Datos, información y conocimiento: ¿Dónde acaba la información y comienza el esnobismo de la transformación digital?

La disrupción de Internet está provocando un seísmo en todos los sectores económicos. La transformación digital, es decir, la aplicación de las tecnologías on line a todos los aspectos y sectores de la economía, está en el centro de este gran cambio que afronta el mundo. Al mismo tiempo, La Sociedad del Conocimiento está provocando que exista una enorme división entre quienes, con una postura totalmente optimista, manifiestan las ventajas de esta realidad y, por otro lado, un grupo cada vez mayor de pesimistas que advierten de los riesgos de engordar esta realidad

Datos, información y conocimiento: promesas y realidades de la red global

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias de la Información, leída el 26-09-2014Fac. de Ciencias de la InformaciónTRUEunpu

Two Novel FAM20C Variants in a Family with Raine Syndrome

Two siblings from a Mexican family who carried lethal Raine syndrome are presented. A newborn term male (case 1) and his 21 gestational week brother (case 2), with a similar osteosclerotic pattern: generalized osteosclerosis, which is more evident in facial bones and cranial base. Prenatal findings at 21 weeks and histopathological features for case 2 are described. A novel combination of biallelic FAM20C pathogenic variants were detected, a maternal cytosine duplication at position 456 and a paternal deletion of a cytosine in position 474 in exon 1, which change the reading frame with a premature termination at codon 207 and 185 respectively. These changes are in concordance with a negative detection of the protein in liver and kidney as shown in case 2. Necropsy showed absence of pancreatic Langerhans Islets, which are reported here for the first time. Corpus callosum absence is added to the few reported cases of brain defects in Raine syndrome. This report shows two new FAM20C variants not described previously, and negative protein detection in the liver and the kidney. We highlight that lethal Raine syndrome is well defined as early as 21 weeks, including mineralization defects and craniofacial features. Pancreas and brain defects found here in FAM20C deficiency extend the functional spectrum of this protein to previously unknown organs

. 46 Tomo XVII (1964) Sexta Época (1939-1966). Anales del Instituto Nacional de Antropología e Historia

Publicación que recopila y difunde cien años de trabajo de la antropología en México (1877-1977), integrada por documentos y manuscritos arqueológicos, antropológicos, históricos, geológicos, botánicos y lingüísticos.- Información general de las actividades del Instituto Nacional de Antropología e Historia durante el año 1964 por Eusebio Dávalos Hurtado. - Investigaciones arqueológicas en las cuevas del sur de Tehuacán, Puebla y sur de Córdoba, Ver. por Agustín Delgado. - La conservación de los murales prehispánicos por Agustín Villagra Caleti. - Tenayuca, exploraciones de 1963 por Jorge R. Acosta. - El adoratorio decorado de las calles de Argentina por Eduardo Matos Moctezuma. - Un estudio longitudinal de crecimiento en México por Johanna Faulhaber. - Cálculo de la estatura e índices cnémico, mérico y lénico en restos óseos de dos cuevas de Coahuila por María Teresa Jaén Esquivel. - Sobre las técnicas de valoración del desarrollo óseo de las áreas carpales por Roberto Jiménez Ovando. - Cinco cráneos procedentes de Tanquián, S.L.P. por Sergio López Alonso. - Recientes adiciones a la colección de dientes mutilados por Javier Romero. - Los préstamos españoles en el zapoteco de Mitla por María Teresa Fernández de Miranda. - Investigación lingüística sobre los grupos indígenas del estado de Baja California por Carlos Robles Uribe. - Tres cuentos mayas por Moisés Romero Castillo. - El carnaval de Tenejapa por Andrés Medina Hernández. - Algunos problemas generales en el muestreo estadístico por Felipe Montemayor. - Ubicación de la etnografía en el cuadro de la investigación antropológica por José de Jesús Montoya Briones. - Los pápagos, habitantes del desierto por Margarita Nolasco Armas. - Relación fidedigna de la provincia agustiniana de Mechoacan. - Suma y memoria de conventos y pueblos de la provincia dominicana de Guatemala y Chiapas por Antonio Pompa y Pompa. - Memorial de religiosos, conventos, colegios y doctrinas de indios de la provincia de Santiago de México. - Memorial de conventos, doctrinas y religiosos de la provincia franciscana de Guatemala, Honduras y Chiapas

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

Background: Antimicrobial resistance is an increasing concern in ICUs worldwide. Infection with an antibiotic resistant (ABR) strain of an organism is associated with greater mortality than infection with the non-resistant strain, but there are few data assessing whether being admitted to an intensive care unit (ICU) with high levels of antimicrobial resistance is associated with a worse outcome than being admitted to an ICU with low rates of resistance. The aim of this study was, therefore, to compare the characteristics of infections and antibiotic treatments and patient outcomes in patients admitted to ICUs in countries considered as having high levels of antibiotic resistance and those admitted to ICUs in countries considered as having low levels of antibiotic resistance. Methods: Data from the large, international EPIC II one-day point prevalence study on infections in patients hospitalized in ICUs were used. For the current study, we compared the data obtained from patients from two groups of countries: countries with reported MRSA rates of greater than= 25% (highABR: Greece, Israel, Italy, Malta, Portugal, Spain, and Turkey) and countries with MRSA rates of less than 5% (lowABR: Denmark, Finland, Netherlands, Norway, and Sweden). Results: On the study day, 1187/2204 (53.9%) patients in the HighABR ICUs were infected and 255/558 (45.7%) in the LowABR ICUs (P less than 0.01). Patients in the HighABR ICUs were more severely ill than those in the LowABR ICUs, as reflected by a higher SAPS II score (35.6 vs 32.7, P less than 0.05) and had longer median ICU (12 days vs 5 days) and hospital (24 days vs 16 days) lengths of stay. They also had higher crude ICU (20.0% vs 15.4%) and hospital (27.0% vs 21.5%) mortality rates (both P less than 0.05). However, after multivariable adjustment and matched pair analysis there were no differences in ICU or hospital mortality rates between High or LowABR ICU patients overall or among those with infections. Conclusions: Being hospitalized in an ICU in a region with high levels of antimicrobial resistance is not associated per se with a worse outcome

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

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Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

Background: Antimicrobial resistance is an increasing concern in ICUs worldwide. Infection with an antibiotic resistant (ABR) strain of an organism is associated with greater mortality than infection with the non-resistant strain, but there are few data assessing whether being admitted to an intensive care unit (ICU) with high levels of antimicrobial resistance is associated with a worse outcome than being admitted to an ICU with low rates of resistance. The aim of this study was, therefore, to compare the characteristics of infections and antibiotic treatments and patient outcomes in patients admitted to ICUs in countries considered as having high levels of antibiotic resistance and those admitted to ICUs in countries considered as having low levels of antibiotic resistance.Methods: Data from the large, international EPIC II one-day point prevalence study on infections in patients hospitalized in ICUs were used. For the current study, we compared the data obtained from patients from two groups of countries: countries with reported MRSA rates of ≥ 25% (highABR: Greece, Israel, Italy, Malta, Portugal, Spain, and Turkey) and countries with MRSA rates of < 5% (lowABR: Denmark, Finland, Netherlands, Norway, and Sweden).Results: On the study day, 1187/2204 (53.9%) patients in the HighABR ICUs were infected and 255/558 (45.7%) in the LowABR ICUs (P < 0.01). Patients in the HighABR ICUs were more severely ill than those in the LowABR ICUs, as reflected by a higher SAPS II score (35.6 vs 32.7, P < 0.05) and had longer median ICU (12 days vs 5 days) and hospital (24 days vs 16 days) lengths of stay. They also had higher crude ICU (20.0% vs 15.4%) and hospital (27.0% vs 21.5%) mortality rates (both P < 0.05). However, after multivariable adjustment and matched pair analysis there were no differences in ICU or hospital mortality rates between High or LowABR ICU patients overall or among those with infections.Conclusions: Being hospitalized in an ICU in a region with high levels of antimicrobial resistance is not associated per se with a worse outcome. © 2014 Hanberger et al.; licensee BioMed Central Ltd