NOD2 mutations and colorectal cancer - Where do we stand?

Due to the overwhelming burden of colorectal cancer (CRC), great effort has been placed on identifying genetic mutations that contribute to disease development and progression. One of the most studied polymorphisms that could potentially increase susceptibility to CRC involves the nucleotide-binding and oligomerization-domain containing 2 (NOD2) gene. There is growing evidence that the biological activity of NOD2 is far greater than previously thought and a link with intestinal microbiota and mucosal immunity is increasingly sought after. In fact, microbial composition may be an important contributor not only to inflammatory bowel diseases (IBD) but also to CRC. Recent studies have showed that deficient NOD2 function confers a communicable risk of colitis and CRC. Despite the evidence from experimental models, population-based studies that tried to link certain NOD2 polymorphisms and an increase in CRC risk have been described as conflicting. Significant geographic discrepancies in the frequency of such polymorphisms and different interpretations of the results may have limited the conclusions of those studies. Since being first associated to IBD and CRC, our understanding of the role of this gene has come a long way, and it is tempting to postulate that it may contribute to identify individuals with susceptible genetic background that may benefit from early CRC screening programs or in predicting response to current therapeutic tools. The aim of this review is to clarify the status quo of NOD2 mutations as genetic risk factors to chronic inflammation and ultimately to CRC. The use of NOD2 as a predictor of certain phenotypic characteristics of the disease will be analyzed as well

Zusammensetzung rezyklierter (Th, U) O2_{2}-Brennelemente mit mitterem U-Anreicherungsgrad und ihre Auswirkung auf den Kernbrennstoffkreislauf

The MEU-HTR fuel element is proposed in order to use lower enriched U and to preserve the potential of the HTR as converter and as process heat source. If the final storage of nuclear fuel is not licensed in the Federal Republic of Germany, a complete fuel cycle must be available for the spent nuclear fuel management of this type of fuel. Therefore, the composition of spent mixed oxide MEU-HTR fuel was calculated in this study, considering various recycling strategies. The following conclusions may be drawn from the resulting data. [...

Using nitrogen concentration and isotopic composition in lichens to spatially assess the relative contribution of atmospheric nitrogen sources in complex landscapes

Reactive nitrogen (Nr) is an important driver of global change, causing alterations in ecosystem biodiversity and functionality. Environmental assessments require monitoring the emission and deposition of both the amount and types of Nr. This is especially important in heterogeneous landscapes, as different land-cover types emit particular forms of Nr to the atmosphere, which can impact ecosystems distinctively. Such assessments require high spatial resolution maps that also integrate temporal variations, and can only be feasibly achieved by using ecological indicators. Our aim was to rank land-cover types according to the amount and form of emitted atmospheric Nr in a complex landscape with multiple sources of N. To do so, we measured and mapped nitrogen concentration and isotopic composition in lichen thalli, which we then related to land-cover data. Results suggested that, at the landscape scale, intensive agriculture and urban areas were the most important sources of Nr to the atmosphere. Additionally, the ocean greatly influences Nr in land, by providing air with low Nr concentration and a unique isotopic composition. These results have important consequences for managing air pollution at the regional level, as they provide critical information for modeling Nr emission and deposition across regional as well as continental scales.Supported by project GISA (funded by private companies: GALP, Repsol, APS, AdSA, AICEP, CARBOGAL, EDP, EuroResinas, KIMAXTRA, REN and GENERG; and managed by local authorities: CCDRA, ARSA and Municipalities of Sines, Santiago do Cacém, Grândola, Álcacer do Sal and Odemira. Further support for researchers from FCT-MCTES (SFRH/BPD/75425/2010, SFRH/BPD/109382/2015 and Investigador FCT contract) and EC-H2020 (NitroPortugal 692331)

Matrix Toda and Volterra lattices

We consider matrix Toda and Volterra lattice equations and their relation with matrix biorthogonal polynomials. From that relation, we give a method for constructing a new solution of these systems from another given one. An illustrative example is presented.publishe

Effects of applying a training program on basketball shooting in young players

The main aim of this study was to determine the effects of the application of a strength program in the accuracy of basketball shooting in young female players. Twenty female basketball players, (mean ± standard deviation: 12.08 ± 0.42 years; 1.55 ± 0.08 height; 44.4 ± 5.54 body mass) participated in the study. The participants were divided into two groups, the Control Group (GC) and the Experimental Group (GE), and were evaluated in 4 throwing exercises before (Pre-Test), after the application of a 6-week strength program (Post-Test), as well as after 4 weeks of detraining. The applied training program includes four exercises: i) Jump with Counter-Movement; ii) Throwing of the Medicinal Ball; iii) Sit-ups; iv) Push-ups. The results suggest that application of the 6-week training program had a positive effect on performance in two the four throwing exercises. In addiction 4 weeks of detraining, did not cause significant changes in the performance of the different throwing exercises compared to the Post-test period. It was concluded that a strength training program with a duration of 6 weeks was sufficient to obtain positive effects in the effectiveness of 2 Point throwing exercises in young female basketball players.This work is supported by national funding through the Portuguese Foundation for Science and Technology, I.P., under project UID04045/2020

The development of basketball players: current perspectives and future directions

The identification and development of talent in basketball has been seen as a dynamic and complex process. Furthermore, there are numerous factors that play an important role in the evolution of the basketball player during childhood and adolescence. In this brief review, we critically analyze the main factors to be considered in the development of young basketball players. Furthermore, it focuses on the importance of key variables considered in the talent detection process and in long-term development programs. It can be concluded that the maturational status of young basketball players should be considered in the formulation of test batteries for talent detection and in long-term development programs to ensure that potential talents are not excluded due to late maturation in relation to their pairs

Effects of Different Recovery Times on Internal and External Load During Small-Sided Games in Soccer

Background: The ability to maintain a high intensity of exercise over several repetitions depends on recovery from previous exercises. This study aimed to identify the effects of different recovery times on internal and external load during small-sided soccer games. Hypothesis: An increase in recovery time will increase the external training load and decrease the internal exercise load, which will result in a greater physical impact of the exercise. Study design: Cross-sectional study. Level of evidence: Level 2. Methods: Twenty male semiprofessional soccer players participated in the present study. They performed the same exercise (5-a-side game format) continuously (1 × 18 minutes) and repeatedly/fractionated (3 × 6 minutes) with different recovery times (30 seconds, 1 minute, 1.5 minutes, and 2 minutes). Their internal load (ie, average heart rate (HR) and maximum HR) and external load (ie, total distance, maximum speed, and ratio meters) were measured using an HR band and an inertial device equipped with a global positioning system, respectively. Results: The manipulation of recovery times induced differences in the internal and external load. For the same total duration, the external and internal load indicators exhibited higher values during the fractionated method, particularly with short recovery periods. Conclusion: The application of small-sided soccer games with different recovery times induced varying responses in training load. To maintain high physical performance and high training load, the fractional method with short recovery periods (ie, 30 seconds) should be used. In contrast, to carefully manage players' efforts and decrease response to training load, continuous or fractional methods with longer recovery periods (ie, 1-2 minutes) should be used. Clinical relevance: The proper prescription of recovery time between exercises facilitates enhanced training efficiency and optimized performance.info:eu-repo/semantics/publishedVersio

Measuring and mapping the effectiveness of the European Air Quality Directive in reducing N and S deposition at the ecosystem level

To protect human health and the environment (namely ecosystems), international air quality protocols and guidelines, like the Gothenburg protocol (1999) and the 2001 EU Air Quality Directive (NECD), conveyed national emission ceilings for atmospheric pollutants (Directive 2001/81/EC), including the reduction of sulfur (S) and nitrogen (N) emissions by 2010. However, to what degree this expected reduction in emissions had reflections at the ecosystem level (i.e. pollutant levels reaching and impacting ecosystems and their organisms) remains unknown. Here, we used lichens as ecological indicators, together with reported air and precipitation pollutant concentrations, to determine and map the consequences of the S and N atmospheric emission's reduction, during the implementation of the 2001 Directive (in 2002 and 2011), due primarily to the industrial-sector. The study area is a mixed-land-use industrialized Mediterranean agroforest ecosystem, in southwest Europe. The reduction of S emissions (2002-2011) was reflected at the ecosystem level, as the same S-declining trend was observed in atmospheric measurement stations and lichens alike (-70%), indicating that most S deposited to the ecosystem had an industrial origin. However, this was not the case for N with a slight N-reduction near industrial facilities, but mostly N-deposition in lichens increased in areas dominated by agricultural land-uses. Taken together, these results highlight the importance of going beyond emissions estimation and modeling, to assess the success of the implementation of the NECD in lowering pollutant accumulation in living organisms and their environment. This can only be achieved by measuring pollutant deposition at the ecosystem level (e.g. living organisms). By doing so, we were able to show that the 2001 NECD was successful in reducing S concentrations from Industry, whereas N remains a challenge. Despite the small reduction in N-emissions, deposition into ecosystems did not reflect these changes as agriculture and transport sectors must reduce NH3 and NOx emissions. (C) 2018 Published by Elsevier B.V.The research was supported by project GISA [funded by private companies: GALP, Repsol, APS, AdSA, AICEP, CARBOGAL, EDP, EuroResinas, KIMAXTRA, REN and GENERG; and managed by local authorities: CCDRA, ARSA and Municipalities of Sines, Santiago do Cacem, Grandola, Alcacer do Sal and Odemira]; article preparation was supported by project NitroPortugal [European Union's Horizon 2020 research and innovation programme under grant agreement No 692331]. NitroPortugal is a co-financer for the project Towards INMS, implemented by UN Environment. Concentration of pollutants in precipitation available in the EBAS database has largely been funded by the UN-ECE CLRTAP (EMEP) and through NILU internal resources

Ecology as a Tool to Assist Conservation of a Rare and Endemic Mediterranean Plantago Species

Reviewing the ecological studies on the endangered endemic Plantago almogravensis Franco, an Al-hyperaccumulator plant, and combining these with morphological, physiological, biochemical, and molecular data, significant knowledge on the limiting factors that cause its narrow geographical distribution and rarity status is achieved, which can contribute to suited conservation guidelines. Emphasis was given on (i) the major factors limiting P. almogravensis’ ecological niche (biotic and abiotic); (ii) phases of the life cycle and population dynamics; and (iii) and the phylogenetically close taxa (Plantago subulata aggregate) in order to fill the knowledge gaps in the uniqueness of P. almogravensis ecology, its phylogeny, and conservation status. The identification of relevant ecological data and using plant functional (morphological and physiological) traits, as well as genetic attributes, substantiate into a powerful tool to guide protection and conservation measures, usable toward this and other endangered hyperaccumulator plant species. Knowledge of the limitations of this strongly narrowly distributed plant allows for better design of conservation measures and to guide value and investment strategies in order to secure the species’ current area (habitat conservation and reclamation), direct the expansion of the existing population (assisting in populational densification and colonization), and/or grant ex situ conservation (genetic resources conservation).info:eu-repo/semantics/publishedVersio