Introduction to the special issue - Digital business models:A multi-disciplinary and multi-stakeholder perspective

The advent and enormous growth of digital technologies, and associated data, force firms to respond to novel digital challenges and increasingly lead them to transform their existing business models. Importantly, given that digital transformation has a strong impact on multiple disciplines, such as logistics, marketing, and strategy, and involves multiple stakeholders, such as service providers, platforms, employees and end-users, it also requires researchers and businesses to adopt a multi-disciplinary, multi-stakeholder perspective, in which multiple research and business fields cooperate in order to create collaborative solutions. In this editorial to the special issue, we aim to bring together insights from multiple research fields to account for the multi-faceted nature of digital transformation. We discuss the relevance of this multi-disciplinary, multi-stakeholder perspective, propose an overarching research framework, and highlight future avenues of research

Switching Intentions of Service Providers and Cultural Orientation

This study performs a cross-cultural comparison to understand how the drivers of switching intentions differ between countries that vary in their long-term orientation (LTO). The authors hypothesize how LTO moderates the influence of the drivers of switching intentions for a mobile phone subscription service. Structural invariance tests between consumer samples of the United States (low LTO) and the Netherlands (high LTO) reveal that, consumers from high LTO nation attribute more importance to relational quality but care less about service recovery in their formation of switching intentions. The theoretical and managerial implications of how differences in time orientation affect the pathways to loyalty are discussed

AKARI observations of ice absorption bands towards edge-on young stellar objects

To investigate the composition and evolution of circumstellar ice around low-mass young stellar objects (YSOs), we observed ice absorption bands in the near infrared (NIR) towards eight YSOs ranging from class 0 to class II, among which seven are associated with edge-on disks. We performed slit-less spectroscopic observations using the grism mode of the InfraRed Camera (IRC) on board AKARI, which enables us to obtain full NIR spectra from 2.5 mu m to 5 mu m, including the CO2 band and the blue wing of the H2O band, which are inaccessible from the ground. We developed procedures to carefully process the spectra of targets with nebulosity. The spectra were fitted with polynomial baselines to derive the absorption spectra. The molecular absorption bands were then fitted with the laboratory database of ice absorption bands, considering the instrumental line profile and the spectral resolution of the grism dispersion element. Towards the class 0-I sources (L1527, IRC-L1041-2, and IRAS 04302), absorption bands of H2O, CO2, CO, and XCN are clearly detected. Column density ratios of CO2 ice and CO ice relative to H2O ice are 21-28% and 13-46%, respectively. If XCN is OCN-, its column density is as high as 2-6% relative to H2O ice. The HDO ice feature at 4.1 mu m is tentatively detected towards the class 0-I sources and HV Tau. Non-detections of the CH-stretching mode features around 3.5 mu m provide upper limits to the CH3OH abundance of 26% (L1527) and 42% (IRAS 04302) relative to H2O. We tentatively detect OCS ice absorption towards IRC-L1041-2. Towards class 0-I sources, the detected features should mostly originate in the cold envelope, while CO gas and OCN-could originate in the region close to the protostar, where there are warm temperatures and UV radiation. We detect H2O ice band towards ASR41 and 2MASSJ 1628137-243139, which are edge-on class II disks. We also detect H2O ice and CO2 ice towards HV Tau, HK Tau, and UY Aur, and tentatively detect CO gas features towards HK Tau and UY Aur

Parental perspectives on ECEC settings that foster child well-being: A comparison across nine European countries

Parents play a vital role in identifying children’s needs for support and Early Childhood Education and Care (ECEC ) features that support children’s well -being.This study examined parental perspectives on features of ECEC that foster young children’s well -being under and above the age of 3 years by interviewing 359 parents across nine European countries (England, Finland, Germany, Greece, Italy, the Netherlands, Norway, Poland, and Portugal). Results revealed that parental perspectives largely converged with quality features discussed in ECEC research. Process quality features were mentioned more frequently than structural features for all children 0- to 6-years-old in almost all countries. However, care -oriented features were mentioned more frequently for under 3 years, and educational-oriented features were mentioned more frequently for the older group. Regarding structural features, patterns of responses across the two age groups were similar in most countries. Age differences were not more pronounced in countries with a split governance system.info:eu-repo/semantics/publishedVersio

Parental perspectives on ECEC settings that foster child well-being: a comparison across nine European countries

Parents play a vital role in identifying children’s needs for support and Early Childhood Education and Care (ECEC) features that support children’s well-being. This study examined parental perspectives on features of ECEC that foster young children’s well-being under and above the age of 3 years by interviewing 359 parents across nine European countries (England, Finland, Germany, Greece, Italy, the Netherlands, Norway, Poland, and Portugal). Results revealed that parental perspectives largely converged with quality features discussed in ECEC research. Process quality features were mentioned more frequently than structural features for all children 0- to 6-years-old in almost all countries. However, care-oriented features were mentioned more frequently for under 3 years, and educational-oriented features were mentioned more frequently for the older group. Regarding structural features, patterns of responses across the two age groups were similar in most countries. Age differences were not more pronounced in countries with a split governance system.publishedVersio

Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV : a pragmatic, multicentre, open-label, randomised clinical trial

This trial was funded from public money by the Netherlands Organisation for Health Research and Development (ZonMW; grant number 171002208). Aardex provided support on the development of the study website. We thank all the HIV nurses and physicians from the seven HIV clinics involved in the AIMS study for their input and collaboration (Academic Medical Centre, Slotervaart hospital, and St. Lucas-Andreas hospital, all in Amsterdam; the Leiden University Medical Centre, Leiden; HAGA hospital, The Hague; Erasmus Medical Centre, Rotterdam; and Isala clinic, Zwolle), the study participants, and the Stichting HIV Monitoring (SHM) for their support in accessing the SHM database for identifying patient inclusion criteria and developing the Markov model. Finally, we thank and remember Herman Schaalma (deceased) for his contribution to the study design and grant application.Peer reviewedPostprin

A Review and Classification of Approaches for Dealing with Uncertainty in Multi-Criteria Decision Analysis for Healthcare Decisions

The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Multi-criteria decision analysis (MCDA) is increasingly used to support decisions in healthcare involving multiple and conflicting criteria. Although uncertainty is usually carefully addressed in health eco-nomic evaluations, whether and how the different sources of uncertainty are dealt with and with what methods in MCDA is less known. The objective of this study is to review how uncertainty can be explicitly taken into account in MCDA and to discuss which approach may be appro-priate for healthcare decision makers. A literature review was conducted in the Scopus and PubMed databases. Two reviewers independently categorized studies according to research areas, the type of MCDA used, and the approach used to quantify uncertainty. Selected full text articles wer

Infrared spectroscopy of solid CO-CO2 mixtures and layers

The spectra of pure, mixed and layered CO and CO2 ices have been studied systematically under laboratory conditions using infrared spectroscopy. This work provides improved resolution spectra (0.5 cm-1) of the CO2 bending and asymmetric stretching mode, as well as the CO stretching mode, extending the existing Leiden database of laboratory spectra to match the spectral resolution reached by modern telescopes and to support the interpretation of the most recent data from Spitzer. It is shown that mixed and layered CO and CO2 ices exhibit very different spectral characteristics, which depend critically on thermal annealing and can be used to distinguish between mixed, layered and thermally annealed CO-CO2 ices. CO only affects the CO2 bending mode spectra in mixed ices below 50K under the current experimental conditions, where it exhibits a single asymmetric band profile in intimate mixtures. In all other ice morphologies the CO2 bending mode shows a double peaked profile, similar to that observed for pure solid CO2. Conversely, CO2 induces a blue-shift in the peak-position of the CO stretching vibration, to a maximum of 2142 cm-1 in mixed ices, and 2140-2146 cm-1 in layered ices. As such, the CO2 bending mode puts clear constraints on the ice morphology below 50K, whereas beyond this temperature the CO2 stretching vibration can distinguish between initially mixed and layered ices. This is illustrated for the low-mass YSO HH46, where the laboratory spectra are used to analyse the observed CO and CO2 band profiles and try to constrain the formation scenarios of CO2.Comment: Accepted in A&

Microscopic Detection of Viable Staphylococcus epidermidis in Peri-Implant Tissue in Experimental Biomaterial-Associated Infection, Identified by Bromodeoxyuridine Incorporation

Infection of biomedical devices is characterized by biofilm formation and colonization of surrounding tissue by the causative pathogens. To investigate whether bacteria detected microscopically in tissue surrounding infected devices were viable, we used bromodeoxyuridine (BrdU), a nucleotide analogue that is incorporated into bacterial DNA and can be detected with antibodies. Infected human tissue was obtained postmortem from patients with intravascular devices, and mouse biopsy specimens were obtained from mice with experimental biomaterial infection. In vitro experiments showed that Staphylococcus epidermidis incorporated BrdU, as judged from staining of the bacteria with anti-BrdU antibodies. After incubation of bacteria with BrdU and subsequent staining of microscopic sections with anti-BrdU antibodies, bacteria could be clearly visualized in the tissue surrounding intravascular devices of deceased patients. With this staining technique, relapse of infection could be visualized in mice challenged with a low dose of S. epidermidis and treated with dexamethasone between 14 and 21 days after challenge to suppress immunity. This confirms and extends our previous findings that pericatheter tissue is a reservoir for bacteria in biomaterial-associated infection. The pathogenesis of the infection and temporo-spatial distribution of viable, dividing bacteria can now be studied at the microscopic level by immunolabeling with BrdU and BrdU antibodie