Electromagnetic radiation screening of microcircuits for long life applications

The utility of X-rays as a stimulus for screening high reliability semiconductor microcircuits was studied. The theory of the interaction of X-rays with semiconductor materials and devices was considered. Experimental measurements of photovoltages, photocurrents, and effects on specified parameters were made on discrete devices and on microcircuits. The test specimens included discrete devices with certain types of identified flaws and symptoms of flaws, and microcircuits exhibiting deviant electrical behavior. With a necessarily limited sample of test specimens, no useful correlation could be found between the X-ray-induced electrical response and the known or suspected presence of flaws

Thirty-fold: Extreme gravitational lensing of a quiescent galaxy at z=1.6z=1.6

We report the discovery of eMACSJ1341-QG-1, a quiescent galaxy at $z=1.594$ located behind the massive galaxy cluster eMACSJ1341.9$-$2442 ($z=0.835$). The system was identified as a gravitationally lensed triple image in Hubble Space Telescope images obtained as part of a snapshot survey of the most X-ray luminous galaxy clusters at $z>0.5$ and spectroscopically confirmed in ground-based follow-up observations with the ESO/X-Shooter spectrograph. From the constraints provided by the triple image, we derive a first, crude model of the mass distribution of the cluster lens, which predicts a gravitational amplification of a factor of $\sim$30 for the primary image and a factor of $\sim$6 for the remaining two images of the source, making eMACSJ1341-QG-1 by far the most strongly amplified quiescent galaxy discovered to date. Our discovery underlines the power of SNAPshot observations of massive, X-ray selected galaxy clusters for lensing-assisted studies of faint background populations

Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab

Background: Pertuzumab, a human epidermal growth factor receptor (HER) 2 dimerization inhibitor, has demonstrated promising efficacy in combination with trastuzumab in patients with metastatic breast cancer. As HER signaling pathways are not only involved in oncogenesis, but also in myocardial homeostasis, an analysis of cardiac safety data was undertaken in a large group of patients treated with pertuzumab. Patients and methods: A complete database of patients treated with full-dose pertuzumab was used to describe the incidence of asymptomatic left ventricular systolic dysfunction (LVSD) and symptomatic heart failure (HF). Results: Information for 598 unique patients was available for the current analysis. Of the patients treated with pertuzumab alone (n = 331) or pertuzumab in combination with a non-anthracycline-containing cytotoxic (n = 175) or trastuzumab (n = 93), 23 (6.9%), 6 (3.4%), and 6 (6.5%), respectively, developed asymptomatic LVSD and 1 (0.3%), 2 (1.1%), and 1 (1.1%), respectively, displayed symptomatic HF. None of the 15 patients receiving both pertuzumab and erlotinib demonstrated LVSD. Conclusions: Patients treated with pertuzumab experienced relatively low levels of asymptomatic LVSD or symptomatic HF. There was no notable increase in cardiac side-effects when pertuzumab was given in combination with other anticancer agent

Instability of the expression of morphological and phenological descriptors to environmental variation in white oat.

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Neural responses to facial and vocal expressions of fear and disgust

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus

Bright galaxies at Hubble's redshift detection frontier: Preliminary results and design from the redshift z~9-10 BoRG pure-parallel HST survey

We present the first results and design from the redshift z~9-10 Brightest of the Reionizing Galaxies {\it Hubble Space Telescope} survey BoRG[z9-10], aimed at searching for intrinsically luminous unlensed galaxies during the first 700 Myr after the Big Bang. BoRG[z9-10] is the continuation of a multi-year pure-parallel near-IR and optical imaging campaign with the Wide Field Camera 3. The ongoing survey uses five filters, optimized for detecting the most distant objects and offering continuous wavelength coverage from {\lambda}=0.35{\mu}m to {\lambda}=1.7{\mu}m. We analyze the initial ~130 arcmin$^2$ of area over 28 independent lines of sight (~25% of the total planned) to search for z>7 galaxies using a combination of Lyman break and photometric redshift selections. From an effective comoving volume of (5-25) $times 10^5$ Mpc$^3$ for magnitudes brighter than $m_{AB}=26.5-24.0$ in the $H_{160}$-band respectively, we find five galaxy candidates at z~8.3-10 detected at high confidence (S/N>8), including a source at z~8.4 with mAB=24.5 (S/N~22), which, if confirmed, would be the brightest galaxy identified at such early times (z>8). In addition, BoRG[z9-10] data yield four galaxies with $7.3 \lesssim z \lesssim 8$. These new Lyman break galaxies with m$\lesssim26.5$ are ideal targets for follow-up observations from ground and space based observatories to help investigate the complex interplay between dark matter growth, galaxy assembly, and reionization.Comment: Accepted for publication on ApJ. 21 pages, 11 figures, 4 table

Photometric Constraints on the Redshift of z~10 candidate UDFj-39546284 from deeper WFC3/IR+ACS+IRAC observations over the HUDF

Ultra-deep WFC3/IR observations on the HUDF from the HUDF09 program revealed just one plausible z~10 candidate UDFj-39546284. UDFj-39546284 had all the properties expected of a galaxy at z~10 showing (1) no detection in the deep ACS+WFC3 imaging data blueward of the F160W band, exhibiting (2) a blue spectral slope redward of the break, and showing (3) no prominent detection in deep IRAC observations. The new, similarly deep WFC3/IR HUDF12 F160W observations over the HUDF09/XDF allow us to further assess this candidate. These observations show that this candidate, previously only detected at ~5.9 sigma in a single band, clearly corresponds to a real source. It is detected at ~5.3 sigma in the new H-band data and at ~7.8 sigma in the full 85-orbit H-band stack. Interestingly, the non-detection of the source (<1 sigma) in the new F140W observations suggests a higher redshift. Formally, the best-fit redshift of the source utilizing all the WFC3+ACS (and IRAC+K-band) observations is 11.8+/-0.3. However, we consider the z~12 interpretation somewhat unlikely, since the source would either need to be ~20x more luminous than expected or show very high-EW Ly-alpha emission (which seems improbable given the extensive neutral gas prevalent early in the reionization epoch). Lower-redshift solutions fail if only continuum models are allowed. Plausible lower-redshift solutions require that the H-band flux be dominated by line emission such as Halpha or [OIII] with extreme EWs. The tentative detection of line emission at 1.6 microns in UDFj-39546284 in a companion paper suggests that such emission may have already been found.Comment: 6 pages, 4 figures, 1 table, accepted for publication in ApJ Letters, updated to match the version in pres

The assembly of "normal" galaxies at z=7 probed by ALMA

We report new deep ALMA observations aimed at investigating the [CII]158um line and continuum emission in three spectroscopically confirmed Lyman Break Galaxies at 6.8<z<7.1, i.e. well within the re-ionization epoch. With Star Formation Rates of SFR ~ 5-15 Msun/yr these systems are much more representative of the high-z galaxy population than other systems targeted in the past by millimeter observations. For the galaxy with the deepest observation we detect [CII] emission at redshift z=7.107, fully consistent with the Lyalpha redshift, but spatially offset by 0.7" (4 kpc) from the optical emission. At the location of the optical emission, tracing both the Lyalpha line and the far-UV continuum, no [CII] emission is detected in any of the three galaxies, with 3sigma upper limits significantly lower than the [CII] emission observed in lower reshift galaxies. These results suggest that molecular clouds in the central parts of primordial galaxies are rapidly disrupted by stellar feedback. As a result, [CII] emission mostly arises from more external accreting/satellite clumps of neutral gas. These findings are in agreement with recent models of galaxy formation. Thermal far-infrared continuum is not detected in any of the three galaxies. However, the upper limits on the infrared-to-UV emission ratio do not exceed those derived in metal- and dust-poor galaxies.Comment: 15 pages, 9 figures, MNRAS in press, replaced with accepted versio

Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile

Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been studied in relation to the glutamate hypothesis of schizophrenia and increases dissociation, positive and negative symptom ratings. Ketamine effects brain function through changes in brain activity; these activity patterns can be modulated by pre-treatment of compounds known to attenuate the effects of ketamine on glutamate release. Ketamine also has marked effects on brain connectivity; we predicted that these changes would also be modulated by compounds known to attenuate glutamate release. Here, we perform task-free pharmacological magnetic resonance imaging (phMRI) to investigate the functional connectivity effects of ketamine in the brain and the potential modulation of these effects by pre-treatment of the compounds lamotrigine and risperidone, compounds hypothesised to differentially modulate glutamate release. Connectivity patterns were assessed by combining windowing, graph theory and multivariate Gaussian process classification. We demonstrate that ketamine has a robust effect on the functional connectivity of the human brain compared to saline (87.5 % accuracy). Ketamine produced a shift from a cortically centred, to a subcortically centred pattern of connections. This effect is strongly modulated by pre-treatment with risperidone (81.25 %) but not lamotrigine (43.75 %). Based on the differential effect of these compounds on ketamine response, we suggest the observed connectivity effects are primarily due to NMDAR blockade rather than downstream glutamatergic effects. The connectivity changes contrast with amplitude of response for which no differential effect between pre-treatments was detected, highlighting the necessity of these techniques in forming an informed view of the mechanistic effects of pharmacological compounds in the human brain