinical effectiveness and cost-effectiveness of adding an optimised exercise programme for hands and upper limbs to standard care for patients with RA; and (2) to qualitatively describe the experience of participants in the trial with a particular emphasis on acceptability of the intervention, exercise behaviours and reasons for adherence/non-adherence.This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 19, No. 19. See the NIHR Journals Library website for further project information. This report has been developed in association with the NIHR Collaboration for Leadership in Applied Health Research and Care Oxford and the NIHR Biomedical Research Unit Funding Scheme. This project benefited from facilities funded through Birmingham Science City Translational Medicine Clinical Research and Infrastructure Trials Platform, with support from Advantage West Midlands

    Strengthening and stretching for rheumatoid arthritis of the hand (SARAH):Design of a randomised controlled trial of a hand and upper limb exercise intervention-ISRCTN89936343

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    Background: Rheumatoid Arthritis (RA) commonly affects the hands and wrists with inflammation, deformity, pain, weakness and restricted mobility leading to reduced function. The effectiveness of exercise for RA hands is uncertain, although evidence from small scale studies is promising. The Strengthening And Stretching for Rheumatoid Arthritis of the Hand (SARAH) trial is a pragmatic, multi-centre randomised controlled trial evaluating the clinical and cost effectiveness of adding an optimised exercise programme for hands and upper limbs to best practice usual care for patients with RA.Methods/design: 480 participants with problematic RA hands will be recruited through 17 NHS trusts. Treatments will be provided by physiotherapists and occupational therapists. Participants will be individually randomised to receive either best practice usual care (joint protection advice, general exercise advice, functional splinting and assistive devices) or best practice usual care supplemented with an individualised exercise programme of strengthening and stretching exercises. The study assessors will be blinded to treatment allocation and will follow participants up at four and 12 months. The primary outcome measure is the Hand function subscale of the Michigan Hand Outcome Questionnaire, and secondary outcomes include hand and wrist impairment measures, quality of life, and resource use. Economic and qualitative studies will also be carried out in parallel.Discussion: This paper describes the design and development of a trial protocol of a complex intervention study based in therapy out-patient departments. The findings will provide evidence to support or refute the use of an optimised exercise programme for RA of the hand in addition to best practice usual care.Trial registration: Current Controlled Trials ISRCTN89936343Keywords: Randomised controlled trial, Rheumatoid arthritis, Exercise, Hand, Rehabilitatio

    Belated Nation: Yugoslav Communists and the Muslim Question, 1919-1971

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    Honors (Bachelor's)HistoryUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/77619/1/buljinah.pd

    Entwicklung und Aufbau zweier Siedeapparaturen zur Untersuchung des Wärmeübergangs weitsiedender binärer niedrig- und hochviskoser Gemische

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    Im Rahmen dieser Arbeit wurden zwei Siedeapparaturen zur Untersuchung des Wärmeübergangs in weit siedenden Gemischen aufgebaut. Der Funktionsnachweis wurde für beide Apparaturen mit n-Pentan in einem Temperaturbereich von 313 K \leq T\it {T} \leq 423 K und einen Druckbereich von 0,1 MPa \leq p\it {p} \leq 1,6 MPa durchgeführt. Mit diesen Anlagen wurde erstmals ein extrem weitsiedendes (Δ\Delta TSN_{SN} = 250,1 K) niedrigviskoses Gemisch (n-Pentan/n-Hexadekan) und ein weitsiedendes hochviskoses Gemisch (n-Pentan/Silikonöl) systematisch vermessen. Die für das n-Pentan/n-Hexadekan-Gemisch gemessenen Wärmeübergangskoeffizienten wurden mit drei veröffentlichten Korrelationen für den Wärmeübergang in siedenden Gemischen verglichen
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