Ritual Commensality between Human and Non-Human Persons: Investigating Native Ontologies in the Late Pre-Columbian Andean World

In anthropology, it has become axiomatic that social relationships are constructed through food practices and embodied in food. This paper suggests that both ritual and quotidian commensality have as either a goal or a consequence the construction of specific relations of sociality, and in this regard are not so different. What may distinguish these spheres of commensality, however, are the types of persons engaged in the act of shared consumption. The paper considers ritual commensality as a means of exploring the social universe and indigenous ontology of native Andean peoples, using both archaeological and ethnohistoric data. The role such commensal activities may have played in the construction of, and engagement with, other-than-human persons in the late pre-Columbian Andes is considered

Investigating Native Ontologies in the Late Pre-Columbian Andean World

In anthropology, it has become axiomatic that social relationships are constructed through food practices and embodied in food. This paper suggests that both ritual and quotidian commensality have as either a goal or a consequence the construction of specific relations of sociality, and in this regard are not so different. What may distinguish these spheres of commensality, however, are the types of persons engaged in the act of shared consumption. The paper considers ritual commensality as a means of exploring the social universe and indigenous ontology of native Andean peoples, using both archaeological and ethnohistoric data. The role such commensal activities may have played in the construction of, and engagement with, other-than-human persons in the late pre-Columbian Andes is considered

An Archaeological Perspective on the Andean Concept of \u3cem\u3eCamaquen\u3c/em\u3e: Thinking Through Late Pre-Columbian \u3cem\u3eOfrendas\u3c/em\u3e and \u3cem\u3eHuacas\u3c/em\u3e

Ethnohistoric sources suggest that the indigenous inhabitants of Andean South America saw both people and things as animated or enlivened by a common vital force (camaquen). In approaching the subject of camaquen archaeologically, I attempt to place objects and their materiality at the analytical center, rather than the normally privileged ethnohistoric or ethnographic data, in order to see what new insights into the nature of precolumbian ontologies might be gained from ‘thinking through things.’ In this, I follow recent theories premised on the idea that the traditional segregation of concepts and things may hinder understanding of alternative worlds. The study focuses specifically on the arrangements, relationality, and referentiality between and among objects found in sacred and offering contexts dating to the Inca period

Marin County Youth Focus Group Project: Youth Perception Regarding Access and Barriers to Equitable Education and Careers

This collaborative project between the Workforce Investment Board of Marin and Dominican University of California emerged through the DUC Service-Learning Director’s involvement in a subcommittee of the Workforce Investment Board of Marin. The subcommittee’s mission is to identify needs of jobseekers, employers, and the future workforce. Youth voice and perception are vital to understanding how to create, maintain, and evolve towards greater sustainability and a thriving workforce with equitable opportunities for everyone. We purposely targeted youth of diverse ethnicities who participate in county and non-profit programs aimed, in a variety of ways, at their empowerment. The purpose of the youth focus groups was to acquire qualitative data based on youth perceptions regarding their educational experience, the opportunities available to them in higher education, and their knowledge of what services are currently available to them in Marin County to support their educational success. This project received funding through a grant from the DUC Provost’s Office and the project proposal, RBPHS Application #5069, was submitted to and approved by the Dominican University Institutional Review Board for the Protection of Human Subjects. Funding allowed us to offer hospitality to focus groups, $10 gift certificates to participants, and to hire the Research and Evaluation Team from Youth Leadership Institute to train our team in focus group methodology–– including question formulation, group facilitation techniques, and documenting, organizing, and analyzing data. The investigators came from outside the field of K-12 education and the findings are based directly on the youth responses and our observations during the groups. Report contents are divided into sections that attempt to make clear how findings were derived and what they might mean for better understanding the educational challenges and needs of youth in Marin County and the ways in which existing programs might come together and new initiatives may be implemented in response. Sections for this report occur in the following manner: An overview summarizes key findings and conclusions in an effort to highlight next steps for addressing educational success for Marin County youth based on the perceptions of participants. Data collection procedures are presented to make clear how information was gathered to assess youth perceptions, which includes the questions posed to them by facilitators to do so. Procedures for analyzing data are presented to explain derivation of findings. Focus group participants are described to understand the sample of youth responses subjected to analyses and how findings might be generalized to other populations. Findings are presented and interpreted to make clear youth perceptions as reported by participants about a variety of topics related to educational equity in their community. Conclusions are drawn from a summary of findings that provide the framework for discussion in the overview. Appendices: Data tables: Appendix A, Profile for Youth Participants; Appendix B, Analyzed Response Breakdown by group for Questions 3,4,5, Appendi

Network meta‐analysis of randomized trials evaluating the comparative efficacy of lipid‐lowering therapies added to maximally tolerated statins for the reduction of low‐density lipoprotein cholesterol

Background: Lowering low‐density lipoprotein cholesterol (LDL‐C) levels decreases major cardiovascular events and is recommended for patients at elevated cardiovascular risk. However, appropriate doses of statin therapy are often insufficient to reduce LDL‐C in accordance with current guidelines. In such cases, treatment could be supplemented with nonstatin lipid‐lowering therapy. Methods and Results: A systematic literature review and network meta‐analysis were conducted on randomized controlled trials of nonstatin lipid‐lowering therapy added to maximally tolerated statins, including statin‐intolerant patients. The primary objective was to assess relative efficacy of nonstatin lipid‐lowering therapy in reducing LDL‐C levels at week 12. Secondary objectives included the following: LDL‐C level reduction at week 24 and change in non–high‐density lipoprotein cholesterol and apolipoprotein B at week 12. There were 48 randomized controlled trials included in the primary network meta‐analysis. All nonstatin agents significantly reduced LDL‐C from baseline versus placebo, regardless of background therapy. At week 12, evolocumab, 140 mg every 2 weeks (Q2W)/420 mg once a month, and alirocumab, 150 mg Q2W, were the most efficacious regimens, followed by alirocumab, 75 mg Q2W, alirocumab, 300 mg once a month, inclisiran, bempedoic acid/ezetimibe fixed‐dose combination, and ezetimibe and bempedoic acid used as monotherapies. Primary end point results were generally consistent at week 24, and for other lipid end points at week 12. Conclusions: Evolocumab, 140 mg Q2W/420 mg once a month, and alirocumab, 150 mg Q2W, were consistently the most efficacious nonstatin regimens when added to maximally tolerated statins to lower LDL‐C, non–high‐density lipoprotein cholesterol, and apolipoprotein B levels and facilitate attainment of guideline‐recommended risk‐stratified lipoprotein levels

Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: The Diabetes Prevention Program

Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polymorphisms modifies the effects of lifestyle and/or metformin interventions on lipid levels and nuclear magnetic resonance (NMR) lipoprotein subfraction size and number. Twenty-three loci previously associated with fasting LDL-C, HDL-C, or triglycerides replicated (P = 0.04–1×10−17). Except for total HDL particles (r = −0.03, P = 0.26), all components of the lipid profile correlated with the GRS (partial |r| = 0.07–0.17, P = 5×10−5–1×10−19). The GRS was associated with higher baseline-adjusted 1-year LDL cholesterol levels (β = +0.87, SEE±0.22 mg/dl/allele, P = 8×10−5, Pinteraction = 0.02) in the lifestyle intervention group, but not in the placebo (β = +0.20, SEE±0.22 mg/dl/allele, P = 0.35) or metformin (β = −0.03, SEE±0.22 mg/dl/allele, P = 0.90; Pinteraction = 0.64) groups. Similarly, a higher GRS predicted a greater number of baseline-adjusted small LDL particles at 1 year in the lifestyle intervention arm (β = +0.30, SEE±0.012 ln nmol/L/allele, P = 0.01, Pinteraction = 0.01) but not in the placebo (β = −0.002, SEE±0.008 ln nmol/L/allele, P = 0.74) or metformin (β = +0.013, SEE±0.008 nmol/L/allele, P = 0.12; Pinteraction = 0.24) groups. Our findings suggest that a high genetic burden confers an adverse lipid profile and predicts attenuated response in LDL-C levels and small LDL particle number to dietary and physical activity interventions aimed at weight loss

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV. For all cohorts, GWAS analysis was performed using additive models after adjusting for age, sex, and population stratification. For both platelet phenotypes, meta-analyses were conducted using inverse-variance weighted fixed-effect models. Platelet aggregation assays in whole blood were performed in the participants of the GeneSTAR cohort. Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p<5×10−8 of which 5 have not been associated with platelet count in previous GWAS. The novel genetic variants associated with platelet count were in the following regions (the most significant SNP, closest gene, and p-value): 6p22 (rs12526480, LRRC16A, p = 9.1×10−9), 7q11 (rs13236689, CD36, p = 2.8×10−9), 10q21 (rs7896518, JMJD1C, p = 2.3×10−12), 11q13 (rs477895, BAD, p = 4.9×10−8), and 20q13 (rs151361, SLMO2, p = 9.4×10−9). Three of these loci (10q21, 11q13, and 20q13) were replicated in European Americans (N = 14,909) and one (11q13) in Hispanic Americans (N = 3,462). For MPV (N = 4,531), genetic variants in 3 regions were significant at p<5×10−8, two of which were also associated with platelet count. Previously reported regions that were also significant in this study were 6p21, 6q23, 7q22, 12q24, and 19p13 for platelet count and 7q22, 17q11, and 19p13 for MPV. The most significant SNP in 1 region was also associated with ADP-induced maximal platelet aggregation in whole blood (12q24). Thus through a meta-analysis of GWAS enrolling African Americans, we have identified 5 novel regions associated with platelet count of which 3 were replicated in other ethnic groups. In addition, we also found one region associated with platelet aggregation that may play a potential role in atherothrombosis

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead