A study of the neglected Galactic HII region NGC 2579 and its companion ESO 370-9

The Galactic HII region NGC 2579 has stayed undeservedly unexplored due to identification problems which persisted until recently. Both NGC 2579 and its companion ESO 370-9 have been misclassified as planetary or reflection nebula, confused with each other and with other objects. Due to its high surface brightness, high excitation, angular size of few arcminutes and relatively low interstellar extinction, NGC 2579 is an ideal object for investigations in the optical range. Located in the outer Galaxy, NGC 2579 is an excellent object for studying the Galactic chemical abundance gradients. In this paper we present the first comprehensive observational study on the nebular and stellar properties of NGC 2579 and ESO 370-9, including the determination of electron temperature, density structure, chemical composition, kinematics, distance, and the identification and spectral classification of the ionizing stars, and discuss the nature of ESO 370-9. Long slit spectrophotometric data in the optical range were used to derive the nebular electron temperature, density and chemical abundances and for the spectral classification of the ionizing star candidates. Halpha and UBV CCD photometry was carried out to derive stellar distances from spectroscopic parallax and to measure the ionizing photon flux.Comment: To be published in Astronomy & Astrophysic

Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review

The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed. In this paper the role of the hypothalamus-pituitary-thyroid axis (HPT-axis) and the hypothalamus-pituitary-adrenal axis (HPA-axis) in the ontogeny of avian thermoregulation is evaluated. The regulatory mechanisms and different important hormones of both axes, which have stimulatory or inhibitory effects, are discussed. Because the onset of functionality of the thermoregulatory system is of great interest, the ontogeny and functionality of the hormonal axes are clarified. There is a great difference between precocial and altricial birds in hormonal events as well as in neural processes which are involved in the emergence of thermoregulation. In precocial avian species the HPT-axis becomes functional during the mid- to late embryonic period while the same axis only becomes fully functional during the first week post-hatch in altricial avian species. As early as the sixties, the emergence of homeothermy in chickens was investigated. It was concluded that the thyroid gland plays an important role in the thermoregulatory mechanisms of newly hatched chicks. More recent studies however were not able to show any direct effect of the thyroid hormones on the thermoregulation of day-old chicks, although blocking the conversion of T4 to T3 caused a decrease in body temperature in young chicks. Thyrotropin releasing hormone (TRH) is known to act in thermoregulation in mammals and several authors have found an effect of TRH on the metabolism of young and older chicks. However, the exact mechanism still remains unclear. Because the HPT- and the HPA-axis show close relationships, the role of the HPA-axis in the ontogeny of thermoregulation is also taken into consideration in this review. In mammals as well as in birds, corticotropin releasing hormone (CRH) is involved in the primary thermoregulation. We conclude that the HPT-axis has an important role in the ontogeny of avian thermoregulation. The exact role of the HPA-axis remains largely unclear although at least CRH is definitely of some importance

Goal-orientated cognitive rehabilitation for dementias associated with Parkinson's disease―A pilot randomised controlled trial

OBJECTIVE: To examine the appropriateness and feasibility of cognitive rehabilitation for people with dementias associated with Parkinson's in a pilot randomised controlled study. METHODS: This was a single-blind pilot randomised controlled trial of goal-oriented cognitive rehabilitation for dementias associated with Parkinson's. After goal setting, participants were randomised to cognitive rehabilitation (n = 10), relaxation therapy (n = 10), or treatment-as-usual (n = 9). Primary outcomes were ratings of goal attainment and satisfaction with goal attainment. Secondary outcomes included quality of life, mood, cognition, health status, everyday functioning, and carers' ratings of goal attainment and their own quality of life and stress levels. Assessments were at 2 and 6 months following randomisation. RESULTS: At 2 months, cognitive rehabilitation was superior to treatment-as-usual and relaxation therapy for the primary outcomes of self-rated goal attainment (d = 1.63 and d = 1.82, respectively) and self-rated satisfaction with goal attainment (d = 2.04 and d = 1.84). At 6 months, cognitive rehabilitation remained superior to treatment-as-usual (d = 1.36) and relaxation therapy (d = 1.77) for self-rated goal attainment. Cognitive rehabilitation was superior to treatment as usual and/or relaxation therapy in a number of secondary outcomes at 2 months (mood, self-efficacy, social domain of quality of life, carers' ratings of participants' goal attainment) and at 6 months (delayed recall, health status, quality of life, carer ratings of participants' goal attainment). Carers receiving cognitive rehabilitation reported better quality of life, health status, and lower stress than those allocated to treatment-as-usual. CONCLUSIONS: Cognitive rehabilitation is feasible and potentially effective for dementias associated with Parkinson's disease

Soliton Magnetization Dynamics in Spin-Orbit Coupled Bose-Einstein Condensates

Ring-trapped Bose-Einstein condensates subject to spin-orbit coupling support localized dark soliton excitations that show periodic density dynamics in real space. In addition to the density feature, solitons also carry a localized pseudo-spin magnetization that exhibits a rich and tunable dynamics. Analytic results for Rashba-type spin-orbit coupling and spin-invariant interactions predict a conserved magnitude and precessional motion for the soliton magnetization that allows for the simulation of spin-related geometric phases recently seen in electronic transport measurements.Comment: 3 figures, 5 page

The Double-Lined Spectrum of LBV 1806-20

Despite much theoretical and observational progress, there is no known firm upper limit to the masses of stars. Our understanding of the interplay between the immense radiation pressure produced by massive stars in formation and the opacity of infalling material is subject to theoretical uncertainties, and many observational claims of ``the most massive star'' have failed the singularity test. LBV 1806-20 is a particularly luminous object, L~10^6 Lsun, for which some have claimed very high mass estimates (M_initial>200 Msun), based, in part, on its similarity to the Pistol Star. We present high-resolution near-infrared spectroscopy of LBV 1806-20, showing that it is possibly a binary system with components separated in velocity by ~70 kms. If correct, then this system is not the most massive star known, yet it is a massive binary system. We argue that a binary, or merged, system is more consistent with the ages of nearby stars in the LBV 1806-20 cluster. In addition, we find that the velocity of V_LSR=36 kms is consistent with a distance of 11.8 kpc, a luminosity of 10^6.3 Lsun, and a system mass of ~130 Msun.Comment: ApJL, accepte

The Dynamic Structure Factor of the 1D Bose Gas near the Tonks-Girardeau Limit

While the 1D Bose gas appears to exhibit superfluid response under certain conditions, it fails the Landau criterion according to the elementary excitation spectrum calculated by Lieb. The apparent riddle is solved by calculating the dynamic structure factor of the Lieb-Liniger 1D Bose gas. A pseudopotential Hamiltonian in the fermionic representation is used to derive a Hartree-Fock operator, which turns out to be well-behaved and local. The Random-Phase approximation for the dynamic structure factor based on this derivation is calculated analytically and is expected to be valid at least up to first order in $1/\gamma$, where $\gamma$ is the dimensionless interaction strength of the model. The dynamic structure factor in this approximation clearly indicates a crossover behavior from the non-superfluid Tonks to the superfluid weakly-interacting regime, which should be observable by Bragg scattering in current experiments.Comment: 4 pages, 2 figures misprints in formulas correcte

Polarizability and dynamic structure factor of the one-dimensional Bose gas near the Tonks-Girardeau limit at finite temperatures

Correlation functions related to the dynamic density response of the one-dimensional Bose gas in the model of Lieb and Liniger are calculated. An exact Bose-Fermi mapping is used to work in a fermionic representation with a pseudopotential Hamiltonian. The Hartree-Fock and generalized random phase approximations are derived and the dynamic polarizability is calculated. The results are valid to first order in 1/\gamma where \gamma is Lieb-Liniger coupling parameter. Approximations for the dynamic and static structure factor at finite temperature are presented. The results preclude superfluidity at any finite temperature in the large-\gamma regime due to the Landau criterion. Due to the exact Bose-Fermi duality, the results apply for spinless fermions with weak p-wave interactions as well as for strongly interacting bosons.Comment: 13 pages, 5 figures, the journal versio

The LIM-Homeodomain Protein Islet Dictates Motor Neuron Electrical Properties by Regulating K+ Channel Expression

Neuron electrical properties are critical to function and generally subtype specific, as are patterns of axonal and dendritic projections. Specification of motoneuron morphology and axon pathfinding has been studied extensively, implicating the combinatorial action of Lim-homeodomain transcription factors. However, the specification of electrical properties is not understood. Here, we address the key issues of whether the same transcription factors that specify morphology also determine subtype specific electrical properties. We show that Drosophila motoneuron subtypes express different K(+) currents and that these are regulated by the conserved Lim-homeodomain transcription factor Islet. Specifically, Islet is sufficient to repress a Shaker-mediated A-type K(+) current, most likely due to a direct transcriptional effect. A reduction in Shaker increases the frequency of action potential firing. Our results demonstrate the deterministic role of Islet on the excitability patterns characteristic of motoneuron subtypes

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

The survival of all microbes depends upon their ability to respond to environmental challenges. To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defences while adapting to dynamic changes in nutrient status within host niches. Studies of C. albicans stress adaptation have generally been performed on glucose-grown cells, leaving the effects of alternative carbon sources upon stress resistance largely unexplored. We have shown that growth on alternative carbon sources, such as lactate, strongly influence the resistance of C. albicans to antifungal drugs, osmotic and cell wall stresses. Similar trends were observed in clinical isolates and other pathogenic Candida species. The increased stress resistance of C. albicans was not dependent on key stress (Hog1) and cell integrity (Mkc1) signalling pathways. Instead, increased stress resistance was promoted by major changes in the architecture and biophysical properties of the cell wall. Glucose- and lactate-grown cells displayed significant differences in cell wall mass, ultrastructure, elasticity and adhesion. Changes in carbon source also altered the virulence of C. albicans in models of systemic candidiasis and vaginitis, confirming the importance of alternative carbon sources within host niches during C. albicans infection