Evaluation of immune responses after nanovectorized internal radiotherapy for glioblastomas

Contribution issue du 4e Workshop européen, orgnaisé par le Cancéropôle Grand-Ouest du 22 au 25 septembre 2010 à l'Ile de Berder en France, autour du thème "Biology of ionizing radiation".International audienc

Intra-arterial injection of lipid nanocapsules loaded with rhenium-188 for the radiotherapy of hepatocellular carcinomas in rats

International audienc

Prevalence and Prognostic Relevance of Ventricular Conduction Disturbances in Patients With Aortic Stenosis

Cardiolog

Optimization of the electrochemical impedance spectroscopy measurement parameters for PEM fuel cell spectrum determination

Currently, electrochemical Impedance Spectroscopy (EIS) is a widely used tool for the study of electrochemical systems, in general; and fuel cells, in particular. A great effort is typically invested in the analysis of the obtained spectra; whereas, little time is usually spent optimizing the measurement parameters used to obtain these spectra. In general, the default settings provided by the control software used to perform the measurements, or the parameters used in similar systems available in literature, are selected to carry out the measurements. The goal of this work is to determine the optimal measurement parameters for obtaining impedance spectra of a commercial PEM fuel cell. In order to achieve this, a 2^5 factorial design was considered. Five factors were considered, the five impedance spectroscopy measurement parameters: maximum integration time; minimum number of integration cycles; number of stabilization cycles; maximum stabilization time; and minimum cycle fraction. For each factor combination envisaged in the experimental design, the cell spectrum was obtained in given operation conditions, for which the reference spectrum of the system was known, since it had been determined in previous works. The experimentally obtained spectra were fitted to the reference electric equivalent circuit. The mean square error between the experimental data fitting and the reference spectrum fitting was determined in each case, and was used as the dependant variable for the experimental design analysis. An analysis of the variance was performed in order to determine which measurement parameters have a significant effect on the dependant variable; and a model relating the dependant variable and the measurement parameters was built. This model was used in order to obtain the optimal value of each one of the measurement parameters that minimized the mean square error of the fit obtained from the experimental data with respect to the reference fit.The authors are very grateful to the Generalitat Valenciana for its economic support in form of Vali+d grant (Ref: ACIF-2013-268).Giner Sanz, JJ.; Ortega Navarro, EM.; Pérez-Herranz, V. (2015). Optimization of the electrochemical impedance spectroscopy measurement parameters for PEM fuel cell spectrum determination. Electrochimica Acta. 174:1290-1298. https://doi.org/10.1016/j.electacta.2015.06.106S1290129817

Administration of 188Re-loaded nanocapsules into the hepatic artery involves neoangiogenesis alterations in a rat hepatocellular carcinoma model

International audienc

Comportamento e bem-estar de peixe beta (Betta splendens) em aquário.

O trabalho será realizado no Instituto Federal de Educação, Ciência e Tecnologia do Espírito Santo/Campus Alegre, no laboratório de Nutrição e Produção de Espécies Ornamentais, localizado no município de Alegre, região Sul do estado do Espírito Santo, Brasil. Serão utilizados 70 exemplares machos de peixe Beta (Betta splendens) com idade entre 90 e 120 dias. Dos quais 15 exemplares de peixe Beta, machos adultos, com aproximadamente 90 dias serão manejados em aquário tipo cruzeta com quatro pontas de mesmo comprimento e distância do centro. Quatro testes serão realizados para analisar a preferência dos peixes quanto a tipo de (T1) substrato, de (T2) vegetações, de (T3) abrigos e de (T4) cores. Em cada teste será oferecido quatro tipos de preferências (P1, P2, P3 e P4) distribuídos aleatoriamente por sorteio. Serão analisados os comportamentos de frequência em cada preferência, duração em cada preferência e tempo de latência. No segundo trabalho serão utilizados 35 exemplares machos de peixe Beta com aproximadamente 90 dias distribuídos aleatoriamente em cinco tipos de alojamento (tratamentos); (T1) copos de 0,3 litros, (T2) beteiras 3 litros sem enriquecimento, (T3) beteiras 3 litros enriquecidas, (T4) aquários 38 litros sem enriquecimento e (T5) aquários 38 litros enriquecidos. Os comportamentos dos animais serão gravados durante todo o período experimental. Será realizado um total de dezesseis horas de observações para cada tratamento. Durante o mesmo período também será realizado observação focal durante cinco minutos intermitentes alternando entre os tratamentos no total de 150 minutos por período. Os comportamentos registrados serão organizados formando um etograma e comparados entre os diferentes tratamentos. No último trabalho serão utilizados os 35 exemplares machos de peixe Beta, advindos do experimento de enriquecimento, com aproximadamente 120 dias em aquário tipo labirinto. Localizado dentro do labirinto haverá quatro pontos; dois objetos estressores, espelho (E1) e predador (E2), e dois objetos recompensa ambiente enriquecido (R1) e alimento (R2). Comportamentos como lateralidade, latência, preferência, frequência e duração serão analisados durante 15 minutos na parta da manhã e 15 minutos na parte da tarde durante dois dias consecutivos. Então os animais terão cinco dias de descanso e retornarão ao labirinto para mais 15 minutos de observações comportamentais na parta da manhã e 15 minutos na parte da tarde durante dois dias consecutivos

The screen test 1915–1930:how stars were born

This article examines the emergence of the screen test as a cultural phenomenon during the silent era in the US and Europe and its role in the development of the star system. The lore that grew up around the screen test almost from its inception held out the possibility for members of the public to cross a threshold into the rarefied world of celebrity. The screen test itself is situated in the liminal space not only between audience and actor, but also between fiction and non-fiction, Europe and Hollywood, the silent era and the talkies, and the public and private spheres. In order to trace the ways in which the screen test as such was narrativized and conceptualized in its foundational stages, this article will analyse accounts from Hollywood and European fan magazines of the silent era, including articles, short fiction, and early cinema apocrypha. The article culminates in a discussion of the film Prix de Beauté / Beauty Prize (Augusto Genina, 1930), which starred Louise Brooks, herself a transnational film icon whose film career spanned the divide between Hollywood and Europe. The film’s final scene, in which a beauty queen is shot dead by her jealous husband as she watches a screen test of herself, has been invoked by a number of film scholars as an allegory of the work performed by cinema, which preserves and disseminates the image of the star far beyond the actor’s physical presence. Speaking to historical conditions of star-making while also capturing its resonance in cultural mythology, the conclusion of Prix de Beauté allows us to consider the origins and functions of screen test discourse itself

Developing a predictive modelling capacity for a climate change-vulnerable blanket bog habitat: Assessing 1961-1990 baseline relationships

Aim: Understanding the spatial distribution of high priority habitats and developing predictive models using climate and environmental variables to replicate these distributions are desirable conservation goals. The aim of this study was to model and elucidate the contributions of climate and topography to the distribution of a priority blanket bog habitat in Ireland, and to examine how this might inform the development of a climate change predictive capacity for peat-lands in Ireland. Methods: Ten climatic and two topographic variables were recorded for grid cells with a spatial resolution of 1010 km, covering 87% of the mainland land surface of Ireland. Presence-absence data were matched to these variables and generalised linear models (GLMs) fitted to identify the main climatic and terrain predictor variables for occurrence of the habitat. Candidate predictor variables were screened for collinearity, and the accuracy of the final fitted GLM was evaluated using fourfold cross-validation based on the area under the curve (AUC) derived from a receiver operating characteristic (ROC) plot. The GLM predicted habitat occurrence probability maps were mapped against the actual distributions using GIS techniques. Results: Despite the apparent parsimony of the initial GLM using only climatic variables, further testing indicated collinearity among temperature and precipitation variables for example. Subsequent elimination of the collinear variables and inclusion of elevation data produced an excellent performance based on the AUC scores of the final GLM. Mean annual temperature and total mean annual precipitation in combination with elevation range were the most powerful explanatory variable group among those explored for the presence of blanket bog habitat. Main conclusions: The results confirm that this habitat distribution in general can be modelled well using the non-collinear climatic and terrain variables tested at the grid resolution used. Mapping the GLM-predicted distribution to the observed distribution produced useful results in replicating the projected occurrence of the habitat distribution over an extensive area. The methods developed will usefully inform future climate change predictive modelling for Irelan

State of the climate in 2013

In 2013, the vast majority of the monitored climate variables reported here maintained trends established in recent decades. ENSO was in a neutral state during the entire year, remaining mostly on the cool side of neutral with modest impacts on regional weather patterns around the world. This follows several years dominated by the effects of either La Niña or El Niño events. According to several independent analyses, 2013 was again among the 10 warmest years on record at the global scale, both at the Earths surface and through the troposphere. Some regions in the Southern Hemisphere had record or near-record high temperatures for the year. Australia observed its hottest year on record, while Argentina and New Zealand reported their second and third hottest years, respectively. In Antarctica, Amundsen-Scott South Pole Station reported its highest annual temperature since records began in 1957. At the opposite pole, the Arctic observed its seventh warmest year since records began in the early 20th century. At 20-m depth, record high temperatures were measured at some permafrost stations on the North Slope of Alaska and in the Brooks Range. In the Northern Hemisphere extratropics, anomalous meridional atmospheric circulation occurred throughout much of the year, leading to marked regional extremes of both temperature and precipitation. Cold temperature anomalies during winter across Eurasia were followed by warm spring temperature anomalies, which were linked to a new record low Eurasian snow cover extent in May. Minimum sea ice extent in the Arctic was the sixth lowest since satellite observations began in 1979. Including 2013, all seven lowest extents on record have occurred in the past seven years. Antarctica, on the other hand, had above-average sea ice extent throughout 2013, with 116 days of new daily high extent records, including a new daily maximum sea ice area of 19.57 million km2 reached on 1 October. ENSO-neutral conditions in the eastern central Pacific Ocean and a negative Pacific decadal oscillation pattern in the North Pacific had the largest impacts on the global sea surface temperature in 2013. The North Pacific reached a historic high temperature in 2013 and on balance the globally-averaged sea surface temperature was among the 10 highest on record. Overall, the salt content in nearsurface ocean waters increased while in intermediate waters it decreased. Global mean sea level continued to rise during 2013, on pace with a trend of 3.2 mm yr-1 over the past two decades. A portion of this trend (0.5 mm yr-1) has been attributed to natural variability associated with the Pacific decadal oscillation as well as to ongoing contributions from the melting of glaciers and ice sheets and ocean warming. Global tropical cyclone frequency during 2013 was slightly above average with a total of 94 storms, although the North Atlantic Basin had its quietest hurricane season since 1994. In the Western North Pacific Basin, Super Typhoon Haiyan, the deadliest tropical cyclone of 2013, had 1-minute sustained winds estimated to be 170 kt (87.5 m s-1) on 7 November, the highest wind speed ever assigned to a tropical cyclone. High storm surge was also associated with Haiyan as it made landfall over the central Philippines, an area where sea level is currently at historic highs, increasing by 200 mm since 1970. In the atmosphere, carbon dioxide, methane, and nitrous oxide all continued to increase in 2013. As in previous years, each of these major greenhouse gases once again reached historic high concentrations. In the Arctic, carbon dioxide and methane increased at the same rate as the global increase. These increases are likely due to export from lower latitudes rather than a consequence of increases in Arctic sources, such as thawing permafrost. At Mauna Loa, Hawaii, for the first time since measurements began in 1958, the daily average mixing ratio of carbon dioxide exceeded 400 ppm on 9 May. The state of these variables, along with dozens of others, and the 2013 climate conditions of regions around the world are discussed in further detail in this 24th edition of the State of the Climate series. © 2014, American Meteorological Society. All rights reserved