6,082 research outputs found
School Learning Gardens as Multicultural Hubs for Sustainability: PSU-PPS Food Systems Partnerships in Outer Southeast Portland
This presentation focuses on how garden-based learning can have a positive effect on children
The Genomic Diversity and Phylogenetic Relationship in the Family Iridoviridae
The Iridoviridae family are large viruses (∼120–200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridoviridae is currently subdivided into five genera: Chloriridovirus, Iridovirus, Lymphocystivirus, Megalocytivirus, and Ranavirus. Iridoviruses have been found to infect invertebrates and poikilothermic vertebrates, including amphibians, reptiles, and fish. With such a diverse array of hosts, there is great diversity in gene content between different genera. To understand the origin of iridoviruses, we explored the phylogenetic relationship between individual iridoviruses and defined the core-set of genes shared by all members of the family. In order to further explore the evolutionary relationship between the Iridoviridae family repetitive sequences were identified and compared. Each genome was found to contain a set of unique repetitive sequences that could be used in future virus identification. Repeats common to more than one virus were also identified and changes in copy number between these repeats may provide a simple method to differentiate between very closely related virus strains. The results of this paper will be useful in identifying new iridoviruses and determining their relationship to other members of the family
The Mass-Size Relation from Clouds to Cores. II. Solar Neighborhood Clouds
We measure the mass and size of cloud fragments in several molecular clouds
continuously over a wide range of spatial scales (0.05 < r / pc < 3). Based on
the recently developed "dendrogram-technique", this characterizes dense cores
as well as the enveloping clouds. "Larson's 3rd Law" of constant column
density, m(r) = C*r^2, is not well suited to describe the derived mass-size
data. Solar neighborhood clouds not forming massive stars (< 10 M_sun; Pipe
Nebula, Taurus, Perseus, and Ophiuchus) obey m(r) < 870 M_sun (r / pc)^1.33 .
In contrast to this, clouds forming massive stars (Orion A, G10.150.34,
G11.110.12) do exceed the aforementioned relation. Thus, this limiting
mass-size relation may approximate a threshold for the formation of massive
stars. Across all clouds, cluster-forming cloud fragments are found to be---at
given radius---more massive than fragments devoid of clusters. The
cluster-bearing fragments are found to roughly obey a mass-size law m =
C*r^1.27 (where the exponent is highly uncertain in any given cloud, but is
certainly smaller than 1.5).Comment: accepted to the Astrophysical Journa
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Predictors of historical change in drug treatment coverage among people who inject drugs in 90 large metropolitan areas in the USA, 1993–2007
Background
Adequate access to effective treatment and medication assisted therapies for opioid dependence has led to improved antiretroviral therapy adherence and decreases in morbidity among people who inject drugs (PWID), and can also address a broad range of social and public health problems. However, even with the success of syringe service programs and opioid substitution programs in European countries (and others) the US remains historically low in terms of coverage and access with regard to these programs. This manuscript investigates predictors of historical change in drug treatment coverage for PWID in 90 US metropolitan statistical areas (MSAs) during 1993–2007, a period in which, overall coverage did not change.
Methods
Drug treatment coverage was measured as the number of PWID in drug treatment, as calculated by treatment entry and census data, divided by numbers of PWID in each MSA. Variables suggested by the Theory of Community Action (i.e., need, resource availability, institutional opposition, organized support, and service symbiosis) were analyzed using mixed-effects multivariate models within dependent variables lagged in time to study predictors of later change in coverage.
Results
Mean coverage was low in 1993 (6.7%; SD 3.7), and did not increase by 2007 (6.4%; SD 4.5). Multivariate results indicate that increases in baseline unemployment rate (β = 0.312; pseudo-p < 0.0002) predict significantly higher treatment coverage; baseline poverty rate (β = − 0.486; pseudo-p < 0.0001), and baseline size of public health and social work workforce (β = 0.425; pseudo-p < 0.0001) were predictors of later mean coverage levels, and baseline HIV prevalence among PWID predicted variation in treatment coverage trajectories over time (baseline HIV * Time: β = 0.039; pseudo-p < 0.001). Finally, increases in black/white poverty disparity from baseline predicted significantly higher treatment coverage in MSAs (β = 1.269; pseudo-p < 0.0001).
Conclusions
While harm reduction programs have historically been contested and difficult to implement in many US communities, and despite efforts to increase treatment coverage for PWID, coverage has not increased. Contrary to our hypothesis, epidemiologic need, seems not to be associated with change in treatment coverage over time. Resource availability and institutional opposition are important predictors of change over time in coverage. These findings suggest that new ways have to be found to increase drug treatment coverage in spite of economic changes and belt-tightening policy changes that will make this difficult
Run 2 Upgrades to the CMS Level-1 Calorimeter Trigger
The CMS Level-1 calorimeter trigger is being upgraded in two stages to
maintain performance as the LHC increases pile-up and instantaneous luminosity
in its second run. In the first stage, improved algorithms including
event-by-event pile-up corrections are used. New algorithms for heavy ion
running have also been developed. In the second stage, higher granularity
inputs and a time-multiplexed approach allow for improved position and energy
resolution. Data processing in both stages of the upgrade is performed with
new, Xilinx Virtex-7 based AMC cards.Comment: 10 pages, 7 figure
The threats endangering Australia's at-risk fauna
Reducing the rate of species extinctions is one of the great challenges of our time. Understanding patterns in the distribution and frequency of both threatened species and the threatening processes affecting them improves our ability to mitigate threats and prioritize management actions. In this quantitative synthesis of processes threatening Australian at-risk fauna, we find that species are impacted by a median of six threats (range 1–19), though there is considerable variation in numbers of threats among major taxonomic groups. Invasive species, habitat loss, biological resource use, natural systems modification and climate change are the processes most commonly affecting Australian threatened species. We identified an uneven distribution of research knowledge among species, with half of the total number of species-specific peer-reviewed scientific publications associated with only 11 threatened species (2.7%). Furthermore, the number of threats associated with each species was correlated with the research effort for that species, and research effort was correlated with body mass. Hence, there appears to be a research bias towards larger-bodied species, and certain charismatic species, that could result in inferences biased towards these favored species. However, after accounting for these effects we found that for birds, amphibians, reptiles and marine mammals body mass is positively correlated with the number of threats associated with each species. Many threats also co-occur, indicating that threat syndromes may be common
The Age, Stellar Content and Star Formation Timescale of the B59 Dense Core
We have used moderate resolution, near-infrared spectra from the SpeX
spectrograph on the NASA Infrared Telescope facility to characterize the
stellar content of Barnard 59 (B59), the most active star-forming core in the
Pipe Nebula. Measuring luminosity and temperature sensitive features in the
spectra of 20 candidate YSOs, we identified likely background giant stars and
measured each star's spectral type, extinction, and NIR continuum excess. We
find that B59 is composed of late type (K4-M6) low-mass (0.9--0.1 M_sun) YSOs
whose median stellar age is comparable to, if not slightly older than, that of
YSOs within the Rho Oph, Taurus, and Chameleon star forming regions. Deriving
absolute age estimates from pre-main sequence models computed by D'Antona et
al., and accounting only for statistical uncertainties, we measure B59's median
stellar age to be 2.6+/-0.8 Myrs. Including potential systematic effects
increases the error budget for B59's median (DM98) stellar age to 2.6+4.1/-2.6
Myrs. We also find that the relative age orderings implied by pre-main sequence
evolutionary tracks depend on the range of stellar masses sampled, as model
isochrones possess significantly different mass dependencies. The maximum
likelihood median stellar age we measure for B59, and the region's observed gas
properties, suggest that the B59 dense core has been stable against global
collapse for roughly 6 dynamical timescales, and is actively forming stars with
a star formation efficiency per dynamical time of ~6%. This maximum likelihood
value agrees well with recent star formation simulations that incorporate
various forms of support against collapse, such as sub-critical magnetic
fields, outflows, and radiative feedback from protostellar heating. [abridged]Comment: 20 pages, 12 figures, accepted for publication in the Astrophysical
Journal; updated to amend acknowledgment
Measuring subluxation of the hemiplegic shoulder: Reliability of a method
Objective: Subluxation of the shoulder after stroke can be measured according to the method described by Van Langenberghe and Hogan. Methods: To evaluate the reliability of this method, the shoulder radiographs of 25 patients were available for this study. Two independent raters each assessed these radiographs twice. Results: The intrarater reliability was good: percentage of agreement was 88 and 84%, weighted κ, 0.69 [95% confidence interval (CI), 0.38-1 0] and 0.78 (95% CI, 0.60-0.95) for raters 1 and 2, respectively. The interrater reliability was poor: percentage of agree ment was 36 and 28%, κ, 0.11 (95% CI, 0.0-0.31) and 0.09 (95% CI, 0.0-0.23) in sessions 1 and 2, respectively. Subsequently the original method was adjusted by com bining two categories (no subluxation and beginning subluxation) into one (“no clin ically important subluxation”). Conclusions: After this adjustment of the categories, the interrater reliability improved [percentage of agreement, 72%, and κ, 0.49 (95% CI, 0.18-0.80)], but did not reach acceptable values
Advances in genetics: widening our understanding of prostate cancer
Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.</ns4:p
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