2,367 research outputs found
Electromagnetic radiation screening of microcircuits for long life applications
The utility of X-rays as a stimulus for screening high reliability semiconductor microcircuits was studied. The theory of the interaction of X-rays with semiconductor materials and devices was considered. Experimental measurements of photovoltages, photocurrents, and effects on specified parameters were made on discrete devices and on microcircuits. The test specimens included discrete devices with certain types of identified flaws and symptoms of flaws, and microcircuits exhibiting deviant electrical behavior. With a necessarily limited sample of test specimens, no useful correlation could be found between the X-ray-induced electrical response and the known or suspected presence of flaws
Thirty-fold: Extreme gravitational lensing of a quiescent galaxy at
We report the discovery of eMACSJ1341-QG-1, a quiescent galaxy at
located behind the massive galaxy cluster eMACSJ1341.92442 (). The
system was identified as a gravitationally lensed triple image in Hubble Space
Telescope images obtained as part of a snapshot survey of the most X-ray
luminous galaxy clusters at and spectroscopically confirmed in
ground-based follow-up observations with the ESO/X-Shooter spectrograph. From
the constraints provided by the triple image, we derive a first, crude model of
the mass distribution of the cluster lens, which predicts a gravitational
amplification of a factor of 30 for the primary image and a factor of
6 for the remaining two images of the source, making eMACSJ1341-QG-1 by
far the most strongly amplified quiescent galaxy discovered to date. Our
discovery underlines the power of SNAPshot observations of massive, X-ray
selected galaxy clusters for lensing-assisted studies of faint background
populations
Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab
Background: Pertuzumab, a human epidermal growth factor receptor (HER) 2 dimerization inhibitor, has demonstrated promising efficacy in combination with trastuzumab in patients with metastatic breast cancer. As HER signaling pathways are not only involved in oncogenesis, but also in myocardial homeostasis, an analysis of cardiac safety data was undertaken in a large group of patients treated with pertuzumab. Patients and methods: A complete database of patients treated with full-dose pertuzumab was used to describe the incidence of asymptomatic left ventricular systolic dysfunction (LVSD) and symptomatic heart failure (HF). Results: Information for 598 unique patients was available for the current analysis. Of the patients treated with pertuzumab alone (n = 331) or pertuzumab in combination with a non-anthracycline-containing cytotoxic (n = 175) or trastuzumab (n = 93), 23 (6.9%), 6 (3.4%), and 6 (6.5%), respectively, developed asymptomatic LVSD and 1 (0.3%), 2 (1.1%), and 1 (1.1%), respectively, displayed symptomatic HF. None of the 15 patients receiving both pertuzumab and erlotinib demonstrated LVSD. Conclusions: Patients treated with pertuzumab experienced relatively low levels of asymptomatic LVSD or symptomatic HF. There was no notable increase in cardiac side-effects when pertuzumab was given in combination with other anticancer agent
Instability of the expression of morphological and phenological descriptors to environmental variation in white oat.
Made available in DSpace on 2018-01-11T23:31:30Z (GMT). No. of bitstreams: 1
445750711013.pdf: 442070 bytes, checksum: 9b519c484cf8867bc90e3d467624c188 (MD5)
Previous issue date: 2018-01-10bitstream/item/170731/1/445750711013.pd
Neural responses to facial and vocal expressions of fear and disgust
Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus
Photometric Constraints on the Redshift of z~10 candidate UDFj-39546284 from deeper WFC3/IR+ACS+IRAC observations over the HUDF
Ultra-deep WFC3/IR observations on the HUDF from the HUDF09 program revealed
just one plausible z~10 candidate UDFj-39546284. UDFj-39546284 had all the
properties expected of a galaxy at z~10 showing (1) no detection in the deep
ACS+WFC3 imaging data blueward of the F160W band, exhibiting (2) a blue
spectral slope redward of the break, and showing (3) no prominent detection in
deep IRAC observations. The new, similarly deep WFC3/IR HUDF12 F160W
observations over the HUDF09/XDF allow us to further assess this candidate.
These observations show that this candidate, previously only detected at ~5.9
sigma in a single band, clearly corresponds to a real source. It is detected at
~5.3 sigma in the new H-band data and at ~7.8 sigma in the full 85-orbit H-band
stack. Interestingly, the non-detection of the source (<1 sigma) in the new
F140W observations suggests a higher redshift. Formally, the best-fit redshift
of the source utilizing all the WFC3+ACS (and IRAC+K-band) observations is
11.8+/-0.3. However, we consider the z~12 interpretation somewhat unlikely,
since the source would either need to be ~20x more luminous than expected or
show very high-EW Ly-alpha emission (which seems improbable given the extensive
neutral gas prevalent early in the reionization epoch). Lower-redshift
solutions fail if only continuum models are allowed. Plausible lower-redshift
solutions require that the H-band flux be dominated by line emission such as
Halpha or [OIII] with extreme EWs. The tentative detection of line emission at
1.6 microns in UDFj-39546284 in a companion paper suggests that such emission
may have already been found.Comment: 6 pages, 4 figures, 1 table, accepted for publication in ApJ Letters,
updated to match the version in pres
Bright galaxies at Hubble's redshift detection frontier: Preliminary results and design from the redshift z~9-10 BoRG pure-parallel HST survey
We present the first results and design from the redshift z~9-10 Brightest of
the Reionizing Galaxies {\it Hubble Space Telescope} survey BoRG[z9-10], aimed
at searching for intrinsically luminous unlensed galaxies during the first 700
Myr after the Big Bang. BoRG[z9-10] is the continuation of a multi-year
pure-parallel near-IR and optical imaging campaign with the Wide Field Camera
3. The ongoing survey uses five filters, optimized for detecting the most
distant objects and offering continuous wavelength coverage from
{\lambda}=0.35{\mu}m to {\lambda}=1.7{\mu}m. We analyze the initial ~130
arcmin of area over 28 independent lines of sight (~25% of the total
planned) to search for z>7 galaxies using a combination of Lyman break and
photometric redshift selections. From an effective comoving volume of (5-25)
Mpc for magnitudes brighter than in the
-band respectively, we find five galaxy candidates at z~8.3-10
detected at high confidence (S/N>8), including a source at z~8.4 with mAB=24.5
(S/N~22), which, if confirmed, would be the brightest galaxy identified at such
early times (z>8). In addition, BoRG[z9-10] data yield four galaxies with . These new Lyman break galaxies with m are
ideal targets for follow-up observations from ground and space based
observatories to help investigate the complex interplay between dark matter
growth, galaxy assembly, and reionization.Comment: Accepted for publication on ApJ. 21 pages, 11 figures, 4 table
Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile
Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been studied in relation to the glutamate hypothesis of schizophrenia and increases dissociation, positive and negative symptom ratings. Ketamine effects brain function through changes in brain activity; these activity patterns can be modulated by pre-treatment of compounds known to attenuate the effects of ketamine on glutamate release. Ketamine also has marked effects on brain connectivity; we predicted that these changes would also be modulated by compounds known to attenuate glutamate release. Here, we perform task-free pharmacological magnetic resonance imaging (phMRI) to investigate the functional connectivity effects of ketamine in the brain and the potential modulation of these effects by pre-treatment of the compounds lamotrigine and risperidone, compounds hypothesised to differentially modulate glutamate release. Connectivity patterns were assessed by combining windowing, graph theory and multivariate Gaussian process classification. We demonstrate that ketamine has a robust effect on the functional connectivity of the human brain compared to saline (87.5Â % accuracy). Ketamine produced a shift from a cortically centred, to a subcortically centred pattern of connections. This effect is strongly modulated by pre-treatment with risperidone (81.25Â %) but not lamotrigine (43.75Â %). Based on the differential effect of these compounds on ketamine response, we suggest the observed connectivity effects are primarily due to NMDAR blockade rather than downstream glutamatergic effects. The connectivity changes contrast with amplitude of response for which no differential effect between pre-treatments was detected, highlighting the necessity of these techniques in forming an informed view of the mechanistic effects of pharmacological compounds in the human brain
The assembly of "normal" galaxies at z=7 probed by ALMA
We report new deep ALMA observations aimed at investigating the [CII]158um
line and continuum emission in three spectroscopically confirmed Lyman Break
Galaxies at 6.8<z<7.1, i.e. well within the re-ionization epoch. With Star
Formation Rates of SFR ~ 5-15 Msun/yr these systems are much more
representative of the high-z galaxy population than other systems targeted in
the past by millimeter observations. For the galaxy with the deepest
observation we detect [CII] emission at redshift z=7.107, fully consistent with
the Lyalpha redshift, but spatially offset by 0.7" (4 kpc) from the optical
emission. At the location of the optical emission, tracing both the Lyalpha
line and the far-UV continuum, no [CII] emission is detected in any of the
three galaxies, with 3sigma upper limits significantly lower than the [CII]
emission observed in lower reshift galaxies. These results suggest that
molecular clouds in the central parts of primordial galaxies are rapidly
disrupted by stellar feedback. As a result, [CII] emission mostly arises from
more external accreting/satellite clumps of neutral gas. These findings are in
agreement with recent models of galaxy formation. Thermal far-infrared
continuum is not detected in any of the three galaxies. However, the upper
limits on the infrared-to-UV emission ratio do not exceed those derived in
metal- and dust-poor galaxies.Comment: 15 pages, 9 figures, MNRAS in press, replaced with accepted versio
- …