Prognostic significance of organ dysfunction in cats with polytrauma

Polytrauma is a common emergency condition in small animals and is frequently associated with higher morbidity and mortality rates compared to minor trauma. Multiple Organ Dysfunction Syndrome (MODS) is a major complication of extensive traumatic injury, carrying a high risk of death despite intensive care treatment. Little is known about the prevalence and the prognostic impact of MODS in feline polytrauma. The current study aimed to prospectively evaluate the occurrence and the prognostic significance of organ dysfunction at admission in a population of polytraumatized cats. Cats with polytrauma requiring intensive care unit hospitalization were included and categorized according to outcome (survivors/non-survivors). Clinical and clinicopathological data, including scores of disease severity [Animal Trauma Triage Score (ATTS), APPLEfast, and APPLEfull], selected organ dysfunction and presence of MODS were evaluated upon admission, and analyzed with respect to mortality. Non-parametric statistics was performed and P < 0.05 was considered significant. Thirty-eight cats met the inclusion criteria: 8/38 (21%) had penetrating trauma, while 30/38 (79%) had blunt trauma. The overall in-hospital mortality was 37% (14/38). Cats with evidence of MODS upon admission had significantly higher frequency of death compared to cats without MODS (9/14 vs. 2/24 P = 0.0004). Hemostatic dysfunction, respiratory dysfunction, and MODS upon admission were significantly associated with mortality in the univariate logistic regression analysis (P = 0.005, P = 0.001, P = 0.001, respectively). The values of APPLEfast, APPLEfull, and ATTS were independently associated with a higher risk of death and positively correlated with the number of dysfunctional organs (P = 0.025, P = 0.004, P = 0.003, r = 0.57, P = 0.0002; r = 0.59, P = 0.0001; r = 0.55, P = 0.0003, respectively). Multiple Organ Dysfunction Syndrome is a common complication of feline polytrauma and its development is associated with increased disease severity and worse outcomes. The presence of hemostatic dysfunction and respiratory dysfunction upon admission is associated with a higher risk of death. The ATTS and the APPLE scores are useful prognostic tools for the assessment of cats with polytrauma

Data model issues in the Cherenkov Telescope Array project

The planned Cherenkov Telescope Array (CTA), a future ground-based Very-High-Energy (VHE) gamma-ray observatory, will be the largest project of its kind. It aims to provide an order of magnitude increase in sensitivity compared to currently operating VHE experiments and open access to guest observers. These features, together with the thirty years lifetime planned for the installation, impose severe constraints on the data model currently being developed for the project. In this contribution we analyze the challenges faced by the CTA data model development and present the requirements imposed to face them. While the full data model is still not completed we show the organization of the work, status of the design, and an overview of the prototyping efforts carried out so far. We also show examples of specific aspects of the data model currently under development.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

The Swift-BAT survey reveals the orbital period of three high-mass X-ray binaries

A growing number of previously hidden Galactic X-ray sources are now detected with recent surveys performed by the Integral and Swift satellites. Most of these new sources eluded past surveys due to their large local X-ray extinction and consequent low soft X-ray flux. The Swift-BAT performs daily monitoring of the sky in an energy band (15-150 keV) which is only marginally affected by X-ray extinction, thus allowing for the search of long periodicities in the light curve and identification of the nature of the X-ray sources. We performed a period search using the folding technique in the Swift-BAT light curves of three Integral sources: IGR J05007-7047, IGR J13186-6257 and IGR J17354-3255. Their periodograms show significant peaks at 30.77$\pm$0.01 d, 19.994$\pm$0.01 d and 8.448$\pm$0.002 d, respectively. We estimate the significance of these features from the chi squared distribution of all the trials, finding a probability less than 1.5$\times10^{-4}$ that the detections occurred due to chance. We complement our analysis with the study of their broadband X-ray emission. We identify the periodicities with the orbital periods of the sources. The periods are typical for the wind accretors X-ray binaries and we support this identification showing that also their energy spectra are compatible with an X-ray spectral emission characteristic of high-mass X-ray binaries. The spectrum of IGR J05007-704 that resides in the Large Magellanic Cloud, does not show any intrinsic local absorption, whereas the spectra of the Galactic sources IGR J17354-3255 and IGR J13186-6257 may be affected by a local absorber. The folded light curve for IGR J13186-6257 suggests a possible Be companion star.Comment: 10 pages, 14 figures. Accepted for publication in A&

Gamma-ray observations of Cygnus X-1 above 100 MeV in the hard and soft states

We present the results of multi-year gamma-ray observations by the AGILE satellite of the black hole binary system Cygnus X-1. In a previous investigation we focused on gamma-ray observations of Cygnus X-1 in the hard state during the period mid-2007/2009. Here we present the results of the gamma-ray monitoring of Cygnus X-1 during the period 2010/mid-2012 carried out for which includes a remarkably prolonged `soft state' phase (June 2010 -- May 2011). Previous 1--10 MeV observations of Cyg X-1 in this state hinted at a possible existence of a non-thermal particle component with substantial modifications of the Comptonized emission from the inner accretion disk. Our AGILE data, averaged over the mid-2010/mid-2011 soft state of Cygnus X-1, provide a significant upper limit for gamma-ray emission above 100 MeV of F_soft < 20 x 10^{-8} ph/cm^2/s, excluding the existence of prominent non-thermal emission above 100 MeV during the soft state of Cygnus X-1. We discuss theoretical implications of our findings in the context of high-energy emission models of black hole accretion. We also discuss possible gamma-ray flares detected by AGILE. In addition to a previously reported episode observed by AGILE in October 2009 during the hard state, we report a weak but important candidate for enhanced emission which occurred at the end of June 2010 (2010-06-30 10:00 - 2010-07-02 10:00 UT) exactly in coincidence with a hard-to-soft state transition and before an anomalous radio flare. An appendix summarizes all previous high-energy observations and possible detections of Cygnus X-1 above 1 MeV.Comment: 16 pages, 12 figures, 1 table, accepted for publication in Ap

A giant radio flare from Cygnus X-3 with associated Gamma-ray emission

With frequent flaring activity of its relativistic jets, Cygnus X-3 is one of the most active microquasars and is the only Galactic black hole candidate with confirmed high energy Gamma-ray emission, thanks to detections by Fermi/LAT and AGILE. In 2011, Cygnus X-3 was observed to transit to a soft X-ray state, which is known to be associated with high-energy Gamma-ray emission. We present the results of a multi-wavelength campaign covering a quenched state, when radio emission from Cygnus X-3 is at its weakest and the X-ray spectrum is very soft. A giant (~ 20 Jy) optically thin radio flare marks the end of the quenched state, accompanied by rising non-thermal hard X-rays. Fermi/LAT observations (E >100 MeV) reveal renewed Gamma-ray activity associated with this giant radio flare, suggesting a common origin for all non-thermal components. In addition, current observations unambiguously show that the Gamma-ray emission is not exclusively related to the rare giant radio flares. A 3-week period of Gamma-ray emission is also detected when Cygnus X-3 was weakly flaring in radio, right before transition to the radio quenched state. No Gamma rays are observed during the ~ one-month long quenched state, when the radio flux is weakest. Our results suggest transitions into and out of the ultrasoft X-ray (radio quenched) state trigger Gamma-ray emission, implying a connection to the accretion process, and also that the Gamma-ray activity is related to the level of radio flux (and possibly shock formation), strengthening the connection to the relativistic jets.Comment: Accepted for publication in MNRAS. 10 pages 5 figures, 1 tabl

AGILE detection of a strong gamma-ray flare from the blazar 3C 454.3

We report the first blazar detection by the AGILE satellite. AGILE detected 3C 454.3 during a period of strongly enhanced optical emission in July 2007. AGILE observed the source with a dedicated repointing during the period 2007 July 24-30 with its two co-aligned imagers, the Gamma-Ray Imaging Detector and the hard X-ray imager Super-AGILE sensitive in the 30 MeV-50 GeV and 18-60 keV, respectively. Over the entire period, AGILE detected gamma-ray emission from 3C 454.3 at a significance level of 13.8-$\sigma$ with an average flux (E$>$100 MeV) of $(280 \pm 40) \times 10^{-8}$ photons cm$^{-2}$ s$^{-1}$. The gamma-ray flux appears to be variable towards the end of the observation. No emission was detected by Super-AGILE in the energy range 20-60 keV, with a 3-$\sigma$ upper limit of $2.3 \times 10^{-3}$ photons cm$^{-2}$ s$^{-1}$. The gamma-ray flux level of 3C 454.3 detected by AGILE is the highest ever detected for this quasar and among the most intense gamma-ray fluxes ever detected from Flat Spectrum Radio Quasars.Comment: Accepted by Astrophysical Journal Letters; 14 pages, 3 EPS Figures, 1 Tabl

Region of Excessive Flux of PeV Cosmic Rays in the Direction Toward Pulsars PSR J1840+5640 and LAT PSR J1836+5925

An analysis of arrival directions of extensive air showers (EAS) registered with the EAS MSU and EAS-1000 prototype arrays has revealed a region of excessive flux of PeV cosmic rays in the direction toward pulsars PSR J1840+5640 and LAT PSR J1836+5925 at significance level up to 4.5sigma. The first of the pulsars was discovered almost 30 years ago and is a well-studied old radio pulsar located at the distance of 1.7pc from the Solar system. The second pulsar belongs to a new type of pulsars, discovered by the space gamma-ray observatory Fermi, pulsations of which are not observed in optical and radio wavelengths but only in the gamma-ray range of energies (gamma-ray-only pulsars). In our opinion, the existence of the region of excessive flux of cosmic rays registered with two different arrays provides a strong evidence that isolated pulsars can give a noticeable contribution to the flux of Galactic cosmic rays in the PeV energy range.Comment: 14 pages; v.2: a few remarks to match a version accepted for Astronomy Letters added. They can be found by redefining the \NEW command in the preamble of the LaTeX fil

Cherenkov Telescope Array Data Management

Very High Energy gamma-ray astronomy with the Cherenkov Telescope Array (CTA) is evolving towards the model of a public observatory. Handling, processing and archiving the large amount of data generated by the CTA instruments and delivering scientific products are some of the challenges in designing the CTA Data Management. The participation of scientists from within CTA Consortium and from the greater worldwide scientific community necessitates a sophisticated scientific analysis system capable of providing unified and efficient user access to data, software and computing resources. Data Management is designed to respond to three main issues: (i) the treatment and flow of data from remote telescopes; (ii) "big-data" archiving and processing; (iii) and open data access. In this communication the overall technical design of the CTA Data Management, current major developments and prototypes are presented.Comment: 8 pages, 2 figures, In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589