Farmers tell us how to help improve their mental health help-seeking

Farmers’ mental health help-seeking is reported to be poor. Mental health help-seeking is seeking help from professionals such as GPs and psychologists for issues relating to distress or mental health (Rickwood & Thomas, 2012). Timely mental health help-seeking behaviour is important because it may minimise any negative outcomes. At present, there is no research that has identified how to target farmers to improve their mental health help-seeking. It is known that tailored approaches to intervention are superior and this is likely to be so for intervening with farmers whom have a strong culture and a vastly different situation than metropolitan populations. This study is part of a body of work exploring the factors that influence mental health help-seeking in farmers. Semi-structured interviews were conducted with 10 farmers (farming as their occupation) as well as 10 farmers’ partners (for their additional insight), all of whom resided/worked in Queensland. Braun and Clarke’s (2006) technique of thematic analysis was used to analyse the data. Based on the data three themes were developed regarding intervention: education (what needs to be taught and how to teach it), the medium (which mediums preferred and engagement with them) and multi-faceted programs (Many aspects important such as community input and role of GPs, family, and friends). This research improves the knowledge on how to target interventions, including the medium, specifically to farmers for mental health help-seeking. The findings could be utilised in the design process to create interventions that are more likely to have an impact, specific for farmers to improve their mental health help-seeking behaviour

Farmers are not seeking help: what does service provision have to do with it?

Aim The rate of suicide in farmers is twice that of the general population. Help-seeking from health professionals, if this occurs in a timely manner, can significantly minimise the negative consequences of mental ill-health. However, it has now been demonstrated that farmers as a group are reluctant to seek help for mental ill-health, which likely contributes to this problem. Previous research has demonstrated that General Practitioners are the most commonly visited health professional in rural farming areas, however, they are under-utilised as a means of seeking help. This research aimed to examine the potential barriers and facilitators of mental health help-seeking in farmers, that relate to the provision of service from the perspective of farmers. Methods The present research draws on findings from semi‐structured interviews with 10 farmers residing in Queensland. The techniques of Braun and Clarke (2006) were used to guide the thematic analysis. Results Several key factors relating to services were identified as having the potential to directly or indirectly influence mental health help-seeking. These include: how services are marketed/packaged and delivered, availability and accessibility, continuity of care, having ‘knowledgeable bush practitioners’ as well as perception of good outcomes. Conclusion It is expected that this research will create a better understanding of the farmers’ perspective relating to service provision for the purpose of seeking help for mental health. The outcomes have implications for developing and providing interventions for farmers to promote services for the purpose of mental health help-seeking as well as create awareness in service provider and other stakeholders of issues that prevent timely help-seeking

Methane mole fraction and δ13^{13}C above and below the trade wind inversion at Ascension Island in air sampled by aerial robotics

The Authors.Ascension Island is a remote South Atlantic equatorial site, ideal for monitoring tropical background CH4. In September 2014 and July 2015, octocopters were used to collect air samples in Tedlar bags from different heights above and below the well-defined Trade Wind Inversion (TWI), sampling a maximum altitude of 2700 m above mean sea level. Sampling captured both remote air in the marine boundary layer below the TWI and also air masses above the TWI that had been lofted by convective systems in the African tropics. Air above the TWI was characterized by higher CH$_{4}$, but no distinct shift in δ$^{13}$C was observed compared to the air below. Back trajectories indicate that lofted CH$_{4}$ emissions from Southern Hemisphere Africa have bulk δ$^{13}$C$_{CH4}$ signatures similar to background, suggesting mixed emissions from wetlands, agriculture, and biomass burning. The campaigns illustrate the usefulness of unmanned aerial system sampling and Ascension's value for atmospheric measurement in an understudied region.This work was part of the investigation of the southern methane anomaly: causes, implications, and relevance to past global events funded by the UK Natural Environment Research Council (NERC) (grant NE/K006045/1) and NERC studentship. Data will be deposited in the UK Centre for Environmental Data Analysis on completion of Rebecca Brownlow’s PhD thesis

Very Strong Atmospheric Methane Growth in the 4 Years 2014–2017:Implications for the Paris Agreement

Atmospheric methane grew very rapidly in 2014 (12.7 ± 0.5 ppb/year), 2015 (10.1 ± 0.7 ppb/year), 2016 (7.0 ± 0.7 ppb/year), and 2017 (7.7 ± 0.7 ppb/year), at rates not observed since the 1980s. The increase in the methane burden began in 2007, with the mean global mole fraction in remote surface background air rising from about 1,775 ppb in 2006 to 1,850 ppb in 2017. Simultaneously the 13 C/ 12 C isotopic ratio (expressed as δ 13 C CH4 ) has shifted, has shifted, now trending negative for more than a decade. The causes of methane's recent mole fraction increase are therefore either a change in the relative proportions (and totals) of emissions from biogenic and thermogenic and pyrogenic sources, especially in the tropics and subtropics, or a decline in the atmospheric sink of methane, or both. Unfortunately, with limited measurement data sets, it is not currently possible to be more definitive. The climate warming impact of the observed methane increase over the past decade, if continued at >5 ppb/year in the coming decades, is sufficient to challenge the Paris Agreement, which requires sharp cuts in the atmospheric methane burden. However, anthropogenic methane emissions are relatively very large and thus offer attractive targets for rapid reduction, which are essential if the Paris Agreement aims are to be attained

Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets.

Platelets protect the vascular system during damage or inflammation, but platelet activation can result in pathological thrombosis. Activated platelets release a variety of extracellular vesicles (EVs). EVs shed from the plasma membrane often expose phosphatidylserine (PS). These EVs are pro-thrombotic and increased in number in many cardiovascular and metabolic diseases. The mechanisms by which PS-exposing EVs are shed from activated platelets are not well characterised. Cholesterol-rich lipid rafts provide a platform for coordinating signalling through receptors and Ca2+ channels in platelets. We show that cholesterol depletion with methyl-β-cyclodextrin or sequestration with filipin prevented the Ca2+-triggered release of PS-exposing EVs. Although calpain activity was required for release of PS-exposing, calpain-dependent cleavage of talin was not affected by cholesterol depletion. P2Y12 and TPα, receptors for ADP and thromboxane A2, respectively, have been reported to be in platelet lipid rafts. However, the P2Y12 antagonist, AR-C69931MX, or the cyclooxygenase inhibitor, aspirin, had no effect on A23187-induced release of PS-exposing EVs. Together, these data show that lipid rafts are required for release of PS-exposing EVs from platelets.Isaac Newton Trust/ Wellcome Trust ISSF/University of Cambridge Joint Research Grant British Heart Foundation grant SP/15/7/3156

Attitudes Toward the Ethics of Research Using Social Media: A Systematic Review.

BACKGROUND: Although primarily used for social networking and often used for social support and dissemination, data on social media platforms are increasingly being used to facilitate research. However, the ethical challenges in conducting social media research remain of great concern. Although much debated in the literature, it is the views of the public that are most pertinent to inform future practice. OBJECTIVE: The aim of our study was to ascertain attitudes on the ethical considerations of using social media as a data source for research as expressed by social media users and researchers. METHODS: A systematic review was conducted, wherein 16 databases and 2 Internet search engines were searched in addition to handsearching, reference checking, citation searching, and contacting authors and experts. Studies that conducted any qualitative methods to collect data on attitudes on the ethical implications of research using social media were included. Quality assessment was conducted using the quality of reporting tool (QuaRT) and findings analyzed using inductive thematic synthesis. RESULTS: In total, 17 studies met the inclusion criteria. Attitudes varied from overly positive with people expressing the views about the essential nature of such research for the public good, to very concerned with views that social media research should not happen. Underlying reasons for this variation related to issues such as the purpose and quality of the research, the researcher affiliation, and the potential harms. The methods used to conduct the research were also important. Many respondents were positive about social media research while adding caveats such as the need for informed consent or use restricted to public platforms only. CONCLUSIONS: Many conflicting issues contribute to the complexity of good ethical practice in social media research. However, this should not deter researchers from conducting social media research. Each Internet research project requires an individual assessment of its own ethical issues. Guidelines on ethical conduct should be based on current evidence and standardized to avoid discrepancies between, and duplication across, different institutions, taking into consideration different jurisdictions

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

The Aurora B abscission checkpoint delays cytokinesis until resolution of DNA trapped in the cleavage furrow. This process involves PKCε phosphorylation of Aurora B S227. Assessing if this PKCε-Aurora B module provides a more widely exploited genome-protective control for the cell cycle, we show Aurora B phosphorylation at S227 by PKCε also occurs during mitosis. Expression of Aurora B S227A phenocopies inhibition of PKCε in by-passing the delay and resolution at anaphase entry that is associated with non-disjunction and catenation of sister chromatids. Implementation of this anaphase delay is reflected in PKCε activation following cell cycle dependent cleavage by caspase 7; knock-down of caspase 7 phenocopies PKCε loss, in a manner rescued by ectopically expressing/generating a free PKCε catalytic domain. Molecular dynamics indicates that Aurora B S227 phosphorylation induces conformational changes and this manifests in a profound switch in specificity towards S29 TopoIIα phosphorylation, a response necessary for catenation resolution during mitosis.This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130).Peer reviewe

Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach

Recently developed atrophic non-union models are a good representation of the clinical situation in which many nonunions develop. Based on previous experimental studies with these atrophic non-union models, it was hypothesized that in order to obtain successful fracture healing, blood vessels, growth factors, and (proliferative) precursor cells all need to be present in the callus at the same time. This study uses a combined in vivo-in silico approach to investigate these different aspects (vasculature, growth factors, cell proliferation). The mathematical model, initially developed for the study of normal fracture healing, is able to capture essential aspects of the in vivo atrophic non-union model despite a number of deviations that are mainly due to simplifications in the in silico model. The mathematical model is subsequently used to test possible treatment strategies for atrophic non-unions (i.e. cell transplant at post-osteotomy, week 3). Preliminary in vivo experiments corroborate the numerical predictions. Finally, the mathematical model is applied to explain experimental observations and identify potentially crucial steps in the treatments and can thereby be used to optimize experimental and clinical studies in this area. This study demonstrates the potential of the combined in silico-in vivo approach and its clinical implications for the early treatment of patients with problematic fractures

1956: Abilene Christian College Bible Lectures - Full Text

Golden Anniversary Edition featuring the theme THEY SHALL ALL BE TAUGHT OF GOD Price: $3.50 FIRM FOUNDATION PUBLISHING HOUSE Box 77 Austin, Texa