17 research outputs found
Stratigraphy of volcanic rock successions of the North Atlantic Rifted Margin : the offshore record of the Faroe Shetland and Rockall Basins
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/06/2021
- Field of study
Open Access via the CUP Read and Publish Agreement Acknowledgements The authors would like to thank Simon Kelley for comments on an earlier draft of the manuscript and for discussions on radiometric age dating. Dougal Jerram and John Faithfull are thanked for their constructive and helpful comments on the manuscript. PGS are thanked for permission to publish FSB MegaSurvey Plus data shown in Figures 6 and 8. PGS and TGS are thanked for permission to publish seismic data from the FSB2012 GeoStreamer survey also shown in Figure 6. Data used in Figure 19 are courtesy of GeoPartners and TGS, processing by DUG. IHS Kingdom Suite and Schlumberger Petrel Software are thanked for their donation of academic licenses to the University of Aberdeen.Peer reviewedPublisher PD
Transcriptome analysis in switchgrass discloses ecotype difference in photosynthetic efficiency
- Author
- A Mortazavi
- A Roberts
- A Roberts
- AM Missaoui
- B Langmead
- C Howald
- C Somerville
- C Trapnell
- C Trapnell
- CF Hardin
- CM Tobias
- CN Hansey
- D Kim
- D Serba
- D Wolfe
- DD Serba
- Desalegn D. Serba
- DJ Parrish
- E Meyer
- EM Leffler
- EM Rubin
- F Lu
- F Rapaport
- G Li
- GP Morris
- H Heberle
- H Li
- H Sonah
- I Chepelev
- J Romiguier
- J Spindel
- J Tang
- JA Poland
- JC Nelson
- JGAML Uitdewilligen
- JO Berry
- K Lu
- K-J Dietz
- Kirankumar S. Mysore
- L Liu
- L Liu
- L Pingault
- M Ashburner
- M Okada
- MA Gore
- MA Harris
- Malay C. Saha
- MR Broadley
- N Palmer
- N Wedel
- NA Palmer
- Nick Krom
- PE López-Calcagno
- R Razeghifard
- S Anders
- SG Rhee
- Shreyartha Mukherjee
- SJ Hultquist
- Srinivasa Rao Uppalapati
- T Thiel
- WA Bekele
- WF Anderson
- Y Wang
- Yuhong Tang
- Z Du
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
2015 Research & Innovation Day Program
- Author
- Aguillon Natalia
- Anderson Megan
- Bennett John
- Bonnett Tina
- Borland Amanda
- Broadfoot Sarah
- Broadley Nick
- Brown Gail
- Butler Carol
- Carter Magdalene
- Catten Colin
- Christie Matthew
- Churchill Alyssa
- Cross Shannon
- Cullen Maureen
- D\u27souza Alvan
- Deluce Aimee
- Durand Tyler
- Dyck Rebecca
- English Leona
- Esfahaninejad Mojgan
- Fandrich Christine
- Farahmandfar Masoud
- Farrington Deion
- Figueiredo Ryan
- Fischer Kelsey
- Fitzgeorge Lyndsay
- Garcia Samuel
- Garzon Johanna
- Germaniuk Samantha
- Ghafouri Farveh
- Goosheh Seyed
- Gramajo Walter
- Haaf Robert
- Hall Jodi
- Hoekstra Ian
- Howie Alexander
- Jazey Teah
- Johnson Karen
- Khadelwal Mona
- Kozlowski Maggie
- Krent David
- Lackenbauer Sandra
- Lai Catherine
- Lindsay Sara
- Lorusso Daniel
- Lorusso Elizabeth
- Lorusso Jenna
- Malik Tanweer
- Marks Cassandra
- Matlovich Emily
- May Brittany
- McDonald Erin E
- McHale Ryan
- McTavish Colleen
- Merrifield Grace
- Milley Jesse
- Mitchell Gary
- Morris Holly
- Morrish Lucas
- Naha Tanya
- Naha Tanya
- Naujokaitis Michell
- Nauss Sydnie
- Nicholson Lauren Marie
- O\u27Driscoll Caitlyn
- Ormsby Alexander
- Piskorski Amanda
- Rayment Coutrney
- Richardson Mitchell
- Robins Christopher
- Rodriguez Fredy
- Roodi Sam
- Sandiford Ben
- Service Julie Marie
- Sevenpifer Donna
- Singh Anand
- Smith Linnea
- Snobelen Susan
- Stewart Jennifer
- Sturm Peter
- Symons Helen
- Taylor Ashley
- Therrien Jasmine
- Thomas John Paul
- Trac Kyla
- Uzoma Jerry
- Van Boven Kalene
- Van Herk Jocelyn
- Van Kessel Karla
- Vauthier Kristen
- Verberne Hatty
- Vogt Krista
- Wallace Dylan
- Webb Shannon
- Webber Catherine
- Wilk Mary
- Woloszyn Annette
- Worobets Glen
- Zareardalan Ronak
- Publication venue
- FIRST: Fanshawe Innovation, Research, Scholarship, Teaching
- Publication date
- 01/01/2015
- Field of study
A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1002/thumbnail.jp
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
- Deans Andrew
- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
- Dewar A.
- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
- Docherty Annemarie B.
- Donaldson A.
- Dong T.
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- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
- Evans H
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- Evans R
- Evans Rachael A
- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
- Fabbri L
- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
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- Flynn Margaret
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- Foote David
- Ford Amber
- Forton D
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- Fuld Jonathan
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- Gleeson Fergus
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- Goodwin Camelia
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- Gupta Ayushman
- Gurram Sambasivarao
- Guthrie E
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- Haggar Ahmed
- Hainey Kera
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- Haldar Pranab
- Hall I
- Hall Lucy
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- Hancock Alyson
- Hancock Kia
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- Haq Sulaimaan
- Hardwick H.E.
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- Hastie Claire
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- Hawkings Nancy
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- Hayday A.
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- Hazeldine J
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- Heeney J L
- Heightman M
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- Henderson M
- Henson Helen
- Hesselden L
- Hewitt Melanie
- Highett Victoria
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- Hiwot T
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- Hoare Amy
- Hoare Michaela
- Hockridge J
- Hogarth Philip
- Holbourn Ailsa
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- Holdsworth L.
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- Holland Maureen
- Holloway Leah
- Holmes Katie
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- Holroyd-Hind B
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- Hormis Anil
- Horsley Alexander
- Hosseini A.
- Hotopf M
- Houchen-Wolloff Linzy
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- Howell Alice
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- Humphries Amy
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- Hutchinson John
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- Jayaraman Bhagy
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- Jezzard Peter
- Jiwa Kasim
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- Magtoto Murphy M.
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- Major E.
- Malein Flora
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- Mallison Georgia
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- Mandal S
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- Mukaetova-Ladinska Elizabeta
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- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
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- Ammeter Barb
- Amoaten Thomas
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- Anderson Beverley
- Anderson Chris
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- Anderson John
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- Anderson Juliette
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- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
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- Ansari Jawaher
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- Rodda Sree
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- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
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- Anderson Naomi
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- Anderson Susan
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- Andrews Kelly
- Andrews Stephen
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- Ansari Jawaher
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- Galway Denise
- Gamble Tina
- Gamble Tina
- Gamez Raquel
- Ganabady Malavika
- Gao Annie
- Garcia Leni Santiago
- Gardiner Fiona
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- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
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- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
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- Giovannini Julia
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- Glaholm John
- Glaholm John
- Gleave Martin E
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- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
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- Griffen Ailsa
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- Griffiths Dorothy
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- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
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- Gujral Sandeep
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- Harinarayanan Sathish
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- Ibrahim Azman
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- Iqbal Fawaad
- Irwin P
- Isaew Andrea
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- Jamieson Ceri
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
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- Jenkins Suzanne
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- Joshi Manisha
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- Kazingizi Memory
- Keane Patrick
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- Keith Sarah
- Kelkar Anand
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- Kendal Wayne S
- Keng-Koh Pek
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- Keni Manjusha
- Kennedy Julie
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- Kent Christopher
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- Khoury Ghassan
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- Kilmartin John
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- King Amy
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- Klapp Kathi
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- Lao Bernadeth
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- Lloyd-Jones Hugh
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- Logue John
- Logue John
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- Macgregor Carol
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- MacIsaac Patricia
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- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
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- Magwaro Sophia
- Magwaro Sophia
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- Mahmood Rana
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- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
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- Mashegede Beverley
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- McClements Jane
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- McFarlane Victoria
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- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
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- Michael Elena
- Michaelidou Andriana
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- Mikropoulos Christos
- Millage Helen
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- Milosevic Michael
- Mirmooji Ramesh
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- Mitra Anita
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- Moore Eleanor
- Moore Eleanor
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- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
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- Mthethwa Thobekile
- Mui Jimmy
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- Musunuru Hima Bindu
- Muthu Kumar Dakshinamoorthy
- Myatt Alison
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- Nabid Abdenour
- Nabid Abdenour
- Nagar Yoodhvir
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- Nathan Kannon
- Nawrozzadeh Mohammed
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- Ngumo Alice
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- Nicholson Alastair
- Nieforth Joan
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- Ong Aldrich D
- Ong Aldrich Dixon
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- Page Nancy
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- Paisey Sangeeta
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- Parker Chris
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- Parmar Mahesh K B
- Parmar Max
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- Partington Lillian
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- Parulekar Wendy
- Parulekar Wendy R
- Paschalis Alec
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- Persad Raj
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- Pervez Nadeem
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- Peters John
- Petersen Peter M
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- Plataniotis George
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- Rose Jim
- Rose Tina
- Rosenfelder Nicola
- Rosoman Alison
- Ross Ashley
- Ross Kristy
- Ross Liliam
- RossSmith Marleen
- Rotherham Carol
- Rousseau Pierre
- Rowe Edward
- Roxburgh Patricia
- Ruane Sarah
- Rudnicki Rayleen
- Ruiz Maria Jose Gaitan
- Russell Emily
- Russell Martin
- Russell Martin
- Russell Simon
- Russell Tamlyn
- Ruszala Elizabeth
- Rutledge Robert DH
- Rutter Charley-Anne
- Ryan Rachel
- Ryan-Smith Janet
- Ryan-Smith Janet
- Rønnengart Eva
- Saad Fred
- Saad Fred
- Sabate Kathryn
- Sabbagh Ahmad
- Sabbagh Robert
- Sabharwal Ami
- Sabharwal Ami
- Sabharwal Ami
- Sadare (Olaleye) Ibiyemi
- Sadare (Olaleye) Ibiyemi
- Sadozye Azmat
- Sahin Sarah
- Saldanha Helen
- Saleem Shamila
- Salyzyn Camryn
- Samanci Ali
- Samkange Grace
- Samra Tarandip
- Samson Julie
- Sanchez Maria
- Sanders Kay
- Sandhu Sandeep
- Sangar Vijay
- Sankighatta Naveen
- Santos Priscilla
- Sargent Sister Tracey
- Sathya Jinka R
- Saunders Daniel
- Savage Sarah
- Sax Lori
- Saxe Charlotte
- Saxton Wendy
- Sayers Ian
- Sayers Ian
- Sayers Rachel
- Scarratt Lyndsay
- Schumacher Ann
- Scrase Christopher
- Searle Claire
- Sears Alison
- Seath Ingrid
- Sebborn Kes
- Segaran Surayne
- Sellars Elizabeth
- Sells Henry
- Seray-Wurie Fatimah
- Serpanchy Rosanne
- Serra Maria
- Sewell Jane
- Sexton Tracy
- Shackley David
- Shaffer Richard
- Shaffer Richard
- Shahid Negin
- Shaji Preetha
- Shakespeare Devadasan
- Shantz Brenda S
- Sharif Shahid
- Sharma Atul
- Sharma Rajesh
- Sharman Emma
- Sharpe Simon
- Shaw Alison
- Shearer Kirsty
- Sheehan Denise
- Sheehan Denise
- Shelton Luke
- Shenfield Carey
- Shenouda George
- Shetty Kavitha
- Shewchuk Caroline
- Shimell Chris
- Shires Heather
- Shiridzinomwa Constance
- Shirley Sian
- Shobrook Bridget
- Shukla Arundhati
- Shum Poh Lin
- Shuttleworth Pam
- Sibug Sheena
- Sicard MarieEve
- Siddiqui Atif
- Sidek Norma
- Sidek Norma
- Sidi Frances
- Sierra Pala Ana
- Sim Van
- Simmonds Mary
- Simmons Elaine
- Simmons Elaine
- Simms Matthew
- Simpson Georgina
- Simpson Julie
- Simpson Robin
- Sims Hannah
- Sims Laura
- Sinclair Glenda
- Sinclair Julie-Ann
- Sinfield Melanie
- Singh Harpreet
- Singizi Bryan
- Singson Angelina
- Siu Bernard
- Sivananthan Gokulan
- Sivananthan Gokulan
- Sivoglo Virgil
- Sizer Bruce
- Skelton Amy
- Skene Anna
- Skewes Johanna
- Skwarski Michael
- Slack Jonathan
- Slessor Janet
- Slevin Kathryn
- Sloan Andrew
- Smale Daisy May
- Smallwood Sarah
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smith Beccy
- Smith Carlie
- Smith Carolyn
- Smith Dan
- Smith Gill
- Smith Jackie
- Smith Lucy
- Smith Lucy
- Smith Lucy
- Smith Margaret
- Smith Matthew
- Smith Nick
- Smith Rachel
- Smith Rowena
- Smith Sandra
- Smith Sarah-Ellen
- Smith Sister Catherine
- Smith Susan
- Smith Suzanne
- So Alan I
- Sohanpal Sundip
- Sohanpal Sundip
- Somasiri Ashane
- Sorice Vittoria
- Souhami Luis
- Southgate Elizabeth
- Spalton Catherine
- Sparrow Geoffrey
- Spearman Mary
- Speed Lesley
- Spence Rachael
- Spencer Craig
- Spencer Hazel
- Spencer Patti
- Spencer Sue
- Spickett Helen
- Spillane Maria
- Spittle Ben
- Spoor Willemijn
- Springall Christine
- Spruce Debbie
- Squires Mandy
- Sreenivasan Thiagarajan
- Sreenivasan Thiagarajan
- Srihari Narayanan
- Srinivasan Rajaguru
- Srinivasan Rajaguru
- Srinivasan Vaiku
- Stacey Wendy
- Stafferton Ruth
- Staffurth John
- Staines Nikki
- Stammers Tracey
- Stancliffe May
- Stanley Laura
- Stapleton Stephanie
- Starling Ellen
- Steele Anita
- Steffensen Kirsten
- Stephens Rebekah
- Stephenson Anna
- Stephenson Anna
- Stevens Christiaan
- Stevens Nicole
- Stevenson Garry
- Stevenson Lesley
- Stevenson Robert
- Steventon Emily
- Stewart David
- Stewart Simon
- Stewart Simon
- Stewart Simon
- Stilling Sine
- Stockdale Andrew
- Stockdale Andrew
- Stockley Emma
- Stockport Jane
- Stoddart Jonathan
- Stone Helena
- Stone Matthew
- Stone Sarah
- Storer Julie
- Storrs Sarah
- Stott Mark
- Stott Matthew
- Stower Michael
- Stranex Stephen
- Stretch Alison
- Strider Paula
- Stringer (pr. Davis) Sally
- Strong-Sheldrake Sophia
- Stuart Robert
- Subramaniam Ramachandran
- Sullivan Frank
- Sumner Lesley
- Sundar Santhanam
- Sundar Santhanam
- Sundaram Subramanian Kanaga
- Sunny Manju
- Sutherland Donna
- Swann Michelle
- Sydes Matthew
- Sydes Matthew R
- Sylvestre Alma
- Symon Lesley
- Syndikus Isabel
- Szolin-Jones Jacob
- Szumacher Ewa
- Szymiczek Kinga
- Tahir Saad
- Tait Ellen
- Tan Matthew
- Tappenden Nancy
- Tapping Sister Hayley
- Tapping Sister Hayley
- Tasker Lorraine
- Tate Janine
- Taussky Daniel
- Tay Jessica
- Taylor Becky
- Taylor Beverley
- Taylor Carol
- Taylor Helen
- Taylor Henry
- Taylor Jacob
- Taylor Jacob
- Taylor Jennifer
- Taylor Jill
- Taylor Jo-Anne
- Taylor Kate
- Taylor Katy
- Taylor Katy
- Taylor Lisa
- Taylor Sister Melanie
- Teahan Seamus
- Teasdale Breanne
- Tedd Gemma
- Tee Elizabeth
- Teh Chiaw Woon
- Teh Jonathan
- Telfer Sheena
- Templeton Maureen
- tenHaaf Darlene
- Tennant Virginia
- Teo Mark
- TetreaultLaflamme Audrey
- Thackray Louis
- Thallury Sheeba
- Tharahan Nanthini
- Thevarajah Vaishaali
- Thibeault Andreanne
- Thim Stine
- Thind Manreet
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thomas Carys
- Thomas Carys
- Thomas Dianne
- Thomas Heather
- Thomas Helen
- Thomas Isobel
- Thomas Jacqueline
- Thomas Rachel
- Thomas Robert
- Thomas Sister Viv
- Thomasson Georgia
- Thominson Bronwen
- Thompson Catherine
- Thompson Catherine
- Thompson Chloe-Anne
- Thompson Emma
- Thompson Jane
- Thoms John
- Thomson Alastair H
- Thomson Sister Jane
- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
- Tiessen Kyoko
- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
- Tikoo Archana
- Timmings Katie
- Tindall Annie
- Tippins Anna
- Tipples Karen
- Todd Anne
- Todd Joanna
- Tolan Shaun
- Toledo Jesusa
- Tomlinson Annabel
- Tomlinson Eve
- Toms Julie
- Topalovich Aleksandra
- Topps Alice
- Torin Lehmann Anna
- Torres Cynthia
- Totten Grace
- Toussi H
- Townley Barbara
- Townley Luke
- Townsend-Thorn Debra
- Towse Jo
- Toy Elizabeth
- Trakalo Kathy
- Tran Anna
- Tran Anna
- Tranter Fiona
- Tranter Helen
- Tranter Helen
- Treasure Ann
- Tree Alison
- Tree Alison
- Treeby Jo
- Treherne Katy
- Tremlett Jean
- Trewsmith Neil
- Tribe Lisa
- Trigg-Hogarth Kate
- Trigonis Ioannis
- Trudel Diane
- Tsakirdis Thedoros
- Tsalic Medy
- Tsang David
- Tsang Lilian
- Tsawayo Tan
- Tse Karen
- Tseng Eric Chia Lin
- Tsuji Debbie
- Tuazon Juel
- Tuck Jonathan
- Tufail Aisha
- Turley Claudia
- Turley Claudia
- Turner Christy
- Turner Nikki
- Turner Sarah
- Turriff Lisa
- Tweedle James
- Tyldesley Scott
- Tyler Jayne
- Tyner Sharah
- Uherek Maja
- Upson Susan
- Urquhart Zoe
- Uscinska Barbara
- Usmani Nawaid
- Vallieres Isabelle
- Vamplew Luke
- Van As Nicholas
- Van der Voet Hans
- Van Someren Chloe
- Van-Koutrik Lynne
- Vandal Mohammad Tanvir
- Vandborg Maria
- Vandecandalaere Elaine
- Varley Gail
- Varro Robert
- Varughese Mohini
- Varughese Mohini
- Vasanthan Subramanian
- Vaughn Jamie
- Vavassis Peter
- Velec Erin
- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
- Venkitaraman Ramachandran
- Vermette Tracy
- Vesprini Danny
- Vickery Kathryn
- Vigneault Eric
- Vijayakumar Vijitha
- Vilarino-Varela Maria
- Vincent Francois
- Vincent LindaSuzanne
- Vinod Cellins
- Virgo Azarel
- Vowell Emma
- Vu Thi
- Wade Lynne
- Wade Rob
- Wadsworth Oliver
- Wakefield Shauna
- Wakelen Paula
- Waldron Eleanor
- Walker Beth
- Walker Caroline
- Walker Georgina
- Walker Georgina
- Walker Heather
- Walker Jayashree
- Walker Julia
- Walker Karen
- Walker Lori
- Walker Suzanne
- Wall Elaine
- Wallace Jan
- Wallace Kris
- Wallbutton Rebecca
- Walmsley Catherine
- Walsh Donna
- Walton Jenny
- Walton Sharon
- Ward Angela
- Ward Colin
- Warde Padraig
- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
- Webb Andrew
- Webb Claire
- Webb Kerrie
- Webb Paula
- Websdale Cheryl
- Webster Christine
- Wei Joyce
- Weir JoAnn
- Wellman Sandie
- Wells Paula
- Wells Paula
- Wells Paula
- Wells Tom
- Welsh Liam
- Welsh Linda
- Westley Rosalyne
- Weston Alison
- Weston Philip
- Westrop Anna
- Westrop Anna
- Westrop Anna
- Wheatley Duncan
- Wheeler Lucie
- Wheelwright Roger
- Whelan Kate
- Whillis David
- Whinn Samantha
- Whitcher Alison
- White Ann
- White Holly
- White Joanna
- Whitehouse James
- Whitehouse James
- Whiteway Chrystal
- Whittle Stacy
- Whotton Nikita
- Wiggins Sarah
- Wightman John
- Wignall Suzy
- Wild Karen
- Wilke Derek
- Wilkie Karen
- Wilkins Marie
- Wilkinson Nicola
- Williams (Née Allen) Sister Tania
- Williams Amanda
- Williams Bethan
- Williams Candra
- Williams Jo
- Williams Joanne
- Williams Rachel
- Williams Rachel
- Williams-Yesson Barbara
- Williamson Elizabeth
- Williamson Nicola
- Willing Stephanie
- Wilson David
- Wilson Jim
- Wilson Jo
- Wilson Mark
- Wilson Paula
- Wilson Paula
- Wilson Russ
- Winn Carol
- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
- Wood Pauline
- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
- Woods Catherine
- Woods Jane
- Woods Martin
- Woodward Cathryn
- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
- Worsley Lucy
- Worthington Hannah
- Wright Ann
- Wright Natalie
- Wright Seonaid
- Wrigley Martha
- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Author response
- Author
- Aguilaniu
- Amon
- Bagriantsev
- Broadley
- Carmichael
- Chai
- Chernoff
- Chiti
- Conde
- Cox
- Cox
- Cushman-Nick
- Derdowski
- Derkatch
- DiSalvo
- Douglas
- Duennwald
- Eaglestone
- Eaglestone
- Erjavec
- Erjavec
- Escusa-Toret
- Gasch
- Gidalevitz
- Glover
- Grimminger
- Hernebring
- Higurashi
- Holmes
- Inoue
- Ishihara
- Jahn
- Jana
- Johnston
- Jung
- Jung
- Kaganovich
- Kawai-Noma
- Kim
- King
- Kirstein-Miles
- Knorre
- Kobayashi
- Kohno
- Kryndushkin
- Kummer
- Lim
- Lindquist
- Liu
- Lo Bianco
- Malinovska
- Mallucci
- Mattoo
- Meriin
- Morimoto
- Morimoto
- Ness
- Newnam
- Olzscha
- Park
- Park
- Patino
- Paushkin
- Pezza
- Powers
- Rampelt
- Rujano
- Sanchez
- Satpute-Krishnan
- Satpute-Krishnan
- Schaffar
- Serio
- Shorter
- Shorter
- Shorter
- Song
- Specht
- Spokoini
- Tam
- Tanaka
- Tariq
- Taylor
- Ter-Avanesyan
- Tessarz
- Tipton
- Torrente
- Tuite
- Tuite
- Unal
- Voisine
- Wang
- Wegrzyn
- Weisberg
- Winkler
- Wolfe
- Wolff
- Yamamoto
- Yang
- Yu
- Zeymer
- Zhou
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- Field of study
High rate of persistent symptoms up to 4 months after community and hospital-managed SARS-CoV-2 infection
- Author
- Abeysuriya Romesh
- Andresen David
- Bablani Laxman
- Balogh Zsolt L
- Beard Frank H
- Begum Husna
- Bell Katy J.L.
- Blakely Tony
- Brew Bruce
- Broadley Tessa
- Burrell Aiden JC
- Byrne Anthony
- Campbell Lewis T
- Carlin John B
- Carvalho Natalie
- Cervin Anders
- Cheng Allen C
- Cheung Winston
- Cooper D James
- Cunningham Philip
- Cysique Lucette
- d'Emden Michael C
- Danny Indra
- Darley David R
- de Jersey Susan J
- Delport Dominic
- Dore Gregory J
- Downes Marnie
- Dwyer Dominic E
- Earnest Arul
- Earnshaw James
- Erickson Simon J
- French Craig J
- Gidding Heather F
- Gosbell Ian B
- Hainsworth Samuel
- Hao Tran Tu
- Heath Katie
- Hendry Alexandra J
- Hennessy Annamarie
- Heriot George S
- Hirani Rena
- Horvath Andrea R
- Hueston Linda
- Irving David O
- Irwig Les
- Jamrozik Euzebiusz
- Johnston Kate
- Kaldor John M
- Kelleher Anthony
- Kerr Cliff C
- Klein Daniel
- Litton Edward
- Loy Clement
- Macartney Kristine
- Machalek Dorothy A
- Masters Jeffrey
- Matthews Gail
- McAllister Richard
- Meyer Lois
- Mistry Dina
- Mistry Sandeep G
- Morgan Lucy
- Murthy Srinivas
- Nichol Alistair
- O'Sullivan Matthew NV
- O’Loughlin Aiden
- Palermo Annamaria
- Palmer Anna
- Pellegrini Breanna
- Plit Marshall
- Plummer Mark
- Quinn Helen E
- Ramanan Mahesh
- Reddi Benjamin
- Reynolds Claire
- Sacks-Davis Rachel
- Salimi Farhad
- Sasikumar Suraj Narayanan
- Scott Nick
- Shilling Hannah
- Stanaway Fiona
- Stevenson Mark
- Stone Emily
- Stuart Robyn
- Tang Helen
- Tarrant Seth M
- Teixeira-Pinto Armando
- Thompson Jason
- Tonga Katrina
- Trapani Tony
- Tyson Chloe
- Udy Andrew
- Ungerer Jacobus PJ
- Vette Kaitlyn
- Walker Wallace
- Way Teagan L
- Webb Steven AR
- Wilhelm Kay A
- Wilson Nick
- Publication venue
- Faculty of Medicine and Health, Sydney School of Public Health
- Publication date
- 01/01/2020
- Field of study
Recovery after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains uncertain. A considerable proportion of patients experience persistent symptoms after SARS-CoV-2 infection which impacts health-related quality of life and physical function
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
- Author
- Abraham Richard
- Anderson Carl A
- Bahlo Melanie
- Bass Nicholas J
- Booth David R
- Brayne Carol
- Broadley Simon
- Brown Kristelle
- Brown Matthew A
- Butzkueven Helmut
- Carroll William M
- Chapman Jade
- Collinge John
- Craig David
- Cruchaga Carlos
- Deloukas Panagiotis
- Dowzell Kimberley
- Field Judith
- Foote Simon J
- Fox Nick
- Frölich Lutz
- Gerrish Amy
- Gill Michael
- Goate Alison
- Goddard Michael E
- Gordon Scott D
- Griffiths Lyn
- Guo Qun
- Gurling Hugh
- Gwilliam Rhian
- Hampel Harald
- Hamshere Marian
- Hardy John
- Harold Denise
- Heard Robert N
- Henders Anjali K
- Heun Reiner
- Heuser Isabella
- Hollingworth Paul
- Holmans Peter
- Holmes Clive
- Hüll Michael
- Jessen Frank
- Jones Nicola
- Kehoe Patrick G
- Kennedy Stephen H
- Kermode Allan G
- Kilpatrick Trevor J
- Kornhuber Johannes
- Kraft Peter
- Kölsch Heike
- Lambert Ann
- Lawlor Brian
- Lechner-Scott Jeannette
- Lee S. Hong
- Livingston Gill
- Love Seth
- Lovestone Simon
- Lupton Michelle K
- Lynch Aoibhinn
- Macgregor Stuart
- Maier Wolfgang
- Mann David
- Marriott Mark
- Martin Dichgans
- Martin Nicholas G
- Mason Deborah
- Mayo Kevin
- McGuinness Bernadette
- McQuillin Andrew
- Mead Simon
- Missmer Stacey A
- Montgomery Grant W
- Morgan Angharad
- Morgan Kevin
- Morris
- Morris Andrew P
- Moscato Pablo
- Moskvina Valentina
- Nowotny Petra
- Nyholt Dale R
- Nöthen Markus M
- O'Donovan Michael
- Owen Michael J
- Pahwa Jaspreet Singh
- Painter Jodie N
- Passmore Peter
- Perreau Victoria
- Powell John
- Proitsi Petroula
- Roseman Fenella
- Rossor Martin
- Rubinsztein David C
- Rubio Justin
- Rujescu Dan
- Schürmann Britta
- Scott Rodney J
- Sims Rebecca
- Slee Mark
- Smith A. David
- Stankovich Jim
- Stewart Graeme J
- Stretton Alexandra
- Taylor Bruce V
- Thomas Charlene
- Todd Stephen
- Treloar Susan A
- van den Bussche Hendrik
- Visscher Peter M
- Wallace Leanne
- Wiley James
- Williams Amy
- Williams Julie
- Wiltfang Jens
- Wray Naomi R
- Zondervan Krina T
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2013
- Field of study
Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for these diseases have identified a number of individual genetic variants contributing to the risk of those diseases. However, the effect size for most variants is small and collectively the known variants explain only a small proportion of the estimated heritability. We used a linear mixed model to fit all single nucleotide polymorphisms (SNPs) simultaneously, and estimated genetic variances on the liability scale using SNPs from GWASs in unrelated individuals for these three diseases. For each of the three diseases, case and control samples were not all genotyped in the same laboratory. We demonstrate that a careful analysis can obtain robust estimates, but also that insufficient quality control (QC) of SNPs can lead to spurious results and that too stringent QC is likely to remove real genetic signals. Our estimates show that common SNPs on commercially available genotyping chips capture significant variation contributing to liability for all three diseases. The estimated proportion of total variation tagged by all SNPs was 0.26 (SE 0.04) for ED, 0.24 (SE 0.03) for AD and 0.30 (SE 0.03) for MS. Further, we partitioned the genetic variance explained into five categories by a minor allele frequency (MAF), by chromosomes and gene annotation. We provide strong evidence that a substantial proportion of variation in liability is explained by common SNPs, and thereby give insights into the genetic architecture of the diseases.10 page(s
Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model
- Author
- A Esquenazi
- A Feigin
- A Haacke
- AE Elia
- AH Brand
- AJ Stoessl
- AM Ellisdon
- AM Ellisdon
- AM Maguire
- AM Wang
- AR Bentivoglio
- BA Hay
- Bingwei Lu
- BJ Winborn
- C Bettencourt
- C Bettencourt
- C Lo Bianco
- C Vacher
- CJ Cummings
- CL Wellington
- CM Dobson
- DA Parsell
- DD Mosser
- F Chiti
- F Dandoy-Dron
- FL Yeh
- G Nicastro
- G Roman
- G Schiavo
- GM Harris
- GP Ritson
- H Braak
- H Olzscha
- H Paulson
- H Rampelt
- HL Paulson
- HL Paulson
- HY Chan
- HY Shen
- J Carmichael
- J Jung
- J Naslund
- J Shen
- J Shorter
- J Shorter
- J Shorter
- J Shorter
- J Shorter
- J Shorter
- James Shorter
- JM Warrick
- JM Warrick
- JM Warrick
- JW Bainbridge
- K Kuhlbrodt
- K Trinh
- KJ Wolfe
- L Masino
- L Masino
- L Masino
- M Armakola
- M Cushman
- M Hallett
- M Simonato
- ME DeSantis
- ME DeSantis
- MG Kaplitt
- Mimi Cushman-Nick
- ML Duennwald
- ML Duennwald
- MS Forman
- Nancy M. Bonini
- P Tessarz
- P Wendler
- P Wendler
- P Westermark
- PJ McLean
- PJ Muchowski
- PJ Muchowski
- PK Auluck
- PM Douglas
- R Halfmann
- RK Graham
- RM Vabulas
- S Alberti
- S DiSalvo
- S Hacein-Bey-Abina
- S Ju
- S Vashist
- SA Broadley
- SH Satyal
- SL Osborne
- SW Davies
- T Osterwalder
- V Perrin
- W San Sebastian
- Y Nekooki-Machida
- Y Sanchez
- Y Sanchez
- Y Takiyama
- Z Sun
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study