Reconciling Taking the Indian out of the Nurse

Currently, we are faced with an important equity gap and opportunity for nursing in higher education related to Indigenous Peoples and health. While Westernized higher education often marginalizes Indigenous Peoples, there is an important opportunity to respectfully engage with Indigenous Knowledges. Furthermore, broadening perspectives beyond a dominant Westernized worldview has the potential to advance higher education for Indigenous and non-Indigenous learners alike. We are concerned that ongoing assimilation of Indigenous learners poses a profound risk of social injustice that is contrary to the aim of higher education. In our effort to reconcile nursing education in this context, we offer this discussion paper of scholarly and grey literature interwoven with story work by Indigenous nursing students regarding their undergraduate experiences in the academy. Two significant interrelated gaps/opportunities are revealed: enactment of cultural safety and respectful engagement with Indigenous Knowledges. Action strategies include heart-mind knowledge connection, contextual learning, and two-way teaching and learning. It is our hope that this discussion will inspire critical conversations and meaningful action for educators to reconcile higher education and address structural racism. While reconciliation may be viewed as a duty in higher education and society, we further recognize it as a natural fit within the caring ethos of nursing. Résumé Nous sommes confrontés à d’importantes inégalités relativement à la santé des Autochtones et aux possibilités d’enseignement supérieur en sciences infirmières pour eux. Alors que l’enseignement supérieur occidentalisé marginalise souvent les peuples autochtones, il a une occasion de faire respectueusement appel à leurs Connaissances. S’ouvrir aux perspectives au-delà de la vision du monde occidentalisée dominante pourrait faire progresser l’enseignement supérieur pour les étudiants autochtones et non autochtones. Nous craignons que l’assimilation en cours des étudiants autochtones constitue un signe important d’injustice sociale contraire à l’objectif de l’enseignement supérieur. Dans un esprit de conciliation de la formation en sciences infirmières, nous proposons ce texte de discussion appuyé de publications universitaires, de la littérature grise et de récits d’étudiantes autochtones en sciences infirmières sur leur parcours universitaire au premier cycle. Deux importantes lacunes/possibilités étroitement inter-reliées ont été mises au jour : la mise en œuvre de la sécurité culturelle et le recours respectueux aux Connaissances Autochtones. Les stratégies d’action préconisées portent notamment sur l’ouverture cœur/esprit aux connaissances, l’apprentissage contextuel ainsi que l’enseignement et l’apprentissage bidirectionnels. Nous espérons que cette discussion inspirera d’importantes conversations et des actions significatives chez les enseignants en vue de rapprocher l’enseignement supérieur et de lutter contre le racisme structurel. Bien que la réconciliation puisse être considérée comme un devoir dans le domaine de l’enseignement supérieur et dans la société, nous reconnaissons également qu’il s’agit d’une adéquation naturelle au sein de la philosophie du soin en sciences infirmières

Flat GL(1∣1)GL(1|1)-connections and fatgraphs

We study the moduli space of flat $GL(1|1)$-connections on a punctured surface from the point of view of graph connections. To each fatgraph, a system of coordinates is assigned, which involves two bosonic and two fermionic variables per edge, subject to certain relations. In the case of trivalent graphs, we provide a closed explicit formula for the Whitehead moves. In addition, we discuss the invariant Poisson bracket.Comment: 13 page

Nursing, Indigenous Health, Water, and Climate Change

Nurses have a duty to uphold the right to health. Clean water is vital for health as an inclusive right for all people, yet access is threatened by climate change. Complex impacts of colonization on climate change has resulted in two key problems: lack of clean water access by Indigenous Peoples and marginalization of Indigenous traditional teachings that support water protection. Indigenous teachings of living in harmony with Mother Earth are important contributions to global water policy and health solutions.  Indigenous traditional laws on water protection may be understood through Indigenous water declarations. Nurses have an important opportunity to respect traditional teachings noting interconnections of health, water, and climate change to advance health. Water is life

iTools: A Framework for Classification, Categorization and Integration of Computational Biology Resources

The advancement of the computational biology field hinges on progress in three fundamental directions – the development of new computational algorithms, the availability of informatics resource management infrastructures and the capability of tools to interoperate and synergize. There is an explosion in algorithms and tools for computational biology, which makes it difficult for biologists to find, compare and integrate such resources. We describe a new infrastructure, iTools, for managing the query, traversal and comparison of diverse computational biology resources. Specifically, iTools stores information about three types of resources–data, software tools and web-services. The iTools design, implementation and resource meta - data content reflect the broad research, computational, applied and scientific expertise available at the seven National Centers for Biomedical Computing. iTools provides a system for classification, categorization and integration of different computational biology resources across space-and-time scales, biomedical problems, computational infrastructures and mathematical foundations. A large number of resources are already iTools-accessible to the community and this infrastructure is rapidly growing. iTools includes human and machine interfaces to its resource meta-data repository. Investigators or computer programs may utilize these interfaces to search, compare, expand, revise and mine meta-data descriptions of existent computational biology resources. We propose two ways to browse and display the iTools dynamic collection of resources. The first one is based on an ontology of computational biology resources, and the second one is derived from hyperbolic projections of manifolds or complex structures onto planar discs. iTools is an open source project both in terms of the source code development as well as its meta-data content. iTools employs a decentralized, portable, scalable and lightweight framework for long-term resource management. We demonstrate several applications of iTools as a framework for integrated bioinformatics. iTools and the complete details about its specifications, usage and interfaces are available at the iTools web page http://iTools.ccb.ucla.edu

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver

Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vitamin B12 and is associated with altered DNA methylation at birth. Altered DNA methylation may be an important mechanism underlying increased disease susceptibility; however, the extent to which this can be induced in the developing fetus is unknown. Methods: In this retrospective study, we measured concentrations of cobalt, vitamin B12, and mRNA transcripts encoding key enzymes in the 1-carbon cycle in 55 fetal human livers obtained from 11 to 21 weeks of gestation elective terminations and matched for gestation and maternal smoking. DNA methylation was measured at critical regions known to be susceptible to the in utero environment. Homocysteine concentrations were analyzed in plasma from 60 fetuses. Results: In addition to identifying baseline sex differences, we found that maternal smoking was associated with sex-specific alterations of fetal liver vitamin B12, plasma homocysteine and expression of enzymes in the 1-carbon cycle in fetal liver. In the majority of the measured parameters which showed a sex difference, maternal smoking reduced the magnitude of that difference. Maternal smoking also altered DNA methylation at the imprinted gene IGF2 and the glucocorticoid receptor (GR/NR3C1). Conclusions: Our unique data strengthen studies linking in utero exposures to altered DNA methylation by showing, for the first time, that such changes are present in fetal life and in a key metabolic target tissue, human fetal liver. Furthermore, these data propose a novel mechanism by which such changes are induced, namely through alterations in methyl donor availability and changes in 1-carbon metabolism

Exome-wide association study to identify rare variants influencing COVID-19 outcomes : Results from the Host Genetics Initiative

Publisher Copyright: Copyright: © 2022 Butler-Laporte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.Peer reviewe

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts